ELVN

SEC source: 0001415889-24-019600 · form4-07162024_090759.xml · nonDerivative · entry 1

Patel Anish · CIK 0001967163 · CHIEF OPERATING OFFICER

10b5-1 filing: Plan reported

Ownership: Indirect · See footnote

Disclosed balance after: 376,552

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 29, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $25.00 to $25.38. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

F3 · ownership.nature: The shares are held by The Patel / Dong Family Trust Dated August 24 2017 for which the Reporting Person serves as trustee.

SEC source: 0001415889-24-019202 · form4-07032024_080732.xml · nonDerivative · entry 1

Lyssikatos Joseph P · CIK 0001967150 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Indirect · See footnote

Disclosed balance after: 1,105,035

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $22.6459 to $23.635. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

F3 · ownership.nature: The shares are held by The Lyssikatos Revocable Trust 12/15/2011 for which the Reporting Person serves as trustee.

SEC source: 0001415889-24-018694 · form4-07022024_120743.xml · derivative · entry 5

Hohl Benjamin · CIK 0001882764 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 212,620

Underlying: Common Stock · 4,250 shares

Expires 2031-08-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F5 · derivative.exercise_date: The option, originally for 262,120 shares, vested as to one-fourth of the shares on August 2, 2022, and the remainder of the shares vest in 36 equal monthly installments thereafter.

SEC source: 0001415889-24-018694 · form4-07022024_120743.xml · nonDerivative · entry 4

Hohl Benjamin · CIK 0001882764 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F4 · price: This transaction was executed in multiple trades at prices ranging from $23.37 to $23.45. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-018694 · form4-07022024_120743.xml · nonDerivative · entry 3

Hohl Benjamin · CIK 0001882764 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,140

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F3 · price: This transaction was executed in multiple trades at prices ranging from $22.2058 to $23.1325. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-018694 · form4-07022024_120743.xml · nonDerivative · entry 2

Hohl Benjamin · CIK 0001882764 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,970

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $21.145 to $22.14. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-018694 · form4-07022024_120743.xml · nonDerivative · entry 1

Hohl Benjamin · CIK 0001882764 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,250

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

SEC source: 0001415889-24-018336 · form4-06272024_080620.xml · nonDerivative · entry 2

Kintz Samuel · CIK 0001967168 · Director · PRESIDENT AND CEO

10b5-1 filing: Plan reported

Ownership: Indirect · See footnote

Disclosed balance after: 1,075,525

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F4 · price: This transaction was executed in multiple trades at prices ranging from $22.2588 to $22.3613. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

F3 · ownership.nature: The shares are held of record by The Kintz & Egan Trust Dated March 30, 2019 for which the reporting person serves as trustee.

SEC source: 0001415889-24-018336 · form4-06272024_080620.xml · nonDerivative · entry 1

Kintz Samuel · CIK 0001967168 · Director · PRESIDENT AND CEO

10b5-1 filing: Plan reported

Ownership: Indirect · See footnote

Disclosed balance after: 1,076,103

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $21.25 to $22.2438. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

F3 · ownership.nature: The shares are held of record by The Kintz & Egan Trust Dated March 30, 2019 for which the reporting person serves as trustee.

SEC source: 0001415889-24-017715 · form4-06202024_110634.xml · nonDerivative · entry 1

Heyman Richard A. · CIK 0001584759 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 134,615

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on July 17, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $21.22 to $22.0783. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-016279 · form4-06102024_100635.xml · derivative · entry 4

Patel Anish · CIK 0001967163 · CHIEF OPERATING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 53,342

Underlying: Common Stock · 1,133 shares

Expires 2031-03-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 29, 2023.

F4 · derivative.exercise_date: The option, originally for 75,620 shares, vests in 48 equal monthly installments beginning on January 14, 2021.

SEC source: 0001415889-24-016279 · form4-06102024_100635.xml · nonDerivative · entry 2

Patel Anish · CIK 0001967163 · CHIEF OPERATING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 29, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $19.785 to $20.41. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-016279 · form4-06102024_100635.xml · nonDerivative · entry 1

Patel Anish · CIK 0001967163 · CHIEF OPERATING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,133

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 29, 2023.

SEC source: 0001415889-24-015031 · form4-05312024_080541.xml · derivative · entry 5

Lyssikatos Joseph P · CIK 0001967150 · Director · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 206,550

Underlying: Common Stock · 12,000 shares

Expires 2030-06-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F5 · derivative.exercise_date: All of the shares subject to this option are fully vested and exercisable as of the date hereof.

SEC source: 0001415889-24-015031 · form4-05312024_080541.xml · nonDerivative · entry 3

Lyssikatos Joseph P · CIK 0001967150 · Director · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F3 · price: This transaction was executed in multiple trades at prices ranging from $22.2051 to $22.7331. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-015031 · form4-05312024_080541.xml · nonDerivative · entry 2

Lyssikatos Joseph P · CIK 0001967150 · Director · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,123

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $21.2024 to $22.19. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-015031 · form4-05312024_080541.xml · nonDerivative · entry 1

Lyssikatos Joseph P · CIK 0001967150 · Director · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

SEC source: 0001415889-24-014915 · form4-05302024_090556.xml · derivative · entry 8

Kintz Samuel · CIK 0001967168 · Director · PRESIDENT AND CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 188,841

Underlying: Common Stock · 12,000 shares

Expires 2030-06-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F7 · derivative.exercise_date: All of the shares subject to this option are fully vested and exercisable as of the date hereof.

SEC source: 0001415889-24-014915 · form4-05302024_090556.xml · nonDerivative · entry 4

Kintz Samuel · CIK 0001967168 · Director · PRESIDENT AND CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

SEC source: 0001415889-24-014915 · form4-05302024_090556.xml · nonDerivative · entry 3

Kintz Samuel · CIK 0001967168 · Director · PRESIDENT AND CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 100

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F3 · price: This transaction was executed in multiple trades at prices ranging from $23.28 to $23.96. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-014915 · form4-05302024_090556.xml · nonDerivative · entry 2

Kintz Samuel · CIK 0001967168 · Director · PRESIDENT AND CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,319

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $22.275 to $23.2719. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-014915 · form4-05302024_090556.xml · nonDerivative · entry 1

Kintz Samuel · CIK 0001967168 · Director · PRESIDENT AND CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

SEC source: 0001415889-24-014914 · form4-05302024_090558.xml · derivative · entry 5

Hohl Benjamin · CIK 0001882764 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 216,870

Underlying: Common Stock · 4,250 shares

Expires 2031-08-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F4 · derivative.exercise_date: The option, originally for 262,120 shares, vested as to one-fourth of the shares on August 2, 2022, and the remainder of the shares vest in 36 equal monthly installments thereafter.

SEC source: 0001415889-24-014914 · form4-05302024_090558.xml · nonDerivative · entry 4

Hohl Benjamin · CIK 0001882764 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

SEC source: 0001415889-24-014914 · form4-05302024_090558.xml · nonDerivative · entry 3

Hohl Benjamin · CIK 0001882764 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F3 · price: This transaction was executed in multiple trades at prices ranging from $23.28 to $23.77. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-014914 · form4-05302024_090558.xml · nonDerivative · entry 2

Hohl Benjamin · CIK 0001882764 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,344

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $22.275 to $23.26. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-014914 · form4-05302024_090558.xml · nonDerivative · entry 1

Hohl Benjamin · CIK 0001882764 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,250

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

SEC source: 0000947871-24-000500 · ownership.xml · nonDerivative · entry 2

ORBIMED ADVISORS LLC · CIK 0001055951 · Director · 10% owner

OrbiMed Capital GP VII LLC · CIK 0001760648 · Director · 10% owner

OrbiMed Genesis GP LLC · CIK 0001808744 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 7,663,349

F2 · ownership.nature: These securities are held of record by OrbiMed Private Investments VII, LP ("OPI VII"). OrbiMed Capital GP VII LLC ("GP VII") is the general partner of OPI VII and OrbiMed Advisors is the managing member of GP VII. By virtue of such relationships, GP VII and OrbiMed Advisors may be deemed to have voting and investment power over the securities held by OPI VII and may be deemed to have beneficial ownership over such securities. OrbiMed Advisors exercises voting and investment power through a management committee comprised of Carl L. Gordon, Sven H. Borho, and W. Carter Neild, each of whom disclaims beneficial ownership of the shares held by OPI VII.

F3 · ownership.nature: This report on Form 4 is filed by OrbiMed Advisors, GP VII, and Genesis GP. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a 1(a) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), except to the extent of its pecuniary interest therein, if any. OrbiMed Advisors and GP VII have designated a representative, Rishi Gupta ("Gupta"), an employee of OrbiMed Advisors, to serve on the Issuer's board of directors. This report on Form 4 shall not be deemed an admission that any of the Reporting Persons or Gupta is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose.

SEC source: 0000947871-24-000500 · ownership.xml · nonDerivative · entry 1

ORBIMED ADVISORS LLC · CIK 0001055951 · Director · 10% owner

OrbiMed Capital GP VII LLC · CIK 0001760648 · Director · 10% owner

OrbiMed Genesis GP LLC · CIK 0001808744 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 254,814

F1 · ownership.nature: These securities are held of record by OrbiMed Genesis Master Fund, L.P. ("Genesis"). OrbiMed Genesis GP LLC ("Genesis GP") is the general partner of Genesis. OrbiMed Advisors LLC ("OrbiMed Advisors"), a registered investment adviser under the Investment Advisers Act, is the managing member of Genesis GP. By virtue of such relationships, Genesis GP and OrbiMed Advisors may be deemed to have voting and investment power over the securities held by Genesis and may be deemed to have beneficial ownership over such securities. OrbiMed Advisors exercises voting and investment power through a management committee comprised of Carl L. Gordon, Sven H. Borho, and W. Carter Neild, each of whom disclaims beneficial ownership of the shares held by Genesis.

F3 · ownership.nature: This report on Form 4 is filed by OrbiMed Advisors, GP VII, and Genesis GP. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a 1(a) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), except to the extent of its pecuniary interest therein, if any. OrbiMed Advisors and GP VII have designated a representative, Rishi Gupta ("Gupta"), an employee of OrbiMed Advisors, to serve on the Issuer's board of directors. This report on Form 4 shall not be deemed an admission that any of the Reporting Persons or Gupta is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose.

SEC source: 0001415889-24-013833 · form4-05202024_110525.xml · nonDerivative · entry 1

Heyman Richard A. · CIK 0001584759 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 135,885

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on July 17, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $23.525 to $24.035. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0000947871-24-000501 · ownership.xml · nonDerivative · entry 2

Gupta Rishi · CIK 0001537370 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 7,663,349

F2 · ownership.nature: These securities are held of record by OrbiMed Private Investments VII, LP ("OPI VII"). OrbiMed Capital GP VII LLC ("GP VII") is the general partner of OPI VII and OrbiMed Advisors is the managing member of GP VII. By virtue of such relationships, GP VII and OrbiMed Advisors may be deemed to have voting and investment power over the securities held by OPI VII and may be deemed to have beneficial ownership over such securities. OrbiMed Advisors exercises voting and investment power through a management committee comprised of Carl L. Gordon, Sven H. Borho, and W. Carter Neild, each of whom disclaims beneficial ownership of the shares held by OPI VII.

F3 · ownership.nature: Each of the Reporting Person, OrbiMed Advisors, GP VII, and Genesis GP disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a 1(a) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), except to the extent of his or its pecuniary interest therein, if any. This report on Form 4 shall not be deemed an admission that any of the Reporting Person, OrbiMed Advisors, GP VII, or Genesis GP is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose.

SEC source: 0000947871-24-000501 · ownership.xml · nonDerivative · entry 1

Gupta Rishi · CIK 0001537370 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 254,814

F1 · ownership.nature: These securities are held of record by OrbiMed Genesis Master Fund, L.P. ("Genesis"). OrbiMed Genesis GP LLC ("Genesis GP") is the general partner of Genesis. OrbiMed Advisors LLC ("OrbiMed Advisors"), a registered investment adviser under the Investment Advisers Act, is the managing member of Genesis GP. By virtue of such relationships, Genesis GP and OrbiMed Advisors may be deemed to have voting and investment power over the securities held by Genesis and may be deemed to have beneficial ownership over such securities. OrbiMed Advisors exercises voting and investment power through a management committee comprised of Carl L. Gordon, Sven H. Borho, and W. Carter Neild, each of whom disclaims beneficial ownership of the shares held by Genesis.

F3 · ownership.nature: Each of the Reporting Person, OrbiMed Advisors, GP VII, and Genesis GP disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a 1(a) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), except to the extent of his or its pecuniary interest therein, if any. This report on Form 4 shall not be deemed an admission that any of the Reporting Person, OrbiMed Advisors, GP VII, or Genesis GP is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose.

SEC source: 0001415889-24-013383 · form4-05162024_110525.xml · derivative · entry 4

Patel Anish · CIK 0001967163 · CHIEF OPERATING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 54,475

Underlying: Common Stock · 1,107 shares

Expires 2031-03-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 29, 2023.

F3 · derivative.exercise_date: The option, originally for 75,620 shares, vests in 48 equal monthly installments beginning on January 14, 2021.

SEC source: 0001415889-24-013383 · form4-05162024_110525.xml · nonDerivative · entry 2

Patel Anish · CIK 0001967163 · CHIEF OPERATING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 29, 2023.

SEC source: 0001415889-24-013383 · form4-05162024_110525.xml · nonDerivative · entry 1

Patel Anish · CIK 0001967163 · CHIEF OPERATING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,107

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 29, 2023.

SEC source: 0001415889-24-013071 · form4-05132024_110543.xml · derivative · entry 4

Patel Anish · CIK 0001967163 · CHIEF OPERATING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 55,582

Underlying: Common Stock · 260 shares

Expires 2031-03-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 29, 2023.

F4 · derivative.exercise_date: The option, originally for 75,620 shares, vests in 48 equal monthly installments beginning on August 14, 2021.

SEC source: 0001415889-24-013071 · form4-05132024_110543.xml · nonDerivative · entry 2

Patel Anish · CIK 0001967163 · CHIEF OPERATING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 29, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $25.00 to $25.155. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-013071 · form4-05132024_110543.xml · nonDerivative · entry 1

Patel Anish · CIK 0001967163 · CHIEF OPERATING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 260

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 29, 2023.

SEC source: 0001415889-24-012652 · form4-05092024_120559.xml · derivative · entry 4

Patel Anish · CIK 0001967163 · CHIEF OPERATING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 55,842

Underlying: Common Stock · 4,875 shares

Expires 2031-03-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 29, 2023.

F4 · derivative.exercise_date: The option, originally for 75,620 shares, vests in 48 equal monthly installments beginning on August 14, 2021.

SEC source: 0001415889-24-012652 · form4-05092024_120559.xml · nonDerivative · entry 2

Patel Anish · CIK 0001967163 · CHIEF OPERATING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 29, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $22.295 to $22.9429. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-012652 · form4-05092024_120559.xml · nonDerivative · entry 1

Patel Anish · CIK 0001967163 · CHIEF OPERATING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,875

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 29, 2023.

SEC source: 0001415889-24-012536 · form4-05072024_100528.xml · derivative · entry 3

Hohl Benjamin · CIK 0001882764 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 221,120

Underlying: Common Stock · 1,000 shares

Expires 2031-08-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F2 · derivative.exercise_date: The option, originally for 262,120 shares, vested as to one-fourth of the shares on August 2, 2022, and the remainder of the shares vest in 36 equal monthly installments thereafter.

SEC source: 0001415889-24-012536 · form4-05072024_100528.xml · nonDerivative · entry 2

Hohl Benjamin · CIK 0001882764 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

SEC source: 0001415889-24-012536 · form4-05072024_100528.xml · nonDerivative · entry 1

Hohl Benjamin · CIK 0001882764 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

SEC source: 0001415889-24-011915 · form4-05012024_110500.xml · derivative · entry 5

Lyssikatos Joseph P · CIK 0001967150 · Director · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 218,550

Underlying: Common Stock · 12,000 shares

Expires 2030-06-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F5 · derivative.exercise_date: All of the shares subject to this option are fully vested and exercisable as of the date hereof.

SEC source: 0001415889-24-011915 · form4-05012024_110500.xml · nonDerivative · entry 3

Lyssikatos Joseph P · CIK 0001967150 · Director · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F3 · price: This transaction was executed in multiple trades at prices ranging from $18.37 to $18.5795. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-011915 · form4-05012024_110500.xml · nonDerivative · entry 2

Lyssikatos Joseph P · CIK 0001967150 · Director · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,013

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $17.369 to $18.3544. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-011915 · form4-05012024_110500.xml · nonDerivative · entry 1

Lyssikatos Joseph P · CIK 0001967150 · Director · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

SEC source: 0001415889-24-011914 · form4-05012024_110511.xml · derivative · entry 3

Hohl Benjamin · CIK 0001882764 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 222,120

Underlying: Common Stock · 3,250 shares

Expires 2031-08-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F3 · derivative.exercise_date: The option, originally for 262,120 shares, vested as to one-fourth of the shares on August 2, 2022, and the remainder of the shares vest in 36 equal monthly installments thereafter.

SEC source: 0001415889-24-011914 · form4-05012024_110511.xml · nonDerivative · entry 2

Hohl Benjamin · CIK 0001882764 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $16.56 to $17.41. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.