GKOS

SEC source: 0001104659-21-063275 · tm2115239-2_4seq1.xml · nonDerivative · entry 4

Gilliam Joseph E · CIK 0001705850 · CFO, SVP Corporate Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,290

F3 · kind: These trades were made pursuant to a Rule 10b5-1 trading plan with pre-determined share amounts and prices.

F2 · balance_after: Includes 18,950 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-063275 · tm2115239-2_4seq1.xml · nonDerivative · entry 3

Gilliam Joseph E · CIK 0001705850 · CFO, SVP Corporate Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,390

F3 · kind: These trades were made pursuant to a Rule 10b5-1 trading plan with pre-determined share amounts and prices.

F5 · price: This transaction was executed in multiple trades at prices ranging from $82.54 to $82.90. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · balance_after: Includes 18,950 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-063275 · tm2115239-2_4seq1.xml · nonDerivative · entry 2

Gilliam Joseph E · CIK 0001705850 · CFO, SVP Corporate Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,533

F3 · kind: These trades were made pursuant to a Rule 10b5-1 trading plan with pre-determined share amounts and prices.

F4 · price: This transaction was executed in multiple trades at prices ranging from $81.49 to $82.43. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · balance_after: Includes 18,950 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-063275 · tm2115239-2_4seq1.xml · nonDerivative · entry 1

Gilliam Joseph E · CIK 0001705850 · CFO, SVP Corporate Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,190

F1 · kind: Consists of shares withheld by the Issuer with respect to income taxes payable by the Reporting Person upon vesting and delivery of shares of common stock underlying restricted stock units previously granted by the Issuer on May 5, 2017, with the vesting schedule in four equal installments on May 5, 2018, May 5, 2019, May 5, 2020 and May 5, 2021.

F2 · balance_after: Includes 18,950 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-061899 · tm2115239-1_4seq1.xml · derivative · entry 7

Gilliam Joseph E · CIK 0001705850 · CFO, SVP Corporate Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,437

Underlying: Common Stock · 5,000 shares

Expires 2028-03-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · kind: These trades were made pursuant to a Rule 10b5-1 trading plan with pre-determined share amounts and prices.

F6 · derivative.exercise_date: These options vest over four years from the grant date, with 25% vesting on the first anniversary of the grant date and the remaining amount vesting in equal monthly installments over the following three years.

SEC source: 0001104659-21-061899 · tm2115239-1_4seq1.xml · derivative · entry 6

Gilliam Joseph E · CIK 0001705850 · CFO, SVP Corporate Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 139,343

Underlying: Common Stock · 10,000 shares

Expires 2027-05-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · kind: These trades were made pursuant to a Rule 10b5-1 trading plan with pre-determined share amounts and prices.

F6 · derivative.exercise_date: These options vest over four years from the grant date, with 25% vesting on the first anniversary of the grant date and the remaining amount vesting in equal monthly installments over the following three years.

SEC source: 0001104659-21-061899 · tm2115239-1_4seq1.xml · nonDerivative · entry 5

Gilliam Joseph E · CIK 0001705850 · CFO, SVP Corporate Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,739

F2 · kind: These trades were made pursuant to a Rule 10b5-1 trading plan with pre-determined share amounts and prices.

F5 · price: This transaction was executed in multiple trades at prices ranging from $94.93 to $95.10. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F1 · balance_after: Includes 35,517 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-061899 · tm2115239-1_4seq1.xml · nonDerivative · entry 4

Gilliam Joseph E · CIK 0001705850 · CFO, SVP Corporate Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,489

F2 · kind: These trades were made pursuant to a Rule 10b5-1 trading plan with pre-determined share amounts and prices.

F4 · price: This transaction was executed in multiple trades at prices ranging from $93.81 to $94.80. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F1 · balance_after: Includes 35,517 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-061899 · tm2115239-1_4seq1.xml · nonDerivative · entry 3

Gilliam Joseph E · CIK 0001705850 · CFO, SVP Corporate Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 58,747

F2 · kind: These trades were made pursuant to a Rule 10b5-1 trading plan with pre-determined share amounts and prices.

F3 · price: This transaction was executed in multiple trades at prices ranging from $92.78 to $93.74. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F1 · balance_after: Includes 35,517 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-061899 · tm2115239-1_4seq1.xml · nonDerivative · entry 2

Gilliam Joseph E · CIK 0001705850 · CFO, SVP Corporate Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 72,739

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 35,517 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-061899 · tm2115239-1_4seq1.xml · nonDerivative · entry 1

Gilliam Joseph E · CIK 0001705850 · CFO, SVP Corporate Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 67,739

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 35,517 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-047246 · tm2112201-1_4seq1.xml · nonDerivative · entry 1

Burns Thomas William · CIK 0001644557 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 348,182

F1 · shares: Consists of shares withheld by the Issuer with respect to income taxes payable by the Reporting Person upon vesting and delivery of shares of common underlying restricted stock units previously granted by the Issuer on March 12, 2020.

F2 · balance_after: Amount reported has been adjusted to correct a mathematical error contained in the Form 4 filed by the Reporting Person on March 22, 2021. Includes 65,471 restricted stock units that have not yet vested or been delivered to the Reporting Person. This number of restricted stock units has also been adjusted to correct a mathematical error contained in the Form 4 filed by the Reporting Person on March 22, 2021.

SEC source: 0001104659-21-039873 · tm2110536-2_4seq1.xml · nonDerivative · entry 2

Gilliam Joseph E · CIK 0001705850 · CFO, SVP Corporate Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 57,739

F3 · shares: Consists of shares withheld by the Issuer with respect to tax withholding obligations of the Reporting Person upon vesting and delivery of shares of common stock underlying restricted stock units previously granted by the Issuer on March 14, 2019.

F4 · balance_after: Includes 35,517 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-039874 · tm2110536-3_4seq1.xml · nonDerivative · entry 4

Burns Thomas William · CIK 0001644557 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 353,705

F7 · shares: Consists of shares withheld by the Issuer with respect to tax withholding obligations of the Reporting Person upon vesting and delivery of shares of common stock underlying restricted stock units previously granted by the Issuer on March 12, 2020.

F8 · balance_after: Includes 70,494 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-039874 · tm2110536-3_4seq1.xml · nonDerivative · entry 3

Burns Thomas William · CIK 0001644557 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 354,466

F5 · shares: Consists of shares withheld by the Issuer with respect to tax withholding obligations of the Reporting Person upon vesting and delivery of shares of common stock underlying restricted stock units previously granted by the Issuer on March 14, 2019.

F6 · balance_after: Includes 78,007 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-039873 · tm2110536-2_4seq1.xml · derivative · entry 3

Gilliam Joseph E · CIK 0001705850 · CFO, SVP Corporate Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,839

Underlying: Common Stock · 6,839 shares

Expires 2030-03-12

F5 · shares: Represents a portion of an option to purchase shares of common stock previously granted by the Issuer on March 12, 2020, the vesting of which was subject to the Issuer's achievement of certain multi-year performance goals. The Compensation Committee of the Issuer's Board of Directors (the "Compensation Committee") determined on March 18, 2021 the level of achievement for the first year of the multi-year performance period. The number of shares of common stock subject to the stock option as reported herein consists of the portion of the award that vested based upon the achievement with respect to the first-year performance goal.

SEC source: 0001104659-21-039873 · tm2110536-2_4seq1.xml · nonDerivative · entry 1

Gilliam Joseph E · CIK 0001705850 · CFO, SVP Corporate Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 58,301

F1 · shares: Granted by the Issuer in the form of restricted stock units which vest over a four-year period, with 25% to vest on each anniversary of the grant date.

F2 · balance_after: Includes 36,606 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-039874 · tm2110536-3_4seq1.xml · derivative · entry 10

Burns Thomas William · CIK 0001644557 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,074

Underlying: Common Stock · 16,074 shares

Expires 2030-03-12

F9 · shares: Represents a portion of an option to purchase shares of common stock previously granted by the Issuer on March 12, 2020, the vesting of which was subject to the Issuer's achievement of certain multi-year performance goals. The Compensation Committee determined on March 18, 2021 the level of achievement for the first year of the multi-year performance period. The Reporting Person elected to receive 50% of this performance grant in the form of restricted stock units and 50% in the form of an option to purchase shares of common stock. The number of shares of common stock subject to the stock option reported herein consists of the portion of the shares subject to the stock option that vested with respect to 50% of the first-year performance goal.

SEC source: 0001104659-21-039874 · tm2110536-3_4seq1.xml · nonDerivative · entry 2

Burns Thomas William · CIK 0001644557 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 356,314

F3 · shares: Granted by the Issuer in the form of restricted stock units which vest over a four-year period, with 25% to vest on each anniversary of the grant date.

F4 · balance_after: Includes 82,861 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-039874 · tm2110536-3_4seq1.xml · nonDerivative · entry 1

Burns Thomas William · CIK 0001644557 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 325,479

F1 · shares: Represents shares of common stock underlying a portion of an award of restricted stock units previously granted by the Issuer on March 12, 2020, the vesting of which was subject to the Issuer's achievement of certain multi-year performance goals. The Compensation Committee of the Issuer's Board of Directors (the "Compensation Committee") determined on March 18, 2021 the level of achievement for the first year of the multi-year performance period. The Reporting Person elected to receive 50% of this performance grant in the form of restricted stock units and 50% in the form of an option to purchase shares of common stock. The number of shares of common stock reported herein consists of the portion of the award that vested based upon the achievement with respect to 50% of the first-year performance goal.

F2 · balance_after: Includes 52,026 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-039872 · tm2110536-1_4seq1.xml · derivative · entry 4

Calcaterra Chris M. · CIK 0001640771 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,562

Underlying: Common Stock · 4,562 shares

Expires 2030-03-12

F6 · shares: Represents an option to purchase shares of common stock previously granted by the Issuer on April 1, 2020 pursuant to the Reporting Person's election to receive a portion of his annual bonus for 2020 in the form of stock options rather than cash (the "Bonus Election"). The Compensation Committee determined on March 18, 2021 the annual bonus payable to the Reporting Person pursuant to the Issuer's 2020 executive bonus plan and the number of shares of common stock subject to the stock option earned by the Reporting Person in accordance with the Bonus Election, subject to continued employment through the vesting date. The option to purchase common stock will vest on April 1, 2021.

SEC source: 0001104659-21-039872 · tm2110536-1_4seq1.xml · derivative · entry 3

Calcaterra Chris M. · CIK 0001640771 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,384

Underlying: Common Stock · 6,384 shares

Expires 2030-03-12

F5 · shares: Represents a portion of an option to purchase shares of common stock previously granted by the Issuer on March 12, 2020, the vesting of which was subject to the Issuer's achievement of certain multi-year performance goals. The Compensation Committee of the Issuer's Board of Directors (the "Compensation Committee") determined on March 18, 2021 the level of achievement for the first year of the multi-year performance period. The number of shares of common stock subject to the stock option as reported herein consists of the portion of the award that vested based upon the achievement with respect to the first-year performance goal.

SEC source: 0001104659-21-039872 · tm2110536-1_4seq1.xml · nonDerivative · entry 2

Calcaterra Chris M. · CIK 0001640771 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 178,522

F3 · shares: Consists of shares withheld by the Issuer with respect to tax withholding obligations of the Reporting Person upon vesting and delivery of shares of common stock underlying restricted stock units previously granted by the Issuer on March 14, 2019.

F4 · balance_after: Includes 19,888 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-039872 · tm2110536-1_4seq1.xml · nonDerivative · entry 1

Calcaterra Chris M. · CIK 0001640771 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 179,305

F1 · shares: Granted by the Issuer in the form of restricted stock units which vest over a four-year period, with 25% to vest on each anniversary of the grant date.

F2 · balance_after: Includes 21,466 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001127602-21-011174 · form4.xml · derivative · entry 3

Gilliam Joseph E · CIK 0001705850 · CFO, SVP Corporate Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,466

Underlying: Common Stock · 5,000 shares

Expires 2030-03-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · kind: These trades were made pursuant to a Rule 10b5-1 trading plan with pre-determined share amounts and prices.

F3 · derivative.exercise_date: These options vest over four years from the grant date, with 25% vesting on the first anniversary of the grant date and the remaining amount vesting in equal monthly installments over the following three years.

SEC source: 0001127602-21-011174 · form4.xml · nonDerivative · entry 2

Gilliam Joseph E · CIK 0001705850 · CFO, SVP Corporate Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,802

F2 · kind: These trades were made pursuant to a Rule 10b5-1 trading plan with pre-determined share amounts and prices.

F1 · balance_after: Includes 21,107 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001127602-21-011174 · form4.xml · nonDerivative · entry 1

Gilliam Joseph E · CIK 0001705850 · CFO, SVP Corporate Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,802

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 21,107 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0000899243-21-010131 · doc4.xml · nonDerivative · entry 4

Kliman Gilbert H · CIK 0001293171 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,394

F2 · kind: Represents pro rata in-kind distribution by IMP10 without consideration to its members in accordance with the terms of the InterWest Management Partners X, LLC Operating Agreement. Includes 680 shares distributed to the Reporting Person.

F6 · balance_after: Includes 4,880 restricted stock units that have not yet vested or been delivered to the Reporting Person

SEC source: 0000899243-21-010131 · doc4.xml · nonDerivative · entry 3

Kliman Gilbert H · CIK 0001293171 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · InterWest Management Partners X, LLC

Disclosed balance after: 0

F2 · kind: Represents pro rata in-kind distribution by IMP10 without consideration to its members in accordance with the terms of the InterWest Management Partners X, LLC Operating Agreement. Includes 680 shares distributed to the Reporting Person.

F3 · ownership.nature: The shares are owned by IP10. The general partner of IP10 is IMP10. The Reporting Person has shared voting and investment control over shares owned by IP10, and disclaims beneficial ownership of those securities, except to the extent of his pecuniary interest therein.

SEC source: 0000899243-21-010131 · doc4.xml · nonDerivative · entry 2

Kliman Gilbert H · CIK 0001293171 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · InterWest Management Partners X, LLC

Disclosed balance after: 3,000

F1 · kind: Represents pro rata in-kind distribution by InterWest Partners X, LP ("IP10") without consideration to its limited and general partners in accordance with the terms of the InterWest Partners X, LP Limited Partnership Agreement. Includes 3,000 shares distributed to InterWest Management Partners X, LLC ("IMP10") its general partner.

F3 · ownership.nature: The shares are owned by IP10. The general partner of IP10 is IMP10. The Reporting Person has shared voting and investment control over shares owned by IP10, and disclaims beneficial ownership of those securities, except to the extent of his pecuniary interest therein.

SEC source: 0000899243-21-010131 · doc4.xml · nonDerivative · entry 1

Kliman Gilbert H · CIK 0001293171 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · InterWest Partners X, LP

Disclosed balance after: 333,917

F1 · kind: Represents pro rata in-kind distribution by InterWest Partners X, LP ("IP10") without consideration to its limited and general partners in accordance with the terms of the InterWest Partners X, LP Limited Partnership Agreement. Includes 3,000 shares distributed to InterWest Management Partners X, LLC ("IMP10") its general partner.

F3 · ownership.nature: The shares are owned by IP10. The general partner of IP10 is IMP10. The Reporting Person has shared voting and investment control over shares owned by IP10, and disclaims beneficial ownership of those securities, except to the extent of his pecuniary interest therein.

SEC source: 0001104659-21-031667 · tm218619-4_4seq1.xml · nonDerivative · entry 2

WEN LEANA · CIK 0001847598 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,528

F3 · security: Represents a grant of restricted stock units received by the reporting person as the prorated portion of the annual equity grant upon appointment to the Issuer's Board of Directors pursuant to the Issuer's Director Compensation Policy. These restricted stock units vest on June 3, 2021.

F2 · balance_after: Consists of restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-031667 · tm218619-4_4seq1.xml · nonDerivative · entry 1

WEN LEANA · CIK 0001847598 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,079

F1 · security: Represents a grant of restricted stock units received by the reporting person as an initial equity grant upon appointment to the Issuer's Board of Directors, pursuant to the Issuer's Director Compensation Policy. One-third of the restricted stock units vest on each of the first three anniversaries of the grant date, and are payable in an equivalent number of shares of the Issuer's common stock.

F2 · balance_after: Consists of restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-031657 · tm218619-3_4seq1.xml · nonDerivative · entry 2

Torres Denice · CIK 0001820278 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,528

F3 · security: Represents a grant of restricted stock units received by the reporting person as the prorated portion of the annual equity grant upon appointment to the Issuer's Board of Directors pursuant to the Issuer's Director Compensation Policy. These restricted stock units vest on June 3, 2021.

F2 · balance_after: Consists of restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-031657 · tm218619-3_4seq1.xml · nonDerivative · entry 1

Torres Denice · CIK 0001820278 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,079

F1 · security: Represents a grant of restricted stock units received by the reporting person as an initial equity grant upon appointment to the Issuer's Board of Directors, pursuant to the Issuer's Director Compensation Policy. One-third of the restricted stock units vest on each of the first three anniversaries of the grant date, and are payable in an equivalent number of shares of the Issuer's common stock.

F2 · balance_after: Consists of restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-020731 · a4.xml · derivative · entry 6

Gilliam Joseph E · CIK 0001705850 · CFO, SVP Corporate Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 149,343

Underlying: Common Stock · 10,000 shares

Expires 2027-05-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · kind: These trades were made pursuant to a Rule 10b5-1 trading plan with pre-determined share amounts and prices.

F5 · derivative.exercise_date: These options vest over four years from the grant date, with 25% vesting on the first anniversary of the grant date and the remaining amount vesting in equal monthly installments over the following three years.

SEC source: 0001104659-21-020731 · a4.xml · derivative · entry 5

Gilliam Joseph E · CIK 0001705850 · CFO, SVP Corporate Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,437

Underlying: Common Stock · 3,750 shares

Expires 2028-03-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · kind: These trades were made pursuant to a Rule 10b5-1 trading plan with pre-determined share amounts and prices.

F5 · derivative.exercise_date: These options vest over four years from the grant date, with 25% vesting on the first anniversary of the grant date and the remaining amount vesting in equal monthly installments over the following three years.

SEC source: 0001104659-21-020731 · a4.xml · nonDerivative · entry 4

Gilliam Joseph E · CIK 0001705850 · CFO, SVP Corporate Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,802

F2 · kind: These trades were made pursuant to a Rule 10b5-1 trading plan with pre-determined share amounts and prices.

F4 · price: This transaction was executed in multiple trades at prices ranging from $96.92 to $97.24. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F1 · balance_after: Includes 21,107 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-020731 · a4.xml · nonDerivative · entry 3

Gilliam Joseph E · CIK 0001705850 · CFO, SVP Corporate Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,064

F2 · kind: These trades were made pursuant to a Rule 10b5-1 trading plan with pre-determined share amounts and prices.

F3 · price: This transaction was executed in multiple trades at prices ranging from $95.91 to $96.90. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F1 · balance_after: Includes 21,107 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-020731 · a4.xml · nonDerivative · entry 2

Gilliam Joseph E · CIK 0001705850 · CFO, SVP Corporate Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,552

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 21,107 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-020731 · a4.xml · nonDerivative · entry 1

Gilliam Joseph E · CIK 0001705850 · CFO, SVP Corporate Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,552

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 21,107 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001127602-21-003721 · form4.xml · derivative · entry 6

Calcaterra Chris M. · CIK 0001640771 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 60,417 shares

Expires 2026-03-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These trades were made pursuant to a Rule 10b5-1 trading plan with pre-determined share amounts and prices.

F7 · derivative.exercise_date: This option was granted on March 10, 2016, and has a four-year vesting schedule in which 25% vests on the first year anniversary date of the grant and the remainder vests in equal monthly installments for 36 months thereafter, such that the stock option vests in full on the four-year anniversary of the grant date.

SEC source: 0001127602-21-003721 · form4.xml · nonDerivative · entry 5

Calcaterra Chris M. · CIK 0001640771 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 163,806

F6 · price: This transaction was executed in multiple trades at prices ranging from $89.23 to $89.97. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · balance_after: Includes 5,967 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001127602-21-003721 · form4.xml · nonDerivative · entry 4

Calcaterra Chris M. · CIK 0001640771 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 180,591

F5 · price: This transaction was executed in multiple trades at prices ranging from $88.23 to $89.22. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · balance_after: Includes 5,967 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001127602-21-003721 · form4.xml · nonDerivative · entry 3

Calcaterra Chris M. · CIK 0001640771 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 204,992

F4 · price: This transaction was executed in multiple trades at prices ranging from $87.235 to $88.22. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · balance_after: Includes 5,967 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001127602-21-003721 · form4.xml · nonDerivative · entry 2

Calcaterra Chris M. · CIK 0001640771 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 211,022

F3 · price: This transaction was executed in multiple trades at prices ranging from $86.22 to $87.19. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · balance_after: Includes 5,967 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001127602-21-003721 · form4.xml · nonDerivative · entry 1

Calcaterra Chris M. · CIK 0001640771 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 224,223

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These trades were made pursuant to a Rule 10b5-1 trading plan with pre-determined share amounts and prices.

F2 · balance_after: Includes 5,967 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-001752 · a4.xml · nonDerivative · entry 1

Hoffmeister David F · CIK 0001305975 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,628

F1 · security: Represents a grant of restricted stock units received by the reporting person in lieu of annual director retainer fees pursuant to a stock-for-fees election under the Issuer's Director Compensation Policy. The units will vest in full on the one-year anniversary of the grant date and are payable in an equivalent number of shares of the Issuer's common stock.

F2 · balance_after: Includes 4,880 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-001754 · a4.xml · nonDerivative · entry 1

Kliman Gilbert H · CIK 0001293171 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,714

F1 · security: Represents a grant of restricted stock units received by the reporting person in lieu of annual director retainer fees pursuant to a stock-for-fees election under the Issuer's Director Compensation Policy. The units will vest in full on the one-year anniversary of the grant date and are payable in an equivalent number of shares of the Issuer's common stock.

F2 · balance_after: Includes 4,880 restricted stock units that have not yet vested or been delivered to the Reporting Person.

SEC source: 0001104659-21-001756 · a4.xml · nonDerivative · entry 1

WEISNER AIMEE S · CIK 0001227308 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,505

F1 · security: Represents a grant of restricted stock units received by the reporting person in lieu of annual director retainer fees pursuant to a stock-for-fees election under the Issuer's Director Compensation Policy. The units will vest in full on the one-year anniversary of the grant date and are payable in an equivalent number of shares of the Issuer's common stock.

F2 · balance_after: Includes 4,880 restricted stock units that have not yet vested or been delivered to the Reporting Person.