HBIO

SEC source: 0000921895-22-000033 · form412799loe_01032022.xml · nonDerivative · entry 1

Loewald Thomas W · CIK 0001538555 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 185,626

F1 · shares: Represents an award of 2,525 restricted stock units that will vest in full on the date of the Issuer's 2022 Annual Meeting of the Stockholders.

F2 · balance_after: Includes (a) the award described in footnote (1) above, (b) an award of 14,400 restricted stock units that fully vest on the earlier to occur of (i) the date of the Issuer's next Annual Meeting of Stockholders after May 18, 2021, immediately prior to the commencement of such meeting, and (ii) May 25, 2022, and (c) 168,701 shares of common stock held by the Reporting Person.

SEC source: 0000921895-22-000032 · form412799gre_01032022.xml · nonDerivative · entry 1

Green James W · CIK 0001400121 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,977,554

F1 · shares: The shares were disposed of to satisfy the Reporting Person's tax withholding obligation in connection with a restricted stock unit award previously granted to the Reporting Person which vested in part on January 1, 2022.

F2 · balance_after: Includes (a) 218,141 remaining restricted stock units that will vest on June 11, 2022 and 2023, (b) 129,799 restricted stock units that will vest in two equal installments on December 29, 2022 and 2023, (c) 109,070 remaining restricted stock units that will vest on December 29, 2022 and 2023, (d) 104,590 remaining restricted stock units that will vest on January 1, 2023, (e) 605,035 restricted stock units with performance based vesting conditions tied to relative total shareholder return, and (f) 810,919 shares of common stock beneficially owned by the Reporting Person.

SEC source: 0000921895-22-000031 · form412799ead_01032022.xml · nonDerivative · entry 1

Eade Katherine A. · CIK 0001721318 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 201,441

F1 · shares: Represents an award of 2,525 restricted stock units that will vest in full on the date of the Issuer's 2022 Annual Meeting of the Stockholders.

F2 · balance_after: Includes (a) the award described in footnote (1) above, (b) an award of 14,400 restricted stock units that fully vest on the earlier to occur of (i) the date of the Issuer's next Annual Meeting of Stockholders after May 18, 2021, immediately prior to the commencement of such meeting, and (ii) May 25, 2022, and (c) 184,516 shares of common stock held by the Reporting Person.

SEC source: 0000921895-22-000030 · form412799ala_01032022.xml · nonDerivative · entry 1

EDRICK ALAN I · CIK 0001195340 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 134,226

F1 · shares: Represents an award of 2,525 restricted stock units that will vest in full on the date of the Issuer's 2022 Annual Meeting of the Stockholders.

F2 · balance_after: Includes (a) the award described in footnote (1) above, (b) an award of 14,400 restricted stock units that fully vest on the earlier to occur of (i) the date of the Issuer's next Annual Meeting of Stockholders after May 18, 2021, immediately prior to the commencement of such meeting, and (ii) May 25, 2022, and (c) 117,301 shares of common stock held by the Reporting Person.

SEC source: 0000921895-21-002906 · form412799001ols_12302021.xml · nonDerivative · entry 2

Olson Kenneth Fletcher · CIK 0001793360 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 155,595

F3 · shares: The shares were disposed of to satisfy the Reporting Person's tax withholding obligation in connection with the performance restricted stock unit award previously granted to the Reporting Person that vested in part on December 29, 2021.

F4 · balance_after: Includes (a) the shares and awards described in footnote (2) above, less (b) the disposition of shares reported in footnote (3) above.

SEC source: 0000921895-21-002906 · form412799001ols_12302021.xml · nonDerivative · entry 1

Olson Kenneth Fletcher · CIK 0001793360 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 158,942

F1 · shares: The shares were disposed of to satisfy the Reporting Person's tax withholding obligation in connection with the performance restricted stock unit award previously granted to the Reporting Person that vested in part on December 29, 2021.

F2 · balance_after: Includes (a) 36,756 remaining restricted stock units that will vest on June 11, 2022 and 2023, (b) 21,870 restricted stock units that will vest in two equal installments on December 29, 2022 and 2023, (c) 31,453 restricted stock units with performance based vesting conditions, (d) 18,378 remaining restricted stock units that will vest on December 29, 2022 and 2023, (e) 5,029 remaining restricted stock units that will vest on November 1, 2022, and (f) 45,456 shares of common stock beneficially owned by the Reporting Person (which includes 3,644 shares acquired under the Issuer's Employee Stock Purchase Plan).

SEC source: 0000921895-21-002905 · form412799001gre_12302021.xml · nonDerivative · entry 2

Green James W · CIK 0001400121 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,024,978

F3 · shares: The shares were disposed of to satisfy the Reporting Person's tax withholding obligation in connection with a restricted stock unit award previously granted to the Reporting Person which vested in part on December 29, 2021.

F4 · balance_after: Includes (a) the shares and awards described in footnote (2) above, less (b) the disposition of shares reported in footnote (3) above.

SEC source: 0000921895-21-002905 · form412799001gre_12302021.xml · nonDerivative · entry 1

Green James W · CIK 0001400121 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,053,761

F1 · shares: The shares were disposed of to satisfy the Reporting Person's tax withholding obligation in connection with a restricted stock unit award previously granted to the Reporting Person which vested in part on December 29, 2021.

F2 · balance_after: Includes (a) 218,141 remaining restricted stock units that will vest on June 11, 2022 and 2023, (b) 129,799 restricted stock units that will vest in two equal installments on December 29, 2022 and 2023, (c) 109,070 remaining restricted stock units that will vest on December 29, 2022 and 2023, (d) 209,180 remaining restricted stock units that will vest on January 1, 2022 and 2023, (e) 605,035 restricted stock units with performance based vesting conditions tied to relative total shareholder return, and (f) 782,536 shares of common stock beneficially owned by the Reporting Person.

SEC source: 0000921895-22-000035 · form412799ros_01032022.xml · nonDerivative · entry 2

Rossi Michael A. · CIK 0001783869 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 224,096

F3 · shares: The shares were disposed of to satisfy the Reporting Person's tax withholding obligation in connection with a performance restricted stock unit award previously granted to the Reporting Person that vested in part on December 29, 2021.

F4 · balance_after: Includes (a) the shares and awards described in footnote (2) above, less (b) the disposition of shares reported in footnote (3) above.

SEC source: 0000921895-22-000035 · form412799ros_01032022.xml · nonDerivative · entry 1

Rossi Michael A. · CIK 0001783869 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 227,859

F1 · shares: The shares were disposed of to satisfy the Reporting Person's tax withholding obligation in connection with a performance restricted stock unit award previously granted to the Reporting Person that vested in part on December 29, 2021.

F2 · balance_after: Includes (a) 43,092 remaining restricted stock units that will vest on June 11, 2022 and 2023, (b) 25,641 restricted stock units that will vest in two equal installments on December 29, 2022 and 2023, (c) 36,876 restricted stock units with performance based vesting conditions, (d) 23,878 remaining restricted stock units that will vest on July 18, 2022, (e) 21,545 remaining restricted stock units that will vest on December 29, 2022 and 2023, and (f) 76,827 shares of common stock beneficially owned by the Reporting Person.

SEC source: 0000921895-21-002902 · form412799001loy_12292021.xml · nonDerivative · entry 1

LOY BERTRAND · CIK 0001197452 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 288,227

F1 · shares: Represents an award of 1,401 restricted stock units that fully vest on December 31, 2021.

F2 · balance_after: Includes (a) the award described in footnote (1) above, (b) an award of 14,400 restricted stock units that fully vest on the earlier to occur of (i) the date of the Issuer's next Annual Meeting of Stockholders after May 18, 2021, immediately prior to the commencement of such meeting, and (ii) May 25, 2022, (c) an award of 5,325 remaining unvested restricted stock units that fully vest on December 29, 2021, and (d) 267,101 shares of common stock held by the Reporting Person.

SEC source: 0000921895-21-002901 · form412799001loe_12292021.xml · nonDerivative · entry 1

Loewald Thomas W · CIK 0001538555 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 183,101

F1 · shares: Represents an award of 1,401 restricted stock units that fully vest on December 31, 2021.

F2 · balance_after: Includes (a) the award described in footnote (1) above, (b) an award of 14,400 restricted stock units that fully vest on the earlier to occur of (i) the date of the Issuer's next Annual Meeting of Stockholders after May 18, 2021, immediately prior to the commencement of such meeting, and (ii) May 25, 2022, (c) an award of 3,825 remaining unvested restricted stock units that fully vest on December 29, 2021, and (d) 163,475 shares of common stock held by the Reporting Person.

SEC source: 0000921895-21-002900 · form412799001edr_12292021.xml · nonDerivative · entry 1

EDRICK ALAN I · CIK 0001195340 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 131,701

F1 · shares: Represents an award of 1,401 restricted stock units that fully vest on December 31, 2021.

F2 · balance_after: Includes (a) the award described in footnote (1) above, (b) an award of 14,400 restricted stock units that fully vest on the earlier to occur of (i) the date of the Issuer's next Annual Meeting of Stockholders after May 18, 2021, immediately prior to the commencement of such meeting, and (ii) May 25, 2022, (c) an award of 4,075 remaining unvested restricted stock units that fully vest on December 29, 2021, and (d) 111,825 shares of common stock held by the Reporting Person.

SEC source: 0000921895-21-002899 · form412799001ead_12292021.xml · nonDerivative · entry 1

Eade Katherine A. · CIK 0001721318 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 198,916

F1 · shares: Represents an award of 1,401 restricted stock units that fully vest on December 31, 2021.

F2 · balance_after: Includes (a) the award described in footnote (1) above, (b) an award of 14,400 restricted stock units that fully vest on the earlier to occur of (i) the date of the Issuer's next Annual Meeting of Stockholders after May 18, 2021, immediately prior to the commencement of such meeting, and (ii) May 25, 2022, (c) an award of 3,550 remaining unvested restricted stock units that fully vest on December 29, 2021, and (d) 179,565 shares of common stock held by the Reporting Person.

SEC source: 0000921895-21-002678 · form412799001_11152021.xml · nonDerivative · entry 1

Green James W · CIK 0001400121 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,077,948

F1 · balance_after: Includes (a) 218,141 remaining restricted stock units that will vest on June 11, 2022 and 2023, (b) 194,698 restricted stock units that will vest in three equal installments on December 31, 2021, 2022 and 2023, (c) 163,606 remaining restricted stock units that will vest on December 31, 2021, 2022 and 2023, (d) 209,180 remaining restricted stock units that will vest on January 1, 2022 and 2023, (e) 605,035 restricted stock units with performance based vesting conditions tied to relative total shareholder return, and (f) 687,288 shares of common stock beneficially owned by the Reporting Person.

SEC source: 0000921895-21-002516 · form412799001_11032021.xml · nonDerivative · entry 1

Olson Kenneth Fletcher · CIK 0001793360 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 161,754

F1 · shares: The shares were disposed of to satisfy the Reporting Person's tax withholding obligation in connection with the performance restricted stock unit award previously granted to the Reporting Person that vested in part on November 1, 2021.

F2 · balance_after: Includes (a) 36,756 remaining restricted stock units that will vest on June 11, 2022 and 2023, (b) 32,805 restricted stock units that will vest in three equal installments on December 31, 2021, 2022 and 2023, (c) 31,453 restricted stock units with performance based vesting conditions, (d) 27,567 remaining restricted stock units that will vest on December 31, 2021, 2022 and 2023, (e) 5,029 remaining restricted stock units that will vest on November 1, 2022, and (f) 28,144 shares of common stock beneficially owned by the Reporting Person (which includes 3,644 shares acquired under the Issuer's Employee Stock Purchase Plan).

SEC source: 0000921895-21-002200 · form412799001_08252021.xml · nonDerivative · entry 1

Green James W · CIK 0001400121 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,091,725

F1 · price: This transaction was executed in multiple trades at prices ranging from $7.97 to $8.10, inclusive. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · balance_after: Includes (a) 218,141 remaining restricted stock units that will vest on June 11, 2022 and 2023, (b) 194,698 restricted stock units that will vest in three equal installments on December 31, 2021, 2022 and 2023, (c) 163,606 remaining restricted stock units that will vest on December 31, 2021, 2022 and 2023, (d) 209,180 remaining restricted stock units that will vest on January 1, 2022 and 2023, (e) 605,035 restricted stock units with performance based vesting conditions tied to relative total shareholder return, and (f) 701,065 shares of common stock beneficially owned by the Reporting Person.

SEC source: 0000921895-21-001884 · form412799001_07202021.xml · nonDerivative · entry 1

Rossi Michael A. · CIK 0001783869 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 231,022

F1 · shares: The shares were disposed of to satisfy the Reporting Person's tax withholding obligation in connection with a performance restricted stock unit award previously granted to the Reporting Person that vested in part on July 18, 2021.

F2 · balance_after: Includes (a) 43,092 remaining restricted stock units that will vest on June 11, 2022 and 2023, (b) 38,462 restricted stock units that will vest in three equal installments on December 31, 2021, 2022 and 2023, (c) 36,876 restricted stock units with performance based vesting conditions, (d) 23,878 remaining restricted stock units that will vest on July 18, 2022, (e) 32,319 remaining restricted stock units that will vest on December 31, 2021, 2022 and 2023, and (f) 56,395 shares of common stock beneficially owned by the Reporting Person.

SEC source: 0000921895-21-001842 · form412799001_07122021.xml · nonDerivative · entry 2

Green James W · CIK 0001400121 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,139,900

F3 · shares: The shares were disposed of to satisfy the Reporting Person's tax withholding obligation in connection with a performance restricted stock unit award previously granted to the Reporting Person that vested in part on July 8, 2021.

F4 · balance_after: Includes (a) the shares and awards described in footnote (2) above, less (b) the disposition of shares reported in footnote (3) above.

SEC source: 0000921895-21-001842 · form412799001_07122021.xml · nonDerivative · entry 1

Green James W · CIK 0001400121 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,232,672

F1 · shares: The shares were disclosed of to satisfy the Reporting Person's tax withholding obligation in connection with a restricted stock award previously granted to the Reporting Person that vested in full on July 8, 2021.

F2 · balance_after: Includes (a) 218,141 remaining restricted stock units that will vest on June 11, 2022 and 2023, (b) 194,698 restricted stock units that will vest in three equal installments on December 31, 2021, 2022 and 2023, (c) 163,606 remaining restricted stock units that will vest on December 31, 2021, 2022 and 2023, (d) 209,180 remaining restricted stock units that will vest on January 1, 2022 and 2023, (e) 605,035 restricted stock units with performance based vesting conditions tied to relative total shareholder return, and (f) 842,012 shares of common stock beneficially owned by the Reporting Person.

SEC source: 0000921895-21-001649 · form412799ros_06152021.xml · nonDerivative · entry 2

Rossi Michael A. · CIK 0001783869 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 237,988

F3 · shares: The shares were disposed of to satisfy the Reporting Person's tax withholding obligation in connection with the performance restricted stock unit award previously granted to the Reporting Person that vested in part on June 11, 2021.

F4 · balance_after: Includes (a) the shares and awards described in footnote (2) above, less (b) the disposition of shares reported in footnote (3) above.

SEC source: 0000921895-21-001649 · form412799ros_06152021.xml · nonDerivative · entry 1

Rossi Michael A. · CIK 0001783869 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 244,160

F1 · shares: On June 11, 2020, the Reporting Person was granted an award of 43,092 restricted stock units with performance based vesting conditions, which vest in equal installments on June 11, 2021, 2022 and 2023, and are linked to the achievement of a relative total shareholder return of the Issuer's common stock from June 11, 2020 to the earlier of (i) June 11, 2021 or (ii) upon a change of control (measured relative to the Nasdaq Biotechnology index). The target number of the restricted stock units that may be earned was reported on the date of grant; the maximum amount is 150% of the number then reported. As a result of the Issuer's performance based on such performance targets, the Reporting Person earned 150% of the target amount, subject to continuation of employment through the remaining vesting dates. Accordingly, the reported transaction reflects the acquisition of 21,546 additional performance restricted stock units earned above the target grant.

F2 · balance_after: Includes (a) 43,092 remaining restricted stock units that will vest on June 11, 2022 and 2023, (b) 38,462 restricted stock units that will vest in three equal installments on December 31, 2021, 2022 and 2023, (c) 36,876 restricted stock units with performance based vesting conditions, (d) 47,753 remaining restricted stock units that will vest on July 18, 2021 and 2022, (e) 32,319 remaining restricted stock units that will vest on December 31, 2021, 2022 and 2023, and (f) 45,658 shares of common stock beneficially owned by the Reporting Person.

SEC source: 0000921895-21-001648 · form412799ols_06152021.xml · nonDerivative · entry 2

Olson Kenneth Fletcher · CIK 0001793360 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 163,293

F3 · shares: The shares were disposed of to satisfy the Reporting Person's tax withholding obligation in connection with the performance restricted stock unit award previously granted to the Reporting Person that vested in part on June 11, 2021.

F4 · balance_after: Includes (a) the shares and awards described in footnote (2) above, less (b) the disposition of shares reported in footnote (3) above.

SEC source: 0000921895-21-001648 · form412799ols_06152021.xml · nonDerivative · entry 1

Olson Kenneth Fletcher · CIK 0001793360 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 169,773

F1 · shares: On June 11, 2020, the Reporting Person was granted an award of 36,756 restricted stock units with performance based vesting conditions, which vest in equal installments on June 11, 2021, 2022 and 2023, and are linked to the achievement of a relative total shareholder return of the Issuer's common stock from June 11, 2020 to the earlier of (i) June 11, 2021 or (ii) upon a change of control (measured relative to the Nasdaq Biotechnology index). The target number of the restricted stock units that may be earned was reported on the date of grant; the maximum amount is 150% of the number then reported. As a result of the Issuer's performance based on such performance targets, the Reporting Person earned 150% of the target amount, subject to continuation of employment through the remaining vesting dates. Accordingly, the reported transaction reflects the acquisition of 18,378 additional performance restricted stock units earned above the target grant.

F2 · balance_after: Includes (a) 36,756 remaining restricted stock units that will vest on June 11, 2022 and 2023, (b) 32,805 restricted stock units that will vest in three equal installments on December 31, 2021, 2022 and 2023, (c) 31,453 restricted stock units with performance based vesting conditions, (d) 27,567 remaining restricted stock units that will vest on December 31, 2021, 2022 and 2023, (e) 10,057 remaining restricted stock units that will vest on November 1, 2021 and 2022, and (f) 31,135 shares of common stock beneficially owned by the Reporting Person (which includes 3,644 shares acquired under the Issuer's Employee Stock Purchase Plan).

SEC source: 0000921895-21-001647 · form412799gre_06152021.xml · nonDerivative · entry 2

Green James W · CIK 0001400121 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,340,475

F3 · shares: The shares were disposed of to satisfy the Reporting Person's tax withholding obligation in connection with the performance restricted stock unit award previously granted to the Reporting Person that vested in part on June 11, 2021.

F4 · balance_after: Includes (a) the shares and awards described in footnote (2) above, less (b) the disposition of shares reported in footnote (3) above.

SEC source: 0000921895-21-001647 · form412799gre_06152021.xml · nonDerivative · entry 1

Green James W · CIK 0001400121 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,388,848

F1 · shares: On June 11, 2020, the Reporting Person was granted an award of 218,141 restricted stock units with performance based vesting conditions, which vest in equal installments on June 11, 2021, 2022 and 2023, and are linked to the achievement of a relative total shareholder return of the Issuer's common stock from June 11, 2020 to the earlier of (i) June 11, 2021 or (ii) upon a change of control (measured relative to the Nasdaq Biotechnology index). The target number of the restricted stock units that may be earned was reported on the date of grant; the maximum amount is 150% of the number then reported. As a result of the Issuer's performance based on such performance targets, the Reporting Person earned 150% of the target amount, subject to continuation of employment through the remaining vesting dates. Accordingly, the reported transaction reflects the acquisition of 109,070 additional performance restricted stock units earned above the target grant.

F2 · balance_after: Includes (a) 218,141 remaining restricted stock units that will vest on June 11, 2022 and 2023, (b) 194,698 restricted stock units that will vest in three equal installments on December 31, 2021, 2022 and 2023, (c) 163,606 remaining restricted stock units that will vest on December 31, 2021, 2022 and 2023, (c) 243,072 restricted stock units that will fully vest on July 8, 2021, (d) 209,180 remaining restricted stock units that will vest on January 1, 2022 and 2023, (e) 605,035 restricted stock units with performance based vesting conditions tied to relative total shareholder return, and (f) 755,116 shares of common stock beneficially owned by the Reporting Person.

SEC source: 0000921895-21-001512 · form412799loe_05272021.xml · nonDerivative · entry 1

Loewald Thomas W · CIK 0001538555 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 181,700

F1 · shares: Represents an award of 14,400 restricted stock units that fully vest on the earlier to occur of (i) the date of the Issuer's next Annual Meeting of Stockholders after May 18, 2021, immediately prior to the commencement of such meeting, and (ii) May 25, 2022.

F2 · balance_after: Includes (a) the award described in footnote (1) above, (b) an award of 11,475 remaining unvested restricted stock units vesting in equal quarterly installments on June 30, 2021, September 30, 2021 and December 31, 2021, and (c) 155,825 shares of common stock held by the Reporting Person.

SEC source: 0000921895-21-001511 · form412799loy_05272021.xml · nonDerivative · entry 1

LOY BERTRAND · CIK 0001197452 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 286,826

F1 · shares: Represents an award of 14,400 restricted stock units that fully vest on the earlier to occur of (i) the date of the Issuer's next Annual Meeting of Stockholders after May 18, 2021, immediately prior to the commencement of such meeting, and (ii) May 25, 2022.

F2 · balance_after: Includes (a) the award described in footnote (1) above, (b) an award of 15,975 remaining unvested restricted stock units vesting in equal quarterly installments on June 30, 2021, September 30, 2021 and December 31, 2021, and (c) 256,451 shares of common stock held by the Reporting Person.

SEC source: 0000921895-21-001510 · form412799ead_05272021.xml · nonDerivative · entry 1

Eade Katherine A. · CIK 0001721318 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 197,515

F1 · shares: Represents an award of 14,400 restricted stock units that fully vest on the earlier to occur of (i) the date of the Issuer's next Annual Meeting of Stockholders after May 18, 2021, immediately prior to the commencement of such meeting, and (ii) May 25, 2022.

F2 · balance_after: Includes (a) the award described in footnote (1) above, (b) an award of 10,650 remaining unvested restricted stock units vesting in equal quarterly installments on June 30, 2021, September 30, 2021 and December 31, 2021, and (c) 172,465 shares of common stock held by the Reporting Person.

SEC source: 0000921895-21-001509 · form412799edr_05272021.xml · nonDerivative · entry 1

EDRICK ALAN I · CIK 0001195340 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130,300

F1 · shares: Represents an award of 14,400 restricted stock units that fully vest on the earlier to occur of (i) the date of the Issuer's next Annual Meeting of Stockholders after May 18, 2021, immediately prior to the commencement of such meeting, and (ii) May 25, 2022.

F2 · balance_after: Includes (a) the award described in footnote (1) above, (b) an award of 12,225 remaining unvested restricted stock units vesting in equal quarterly installments on June 30, 2021, September 30, 2021 and December 31, 2021, and (c) 103,675 shares of common stock held by the Reporting Person.

SEC source: 0000921895-21-001485 · form412799001_05252021.xml · derivative · entry 3

Green James W · CIK 0001400121 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 352,690

Underlying: Common Stock · 24,312 shares

Expires 2027-06-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The options vest in four equal installments on December 31, 2020, 2021, 2022 and 2023.

SEC source: 0000921895-21-001485 · form412799001_05252021.xml · nonDerivative · entry 2

Green James W · CIK 0001400121 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,279,778

F2 · price: This transaction was executed in multiple trades at prices ranging from $7.04 to $7.20, inclusive. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes (a) the shares and awards described in footnote (1) above, less (b) the disposition of shares reported in footnote (2) above.

SEC source: 0000921895-21-001485 · form412799001_05252021.xml · nonDerivative · entry 1

Green James W · CIK 0001400121 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,304,090

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes (a) an award of 194,698 restricted stock units that will vest in three equal installments on December 31, 2021, 2022 and 2023, subject to the terms set forth in an award agreement between the Issuer and the Reporting Person, (b) 163,606 remaining restricted stock units that will vest on December 31, 2021, 2022 and 2023, (c) 243,072 restricted stock units that will fully vest on July 8, 2021, (d) 209,180 remaining restricted stock units that will vest on January 1, 2022 and 2023, (e) 823,176 restricted stock units with performance based vesting conditions tied to relative total shareholder return, and (f) 670,358 shares of common stock beneficially owned by the Reporting Person.

SEC source: 0000921895-21-001455 · form412799001_05212021.xml · derivative · entry 6

Green James W · CIK 0001400121 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 377,002

Underlying: Common Stock · 14,876 shares

Expires 2027-06-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · derivative.exercise_date: The options vest in four equal installments on December 31, 2020, 2021, 2022 and 2023.

SEC source: 0000921895-21-001455 · form412799001_05212021.xml · nonDerivative · entry 4

Green James W · CIK 0001400121 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,279,778

F5 · price: This transaction was executed in multiple trades at prices ranging from $7.02 to $7.05, inclusive. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

F6 · balance_after: Includes (a) the shares and awards described in footnote (4) above, less (b) the disposition of shares reported in footnote (5) above.

SEC source: 0000921895-21-001455 · form412799001_05212021.xml · nonDerivative · entry 3

Green James W · CIK 0001400121 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,294,654

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · balance_after: Includes (a) the shares and awards described in footnote (3) above, plus (b) the acquisition of 14,876 shares of common stock pursuant to the exercise of stock options as reported on this Form 4.

SEC source: 0000921895-21-001455 · form412799001_05212021.xml · derivative · entry 5

Green James W · CIK 0001400121 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 391,878

Underlying: Common Stock · 39,188 shares

Expires 2027-06-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · derivative.exercise_date: The options vest in four equal installments on December 31, 2020, 2021, 2022 and 2023.

SEC source: 0000921895-21-001455 · form412799001_05212021.xml · nonDerivative · entry 2

Green James W · CIK 0001400121 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,279,778

F2 · price: This transaction was executed in multiple trades at prices ranging from $7.07 to $7.26, inclusive. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes (a) the shares and awards described in footnote (1) above, less (b) the disposition of shares reported in footnote (2) above.

SEC source: 0000921895-21-001455 · form412799001_05212021.xml · nonDerivative · entry 1

Green James W · CIK 0001400121 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,318,966

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes (a) an award of 194,698 restricted stock units that will vest in three equal installments on December 31, 2021, 2022 and 2023, subject to the terms set forth in an award agreement between the Issuer and the Reporting Person, (b) 163,606 remaining restricted stock units that will vest on December 31, 2021, 2022 and 2023, (c) 243,072 restricted stock units that will fully vest on July 8, 2021, (d) 209,180 remaining restricted stock units that will vest on January 1, 2022 and 2023, (e) 823,176 restricted stock units with performance based vesting conditions tied to relative total shareholder return, and (f) 685,234 shares of common stock beneficially owned by the Reporting Person.

SEC source: 0000921895-21-001420 · form412799001_05192021.xml · derivative · entry 3

Green James W · CIK 0001400121 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 431,066

Underlying: Common Stock · 39,188 shares

Expires 2027-06-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The options vest in four equal installments on December 31, 2020, 2021, 2022 and 2023.

SEC source: 0000921895-21-001420 · form412799001_05192021.xml · nonDerivative · entry 2

Green James W · CIK 0001400121 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,279,788

F2 · price: This transaction was executed in multiple trades at prices ranging from $7.34 to $7.52, inclusive. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes (a) the shares and awards described in footnote (1) above, less (b) the disposition of shares reported in footnote (2) above.

SEC source: 0000921895-21-001420 · form412799001_05192021.xml · nonDerivative · entry 1

Green James W · CIK 0001400121 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,318,966

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes (a) an award of 194,698 restricted stock units that will vest in three equal installments on December 31, 2021, 2022 and 2023, subject to the terms set forth in an award agreement between the Issuer and the Reporting Person, (b) 163,606 remaining restricted stock units that will vest on December 31, 2021, 2022 and 2023, (c) 243,072 restricted stock units that will fully vest on July 8, 2021, (d) 209,180 remaining restricted stock units that will vest on January 1, 2022 and 2023, (e) 823,176 restricted stock units with performance based vesting conditions tied to relative total shareholder return, and (f) 685,234 shares of common stock beneficially owned by the Reporting Person.

SEC source: 0000921895-21-000870 · form412799001_03262021.xml · nonDerivative · entry 1

KENNEDY JOHN F · CIK 0001138315 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 323,344

F1 · price: This transaction involved a gift of securities by the Reporting Person. Disposition price is not applicable as this transaction was a bona fide gift.

F2 · balance_after: Includes (a) a deferred stock award of 13,200 restricted stock units which vest quarterly in equal installments on March 31, 2021, June 30, 2021, September 30, 2021 and December 31, 2021 and are subject to continued service as a non-employee director on the applicable vesting dates, (b) an award of 28,100 restricted stock units that fully vest on the earlier to occur of (i) the date of the Issuer's next Annual Meeting of Stockholders after June 11, 2020, immediately prior to the commencement of such meeting, or (ii) June 18, 2021, and (c) 282,044 shares of common stock held by the Reporting Person.

SEC source: 0000921895-21-000798 · form412799hbio_03192021.xml · nonDerivative · entry 2

KENNEDY JOHN F · CIK 0001138315 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 330,239

F3 · price: This transaction involved a gift of securities by the Reporting Person. Disposition price is not applicable as this transaction was a bona fide gift.

F4 · balance_after: Includes (a) the shares and awards described in footnote (2) above, less (b) the disposition of shares reported in footnote (3) above.

SEC source: 0000921895-21-000798 · form412799hbio_03192021.xml · nonDerivative · entry 1

KENNEDY JOHN F · CIK 0001138315 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 336,489

F1 · price: This transaction involved a gift of securities by the Reporting Person. Disposition price is not applicable as this transaction was a bona fide gift.

F2 · balance_after: Includes (a) a deferred stock award of 13,200 restricted stock units which vest quarterly in equal installments on March 31, 2021, June 30, 2021, September 30, 2021 and December 31, 2021 and are subject to continued service as a non-employee director on the applicable vesting dates, (b) an award of 28,100 restricted stock units that fully vest on the earlier to occur of (i) the date of the Issuer's next Annual Meeting of Stockholders after June 11, 2020, immediately prior to the commencement of such meeting, or (ii) June 18, 2021, and (c) 295,189 shares of common stock held by the Reporting Person.

SEC source: 0000921895-21-000761 · form412799001_03162021.xml · nonDerivative · entry 1

Green James W · CIK 0001400121 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,279,778

F1 · price: This transaction was executed in multiple trades at prices ranging from $5.98 to $6.07, inclusive. The price reported above reflects the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · balance_after: Includes (a) an award of 194,698 restricted stock units that will vest in three equal installments on December 31, 2021, 2022 and 2023, subject to the terms set forth in an award agreement between the Issuer and the Reporting Person, (b) 163,606 remaining restricted stock units that will vest on December 31, 2021, 2022 and 2023, (c) 243,072 restricted stock units that will fully vest on July 8, 2021, (d) 209,180 remaining restricted stock units that will vest on January 1, 2022 and 2023, (e) 823,176 restricted stock units with performance based vesting conditions tied to relative total shareholder return, and (f) 646,046 shares of common stock beneficially owned by the Reporting Person.

SEC source: 0000921895-21-000618 · form412799gre_03032021.xml · nonDerivative · entry 2

Green James W · CIK 0001400121 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,314,778

F3 · shares: Represents an award of 186,674 restricted stock units with performance based vesting conditions. These restricted stock units will vest upon the achievement of a relative total shareholder return of the Issuer's common stock during the period from March 1, 2021 to the earlier of (i) December 31, 2023, and (ii) the date of a change of control (the "Measurement Period"), measured relative to the Russell 2000 index and based on the 20-day trading average beginning on the first day of the Measurement Period and ending on the last day of the Measurement Period, subject to the terms set forth in an award agreement between the Issuer and the Reporting Person. The target number of these restricted stock units that may be earned is reported above; the maximum amount is 150% of the number reported.

F4 · balance_after: Includes (a) the shares and awards described in footnote (2) above, and (b) the award described in footnote (3) above.

SEC source: 0000921895-21-000618 · form412799gre_03032021.xml · nonDerivative · entry 1

Green James W · CIK 0001400121 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,128,104

F1 · shares: Represents an award of 194,698 restricted stock units that will vest in three equal installments on December 31, 2021, 2022 and 2023, subject to the terms set forth in an award agreement between the Issuer and the Reporting Person.

F2 · balance_after: Includes (a) the award described in footnote (1) above, (b) 163,606 remaining restricted stock units that will vest on December 31, 2021, 2022 and 2023, (c) 243,072 restricted stock units that will fully vest on July 8, 2021, (d) 209,180 remaining restricted stock units that will vest on January 1, 2022 and 2023, (e) 636,502 restricted stock units with performance based vesting conditions tied to relative total shareholder return, and (f) 681,046 shares of common stock beneficially owned by the Reporting Person.

SEC source: 0000921895-21-000617 · form412799ros_03032021.xml · nonDerivative · entry 2

Rossi Michael A. · CIK 0001783869 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 222,614

F3 · shares: Represents an award of 36,876 restricted stock units with performance based vesting conditions. These restricted stock units will vest upon the achievement of a relative total shareholder return of the Issuer's common stock during the period from March 1, 2021 to the earlier of (i) December 31, 2023, and (ii) the date of a change of control (the "Measurement Period"), measured relative to the Russell 2000 index and based on the 20-day trading average beginning on the first day of the Measurement Period and ending on the last day of the Measurement Period, subject to the terms set forth in an award agreement between the Issuer and the Reporting Person. The target number of these restricted stock units that may be earned is reported above; the maximum amount is 150% of the number reported.

F4 · balance_after: Includes (a) the shares and awards described in footnote (2) above, and (b) the award described in footnote (3) above.

SEC source: 0000921895-21-000617 · form412799ros_03032021.xml · nonDerivative · entry 1

Rossi Michael A. · CIK 0001783869 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 185,738

F1 · shares: Represents an award of 38,462 restricted stock units that will vest in three equal installments on December 31, 2021, 2022 and 2023, subject to the terms set forth in an award agreement between the Issuer and the Reporting Person.

F2 · balance_after: Includes (a) the award described in footnote (1) above, (b) 47,753 remaining restricted stock units that will vest on July 18, 2021 and 2022, (c) 32,319 remaining restricted stock units that will vest on December 31, 2021, 2022 and 2023, (d) 43,092 restricted stock units with performance based vesting conditions tied to relative total shareholder return that will vest on June 11, 2021, 2022 and 2023, and (e) 24,112 shares of common stock beneficially owned by the Reporting Person.