IMNM

SEC source: 0001405684-26-000003 · form4-06122026_090615.xml · derivative · entry 1

WAGENHEIM PHILIP · CIK 0001405684 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,897

Underlying: Common Stock · 9,897 shares

Expires 2036-06-09

F1 · derivative.exercise_date: The option vests in four equal quarterly installments, commencing from June 10, 2026 until the one-year anniversary thereafter, occurring on the same day of each succeeding fiscal quarter, subject to the Reporting Person's continuous service with the Company on each respective vesting date.

SEC source: 0001953094-26-000002 · form4-06122026_090648.xml · derivative · entry 1

Boylan James P · CIK 0001953094 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,897

Underlying: Common Stock · 9,897 shares

Expires 2036-06-09

F1 · shares: Mr. Boylan has agreed to receive and hold for the benefit of Enavate Sciences, LP, any securities granted to him for his service as a director on the Company's board of directors. As such, Mr. Boylan disclaims beneficial ownership of, and all right, title and interest in, the reported securities.

F2 · derivative.exercise_date: The option vests in four equal quarterly installments, commencing from June 10, 2026 until the one-year anniversary thereafter, occurring on the same day of each succeeding fiscal quarter, subject to the Mr. Boylan's continuous service with the Company on each respective vesting date.

SEC source: 0001221590-26-000018 · form4-06122026_090608.xml · derivative · entry 1

BIENAIME JEAN JACQUES · CIK 0001221590 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,897

Underlying: Common Stock · 9,897 shares

Expires 2036-06-09

F1 · derivative.exercise_date: The option vests in four equal quarterly installments, commencing from June 10, 2026 until the one-year anniversary thereafter, occurring on the same day of each succeeding fiscal quarter, subject to the Reporting Person's continuous service with the Company on each respective vesting date.

SEC source: 0001272181-26-000006 · form4-06122026_090636.xml · derivative · entry 1

SCHAFER CAROL · CIK 0001272181 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,897

Underlying: Common Stock · 9,897 shares

Expires 2036-06-09

F1 · derivative.exercise_date: The option vests in four equal quarterly installments, commencing from June 10, 2026 until the one-year anniversary thereafter, occurring on the same day of each succeeding fiscal quarter, subject to the Reporting Person's continuous service with the Company on each respective vesting date.

SEC source: 0001221590-26-000015 · form4-06092026_090607.xml · nonDerivative · entry 5

BIENAIME JEAN JACQUES · CIK 0001221590 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,415

F1 · kind: The sales by the reporting person reported herein were matchable under Section 16(b) of the Securities Exchange Act of 1934 with the purchase of 1,000 shares of the Issuer's common stock by the reporting person at the price of $19.27 per share on June 5, 2026. The reporting person has agreed to pay to the Issuer upon settlement of the sale, $155, representing the full amount of the profit realized in connection with the short-swing transaction.

F2 · kind: The reporting person sold and reacquired the same aggregate number of shares on June 5, 2026.

SEC source: 0001221590-26-000015 · form4-06092026_090607.xml · nonDerivative · entry 4

BIENAIME JEAN JACQUES · CIK 0001221590 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,415

F2 · kind: The reporting person sold and reacquired the same aggregate number of shares on June 5, 2026.

SEC source: 0001221590-26-000015 · form4-06092026_090607.xml · nonDerivative · entry 3

BIENAIME JEAN JACQUES · CIK 0001221590 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 38,915

F2 · kind: The reporting person sold and reacquired the same aggregate number of shares on June 5, 2026.

SEC source: 0001221590-26-000015 · form4-06092026_090607.xml · nonDerivative · entry 2

BIENAIME JEAN JACQUES · CIK 0001221590 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,915

F1 · kind: The sales by the reporting person reported herein were matchable under Section 16(b) of the Securities Exchange Act of 1934 with the purchase of 1,000 shares of the Issuer's common stock by the reporting person at the price of $19.27 per share on June 5, 2026. The reporting person has agreed to pay to the Issuer upon settlement of the sale, $155, representing the full amount of the profit realized in connection with the short-swing transaction.

F2 · kind: The reporting person sold and reacquired the same aggregate number of shares on June 5, 2026.

SEC source: 0001221590-26-000015 · form4-06092026_090607.xml · nonDerivative · entry 1

BIENAIME JEAN JACQUES · CIK 0001221590 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,915

F1 · kind: The sales by the reporting person reported herein were matchable under Section 16(b) of the Securities Exchange Act of 1934 with the purchase of 1,000 shares of the Issuer's common stock by the reporting person at the price of $19.27 per share on June 5, 2026. The reporting person has agreed to pay to the Issuer upon settlement of the sale, $155, representing the full amount of the profit realized in connection with the short-swing transaction.

F2 · kind: The reporting person sold and reacquired the same aggregate number of shares on June 5, 2026.

SEC source: 0001221590-26-000007 · form4-05192026_110547.xml · nonDerivative · entry 1

BIENAIME JEAN JACQUES · CIK 0001221590 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,415

F1 · price: The weighted average purchase price for the transaction report was $20.70, and the range of prices were between $20.645 and $20.72, inclusive. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares purchased at each separate price will be provided.

SEC source: 0001994071-26-000002 · form4-04032026_110446.xml · derivative · entry 6

Rosett Max · CIK 0001994071 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 39,713 shares

Expires 2032-03-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option is fully vested.

SEC source: 0001994071-26-000002 · form4-04032026_110446.xml · derivative · entry 5

Rosett Max · CIK 0001994071 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Common Stock · 31,848 shares

Expires 2033-03-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option is fully vested.

SEC source: 0001994071-26-000002 · form4-04032026_110446.xml · nonDerivative · entry 4

Rosett Max · CIK 0001994071 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 54,037

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 26, 2025.

F3 · price: The weighted average purchase price for the transaction report was $22.48, and the range of prices were between $22.45 and $22.56, inclusive. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares purchased at each separate price will be provided.

SEC source: 0001994071-26-000002 · form4-04032026_110446.xml · nonDerivative · entry 3

Rosett Max · CIK 0001994071 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 55,381

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 26, 2025.

F2 · price: The weighted average purchase price for the transaction report was $21.91, and the range of prices were between $21.44 and $22.44, inclusive. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares purchased at each separate price will be provided.

SEC source: 0001994071-26-000002 · form4-04032026_110446.xml · nonDerivative · entry 2

Rosett Max · CIK 0001994071 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 119,037

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001994071-26-000002 · form4-04032026_110446.xml · nonDerivative · entry 1

Rosett Max · CIK 0001994071 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 79,324

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001993684-26-000004 · form4-04032026_110409.xml · nonDerivative · entry 1

Higgins Jack · CIK 0001993684 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,000

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 19, 2025.

SEC source: 0001993684-26-000002 · form4-04012026_090411.xml · nonDerivative · entry 1

Higgins Jack · CIK 0001993684 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,438

SEC source: 0001167496-26-000003 · form4-03312026_110335.xml · nonDerivative · entry 1

SIEGALL CLAY B · CIK 0001167496 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 690,704

F1 · price: The weighted average purchase price for the transaction report was $19.67, and the range of prices were between $19.63 and $19.70, inclusive. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares purchased at each separate price will be provided.

SEC source: 0001405684-26-000002 · form4-03242026_010325.xml · nonDerivative · entry 2

WAGENHEIM PHILIP · CIK 0001405684 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 341,147

F2 · price: The weighted average sale price for the transaction report was $20.65, and the range of prices were between $20.15 and $20.84, inclusive. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price will be provided.

SEC source: 0001405684-26-000002 · form4-03242026_010325.xml · nonDerivative · entry 1

WAGENHEIM PHILIP · CIK 0001405684 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 369,347

F1 · price: The weighted average sale price for the transaction report was $20.47, and the range of prices were between $20.07 and $20.96, inclusive. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price will be provided.

SEC source: 0001221590-26-000003 · form4-03122026_060301.xml · nonDerivative · entry 2

BIENAIME JEAN JACQUES · CIK 0001221590 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 38,415

SEC source: 0001221590-26-000003 · form4-03122026_060301.xml · nonDerivative · entry 1

BIENAIME JEAN JACQUES · CIK 0001221590 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,415

SEC source: 0001167496-25-000010 · form4-12302025_111219.xml · nonDerivative · entry 1

SIEGALL CLAY B · CIK 0001167496 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 665,254

SEC source: 0001808343-25-000004 · form4-12232025_091227.xml · nonDerivative · entry 2

Barchas Isaac · CIK 0001808343 · Director

10b5-1 filing: Plan reported

Ownership: Indirect · See footnote

Disclosed balance after: 2,031,181

F1 · kind: The reported sale of these shares occurred automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 23, 2024.

F6 · shares: The shares were sold as follows: 6,851 shares were sold by ABV II and 4,400 shares were sold by ABV II-B.

F7 · price: The weighted average sale price for the transaction report was $22.34, and the range of prices were between $22.31 and $22.38, inclusive. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price will be provided.

F8 · balance_after: Following this transaction, ABV II and ABV II-B own 1,238,282 shares of Issuer common stock and 792,899 shares of Issuer common stock, respectively.

F5 · ownership.nature: Mr. Barchas is a co-founder and holder of a power of attorney with the ability to exercise voting and investment power over the shares held by ABV II and ABV II-B. Mr. Barchas disclaims beneficial ownership of these shares, except to the extent of his pecuniary interest in such shares, if any. This report shall not be deemed an admission that Mr. Barchas is the beneficial owner of such shares.

SEC source: 0001808343-25-000004 · form4-12232025_091227.xml · nonDerivative · entry 1

Barchas Isaac · CIK 0001808343 · Director

10b5-1 filing: Plan reported

Ownership: Indirect · See footnotes

Disclosed balance after: 2,042,432

F1 · kind: The reported sale of these shares occurred automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 23, 2024.

F2 · shares: The shares were sold as follows: 226,480 shares were sold by Arsenal Bridge Venture II, LLC ("ABV II") and 145,469 shares were sold by Arsenal Bridge Venture II-B, LLC ("ABV II-B" and collectively with ABV II, the "ABV Entities").

F3 · price: The weighted average sale price for the transaction report was $21.72, and the range of prices were between $21.31 and $22.30, inclusive. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price will be provided.

F4 · balance_after: Following this transaction, ABV II and ABV II-B own 1,245,133 shares of Issuer common stock and 797,299 shares of Issuer common stock, respectively.

F5 · ownership.nature: Mr. Barchas is a co-founder and holder of a power of attorney with the ability to exercise voting and investment power over the shares held by ABV II and ABV II-B. Mr. Barchas disclaims beneficial ownership of these shares, except to the extent of his pecuniary interest in such shares, if any. This report shall not be deemed an admission that Mr. Barchas is the beneficial owner of such shares.

SEC source: 0001167496-25-000008 · form4-12222025_121251.xml · nonDerivative · entry 2

SIEGALL CLAY B · CIK 0001167496 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 660,525

F2 · kind: The Reporting Person gifted the shares of the Issuer's common stock to the Clay B. Siegall 2025 Grantor Retained Annuity Trust, of which the Reporting Person's brother is the trustee and the Reporting Person's children are the beneficiaries. The Reporting Person does not have or share investment control over these shares.

F3 · shares: The shares are subject to a lockup agreement entered into by the Reporting Person on December 15, 2025 (the "Lock-Up Agreement"). The transferee has agreed to be bound by the terms of the Lock-Up Agreement.

SEC source: 0001167496-25-000008 · form4-12222025_121251.xml · nonDerivative · entry 1

SIEGALL CLAY B · CIK 0001167496 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 860,525

F1 · price: The weighted average purchase price for the transaction report was $20.48, and the range of prices were between $20.36 and $20.50, inclusive. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares purchased at each separate price will be provided.

SEC source: 0002026600-25-000004 · form4-12222025_121251.xml · nonDerivative · entry 1

Tsai Philip · CIK 0002026600 · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,300

SEC source: 0001993684-25-000004 · form4-12222025_121242.xml · nonDerivative · entry 6

Higgins Jack · CIK 0001993684 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Indirect · As Custodian for Child 3

Disclosed balance after: 1,000

F1 · kind: Reflects the gift of shares by the Reporting Person to a custodial account for the child of the Reporting Person established pursuant to the Uniform Transfer to Minors Act, for which the Reporting Person serves as a custodian. The Reporting Person disclaims beneficial ownership of these shares, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such shares for purposes of Section 16 or for any other purpose.

F2 · shares: The shares are subject to a lockup agreement entered into by the Reporting Person on December 15, 2025 (the "Lock-up Agreement"). The transferee has agreed to be bound by the terms of the Lock-up Agreement.

SEC source: 0001993684-25-000004 · form4-12222025_121242.xml · nonDerivative · entry 5

Higgins Jack · CIK 0001993684 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,729

F1 · kind: Reflects the gift of shares by the Reporting Person to a custodial account for the child of the Reporting Person established pursuant to the Uniform Transfer to Minors Act, for which the Reporting Person serves as a custodian. The Reporting Person disclaims beneficial ownership of these shares, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such shares for purposes of Section 16 or for any other purpose.

SEC source: 0001993684-25-000004 · form4-12222025_121242.xml · nonDerivative · entry 4

Higgins Jack · CIK 0001993684 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Indirect · As Custodian for Child 2

Disclosed balance after: 1,000

F1 · kind: Reflects the gift of shares by the Reporting Person to a custodial account for the child of the Reporting Person established pursuant to the Uniform Transfer to Minors Act, for which the Reporting Person serves as a custodian. The Reporting Person disclaims beneficial ownership of these shares, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such shares for purposes of Section 16 or for any other purpose.

F2 · shares: The shares are subject to a lockup agreement entered into by the Reporting Person on December 15, 2025 (the "Lock-up Agreement"). The transferee has agreed to be bound by the terms of the Lock-up Agreement.

SEC source: 0001993684-25-000004 · form4-12222025_121242.xml · nonDerivative · entry 3

Higgins Jack · CIK 0001993684 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 38,729

F1 · kind: Reflects the gift of shares by the Reporting Person to a custodial account for the child of the Reporting Person established pursuant to the Uniform Transfer to Minors Act, for which the Reporting Person serves as a custodian. The Reporting Person disclaims beneficial ownership of these shares, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such shares for purposes of Section 16 or for any other purpose.

SEC source: 0001993684-25-000004 · form4-12222025_121242.xml · nonDerivative · entry 2

Higgins Jack · CIK 0001993684 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Indirect · As Custodian for Child 1

Disclosed balance after: 1,000

F1 · kind: Reflects the gift of shares by the Reporting Person to a custodial account for the child of the Reporting Person established pursuant to the Uniform Transfer to Minors Act, for which the Reporting Person serves as a custodian. The Reporting Person disclaims beneficial ownership of these shares, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such shares for purposes of Section 16 or for any other purpose.

F2 · shares: The shares are subject to a lockup agreement entered into by the Reporting Person on December 15, 2025 (the "Lock-up Agreement"). The transferee has agreed to be bound by the terms of the Lock-up Agreement.

SEC source: 0001993684-25-000004 · form4-12222025_121242.xml · nonDerivative · entry 1

Higgins Jack · CIK 0001993684 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,729

F1 · kind: Reflects the gift of shares by the Reporting Person to a custodial account for the child of the Reporting Person established pursuant to the Uniform Transfer to Minors Act, for which the Reporting Person serves as a custodian. The Reporting Person disclaims beneficial ownership of these shares, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such shares for purposes of Section 16 or for any other purpose.

SEC source: 0001167496-25-000006 · form4-12182025_101250.xml · nonDerivative · entry 1

SIEGALL CLAY B · CIK 0001167496 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 853,247

F1 · kind: The Reporting Person purchased the shares in connection with the Issuer's recently completed underwritten public offering of common stock.

SEC source: 0001415889-25-024319 · form4-09122025_010912.xml · derivative · entry 2

Higgins Jack · CIK 0001993684 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 151,840

Underlying: Common Stock · 22,000 shares

Expires 2032-06-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 25% of the shares vested on May 1, 2023, and the remaining shares shall vest in 36 equal monthly installments thereafter.

SEC source: 0001415889-25-024319 · form4-09122025_010912.xml · nonDerivative · entry 1

Higgins Jack · CIK 0001993684 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,729

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001415889-25-020782 · form4-07312025_100706.xml · derivative · entry 1

SIEGALL CLAY B · CIK 0001167496 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 800,000

Underlying: Common Stock · 800,000 shares

Expires 2035-07-28

F1 · derivative.exercise_date: 25% of the shares subject to the options vest on July 29, 2026, and one-thirty-sixth (1/36th) of the remaining shares subject to the options shall vest every month thereafter.

SEC source: 0001415889-25-020788 · form4-07312025_110740.xml · derivative · entry 1

Tsai Philip · CIK 0002026600 · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 190,000

Underlying: Common Stock · 190,000 shares

Expires 2035-07-28

F1 · derivative.exercise_date: 25% of the shares subject to the options vest on July 29, 2026, and one-thirty-sixth (1/36th) of the remaining shares subject to the options shall vest every month thereafter.

SEC source: 0001415889-25-020787 · form4-07312025_100711.xml · derivative · entry 1

Rosett Max · CIK 0001994071 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 207,000

Underlying: Common Stock · 207,000 shares

Expires 2035-07-28

F1 · derivative.exercise_date: 25% of the shares subject to the options vest on July 29, 2026, and one-thirty-sixth (1/36th) of the remaining shares subject to the options shall vest every month thereafter.

SEC source: 0001415889-25-020786 · form4-07312025_100718.xml · derivative · entry 1

Lechleider Robert · CIK 0001997584 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 242,000

Underlying: Common Stock · 242,000 shares

Expires 2035-07-28

F1 · derivative.exercise_date: 25% of the shares subject to the options vest on July 29, 2026, and one-thirty-sixth (1/36th) of the remaining shares subject to the options shall vest every month thereafter.

SEC source: 0001415889-25-020785 · form4-07312025_100734.xml · derivative · entry 1

Horn Kinney · CIK 0001831215 · CHIEF BUSINESS OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 161,000

Underlying: Common Stock · 161,000 shares

Expires 2035-07-28

F1 · derivative.exercise_date: 25% of the shares subject to the options vest on July 29, 2026, and one-thirty-sixth (1/36th) of the remaining shares subject to the options shall vest every month thereafter.

SEC source: 0001415889-25-020784 · form4-07312025_100740.xml · derivative · entry 1

Higgins Jack · CIK 0001993684 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 196,000

Underlying: Common Stock · 196,000 shares

Expires 2035-07-28

F1 · derivative.exercise_date: 25% of the shares subject to the options vest on July 29, 2026, and one-thirty-sixth (1/36th) of the remaining shares subject to the options shall vest every month thereafter.

SEC source: 0001415889-25-020779 · form4-07312025_100744.xml · derivative · entry 1

Stoneman Sandra G. · CIK 0001831144 · CHIEF LEGAL OFFICER & GC

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 190,000

Underlying: Common Stock · 190,000 shares

Expires 2035-07-28

F1 · derivative.exercise_date: 25% of the shares subject to the options vest on July 29, 2026, and one-thirty-sixth (1/36th) of the remaining shares subject to the options shall vest every month thereafter.

SEC source: 0001415889-25-016982 · form4-06122025_080607.xml · derivative · entry 1

Barchas Isaac · CIK 0001808343 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,864

Underlying: Common Stock · 18,864 shares

Expires 2035-06-09

F1 · derivative.exercise_date: The option vests in four quarterly installments, commencing from June 10, 2025 until the one-year anniversary thereafter, occurring on the same day of each succeeding fiscal quarter, subject to the Reporting Person's continuous service with the Company on each respective vesting date.

SEC source: 0001415889-25-016991 · form4-06122025_080657.xml · derivative · entry 1

Boylan James P · CIK 0001953094 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,864

Underlying: Common Stock · 18,864 shares

Expires 2035-06-09

F1 · shares: Mr. Boylan has agreed to receive and hold for the benefit of Enavate Sciences, LP, any securities granted to him for his service as a director on the Company's board of directors. As such, Mr. Boylan disclaims beneficial ownership of, and all right, title and interest in, the reported securities.

F2 · derivative.exercise_date: The option vests in four quarterly installments, commencing from June 10, 2025 until the one-year anniversary thereafter, occurring on the same day of each succeeding fiscal quarter, subject to Mr. Boylan's continuous service with the Company on each respective vesting date.

SEC source: 0001415889-25-016990 · form4-06122025_080630.xml · derivative · entry 1

SCHAFER CAROL · CIK 0001272181 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,864

Underlying: Common Stock · 18,864 shares

Expires 2035-06-09

F1 · derivative.exercise_date: The option vests in four quarterly installments, commencing from June 10, 2025 until the one-year anniversary thereafter, occurring on the same day of each succeeding fiscal quarter, subject to the Reporting Person's continuous service with the Company on each respective vesting date.

SEC source: 0001415889-25-016987 · form4-06122025_080651.xml · derivative · entry 1

WAGENHEIM PHILIP · CIK 0001405684 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,864

Underlying: Common Stock · 18,864 shares

Expires 2035-06-09

F1 · derivative.exercise_date: The option vests in four quarterly installments, commencing from June 10, 2025 until the one-year anniversary thereafter, occurring on the same day of each succeeding fiscal quarter, subject to the Reporting Person's continuous service with the Company on each respective vesting date.

SEC source: 0001415889-25-016980 · form4-06122025_080623.xml · derivative · entry 1

BIENAIME JEAN JACQUES · CIK 0001221590 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,864

Underlying: Common Stock · 18,864 shares

Expires 2035-06-09

F1 · derivative.exercise_date: The option vests in four quarterly installments, commencing from June 10, 2025 until the one-year anniversary thereafter, occurring on the same day of each succeeding fiscal quarter, subject to the Reporting Person's continuous service with the Company on each respective vesting date.