INO

SEC source: 0001770390-26-000003 · wk-form4_1772747737.xml · derivative · entry 1

Humeau Laurent · CIK 0001770390 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,840

Underlying: Common Stock · 26,840 shares

Expires 2036-02-26

F1 · derivative.exercise_date: The vesting schedule for the 26,840 options granted on March 4, 2026 was as follows: 8,947 shares will vest on February 26, 2027; 8,947 shares will vest on February 26, 2028; 8,946 shares will vest on February 26, 2029.

SEC source: 0001771498-26-000003 · wk-form4_1772747707.xml · derivative · entry 2

Shea Jacqueline Elizabeth · CIK 0001771498 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 78,760

Underlying: Common Stock · 78,760 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 78,760 restricted stock units granted on March 4, 2026 was as follows: 26,254 shares will vest on February 26, 2027; 26,253 shares will vest on February 26, 2028; and 26,253 shares will vest on February 26, 2029. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F2 · derivative.exercise_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 78,760 restricted stock units granted on March 4, 2026 was as follows: 26,254 shares will vest on February 26, 2027; 26,253 shares will vest on February 26, 2028; and 26,253 shares will vest on February 26, 2029. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F2 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 78,760 restricted stock units granted on March 4, 2026 was as follows: 26,254 shares will vest on February 26, 2027; 26,253 shares will vest on February 26, 2028; and 26,253 shares will vest on February 26, 2029. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

SEC source: 0001771498-26-000003 · wk-form4_1772747707.xml · derivative · entry 1

Shea Jacqueline Elizabeth · CIK 0001771498 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 97,240

Underlying: Common Stock · 97,240 shares

Expires 2036-02-26

F1 · derivative.exercise_date: The vesting schedule for the 97,240 options granted on March 4, 2026 was as follows: 32,414 shares will vest on February 26, 2027; 32,413 shares will vest on February 26, 2028; 32,413 shares will vest on February 26, 2029.

SEC source: 0001936799-26-000003 · wk-form4_1772747679.xml · derivative · entry 2

Sumner Michael John · CIK 0001936799 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,608

Underlying: Common Stock · 29,608 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 29,608 restricted stock units granted on March 4, 2026 was as follows: 9,870 shares will vest on February 26, 2027; 9,869 shares will vest on February 26, 2028; and 9,869 shares will vest on February 26, 2029. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F2 · derivative.exercise_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 29,608 restricted stock units granted on March 4, 2026 was as follows: 9,870 shares will vest on February 26, 2027; 9,869 shares will vest on February 26, 2028; and 9,869 shares will vest on February 26, 2029. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F2 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 29,608 restricted stock units granted on March 4, 2026 was as follows: 9,870 shares will vest on February 26, 2027; 9,869 shares will vest on February 26, 2028; and 9,869 shares will vest on February 26, 2029. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

SEC source: 0001936799-26-000003 · wk-form4_1772747679.xml · derivative · entry 1

Sumner Michael John · CIK 0001936799 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,832

Underlying: Common Stock · 36,832 shares

Expires 2036-02-26

F1 · derivative.exercise_date: The vesting schedule for the 36,832 options granted on March 4, 2026 was as follows: 12,278 shares will vest on February 26, 2027; 12,277 shares will vest on February 26, 2028; 12,277 shares will vest on February 26, 2029.

SEC source: 0001259780-26-000004 · wk-form4_1772747645.xml · derivative · entry 2

KIES PETER · CIK 0001259780 · CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,520

Underlying: Common Stock · 25,520 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 25,520 restricted stock units granted on March 4, 2026 was as follows: 8,507 shares will vest on February 26, 2027; 8,507 shares will vest on February 26, 2028; and 8,506 shares will vest on February 26, 2029. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F2 · derivative.exercise_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 25,520 restricted stock units granted on March 4, 2026 was as follows: 8,507 shares will vest on February 26, 2027; 8,507 shares will vest on February 26, 2028; and 8,506 shares will vest on February 26, 2029. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F2 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 25,520 restricted stock units granted on March 4, 2026 was as follows: 8,507 shares will vest on February 26, 2027; 8,507 shares will vest on February 26, 2028; and 8,506 shares will vest on February 26, 2029. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

SEC source: 0001259780-26-000004 · wk-form4_1772747645.xml · derivative · entry 1

KIES PETER · CIK 0001259780 · CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,240

Underlying: Common Stock · 31,240 shares

Expires 2036-02-26

F1 · derivative.exercise_date: The vesting schedule for the 31,240 options granted on March 4, 2026 was as follows: 10,414 shares will vest on February 26, 2027; 10,413 shares will vest on February 26, 2028; 10,413 shares will vest on February 26, 2029.

SEC source: 0001770390-26-000002 · wk-form4_1772228940.xml · derivative · entry 6

Humeau Laurent · CIK 0001770390 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,732

Underlying: Common Stock · 7,366 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 22,098 restricted stock units granted on February 27, 2025 was as follows: 7,366 shares vested on February 26, 2026; 7,366 shares will vest on February 26, 2027; 7,366 shares will vest on February 26, 2028. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F3 · derivative.exercise_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 22,098 restricted stock units granted on February 27, 2025 was as follows: 7,366 shares vested on February 26, 2026; 7,366 shares will vest on February 26, 2027; 7,366 shares will vest on February 26, 2028. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F3 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 22,098 restricted stock units granted on February 27, 2025 was as follows: 7,366 shares vested on February 26, 2026; 7,366 shares will vest on February 26, 2027; 7,366 shares will vest on February 26, 2028. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

SEC source: 0001770390-26-000002 · wk-form4_1772228940.xml · derivative · entry 5

Humeau Laurent · CIK 0001770390 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,009

Underlying: Common Stock · 5,010 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 15,029 restricted stock units granted on February 28, 2024 was as follows: 5,010 shares vested on February 26, 2025; 5,010 shares vested on February 26, 2026; and 5,009 shares will vest on February 26, 2027. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F1 · derivative.exercise_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 15,029 restricted stock units granted on February 28, 2024 was as follows: 5,010 shares vested on February 26, 2025; 5,010 shares vested on February 26, 2026; and 5,009 shares will vest on February 26, 2027. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F1 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 15,029 restricted stock units granted on February 28, 2024 was as follows: 5,010 shares vested on February 26, 2025; 5,010 shares vested on February 26, 2026; and 5,009 shares will vest on February 26, 2027. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

SEC source: 0001770390-26-000002 · wk-form4_1772228940.xml · nonDerivative · entry 4

Humeau Laurent · CIK 0001770390 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,900

F4 · shares: The transaction reported represents the withholding of shares by the issuer to satisfy the reporting person's tax withholding obligations in connection with the vesting and settlement of the restricted stock unit award reported in the immediately preceding row and described in footnote (3) herein.

SEC source: 0001770390-26-000002 · wk-form4_1772228940.xml · nonDerivative · entry 3

Humeau Laurent · CIK 0001770390 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,934

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 22,098 restricted stock units granted on February 27, 2025 was as follows: 7,366 shares vested on February 26, 2026; 7,366 shares will vest on February 26, 2027; 7,366 shares will vest on February 26, 2028. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

SEC source: 0001770390-26-000002 · wk-form4_1772228940.xml · nonDerivative · entry 2

Humeau Laurent · CIK 0001770390 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,568

F2 · shares: The transaction reported represents the withholding of shares by the issuer to satisfy the reporting person's tax withholding obligations in connection with the vesting and settlement of the restricted stock unit award reported in the immediately preceding row and described in footnote (1) herein.

SEC source: 0001770390-26-000002 · wk-form4_1772228940.xml · nonDerivative · entry 1

Humeau Laurent · CIK 0001770390 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,632

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 15,029 restricted stock units granted on February 28, 2024 was as follows: 5,010 shares vested on February 26, 2025; 5,010 shares vested on February 26, 2026; and 5,009 shares will vest on February 26, 2027. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

SEC source: 0001259780-26-000002 · wk-form4_1772228904.xml · derivative · entry 7

KIES PETER · CIK 0001259780 · CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,266

Underlying: Common Stock · 10,634 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 31,900 restricted stock units granted on February 27, 2025 was as follows: 10,634 shares vested on February 26, 2026; 10,633 shares will vest on February 26, 2027; 10,633 shares will vest on February 26, 2028. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F3 · derivative.exercise_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 31,900 restricted stock units granted on February 27, 2025 was as follows: 10,634 shares vested on February 26, 2026; 10,633 shares will vest on February 26, 2027; 10,633 shares will vest on February 26, 2028. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F3 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 31,900 restricted stock units granted on February 27, 2025 was as follows: 10,634 shares vested on February 26, 2026; 10,633 shares will vest on February 26, 2027; 10,633 shares will vest on February 26, 2028. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

SEC source: 0001259780-26-000002 · wk-form4_1772228904.xml · derivative · entry 6

KIES PETER · CIK 0001259780 · CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,009

Underlying: Common Stock · 5,010 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 15,029 restricted stock units granted on February 28, 2024 was as follows: 5,010 shares vested on February 26, 2025; 5,010 shares vested on February 26, 2026; and 5,009 shares will vest on February 26, 2027. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F1 · derivative.exercise_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 15,029 restricted stock units granted on February 28, 2024 was as follows: 5,010 shares vested on February 26, 2025; 5,010 shares vested on February 26, 2026; and 5,009 shares will vest on February 26, 2027. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F1 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 15,029 restricted stock units granted on February 28, 2024 was as follows: 5,010 shares vested on February 26, 2025; 5,010 shares vested on February 26, 2026; and 5,009 shares will vest on February 26, 2027. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

SEC source: 0001259780-26-000002 · wk-form4_1772228904.xml · nonDerivative · entry 4

KIES PETER · CIK 0001259780 · CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,642

F4 · shares: The transaction reported represents the withholding of shares by the issuer to satisfy the reporting person's tax withholding obligations in connection with the vesting and settlement of the restricted stock unit award reported in the immediately preceding row and described in footnote (3) herein.

SEC source: 0001259780-26-000002 · wk-form4_1772228904.xml · nonDerivative · entry 3

KIES PETER · CIK 0001259780 · CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,936

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 31,900 restricted stock units granted on February 27, 2025 was as follows: 10,634 shares vested on February 26, 2026; 10,633 shares will vest on February 26, 2027; 10,633 shares will vest on February 26, 2028. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

SEC source: 0001259780-26-000002 · wk-form4_1772228904.xml · nonDerivative · entry 2

KIES PETER · CIK 0001259780 · CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,302

F2 · shares: The transaction reported represents the withholding of shares by the issuer to satisfy the reporting person's tax withholding obligations in connection with the vesting and settlement of the restricted stock unit award reported in the immediately preceding row and described in footnote (1) herein.

SEC source: 0001259780-26-000002 · wk-form4_1772228904.xml · nonDerivative · entry 1

KIES PETER · CIK 0001259780 · CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,267

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 15,029 restricted stock units granted on February 28, 2024 was as follows: 5,010 shares vested on February 26, 2025; 5,010 shares vested on February 26, 2026; and 5,009 shares will vest on February 26, 2027. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

SEC source: 0001936799-26-000002 · wk-form4_1772228830.xml · derivative · entry 5

Sumner Michael John · CIK 0001936799 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,100

Underlying: Common Stock · 11,550 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 34,650 restricted stock units granted on February 27, 2025 was as follows: 11,550 shares vested on February 26, 2026; 11,550 shares will vest on February 26, 2027; 11,550 shares will vest on February 26, 2028. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F2 · derivative.exercise_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 34,650 restricted stock units granted on February 27, 2025 was as follows: 11,550 shares vested on February 26, 2026; 11,550 shares will vest on February 26, 2027; 11,550 shares will vest on February 26, 2028. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F2 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 34,650 restricted stock units granted on February 27, 2025 was as follows: 11,550 shares vested on February 26, 2026; 11,550 shares will vest on February 26, 2027; 11,550 shares will vest on February 26, 2028. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

SEC source: 0001936799-26-000002 · wk-form4_1772228830.xml · derivative · entry 4

Sumner Michael John · CIK 0001936799 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,009

Underlying: Common Stock · 5,010 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 15,029 restricted stock units granted on February 28, 2024 was as follows: 5,010 shares vested on February 26, 2025; 5,010 shares vested on February 26, 2026; and 5,009 shares will vest on February 26, 2027. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F1 · derivative.exercise_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 15,029 restricted stock units granted on February 28, 2024 was as follows: 5,010 shares vested on February 26, 2025; 5,010 shares vested on February 26, 2026; and 5,009 shares will vest on February 26, 2027. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F1 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 15,029 restricted stock units granted on February 28, 2024 was as follows: 5,010 shares vested on February 26, 2025; 5,010 shares vested on February 26, 2026; and 5,009 shares will vest on February 26, 2027. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

SEC source: 0001936799-26-000002 · wk-form4_1772228830.xml · nonDerivative · entry 3

Sumner Michael John · CIK 0001936799 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,507

F3 · shares: The transaction reported represents the withholding of shares by the issuer to satisfy the reporting person's tax withholding obligations in connection with the vesting and settlement of the restricted stock unit award reported in the immediately preceding row and described in footnote (2) herein.

SEC source: 0001936799-26-000002 · wk-form4_1772228830.xml · nonDerivative · entry 2

Sumner Michael John · CIK 0001936799 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,410

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · price: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 34,650 restricted stock units granted on February 27, 2025 was as follows: 11,550 shares vested on February 26, 2026; 11,550 shares will vest on February 26, 2027; 11,550 shares will vest on February 26, 2028. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

SEC source: 0001936799-26-000002 · wk-form4_1772228830.xml · nonDerivative · entry 1

Sumner Michael John · CIK 0001936799 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,860

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 15,029 restricted stock units granted on February 28, 2024 was as follows: 5,010 shares vested on February 26, 2025; 5,010 shares vested on February 26, 2026; and 5,009 shares will vest on February 26, 2027. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

SEC source: 0001771498-26-000002 · wk-form4_1772228868.xml · derivative · entry 6

Shea Jacqueline Elizabeth · CIK 0001771498 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 56,800

Underlying: Common Stock · 28,401 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 85,201 restricted stock units granted on February 27, 2025 was as follows: 28,401 shares vested on February 26, 2026; 28,400 shares will vest on February 26, 2027; 28,400 shares will vest on February 26, 2028. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F3 · derivative.exercise_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 85,201 restricted stock units granted on February 27, 2025 was as follows: 28,401 shares vested on February 26, 2026; 28,400 shares will vest on February 26, 2027; 28,400 shares will vest on February 26, 2028. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F3 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 85,201 restricted stock units granted on February 27, 2025 was as follows: 28,401 shares vested on February 26, 2026; 28,400 shares will vest on February 26, 2027; 28,400 shares will vest on February 26, 2028. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

SEC source: 0001771498-26-000002 · wk-form4_1772228868.xml · derivative · entry 5

Shea Jacqueline Elizabeth · CIK 0001771498 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,631

Underlying: Common Stock · 18,632 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 55,895 restricted stock units granted on February 28, 2024 was as follows: 18,632 shares vested on February 26, 2025; 18,632 shares vested on February 26, 2026; and 18,631 shares will vest on February 26, 2027. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F1 · derivative.exercise_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 55,895 restricted stock units granted on February 28, 2024 was as follows: 18,632 shares vested on February 26, 2025; 18,632 shares vested on February 26, 2026; and 18,631 shares will vest on February 26, 2027. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F1 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 55,895 restricted stock units granted on February 28, 2024 was as follows: 18,632 shares vested on February 26, 2025; 18,632 shares vested on February 26, 2026; and 18,631 shares will vest on February 26, 2027. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

SEC source: 0001771498-26-000002 · wk-form4_1772228868.xml · nonDerivative · entry 4

Shea Jacqueline Elizabeth · CIK 0001771498 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 85,004

F4 · shares: The transaction reported represents the withholding of shares by the issuer to satisfy the reporting person's tax withholding obligations in connection with the vesting and settlement of the restricted stock unit award reported in the immediately preceding row and described in footnote (3) herein.

SEC source: 0001771498-26-000002 · wk-form4_1772228868.xml · nonDerivative · entry 3

Shea Jacqueline Elizabeth · CIK 0001771498 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 98,661

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 85,201 restricted stock units granted on February 27, 2025 was as follows: 28,401 shares vested on February 26, 2026; 28,400 shares will vest on February 26, 2027; 28,400 shares will vest on February 26, 2028. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

SEC source: 0001771498-26-000002 · wk-form4_1772228868.xml · nonDerivative · entry 2

Shea Jacqueline Elizabeth · CIK 0001771498 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 70,260

F2 · shares: The transaction reported represents the withholding of shares by the issuer to satisfy the reporting person's tax withholding obligations in connection with the vesting and settlement of the restricted stock unit award reported in the immediately preceding row and described in footnote (1) herein.

SEC source: 0001771498-26-000002 · wk-form4_1772228868.xml · nonDerivative · entry 1

Shea Jacqueline Elizabeth · CIK 0001771498 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 78,317

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 55,895 restricted stock units granted on February 28, 2024 was as follows: 18,632 shares vested on February 26, 2025; 18,632 shares vested on February 26, 2026; and 18,631 shares will vest on February 26, 2027. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

SEC source: 0001669080-26-000002 · wk-form4_1772228657.xml · derivative · entry 2

Weiner David B. · CIK 0001669080 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 972 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 2,916 restricted stock units granted on February 27, 2023 was as follows: 972 shares vested on February 26, 2024; 972 shares vested on February 26, 2025; and 972 shares vested on February 26, 2026. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F1 · derivative.exercise_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 2,916 restricted stock units granted on February 27, 2023 was as follows: 972 shares vested on February 26, 2024; 972 shares vested on February 26, 2025; and 972 shares vested on February 26, 2026. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F1 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 2,916 restricted stock units granted on February 27, 2023 was as follows: 972 shares vested on February 26, 2024; 972 shares vested on February 26, 2025; and 972 shares vested on February 26, 2026. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

SEC source: 0001669080-26-000002 · wk-form4_1772228657.xml · nonDerivative · entry 1

Weiner David B. · CIK 0001669080 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 87,592

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 2,916 restricted stock units granted on February 27, 2023 was as follows: 972 shares vested on February 26, 2024; 972 shares vested on February 26, 2025; and 972 shares vested on February 26, 2026. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

SEC source: 0001055726-25-000046 · wk-form4_1751400477.xml · derivative · entry 2

Sumner Michael John · CIK 0001936799 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,916 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 8,749 restricted stock units was as follows: 2,916 shares vested on June 30, 2023; 2,917 shares vested on June 30, 2024; and 2,916 shares vested on June 30, 2025. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F1 · derivative.exercise_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 8,749 restricted stock units was as follows: 2,916 shares vested on June 30, 2023; 2,917 shares vested on June 30, 2024; and 2,916 shares vested on June 30, 2025. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F1 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 8,749 restricted stock units was as follows: 2,916 shares vested on June 30, 2023; 2,917 shares vested on June 30, 2024; and 2,916 shares vested on June 30, 2025. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

SEC source: 0001055726-25-000046 · wk-form4_1751400477.xml · nonDerivative · entry 1

Sumner Michael John · CIK 0001936799 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,850

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 8,749 restricted stock units was as follows: 2,916 shares vested on June 30, 2023; 2,917 shares vested on June 30, 2024; and 2,916 shares vested on June 30, 2025. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

SEC source: 0001055726-25-000040 · wk-form4_1747861110.xml · derivative · entry 2

Zoth Lota S. · CIK 0001278219 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,167 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

F1 · derivative.exercise_date: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

F1 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

SEC source: 0001055726-25-000040 · wk-form4_1747861110.xml · nonDerivative · entry 1

Zoth Lota S. · CIK 0001278219 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,726

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

SEC source: 0001055726-25-000039 · wk-form4_1747861099.xml · derivative · entry 2

Miller Ann Calby · CIK 0001771423 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,167 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

F1 · derivative.exercise_date: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

F1 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

SEC source: 0001055726-25-000039 · wk-form4_1747861099.xml · nonDerivative · entry 1

Miller Ann Calby · CIK 0001771423 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,877

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

SEC source: 0001055726-25-000038 · wk-form4_1747861088.xml · derivative · entry 2

Shepard Jay · CIK 0001587788 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,167 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

F1 · derivative.exercise_date: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

F1 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

SEC source: 0001055726-25-000038 · wk-form4_1747861088.xml · nonDerivative · entry 1

Shepard Jay · CIK 0001587788 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,209

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

SEC source: 0001055726-25-000037 · wk-form4_1747861076.xml · derivative · entry 2

BENITO SIMON X · CIK 0001273306 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,167 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

F1 · derivative.exercise_date: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

F1 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

SEC source: 0001055726-25-000037 · wk-form4_1747861076.xml · nonDerivative · entry 1

BENITO SIMON X · CIK 0001273306 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,191

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

SEC source: 0001055726-25-000036 · wk-form4_1747861066.xml · derivative · entry 2

YARNO WENDY L · CIK 0001181186 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,167 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

F1 · derivative.exercise_date: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

F1 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

SEC source: 0001055726-25-000036 · wk-form4_1747861066.xml · nonDerivative · entry 1

YARNO WENDY L · CIK 0001181186 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,512

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

SEC source: 0001055726-25-000034 · wk-form4_1747861045.xml · derivative · entry 2

DANSEY ROGER D · CIK 0001741836 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,167 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

F1 · derivative.exercise_date: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

F1 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

SEC source: 0001055726-25-000034 · wk-form4_1747861045.xml · nonDerivative · entry 1

DANSEY ROGER D · CIK 0001741836 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,916

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

SEC source: 0001055726-25-000032 · wk-form4_1747861024.xml · derivative · entry 2

Weiner David B. · CIK 0001669080 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,167 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

F1 · derivative.exercise_date: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

F1 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

SEC source: 0001055726-25-000032 · wk-form4_1747861024.xml · nonDerivative · entry 1

Weiner David B. · CIK 0001669080 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 86,620

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vested 100% on May 21, 2025.

SEC source: 0001055726-25-000042 · wk-form4_1747861132.xml · derivative · entry 2

Shea Jacqueline Elizabeth · CIK 0001771498 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 105,262

Underlying: Common Stock · 105,262 shares

Expires 2035-05-20

F2 · derivative.exercise_date: The vesting schedule for the 105,262 options is as follows: 52,631 shares will vest on May 20, 2027 and 52,631 shares will vest on May 20, 2028.

SEC source: 0001055726-25-000042 · wk-form4_1747861132.xml · derivative · entry 1

Shea Jacqueline Elizabeth · CIK 0001771498 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 84,888

Underlying: Common Stock · 84,888 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 84,888 restricted stock units is as follows: 28,296 shares will vest on May 20, 2026; 28,296 shares will vest on May 20, 2027; and 28,296 shares will vest on May 20, 2028. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F1 · derivative.exercise_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 84,888 restricted stock units is as follows: 28,296 shares will vest on May 20, 2026; 28,296 shares will vest on May 20, 2027; and 28,296 shares will vest on May 20, 2028. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.

F1 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 84,888 restricted stock units is as follows: 28,296 shares will vest on May 20, 2026; 28,296 shares will vest on May 20, 2027; and 28,296 shares will vest on May 20, 2028. Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.