IRON

SEC source: 0000950170-25-019092 · ownership.xml · nonDerivative · entry 1

Franchi Jean M. · CIK 0001653053 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 72,666

F1 · shares: Represents restricted stock units ("RSUs"), each representing a contingent right to receive one share of the Issuer's Common Stock. The RSUs shall vest annually in four 25% installments commencing on February 15, 2026, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0000950170-25-019085 · ownership.xml · derivative · entry 6

Savage William Jacob · CIK 0001951852 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,000

Underlying: Common Stock · 36,000 shares

Expires 2035-02-09

F4 · derivative.exercise_date: The shares underlying this option vest in 48 equal monthly installments commencing on March 10, 2025, subject to the Reporting Person's continuted service on each such vesting date.

SEC source: 0000950170-25-019085 · ownership.xml · nonDerivative · entry 3

Savage William Jacob · CIK 0001951852 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 70,136

F1 · shares: Represents restricted stock units ("RSUs"), each representing a contingent right to receive one share of the Issuer's Common Stock. The RSUs shall vest annually in four 25% installments commencing on February 15, 2026, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0000950170-25-013714 · ownership.xml · derivative · entry 4

Khara Rahul · CIK 0001951850 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 64,804

Underlying: Common Stock · 7,500 shares

Expires 2032-02-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on September 25, 2024.

F4 · derivative.exercise_date: 25% of the shares underlying this option vested on December 20, 2022, with the remaining shares vesting in 36 equal monthly installments thereafter, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0000950170-25-013714 · ownership.xml · nonDerivative · entry 3

Khara Rahul · CIK 0001951850 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 14,035

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on September 25, 2024.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $55.87 to $56.28, inclusive.

SEC source: 0000950170-25-013714 · ownership.xml · nonDerivative · entry 2

Khara Rahul · CIK 0001951850 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,848

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on September 25, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $54.87 to $55.85, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) and (3) to this Form 4.

SEC source: 0000950170-25-013714 · ownership.xml · nonDerivative · entry 1

Khara Rahul · CIK 0001951850 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 21,535

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on September 25, 2024.

SEC source: 0000950170-25-019085 · ownership.xml · derivative · entry 5

Savage William Jacob · CIK 0001951852 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,498 shares

Expires 2030-10-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: 2,140 shares underlying this option vested on August 3, 2021, with the remaining shares vesting in 38 equal monthly installments thereafter, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0000950170-25-019085 · ownership.xml · derivative · entry 4

Savage William Jacob · CIK 0001951852 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 4,233 shares

Expires 2030-08-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: 25% of the shares underlying this option vested on August 3, 2021, with the remaining shares vesting in 36 equal monthly installments thereafter, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0000950170-25-019085 · ownership.xml · nonDerivative · entry 2

Savage William Jacob · CIK 0001951852 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 46,136

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-25-019085 · ownership.xml · nonDerivative · entry 1

Savage William Jacob · CIK 0001951852 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 44,638

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-25-002373 · ownership.xml · derivative · entry 5

Khara Rahul · CIK 0001951850 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 72,304

Underlying: Common Stock · 7,500 shares

Expires 2032-02-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on September 25, 2024.

F5 · derivative.exercise_date: 25% of the shares underlying this option vested on December 20, 2022, with the remaining shares vesting in 36 equal monthly installments thereafter, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0000950170-25-002373 · ownership.xml · nonDerivative · entry 4

Khara Rahul · CIK 0001951850 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 14,035

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on September 25, 2024.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $63.83 to $64.54, inclusive.

SEC source: 0000950170-25-002373 · ownership.xml · nonDerivative · entry 3

Khara Rahul · CIK 0001951850 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 16,135

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on September 25, 2024.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $62.56 to $63.48, inclusive.

SEC source: 0000950170-25-002373 · ownership.xml · nonDerivative · entry 2

Khara Rahul · CIK 0001951850 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 17,535

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on September 25, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $61.52 to $62.49, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (3) and (4) to this Form 4.

SEC source: 0000950170-25-002373 · ownership.xml · nonDerivative · entry 1

Khara Rahul · CIK 0001951850 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 21,535

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on September 25, 2024.

SEC source: 0000950170-25-000617 · ownership.xml · derivative · entry 6

Quisel John D · CIK 0001586788 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 215,420

Underlying: Common Stock · 10,000 shares

Expires 2030-03-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The shares underlying this option are fully vested and exercisable as of the date hereof.

SEC source: 0000950170-25-000617 · ownership.xml · nonDerivative · entry 4

Quisel John D · CIK 0001586788 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 82,065

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-25-000617 · ownership.xml · derivative · entry 5

Quisel John D · CIK 0001586788 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 155,375

Underlying: Common Stock · 13,012 shares

Expires 2031-09-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 2, 2024.

F4 · derivative.exercise_date: The shares underlying this option vest in 48 equal monthly installments following September 1, 2021, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0000950170-25-000617 · ownership.xml · nonDerivative · entry 3

Quisel John D · CIK 0001586788 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 72,065

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 2, 2024.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $62.31 to $62.58, inclusive.

SEC source: 0000950170-25-000617 · ownership.xml · nonDerivative · entry 2

Quisel John D · CIK 0001586788 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 73,965

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 2, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $61.29 to $62.27, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) and (3) to this Form 4.

SEC source: 0000950170-25-000617 · ownership.xml · nonDerivative · entry 1

Quisel John D · CIK 0001586788 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 85,077

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 2, 2024.

SEC source: 0000950170-24-140502 · ownership.xml · derivative · entry 5

Quisel John D · CIK 0001586788 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 41,830

Underlying: Common Stock · 19,820 shares

Expires 2030-10-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 2, 2024.

F5 · derivative.exercise_date: The shares underlying this option are fully vested and exercisable as of the date hereof.

SEC source: 0000950170-24-140502 · ownership.xml · nonDerivative · entry 4

Quisel John D · CIK 0001586788 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 72,065

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 2, 2024.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $63.695 to $63.86, inclusive.

SEC source: 0000950170-24-140502 · ownership.xml · nonDerivative · entry 3

Quisel John D · CIK 0001586788 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 76,277

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 2, 2024.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $62.66 to $63.655, inclusive.

SEC source: 0000950170-24-140502 · ownership.xml · nonDerivative · entry 2

Quisel John D · CIK 0001586788 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 88,471

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 2, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $61.66 to $62.65, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (3) and (4) to this Form 4.

SEC source: 0000950170-24-140502 · ownership.xml · nonDerivative · entry 1

Quisel John D · CIK 0001586788 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 91,885

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 2, 2024.

SEC source: 0000950170-24-138086 · ownership.xml · derivative · entry 6

Quisel John D · CIK 0001586788 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 225,420

Underlying: Common Stock · 12,791 shares

Expires 2030-03-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 2, 2024.

F6 · derivative.exercise_date: The shares underlying this option are fully vested and exercisable as of the date hereof.

SEC source: 0000950170-24-138086 · ownership.xml · nonDerivative · entry 5

Quisel John D · CIK 0001586788 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 72,065

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 2, 2024.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $67.04 to $67.54, inclusive.

SEC source: 0000950170-24-138086 · ownership.xml · nonDerivative · entry 4

Quisel John D · CIK 0001586788 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 72,565

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 2, 2024.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $66.04 to $67.01, inclusive.

SEC source: 0000950170-24-138086 · ownership.xml · nonDerivative · entry 3

Quisel John D · CIK 0001586788 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 78,870

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 2, 2024.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $65.04 to $66.03, inclusive.

SEC source: 0000950170-24-138086 · ownership.xml · nonDerivative · entry 2

Quisel John D · CIK 0001586788 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 84,637

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 2, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $64.04 to $65.02, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (3), (4) and (5) to this Form 4.

SEC source: 0000950170-24-138086 · ownership.xml · nonDerivative · entry 1

Quisel John D · CIK 0001586788 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 84,856

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 2, 2024.

SEC source: 0000950170-24-133441 · ownership.xml · derivative · entry 7

White William Richard · CIK 0001778739 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,804

Underlying: Common Stock · 201 shares

Expires 2031-09-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on December 13, 2023.

F6 · derivative.exercise_date: The shares underlying this option vest in 48 equal monthly installments following September 1, 2021, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0000950170-24-133441 · ownership.xml · derivative · entry 6

White William Richard · CIK 0001778739 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,756 shares

Expires 2030-11-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on December 13, 2023.

F5 · derivative.exercise_date: The shares underlying this option vest in 16 equal quarterly installments following November 27, 2020, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0000950170-24-133441 · ownership.xml · nonDerivative · entry 5

White William Richard · CIK 0001778739 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on December 13, 2023.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $65.185 to $65.495, inclusive.

SEC source: 0000950170-24-133441 · ownership.xml · nonDerivative · entry 4

White William Richard · CIK 0001778739 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 173

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on December 13, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $64.185 to $65.15, inclusive.

SEC source: 0000950170-24-133441 · ownership.xml · nonDerivative · entry 3

White William Richard · CIK 0001778739 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,935

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on December 13, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $63.16 to $63.895, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (3) and (4) to this Form 4.

SEC source: 0000950170-24-133441 · ownership.xml · nonDerivative · entry 2

White William Richard · CIK 0001778739 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,957

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on December 13, 2023.

SEC source: 0000950170-24-133441 · ownership.xml · nonDerivative · entry 1

White William Richard · CIK 0001778739 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,756

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on December 13, 2023.

SEC source: 0000950170-24-131211 · ownership.xml · derivative · entry 7

Savage William Jacob · CIK 0001951852 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 30,004

Underlying: Common Stock · 8,920 shares

Expires 2032-12-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 18, 2024.

F6 · derivative.exercise_date: The shares underlying this option vest in 48 equal monthly installments following December 29, 2022, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0000950170-24-131211 · ownership.xml · derivative · entry 6

Savage William Jacob · CIK 0001951852 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,258

Underlying: Common Stock · 5,263 shares

Expires 2031-09-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 18, 2024.

F5 · derivative.exercise_date: The shares underlying this option vest in 48 equal monthly installments following July 1, 2021, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0000950170-24-131211 · ownership.xml · nonDerivative · entry 5

Savage William Jacob · CIK 0001951852 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 40,405

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 18, 2024.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $66.44 to $67.32, inclusive.

SEC source: 0000950170-24-131211 · ownership.xml · nonDerivative · entry 4

Savage William Jacob · CIK 0001951852 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 42,309

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 18, 2024.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $65.44 to $66.41, inclusive.

SEC source: 0000950170-24-131211 · ownership.xml · nonDerivative · entry 3

Savage William Jacob · CIK 0001951852 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 45,851

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 18, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $64.44 to $65.43, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (3) and (4) to this Form 4.

SEC source: 0000950170-24-131211 · ownership.xml · nonDerivative · entry 2

Savage William Jacob · CIK 0001951852 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 54,588

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 18, 2024.

SEC source: 0000950170-24-131211 · ownership.xml · nonDerivative · entry 1

Savage William Jacob · CIK 0001951852 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 45,668

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 18, 2024.

SEC source: 0000950170-24-128925 · ownership.xml · derivative · entry 5

Savage William Jacob · CIK 0001951852 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 36,034

Underlying: Common Stock · 9,158 shares

Expires 2031-09-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 18, 2024.

F4 · derivative.exercise_date: The shares underlying this option vest in 48 equal monthly installments following September 1, 2021, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0000950170-24-128925 · ownership.xml · nonDerivative · entry 4

Savage William Jacob · CIK 0001951852 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 40,405

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 18, 2024.

SEC source: 0000950170-24-128925 · ownership.xml · nonDerivative · entry 3

Savage William Jacob · CIK 0001951852 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 40,505

F1 · kind: The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on July 18, 2024.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $59.92 to $60.54, inclusive.