EXEL

SEC source: 0000939767-25-000134 · wk-form4_1763079150.xml · nonDerivative · entry 1

Beckerle Mary C · CIK 0001520181 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 46,002

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 21,380 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-25-000118 · wk-form4_1760137034.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · EVP, Research & Development

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 713,161

F1 · date: Represents shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon the vesting of restricted stock units ("RSUs"). The RSUs were granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 1/4th of the original number of shares subject to the RSU award on November 15, 2026 and thereafter as to 1/4th of the original number of shares subject to the RSU award on each November 15th until fully vested.

F1 · shares: Represents shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon the vesting of restricted stock units ("RSUs"). The RSUs were granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 1/4th of the original number of shares subject to the RSU award on November 15, 2026 and thereafter as to 1/4th of the original number of shares subject to the RSU award on each November 15th until fully vested.

F2 · balance_after: Includes 431,306 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs.

SEC source: 0000939767-25-000098 · wk-form4_1749081442.xml · nonDerivative · entry 1

WYSZOMIERSKI JACK L · CIK 0001023225 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 358,882

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 29, 2024.

F2 · price: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $42.70 to $43.49. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 2 to this Form 4.

F3 · balance_after: Includes 9,812 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-25-000099 · wk-form4_1749081453.xml · nonDerivative · entry 2

Eckhardt Sue Gail · CIK 0001823769 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 21,380

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on October 30, 2024.

F3 · balance_after: Includes 21,380 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-25-000099 · wk-form4_1749081453.xml · nonDerivative · entry 1

Eckhardt Sue Gail · CIK 0001823769 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 21,384

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on October 30, 2024.

F2 · price: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $42.48 to $43.33. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 2 to this Form 4.

F3 · balance_after: Includes 21,380 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-25-000094 · wk-form4_1748646900.xml · nonDerivative · entry 1

Beckerle Mary C · CIK 0001520181 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,218

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock ("Common Stock"). The RSUs will vest as to 100% of the shares subject to the RSU award on May 29, 2026, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 40,218 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs.

SEC source: 0000939767-25-000093 · wk-form4_1748646876.xml · nonDerivative · entry 1

Oliver Bob · CIK 0001694534 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,326

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock ("Common Stock"). The RSUs will vest as to 100% of the shares subject to the RSU award on May 29, 2026, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 42,282 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs.

SEC source: 0000939767-25-000092 · wk-form4_1748646854.xml · nonDerivative · entry 1

Heyman Tomas J. · CIK 0001814673 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,282

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock ("Common Stock"). The RSUs will vest as to 100% of the shares subject to the RSU award on May 29, 2026, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 42,282 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs.

SEC source: 0000939767-25-000091 · wk-form4_1748646831.xml · nonDerivative · entry 1

POSTE GEORGE · CIK 0001180770 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 178,832

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock ("Common Stock"). The RSUs will vest as to 100% of the shares subject to the RSU award on May 29, 2026, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 28,650 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs.

SEC source: 0000939767-25-000090 · wk-form4_1748646811.xml · nonDerivative · entry 1

WYSZOMIERSKI JACK L · CIK 0001023225 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 366,417

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock ("Common Stock"). The RSUs will vest as to 100% of the shares subject to the RSU award on May 29, 2026, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 28,650 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs.

SEC source: 0000939767-25-000089 · wk-form4_1748646788.xml · nonDerivative · entry 1

Freire Maria C · CIK 0001547999 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,819

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock ("Common Stock"). The RSUs will vest as to 100% of the shares subject to the RSU award on May 29, 2026, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 28,650 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs.

SEC source: 0000939767-25-000088 · wk-form4_1748646758.xml · nonDerivative · entry 1

PAPADOPOULOS STELIOS · CIK 0001202098 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,289,228

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock ("Common Stock"). The RSUs will vest as to 100% of the shares subject to the RSU award on May 29, 2026, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 28,650 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs.

SEC source: 0000939767-25-000087 · wk-form4_1748646733.xml · nonDerivative · entry 1

Eckhardt Sue Gail · CIK 0001823769 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,218

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock ("Common Stock"). The RSUs will vest as to 100% of the shares subject to the RSU award on May 29, 2026, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 40,218 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs.

SEC source: 0000939767-25-000086 · wk-form4_1748646713.xml · nonDerivative · entry 1

Smith Julie · CIK 0001557928 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,590

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock ("Common Stock"). The RSUs will vest as to 100% of the shares subject to the RSU award on May 29, 2026, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 19,827 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs.

SEC source: 0000902664-25-002613 · ownership.xml · derivative · entry 1

JOHNSON DAVID EDWARD · CIK 0001785557 · Director

Caligan Partners LP · CIK 0001727492 · Director · See Remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,464

Underlying: Common Stock · 21,464 shares

Expires 2032-05-28

F1 · derivative.exercise_date: Option granted to David Johnson ("Mr. Johnson") pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The option is exercisable immediately, subject to repurchase provisions, and will vest as to 100% of the shares subject to the option on the first anniversary of the date of grant, subject to Mr. Johnson's continuous service through such date.

F2 · ownership.direct: Mr. Johnson is deemed to hold the securities reported herein for the benefit of Caligan Partners Master Fund LP (the "Caligan Master Fund") and managed accounts to which Caligan Partners LP ("Caligan") serves as investment manager (the "Caligan Accounts", together with the Caligan Master Fund, the "Caligan Fund and Accounts"), and may, after vesting, if applicable, transfer the securities directly to the Caligan Fund and Accounts.

SEC source: 0000939767-25-000084 · wk-form4_1747956301.xml · nonDerivative · entry 1

Heyman Tomas J. · CIK 0001814673 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,470

F1 · balance_after: Includes 32,470 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-25-000085 · wk-form4_1747956313.xml · nonDerivative · entry 1

Haley Patrick J. · CIK 0001692954 · EVP, Commercial

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 412,072

F1 · price: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $44.05 to $44.13. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 1 to this Form 4.

F2 · balance_after: Includes 374,029 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs") and performance-based restricted stock units ("PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-25-000083 · wk-form4_1747443499.xml · derivative · entry 3

POSTE GEORGE · CIK 0001180770 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 20,634 shares

Expires 2026-05-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option, representing the right to purchase a total of 20,634 shares of Common Stock, became fully exercisable on May 23, 2019.

SEC source: 0000939767-25-000083 · wk-form4_1747443499.xml · nonDerivative · entry 2

POSTE GEORGE · CIK 0001180770 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 169,020

F1 · balance_after: Includes 18,838 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-25-000083 · wk-form4_1747443499.xml · nonDerivative · entry 1

POSTE GEORGE · CIK 0001180770 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 189,654

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 18,838 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-25-000081 · wk-form4_1747443475.xml · derivative · entry 5

Senner Christopher J. · CIK 0001648367 · EVP and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 100,000 shares

Expires 2025-09-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option, representing the right to purchase a total of 100,000 shares of Common Stock, became fully exercisable on September 10, 2022.

SEC source: 0000939767-25-000081 · wk-form4_1747443475.xml · nonDerivative · entry 3

Senner Christopher J. · CIK 0001648367 · EVP and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 967,842

F2 · balance_after: Includes 419,440 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of RSUs and performance-based restricted stock units ("PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-25-000081 · wk-form4_1747443475.xml · nonDerivative · entry 2

Senner Christopher J. · CIK 0001648367 · EVP and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,067,842

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · balance_after: Includes 419,440 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of RSUs and performance-based restricted stock units ("PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-25-000079 · wk-form4_1747443453.xml · nonDerivative · entry 5

MORRISSEY MICHAEL · CIK 0001202096 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · By Trust

Disclosed balance after: 1,852,856

F4 · kind: On May 16, 2025, the Reporting Person gifted 87,871 shares of Common Stock to Michael M. Morrissey and Meghan D. Morrissey, Trustees of the Morrissey Family Trust dated July 21, 1994, as amended.

F5 · balance_after: Shares held by Michael M. Morrissey and Meghan D. Morrissey, Trustees of the Morrissey Family Living Trust dated July 21, 1994, as amended.

SEC source: 0000939767-25-000079 · wk-form4_1747443453.xml · nonDerivative · entry 4

MORRISSEY MICHAEL · CIK 0001202096 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,518,240

F4 · kind: On May 16, 2025, the Reporting Person gifted 87,871 shares of Common Stock to Michael M. Morrissey and Meghan D. Morrissey, Trustees of the Morrissey Family Trust dated July 21, 1994, as amended.

F1 · balance_after: Includes 1,416,692 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs") and performance-based restricted stock units ("PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-25-000076 · wk-form4_1747443419.xml · derivative · entry 4

Peterson Amy C. · CIK 0001682735 · EVP Prod Dev & Med Aff & CMO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 120,000

Underlying: Common Stock · 40,000 shares

Expires 2030-08-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option, representing the right to purchase a total of 160,000 shares of Common Stock, 40,000 shares became exercisable on August 24, 2024 and the remainder will become fully exercisable on August 24, 2027.

SEC source: 0000939767-25-000076 · wk-form4_1747443419.xml · nonDerivative · entry 3

Peterson Amy C. · CIK 0001682735 · EVP Prod Dev & Med Aff & CMO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 465,393

F3 · price: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $45.08 to $46.44. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 3 to this Form 4.

F2 · balance_after: Includes 453,166 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of RSUs and performance-based restricted stock units ("PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-25-000076 · wk-form4_1747443419.xml · nonDerivative · entry 2

Peterson Amy C. · CIK 0001682735 · EVP Prod Dev & Med Aff & CMO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 538,169

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · balance_after: Includes 453,166 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of RSUs and performance-based restricted stock units ("PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-25-000082 · wk-form4_1747443488.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 662,488

F1 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units ("RSUs") awarded on March 4, 2021, March 4, 2022, April 3, 2023, and February 23, 2024.

F2 · balance_after: Includes 380,633 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of RSUs and performance-based restricted stock units ("PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-25-000081 · wk-form4_1747443475.xml · nonDerivative · entry 1

Senner Christopher J. · CIK 0001648367 · EVP and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 967,842

F1 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units ("RSUs") awarded on March 4, 2021, March 4, 2022, April 3, 2023, and February 23, 2024.

F2 · balance_after: Includes 419,440 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of RSUs and performance-based restricted stock units ("PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-25-000080 · wk-form4_1747443463.xml · derivative · entry 6

PAPADOPOULOS STELIOS · CIK 0001202098 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 15,874 shares

Expires 2025-05-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option, representing the right to purchase a total of 15,874 shares of Common Stock, became fully exercisable on May 24, 2018.

SEC source: 0000939767-25-000080 · wk-form4_1747443463.xml · derivative · entry 5

PAPADOPOULOS STELIOS · CIK 0001202098 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 20,634 shares

Expires 2026-05-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option, representing the right to purchase a total of 20,634 shares of Common Stock, became fully exercisable on May 23, 2019.

SEC source: 0000939767-25-000080 · wk-form4_1747443463.xml · nonDerivative · entry 4

PAPADOPOULOS STELIOS · CIK 0001202098 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,279,416

F1 · balance_after: Includes 18,838 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-25-000080 · wk-form4_1747443463.xml · nonDerivative · entry 3

PAPADOPOULOS STELIOS · CIK 0001202098 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,295,290

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 18,838 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-25-000080 · wk-form4_1747443463.xml · nonDerivative · entry 2

PAPADOPOULOS STELIOS · CIK 0001202098 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,279,416

F1 · balance_after: Includes 18,838 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-25-000080 · wk-form4_1747443463.xml · nonDerivative · entry 1

PAPADOPOULOS STELIOS · CIK 0001202098 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,300,050

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 18,838 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-25-000079 · wk-form4_1747443453.xml · nonDerivative · entry 3

MORRISSEY MICHAEL · CIK 0001202096 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,606,111

F3 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of RSUs awarded on March 4, 2022, April 3, 2023, and February 23, 2024.

F1 · balance_after: Includes 1,416,692 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs") and performance-based restricted stock units ("PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-25-000078 · wk-form4_1747443441.xml · nonDerivative · entry 2

Hessekiel Jeffrey · CIK 0001599803 · EVP & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 693,396

F3 · price: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $46.04 to $46.48. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 3 to this Form 4.

F2 · balance_after: Includes 369,995 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of RSUs and performance-based restricted stock units ("PSUs") and 753 shares of Common Stock acquired on April 30, 2025, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan. Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-25-000078 · wk-form4_1747443441.xml · nonDerivative · entry 1

Hessekiel Jeffrey · CIK 0001599803 · EVP & General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 718,396

F1 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units ("RSUs") awarded on March 4, 2021, March 4, 2022, April 3, 2023, and February 23, 2024.

F2 · balance_after: Includes 369,995 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of RSUs and performance-based restricted stock units ("PSUs") and 753 shares of Common Stock acquired on April 30, 2025, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan. Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-25-000077 · wk-form4_1747443430.xml · derivative · entry 8

Haley Patrick J. · CIK 0001692954 · EVP, Commercial

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 116,383 shares

Expires 2025-09-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The option, representing the right to purchase a total of 116,383 shares of Common Stock, became fully exercisable on September 10, 2022.

SEC source: 0000939767-25-000077 · wk-form4_1747443430.xml · nonDerivative · entry 5

Haley Patrick J. · CIK 0001692954 · EVP, Commercial

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 446,459

F4 · price: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $48.05 to $48.16. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 4 to this Form 4.

F2 · balance_after: Includes 374,029 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs") and performance-based restricted stock units ("PSUs") and 753 shares of Common Stock acquired on April 30, 2025, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan. Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-25-000077 · wk-form4_1747443430.xml · nonDerivative · entry 4

Haley Patrick J. · CIK 0001692954 · EVP, Commercial

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 562,842

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · balance_after: Includes 374,029 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs") and performance-based restricted stock units ("PSUs") and 753 shares of Common Stock acquired on April 30, 2025, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan. Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-25-000077 · wk-form4_1747443430.xml · nonDerivative · entry 3

Haley Patrick J. · CIK 0001692954 · EVP, Commercial

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 446,459

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 19, 2024.

F2 · balance_after: Includes 374,029 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs") and performance-based restricted stock units ("PSUs") and 753 shares of Common Stock acquired on April 30, 2025, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan. Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-25-000077 · wk-form4_1747443430.xml · nonDerivative · entry 2

Haley Patrick J. · CIK 0001692954 · EVP, Commercial

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 456,459

F3 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of RSUs awarded on March 4, 2021, March 4, 2022, April 3, 2023, and February 23, 2024.

F2 · balance_after: Includes 374,029 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs") and performance-based restricted stock units ("PSUs") and 753 shares of Common Stock acquired on April 30, 2025, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan. Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-25-000076 · wk-form4_1747443419.xml · nonDerivative · entry 1

Peterson Amy C. · CIK 0001682735 · EVP Prod Dev & Med Aff & CMO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 498,169

F1 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units ("RSUs") awarded February 23, 2024.

F2 · balance_after: Includes 453,166 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of RSUs and performance-based restricted stock units ("PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-25-000079 · wk-form4_1747443453.xml · derivative · entry 7

MORRISSEY MICHAEL · CIK 0001202096 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 308,365 shares

Expires 2025-09-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · derivative.exercise_date: The option, representing the right to purchase a total of 308,365 shares of Common Stock, became fully exercisable on September 10, 2022.

SEC source: 0000939767-25-000079 · wk-form4_1747443453.xml · nonDerivative · entry 2

MORRISSEY MICHAEL · CIK 0001202096 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,710,880

F2 · shares: Represents a "net exercise" of an outstanding stock option to purchase 308,365 shares, and pursuant to which the Reporting Person received 87,871 shares, of Common Stock. The Issuer withheld 220,494 shares of Common Stock underlying the stock option for payment of the exercise price and tax withholding using the closing stock price on May 14, 2025 of $44.65.

F1 · balance_after: Includes 1,416,692 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs") and performance-based restricted stock units ("PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-25-000079 · wk-form4_1747443453.xml · nonDerivative · entry 1

MORRISSEY MICHAEL · CIK 0001202096 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,931,374

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 1,416,692 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs") and performance-based restricted stock units ("PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-25-000077 · wk-form4_1747443430.xml · nonDerivative · entry 1

Haley Patrick J. · CIK 0001692954 · EVP, Commercial

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 491,164

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 19, 2024.

F2 · balance_after: Includes 374,029 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs") and performance-based restricted stock units ("PSUs") and 753 shares of Common Stock acquired on April 30, 2025, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan. Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-25-000064 · wk-form4_1746486720.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 693,181

F1 · balance_after: Includes 441,071 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs") and performance-based restricted stock units ("PSUs") and 753 shares of Common Stock acquired on April 30, 2025, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan. Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.