EXEL

SEC source: 0000939767-26-000101 · wk-form4_1786577638.xml · nonDerivative · entry 1

Beckerle Mary C · CIK 0001520181 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 16,079

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 8, 2026.

F2 · price: Represents the weighted average sales price. The shares of Exelixis, Inc. common stock ("Common Stock") were sold in multiple transactions at prices ranging from $53.16 to $54.02. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 2 to this Form 4.

F3 · balance_after: Includes 16,079 shares of Common Stock that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-26-000085 · wk-form4_1780527122.xml · nonDerivative · entry 1

WYSZOMIERSKI JACK L · CIK 0001023225 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 284,384

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 19, 2025.

F2 · balance_after: Includes 8,367 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-26-000084 · wk-form4_1780527116.xml · nonDerivative · entry 1

Eckhardt Sue Gail · CIK 0001823769 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 16,079

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 11, 2025.

F2 · price: Represents the weighted average sales price. The shares of Exelixis, Inc. common Stock ("Common Stock") were sold in multiple transactions at prices ranging from $49.73 to $50.61. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 2 to this Form 4.

F3 · balance_after: Includes 16,079 shares of Common Stock that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-26-000083 · wk-form4_1780091030.xml · nonDerivative · entry 1

PAPADOPOULOS STELIOS · CIK 0001202098 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,197,595

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock ("Common Stock"). The RSUs will vest as to 100% of the shares subject to the RSU award on May 27, 2027, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 8,367 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs.

SEC source: 0000939767-26-000082 · wk-form4_1780091024.xml · nonDerivative · entry 1

Heyman Tomas J. · CIK 0001814673 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,649

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock ("Common Stock"). The RSUs will vest as to 100% of the shares subject to the RSU award on May 27, 2027, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 17,455 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs.

SEC source: 0000939767-26-000079 · wk-form4_1780091007.xml · nonDerivative · entry 1

Freire Maria C · CIK 0001547999 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 109,186

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock ("Common Stock"). The RSUs will vest as to 100% of the shares subject to the RSU award on May 27, 2027, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 8,367 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs.

SEC source: 0000939767-26-000081 · wk-form4_1780091018.xml · nonDerivative · entry 1

Eckhardt Sue Gail · CIK 0001823769 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,891

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock ("Common Stock"). The RSUs will vest as to 100% of the shares subject to the RSU award on May 27, 2027, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 16,079 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs.

SEC source: 0000939767-26-000080 · wk-form4_1780091013.xml · nonDerivative · entry 1

Smith Julie · CIK 0001557928 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,957

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock ("Common Stock"). The RSUs will vest as to 100% of the shares subject to the RSU award on May 27, 2027, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 8,367 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs.

SEC source: 0000939767-26-000078 · wk-form4_1780091001.xml · nonDerivative · entry 1

Beckerle Mary C · CIK 0001520181 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,891

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock ("Common Stock"). The RSUs will vest as to 100% of the shares subject to the RSU award on May 27, 2027, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 16,079 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs.

SEC source: 0000939767-26-000077 · wk-form4_1780090995.xml · nonDerivative · entry 1

Oliver Bob · CIK 0001694534 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,487

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock ("Common Stock"). The RSUs will vest as to 100% of the shares subject to the RSU award on May 27, 2027, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 17,455 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs.

SEC source: 0000939767-26-000076 · wk-form4_1780090989.xml · nonDerivative · entry 1

WYSZOMIERSKI JACK L · CIK 0001023225 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 288,309

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock ("Common Stock"). The RSUs will vest as to 100% of the shares subject to the RSU award on May 27, 2027, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 8,367 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs.

SEC source: 0000939767-26-000075 · wk-form4_1780090983.xml · nonDerivative · entry 1

POSTE GEORGE · CIK 0001180770 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 127,199

F1 · shares: Represents restricted stock units ("RSUs") granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock ("Common Stock"). The RSUs will vest as to 100% of the shares subject to the RSU award on May 27, 2027, subject to the Reporting Person's continuous service through that date.

F2 · balance_after: Includes 8,367 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs.

SEC source: 0000902664-26-002641 · ownership.xml · derivative · entry 1

JOHNSON DAVID EDWARD · CIK 0001785557 · Director

Caligan Partners LP · CIK 0001727492 · Director · See Remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,133

Underlying: Common Stock · 19,133 shares

Expires 2033-05-26

F1 · derivative.exercise_date: Option granted to David Johnson ("Mr. Johnson") pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The option is exercisable immediately, subject to repurchase provisions, and will vest as to 100% of the shares subject to the option on the first anniversary of the date of grant, subject to Mr. Johnson's continuous service through such date.

F2 · ownership.direct: Mr. Johnson is deemed to hold the securities reported herein for the benefit of Caligan Partners Master Fund LP (the "Caligan Master Fund") and managed accounts to which Caligan Partners LP ("Caligan") serves as investment manager (the "Caligan Accounts", together with the Caligan Master Fund, the "Caligan Master Fund and Accounts"), and may, after vesting, if applicable, transfer the securities directly to the Caligan Master Fund and Accounts.

SEC source: 0000939767-26-000070 · wk-form4_1780007115.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · EVP, Research and Development

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 594,741

F1 · balance_after: Includes 405,966 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"), and the performance-based restricted stock unit award granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000069 · wk-form4_1779483702.xml · nonDerivative · entry 1

Haley Patrick J. · CIK 0001692954 · EVP, Commercial

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 357,638

F1 · price: Represents the weighted average sales price. The shares of Exelixis, Inc. common stock ("Common Stock") were sold in multiple transactions at prices ranging from $49.80 to $49.89. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 1 to this Form 4.

F2 · balance_after: Includes 356,992 shares of Common Stock that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"), and the performance-based restricted stock unit award granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000068 · wk-form4_1779231526.xml · nonDerivative · entry 3

MORRISSEY MICHAEL · CIK 0001202096 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · By Trust

Disclosed balance after: 2,004,327

F3 · shares: On May 18, 2026, the Reporting Person gifted 124,047 shares of Common Stock to Michael M. Morrissey and Meghan D. Morrissey, Trustees of the Morrissey Family Living Trust dated July 21, 1994, as amended.

F4 · balance_after: Shares of Common Stock held by Michael M. Morrissey and Meghan D. Morrissey, Trustees of the Morrissey Family Living Trust dated July 21, 1994, as amended.

SEC source: 0000939767-26-000068 · wk-form4_1779231526.xml · nonDerivative · entry 2

MORRISSEY MICHAEL · CIK 0001202096 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,362,008

F3 · shares: On May 18, 2026, the Reporting Person gifted 124,047 shares of Common Stock to Michael M. Morrissey and Meghan D. Morrissey, Trustees of the Morrissey Family Living Trust dated July 21, 1994, as amended.

F2 · balance_after: Includes 1,362,008 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of RSUs and the performance-based restricted stock unit award granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000067 · wk-form4_1779231521.xml · nonDerivative · entry 2

Senner Christopher J. · CIK 0001648367 · EVP and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 952,317

F3 · price: Represents the weighted average sales price. The shares of Common Stock were sold in multiple transactions at prices ranging from $50.00 to $50.07. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 3 to this Form 4.

F2 · balance_after: Includes 403,915 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of RSUs and the performance-based restricted stock unit award granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000065 · wk-form4_1779231509.xml · nonDerivative · entry 2

Hefti Brenda · CIK 0002097579 · SVP and General Counsel

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 106,762

F3 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 19, 2025.

F4 · price: Represents the weighted average sales price. The shares of Common Stock were sold in multiple transactions at prices ranging from $49.84 to $50.51. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 4 to this Form 4.

F2 · balance_after: Includes 106,039 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of RSUs, the performance-based restricted stock unit award granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs") and 167 shares of Common Stock acquired on April 30, 2026, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan. Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000068 · wk-form4_1779231526.xml · nonDerivative · entry 1

MORRISSEY MICHAEL · CIK 0001202096 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,486,055

F1 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units ("RSUs") awarded on March 4, 2022, April 3, 2023, February 23, 2024, and February 26, 2025.

F2 · balance_after: Includes 1,362,008 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of RSUs and the performance-based restricted stock unit award granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000067 · wk-form4_1779231521.xml · nonDerivative · entry 1

Senner Christopher J. · CIK 0001648367 · EVP and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 987,218

F1 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units ("RSUs") awarded on March 4, 2022, April 3, 2023, February 23, 2024, and February 26, 2025.

F2 · balance_after: Includes 403,915 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of RSUs and the performance-based restricted stock unit award granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000066 · wk-form4_1779231515.xml · nonDerivative · entry 1

Haley Patrick J. · CIK 0001692954 · EVP, Commercial

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 389,748

F1 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units ("RSUs") awarded on March 4, 2022, April 3, 2023, February 23, 2024, and February 26, 2025.

F2 · balance_after: Includes 356,992 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of RSUs, the performance-based restricted stock unit award granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs") and 646 shares of Common Stock acquired on April 30, 2026, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan. Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000065 · wk-form4_1779231509.xml · nonDerivative · entry 1

Hefti Brenda · CIK 0002097579 · SVP and General Counsel

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 113,387

F1 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units ("RSUs") awarded on March 4, 2022, February 29, 2024, and February 26, 2025.

F2 · balance_after: Includes 106,039 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of RSUs, the performance-based restricted stock unit award granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs") and 167 shares of Common Stock acquired on April 30, 2026, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan. Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000064 · wk-form4_1779231503.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · EVP, Research and Development

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 638,192

F1 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units ("RSUs") awarded on March 4, 2022, April 3, 2023, February 23, 2024, and February 26, 2025.

F2 · balance_after: Includes 405,966 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of RSUs, the performance-based restricted stock unit award granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs") and 646 shares of Common Stock acquired on April 30, 2026, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan. Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000063 · wk-form4_1778281427.xml · derivative · entry 3

Beckerle Mary C · CIK 0001520181 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,854

Underlying: Common Stock · 3,856 shares

Expires 2031-01-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option, representing the right to purchase a total of 30,848 shares of Common Stock, became fully exercisable on January 5, 2024.

SEC source: 0000939767-26-000063 · wk-form4_1778281427.xml · nonDerivative · entry 2

Beckerle Mary C · CIK 0001520181 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,524

F1 · balance_after: Includes 17,524 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-26-000063 · wk-form4_1778281427.xml · nonDerivative · entry 1

Beckerle Mary C · CIK 0001520181 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,236

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 17,524 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-26-000062 · wk-form4_1778281421.xml · derivative · entry 3

Freire Maria C · CIK 0001547999 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 20,634 shares

Expires 2026-05-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option, representing the right to purchase a total of 20,634 shares of Common Stock, became fully exercisable on May 23, 2019.

SEC source: 0000939767-26-000062 · wk-form4_1778281421.xml · nonDerivative · entry 2

Freire Maria C · CIK 0001547999 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,819

F1 · balance_after: Includes 9,812 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-26-000062 · wk-form4_1778281421.xml · nonDerivative · entry 1

Freire Maria C · CIK 0001547999 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 121,453

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 9,812 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-26-000061 · wk-form4_1778281415.xml · nonDerivative · entry 1

POSTE GEORGE · CIK 0001180770 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 118,832

F1 · price: Represents the weighted average sales price. The shares of Exelixis, Inc. common stock ("Common Stock") were sold in multiple transactions at prices ranging from $45.65 to $45.85. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 1 to this Form 4.

F2 · balance_after: Includes 9,812 shares of Common Stock that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-26-000060 · wk-form4_1778281409.xml · nonDerivative · entry 1

MORRISSEY MICHAEL · CIK 0001202096 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · By Trust

Disclosed balance after: 1,880,280

F1 · kind: On May 6, 2026, the Reporting Person gifted 109,676 shares of Exelixis, Inc. common stock ("Common Stock") to the Bombora Rise Foundation.

F2 · balance_after: Shares of Common Stock held by Michael M. Morrissey and Meghan D. Morrissey, Trustees of the Morrissey Family Living Trust dated July 21, 1994, as amended.

SEC source: 0000939767-26-000037 · wk-form4_1772499575.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · EVP, Research and Development

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 668,124

F1 · date: Represents shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon the vesting of restricted stock units ("RSUs"). The RSUs were granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 1/4th of the original number of shares subject to the RSU award on May 15, 2027 and thereafter as to 1/4th of the original number of shares subject to the RSU award on each May 15th until fully vested.

F1 · shares: Represents shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon the vesting of restricted stock units ("RSUs"). The RSUs were granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 1/4th of the original number of shares subject to the RSU award on May 15, 2027 and thereafter as to 1/4th of the original number of shares subject to the RSU award on each May 15th until fully vested.

F2 · balance_after: Includes 466,061 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs and the performance-based restricted stock unit award granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000035 · wk-form4_1772499563.xml · nonDerivative · entry 1

Hefti Brenda · CIK 0002097579 · SVP and General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 119,631

F1 · date: Represents shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon the vesting of restricted stock units ("RSUs"). The RSUs were granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 1/4th of the original number of shares subject to the RSU award on May 15, 2027 and thereafter as to 1/4th of the original number of shares subject to the RSU award on each May 15th until fully vested.

F1 · shares: Represents shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon the vesting of restricted stock units ("RSUs"). The RSUs were granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 1/4th of the original number of shares subject to the RSU award on May 15, 2027 and thereafter as to 1/4th of the original number of shares subject to the RSU award on each May 15th until fully vested.

F2 · balance_after: Includes 119,075 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs and the performance-based restricted stock unit award granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000036 · wk-form4_1772499569.xml · nonDerivative · entry 1

Senner Christopher J. · CIK 0001648367 · EVP and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,028,110

F1 · date: Represents shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon the vesting of restricted stock units ("RSUs"). The RSUs were granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 1/4th of the original number of shares subject to the RSU award on May 15, 2027 and thereafter as to 1/4th of the original number of shares subject to the RSU award on each May 15th until fully vested.

F1 · shares: Represents shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon the vesting of restricted stock units ("RSUs"). The RSUs were granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 1/4th of the original number of shares subject to the RSU award on May 15, 2027 and thereafter as to 1/4th of the original number of shares subject to the RSU award on each May 15th until fully vested.

F2 · balance_after: Includes 479,708 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs and the performance-based restricted stock unit award granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000034 · wk-form4_1772499558.xml · nonDerivative · entry 1

Haley Patrick J. · CIK 0001692954 · EVP, Commercial

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 422,367

F1 · date: Represents shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon the vesting of restricted stock units ("RSUs"). The RSUs were granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 1/4th of the original number of shares subject to the RSU award on May 15, 2027 and thereafter as to 1/4th of the original number of shares subject to the RSU award on each May 15th until fully vested.

F1 · shares: Represents shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon the vesting of restricted stock units ("RSUs"). The RSUs were granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 1/4th of the original number of shares subject to the RSU award on May 15, 2027 and thereafter as to 1/4th of the original number of shares subject to the RSU award on each May 15th until fully vested.

F2 · balance_after: Includes 422,367 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs and the performance-based restricted stock unit award granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000033 · wk-form4_1772499552.xml · nonDerivative · entry 2

MORRISSEY MICHAEL · CIK 0001202096 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,614,552

F3 · date: Represents shares of Common Stock that will be issued to the Reporting Person upon the vesting of restricted stock units ("RSUs"). The RSUs were granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 1/4th of the original number of shares subject to the RSU award on May 15, 2027 and thereafter as to 1/4th of the original number of shares subject to the RSU award on each May 15th until fully vested.

F3 · shares: Represents shares of Common Stock that will be issued to the Reporting Person upon the vesting of restricted stock units ("RSUs"). The RSUs were granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 1/4th of the original number of shares subject to the RSU award on May 15, 2027 and thereafter as to 1/4th of the original number of shares subject to the RSU award on each May 15th until fully vested.

F4 · balance_after: Includes 1,614,552 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs and the performance-based restricted stock unit award granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000032 · wk-form4_1772149294.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · EVP, Research and Development

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 616,106

F1 · balance_after: Includes 414,043 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs") and PSUs granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000033 · wk-form4_1772499552.xml · nonDerivative · entry 1

MORRISSEY MICHAEL · CIK 0001202096 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · By Trust

Disclosed balance after: 1,989,956

F1 · kind: On February 24, 2026, the Reporting Person gifted 100,278 shares of Exelixis, Inc. common stock ("Common Stock") to the Bombora Rise Foundation.

F2 · balance_after: Shares held by Michael M. Morrissey and Meghan D. Morrissey, Trustees of the Morrissey Family Living Trust dated July 21, 1994, as amended.

SEC source: 0000939767-26-000031 · wk-form4_1771890600.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · EVP, Research and Development

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 664,024

F1 · balance_after: Includes 414,043 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs") and PSUs granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000026 · wk-form4_1771465753.xml · nonDerivative · entry 7

MORRISSEY MICHAEL · CIK 0001202096 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · By Trust

Disclosed balance after: 2,090,234

F6 · kind: On February 18, 2026, the Reporting Person gifted 125,094 shares of Common Stock to Michael M. Morrissey and Meghan D. Morrissey, Trustees of the Morrissey Family Trust dated July 21, 1994, as amended.

F5 · balance_after: Shares held by Michael M. Morrissey and Meghan D. Morrissey, Trustees of the Morrissey Family Living Trust dated July 21, 1994, as amended.

SEC source: 0000939767-26-000026 · wk-form4_1771465753.xml · nonDerivative · entry 6

MORRISSEY MICHAEL · CIK 0001202096 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,454,115

F6 · kind: On February 18, 2026, the Reporting Person gifted 125,094 shares of Common Stock to Michael M. Morrissey and Meghan D. Morrissey, Trustees of the Morrissey Family Trust dated July 21, 1994, as amended.

F1 · balance_after: Includes 1,454,115 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs") and PSUs granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000022 · wk-form4_1771465726.xml · nonDerivative · entry 2

Hefti Brenda · CIK 0002097579 · SVP and General Counsel

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 96,512

F3 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 19, 2025.

F4 · price: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $43.32 to $44.49. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 4 to this Form 4.

F2 · balance_after: Includes 95,956 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs") and PSUs granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000029 · wk-form4_1771546714.xml · derivative · entry 9

Smith Julie · CIK 0001557928 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 20,030 shares

Expires 2031-05-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The option, representing the right to purchase a total of 20,030 shares of Common Stock, became fully exercisable on May 31, 2024.

SEC source: 0000939767-26-000029 · wk-form4_1771546714.xml · derivative · entry 8

Smith Julie · CIK 0001557928 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 44,087 shares

Expires 2030-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option, representing the right to purchase a total of 44,087 shares of Common Stock, became fully exercisable on June 1, 2023.

SEC source: 0000939767-26-000029 · wk-form4_1771546714.xml · nonDerivative · entry 6

Smith Julie · CIK 0001557928 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,590

F1 · balance_after: Includes 9,812 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-26-000029 · wk-form4_1771546714.xml · nonDerivative · entry 5

Smith Julie · CIK 0001557928 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,620

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 9,812 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-26-000029 · wk-form4_1771546714.xml · nonDerivative · entry 4

Smith Julie · CIK 0001557928 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,590

F1 · balance_after: Includes 9,812 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-26-000029 · wk-form4_1771546714.xml · nonDerivative · entry 3

Smith Julie · CIK 0001557928 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 64,677

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 9,812 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-26-000030 · wk-form4_1771637788.xml · derivative · entry 3

WYSZOMIERSKI JACK L · CIK 0001023225 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 20,634 shares

Expires 2026-05-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option, representing the right to purchase a total of 20,634 shares of Common Stock, became fully exercisable on May 23, 2019.