EXEL

SEC source: 0000939767-24-000131 · wk-form4_1724886421.xml · nonDerivative · entry 2

Hessekiel Jeffrey · CIK 0001599803 · EVP, General Counsel & Sec

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 630,325

F2 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on February 29, 2024.

F3 · price: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $25.68 to $25.87. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 3 to this Form 4.

F1 · balance_after: Includes 236,022 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock.

SEC source: 0000939767-24-000131 · wk-form4_1724886421.xml · nonDerivative · entry 1

Hessekiel Jeffrey · CIK 0001599803 · EVP, General Counsel & Sec

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 650,325

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 236,022 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock.

SEC source: 0000939767-24-000130 · wk-form4_1723851308.xml · nonDerivative · entry 1

Freire Maria C · CIK 0001547999 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 91,007

F1 · balance_after: Includes 18,838 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock.

SEC source: 0000939767-24-000129 · wk-form4_1723767514.xml · nonDerivative · entry 1

Smith Julie · CIK 0001557928 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,778

F1 · shares: Reflects transfer of 4,682 shares to ex-spouse pursuant to a settlement agreement.

F2 · balance_after: Includes 10,015 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock.

SEC source: 0000939767-24-000128 · wk-form4_1723677152.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 500,107

F1 · price: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $27.05 to $27.09. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 1 to this Form 4.

F2 · balance_after: Includes 288,932 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock.

SEC source: 0000939767-24-000123 · wk-form4_1723246304.xml · derivative · entry 4

Senner Christopher J. · CIK 0001648367 · EVP and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 125,000 shares

Expires 2024-10-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option, representing the right to purchase a total of 125,000 shares of Exelixis, Inc. common stock became fully exercisable on October 3, 2021.

SEC source: 0000939767-24-000123 · wk-form4_1723246304.xml · nonDerivative · entry 2

Senner Christopher J. · CIK 0001648367 · EVP and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 721,680

F2 · price: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $27.08 to $27.35. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 2 to this Form 4.

F1 · balance_after: Includes 272,874 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-24-000123 · wk-form4_1723246304.xml · nonDerivative · entry 1

Senner Christopher J. · CIK 0001648367 · EVP and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 846,680

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 272,874 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-24-000127 · wk-form4_1723504947.xml · nonDerivative · entry 1

POSTE GEORGE · CIK 0001180770 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 199,020

F1 · price: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $26.86 to $26.96. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 1 to this Form 4.

F2 · balance_after: Includes 18,838 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock.

SEC source: 0000939767-24-000126 · wk-form4_1723246333.xml · derivative · entry 4

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 95,000 shares

Expires 2024-10-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option, representing the right to purchase a total of 95,000 shares of Exelixis, Inc. common stock became fully exercisable on October 3, 2021.

SEC source: 0000939767-24-000126 · wk-form4_1723246333.xml · nonDerivative · entry 2

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 520,990

F2 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 25, 2023.

F1 · balance_after: Includes 288,932 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-24-000126 · wk-form4_1723246333.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 615,990

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 288,932 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-24-000125 · wk-form4_1723246324.xml · nonDerivative · entry 1

Haley Patrick J. · CIK 0001692954 · EVP, Commercial

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 341,036

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 7, 2023.

F2 · balance_after: Includes 239,572 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-24-000124 · wk-form4_1723246314.xml · derivative · entry 4

Hessekiel Jeffrey · CIK 0001599803 · EVP, General Counsel & Sec

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 80,000 shares

Expires 2024-10-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The option, representing the right to purchase a total of 100,000 shares of Exelixis, Inc. common stock became fully exercisable on October 3, 2021.

SEC source: 0000939767-24-000124 · wk-form4_1723246314.xml · nonDerivative · entry 2

Hessekiel Jeffrey · CIK 0001599803 · EVP, General Counsel & Sec

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 630,325

F2 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on February 29, 2024.

F3 · price: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $25.95 to $26.07. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 3 to this Form 4.

F1 · balance_after: Includes 236,022 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-24-000124 · wk-form4_1723246314.xml · nonDerivative · entry 1

Hessekiel Jeffrey · CIK 0001599803 · EVP, General Counsel & Sec

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 710,325

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 236,022 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-24-000103 · wk-form4_1717720669.xml · nonDerivative · entry 1

WYSZOMIERSKI JACK L · CIK 0001023225 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 349,499

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on February 12, 2024.

F2 · price: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $21.88 to $22.15. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 2 to this Form 4.

F3 · balance_after: Includes 18,838 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock.

SEC source: 0000939767-24-000102 · wk-form4_1717546868.xml · nonDerivative · entry 1

PAPADOPOULOS STELIOS · CIK 0001202098 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,279,416

F1 · date: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 100% of the shares subject to the RSU award on May 31, 2025, subject to the Reporting Person's continuous service through that date.

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 100% of the shares subject to the RSU award on May 31, 2025, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 39,556 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of RSUs. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock.

SEC source: 0000939767-24-000101 · wk-form4_1717546855.xml · nonDerivative · entry 1

POSTE GEORGE · CIK 0001180770 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 232,745

F1 · date: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 100% of the shares subject to the RSU award on May 31, 2025, subject to the Reporting Person's continuous service through that date.

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 100% of the shares subject to the RSU award on May 31, 2025, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 39,556 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of RSUs. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock.

SEC source: 0000939767-24-000100 · wk-form4_1717546840.xml · nonDerivative · entry 1

Freire Maria C · CIK 0001547999 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 99,257

F1 · date: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 100% of the shares subject to the RSU award on May 31, 2025, subject to the Reporting Person's continuous service through that date.

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 100% of the shares subject to the RSU award on May 31, 2025, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 39,556 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of RSUs. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock.

SEC source: 0000939767-24-000099 · wk-form4_1717546826.xml · nonDerivative · entry 1

Heyman Tomas J. · CIK 0001814673 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,014

F1 · date: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 100% of the shares subject to the RSU award on May 31, 2025, subject to the Reporting Person's continuous service through that date.

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 100% of the shares subject to the RSU award on May 31, 2025, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 32,470 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of RSUs. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock.

SEC source: 0000939767-24-000098 · wk-form4_1717546813.xml · nonDerivative · entry 1

Oliver Bob · CIK 0001694534 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,014

F1 · date: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 100% of the shares subject to the RSU award on May 31, 2025, subject to the Reporting Person's continuous service through that date.

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 100% of the shares subject to the RSU award on May 31, 2025, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 32,470 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of RSUs. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock.

SEC source: 0000939767-24-000097 · wk-form4_1717546800.xml · nonDerivative · entry 1

WYSZOMIERSKI JACK L · CIK 0001023225 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 357,786

F1 · date: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 100% of the shares subject to the RSU award on May 31, 2025, subject to the Reporting Person's continuous service through that date.

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 100% of the shares subject to the RSU award on May 31, 2025, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 39,556 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of RSUs. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock.

SEC source: 0000939767-24-000096 · wk-form4_1717546784.xml · nonDerivative · entry 1

Eckhardt Sue Gail · CIK 0001823769 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,262

F1 · date: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 100% of the shares subject to the RSU award on May 31, 2025, subject to the Reporting Person's continuous service through that date.

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 100% of the shares subject to the RSU award on May 31, 2025, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 34,262 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of RSUs. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock.

SEC source: 0000939767-24-000095 · wk-form4_1717546773.xml · nonDerivative · entry 1

Beckerle Mary C · CIK 0001520181 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,262

F1 · date: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 100% of the shares subject to the RSU award on May 31, 2025, subject to the Reporting Person's continuous service through that date.

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 100% of the shares subject to the RSU award on May 31, 2025, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 34,262 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of RSUs. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock.

SEC source: 0000939767-24-000094 · wk-form4_1717546761.xml · derivative · entry 2

Smith Julie · CIK 0001557928 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,030

Underlying: Common Stock · 20,030 shares

Expires 2031-05-30

F3 · derivative.exercise_date: Option granted pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The option is exercisable immediately, subject to repurchase provisions, and will vest as to 100% of the shares subject to the option on the one-year anniversary of the Transaction Date, subject to the Reporting Person's continuous service through such date.

SEC source: 0000939767-24-000094 · wk-form4_1717546761.xml · nonDerivative · entry 1

Smith Julie · CIK 0001557928 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,460

F1 · date: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 100% of the shares subject to the RSU award on May 31, 2025, subject to the Reporting Person's continuous service through that date.

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 100% of the shares subject to the RSU award on May 31, 2025, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 10,015 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of RSUs. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock.

SEC source: 0000902664-24-004028 · ownership.xml · derivative · entry 1

JOHNSON DAVID EDWARD · CIK 0001785557 · Director

Caligan Partners LP · CIK 0001727492 · Director · See Remarks.

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,767

Underlying: Common Stock · 42,767 shares

Expires 2031-05-30

F1 · derivative.exercise_date: Option granted to David Johnson ("Mr. Johnson") pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The option is exercisable immediately, subject to repurchase provisions, and will vest as to 100% of the shares subject to the option on the first anniversary of the date of grant, subject to Mr. Johnson's continuous service through such date.

F2 · ownership.direct: Mr. Johnson is deemed to hold the securities reported herein for the benefit of Caligan Partners Master Fund LP (the "Caligan Master Fund") and managed accounts to which Caligan Partners LP ("Caligan") serves as investment manager (the "Caligan Accounts", together with the Caligan Master Fund, the "Caligan Master Fund and Accounts"), and may, after vesting, if applicable, transfer the securities directly to the Caligan Master Fund and Accounts.

SEC source: 0000902664-24-003949 · ownership.xml · nonDerivative · entry 2

JOHNSON DAVID EDWARD · CIK 0001785557 · Director

Caligan Partners LP · CIK 0001727492 · Director · See Remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 1,525,730

F3 · price: The price reported in Column 4 is a weighted average price. These shares were purchased by Caligan Master Fund (as defined below) in multiple transactions at prices ranging from $20.40 to $20.885, inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth herein.

F2 · ownership.nature: This Form 4 is filed by David Johnson ("Mr. Johnson") and Caligan Partners LP ("Caligan") with respect to the securities held by Caligan Partners Master Fund LP ("Caligan Master Fund"), a Cayman Islands limited partnership, and managed accounts ("Caligan Accounts", together with the Caligan Master Fund, the "Caligan Fund and Accounts") to which Caligan serves as investment manager. Mr. Johnson is the Managing Partner of Caligan and a Managing Member of Caligan Partners GP LLC, the general partner of Caligan.

SEC source: 0000902664-24-003949 · ownership.xml · nonDerivative · entry 1

JOHNSON DAVID EDWARD · CIK 0001785557 · Director

Caligan Partners LP · CIK 0001727492 · Director · See Remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 1,300,730

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased by Caligan Master Fund (as defined below) in multiple transactions at prices ranging from $20.22 to $20.375, inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth herein.

F2 · ownership.nature: This Form 4 is filed by David Johnson ("Mr. Johnson") and Caligan Partners LP ("Caligan") with respect to the securities held by Caligan Partners Master Fund LP ("Caligan Master Fund"), a Cayman Islands limited partnership, and managed accounts ("Caligan Accounts", together with the Caligan Master Fund, the "Caligan Fund and Accounts") to which Caligan serves as investment manager. Mr. Johnson is the Managing Partner of Caligan and a Managing Member of Caligan Partners GP LLC, the general partner of Caligan.

SEC source: 0000939767-24-000076 · wk-form4_1716420188.xml · derivative · entry 3

POSTE GEORGE · CIK 0001180770 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 11,686 shares

Expires 2024-05-24

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option, representing the right to purchase a total of 11,686 shares of Exelixis, Inc. common stock, became fully exercisable on May 25, 2017.

SEC source: 0000939767-24-000076 · wk-form4_1716420188.xml · nonDerivative · entry 2

POSTE GEORGE · CIK 0001180770 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 213,907

F2 · price: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $20.95 to $20.99. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 2 to this Form 4.

F1 · balance_after: Includes 20,718 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-24-000076 · wk-form4_1716420188.xml · nonDerivative · entry 1

POSTE GEORGE · CIK 0001180770 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 225,593

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 20,718 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-24-000077 · wk-form4_1716504931.xml · nonDerivative · entry 1

Smith Julie · CIK 0001557928 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,445

F1 · price: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $21.11 to $21.17. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 1 to this Form 4.

SEC source: 0000939767-24-000075 · wk-form4_1716420171.xml · derivative · entry 3

PAPADOPOULOS STELIOS · CIK 0001202098 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 11,686 shares

Expires 2024-05-24

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option, representing the right to purchase a total of 11,686 shares of Exelixis, Inc. common stock, became fully exercisable on May 25, 2017.

SEC source: 0000939767-24-000075 · wk-form4_1716420171.xml · nonDerivative · entry 2

PAPADOPOULOS STELIOS · CIK 0001202098 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,260,578

F2 · price: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $20.99 to $21.02. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 2 to this Form 4.

F1 · balance_after: Includes 20,718 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-24-000075 · wk-form4_1716420171.xml · nonDerivative · entry 1

PAPADOPOULOS STELIOS · CIK 0001202098 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,272,015

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 20,718 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-24-000071 · wk-form4_1715990305.xml · nonDerivative · entry 2

MORRISSEY MICHAEL · CIK 0001202096 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 964,384

F3 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units awarded April 3, 2023.

F2 · balance_after: Includes 830,957 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-24-000071 · wk-form4_1715990305.xml · nonDerivative · entry 1

MORRISSEY MICHAEL · CIK 0001202096 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,004,065

F1 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units awarded March 4, 2022.

F2 · balance_after: Includes 830,957 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-24-000070 · wk-form4_1715990289.xml · nonDerivative · entry 3

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 520,990

F4 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units awarded April 3, 2023.

F2 · balance_after: Includes 288,932 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units and 1,214 shares of Exelixis, Inc. common stock acquired on April 30, 2024, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan.

SEC source: 0000939767-24-000070 · wk-form4_1715990289.xml · nonDerivative · entry 2

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 529,648

F3 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units awarded March 4, 2022.

F2 · balance_after: Includes 288,932 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units and 1,214 shares of Exelixis, Inc. common stock acquired on April 30, 2024, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan.

SEC source: 0000939767-24-000070 · wk-form4_1715990289.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 537,186

F1 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units awarded March 4, 2021.

F2 · balance_after: Includes 288,932 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units and 1,214 shares of Exelixis, Inc. common stock acquired on April 30, 2024, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan.

SEC source: 0000939767-24-000069 · wk-form4_1715990277.xml · nonDerivative · entry 4

Haley Patrick J. · CIK 0001692954 · EVP, Commercial

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 355,036

F5 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units awarded April 3, 2023.

F2 · balance_after: Includes 239,572 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units and 1,214 shares of Exelixis, Inc. common stock acquired on April 30, 2024, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan.

SEC source: 0000939767-24-000069 · wk-form4_1715990277.xml · nonDerivative · entry 3

Haley Patrick J. · CIK 0001692954 · EVP, Commercial

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 365,137

F4 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units awarded March 4, 2022.

F2 · balance_after: Includes 239,572 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units and 1,214 shares of Exelixis, Inc. common stock acquired on April 30, 2024, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan.

SEC source: 0000939767-24-000069 · wk-form4_1715990277.xml · nonDerivative · entry 2

Haley Patrick J. · CIK 0001692954 · EVP, Commercial

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 374,097

F3 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units awarded March 4, 2021.

F2 · balance_after: Includes 239,572 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units and 1,214 shares of Exelixis, Inc. common stock acquired on April 30, 2024, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan.

SEC source: 0000939767-24-000069 · wk-form4_1715990277.xml · nonDerivative · entry 1

Haley Patrick J. · CIK 0001692954 · EVP, Commercial

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 381,645

F1 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units awarded February 19, 2020.

F2 · balance_after: Includes 239,572 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units and 1,214 shares of Exelixis, Inc. common stock acquired on April 30, 2024, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan.

SEC source: 0000939767-24-000067 · wk-form4_1715990248.xml · nonDerivative · entry 3

Senner Christopher J. · CIK 0001648367 · EVP and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 721,680

F4 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units awarded April 3, 2023.

F2 · balance_after: Includes 272,874 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-24-000067 · wk-form4_1715990248.xml · nonDerivative · entry 2

Senner Christopher J. · CIK 0001648367 · EVP and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 733,158

F3 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units awarded March 4, 2022.

F2 · balance_after: Includes 272,874 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-24-000067 · wk-form4_1715990248.xml · nonDerivative · entry 1

Senner Christopher J. · CIK 0001648367 · EVP and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 743,369

F1 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units awarded March 4, 2021.

F2 · balance_after: Includes 272,874 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-24-000068 · wk-form4_1715990263.xml · nonDerivative · entry 3

Hessekiel Jeffrey · CIK 0001599803 · EVP, General Counsel & Sec

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 630,325

F4 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units awarded April 3, 2023.

F2 · balance_after: Includes 287,204 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units and 1,214 shares of Exelixis, Inc. common stock acquired on April 30, 2024, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan.