ELVN

SEC source: 0001415889-24-009450 · form4-03292024_090320.xml · derivative · entry 4

Hohl Benjamin · CIK 0001882764 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 239,370

Underlying: Common Stock · 3,250 shares

Expires 2031-08-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F4 · derivative.exercise_date: The option, originally for 262,120 shares, vested as to one-fourth of the shares on August 2, 2022, and the remainder of the shares vest in 36 equal monthly installments thereafter.

SEC source: 0001415889-24-009450 · form4-03292024_090320.xml · nonDerivative · entry 3

Hohl Benjamin · CIK 0001882764 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F3 · price: This transaction was executed in multiple trades at prices ranging from $18.69 to $18.755. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-009450 · form4-03292024_090320.xml · nonDerivative · entry 2

Hohl Benjamin · CIK 0001882764 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 182

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $17.69 to $18.66. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-009450 · form4-03292024_090320.xml · nonDerivative · entry 1

Hohl Benjamin · CIK 0001882764 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,250

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

SEC source: 0001415889-24-009220 · form4-03272024_090352.xml · derivative · entry 7

Kintz Samuel · CIK 0001967168 · Director · PRESIDENT AND CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 260,550

Underlying: Common Stock · 12,000 shares

Expires 2030-06-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F7 · derivative.exercise_date: The option, originally for 344,550 shares, is subject to an early exercise provision and is immediately exercisable. Shares subject to the option vest in 48 equal monthly installments beginning on May 3, 2020.

SEC source: 0001415889-24-009220 · form4-03272024_090352.xml · nonDerivative · entry 3

Kintz Samuel · CIK 0001967168 · Director · PRESIDENT AND CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F3 · price: This transaction was executed in multiple trades at prices ranging from $17.96 to $18.80. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-009220 · form4-03272024_090352.xml · nonDerivative · entry 2

Kintz Samuel · CIK 0001967168 · Director · PRESIDENT AND CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,671

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $16.90 to $17.59. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-009220 · form4-03272024_090352.xml · nonDerivative · entry 1

Kintz Samuel · CIK 0001967168 · Director · PRESIDENT AND CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

SEC source: 0001415889-24-009019 · form4-03222024_110316.xml · derivative · entry 3

Ballal Rahul D. · CIK 0001805097 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 19,571

Underlying: Common Stock · 13,278 shares

Expires 2032-01-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on October 19, 2023.

F4 · derivative.exercise_date: The option, originally for 32,849 shares, which share amount reflects the Stock Split, vested as to one-fourth of the shares on January 28, 2023, and the remainder of the shares vest in 12 equal quarterly installments thereafter.

F2 · balance_after: The number of shares beneficially owned (i) reflects the 1-for-4 reverse stock split of the Issuer's Common Stock effected February 23, 2023 (the "Stock Split") and (ii) has been adjusted following an internal review of the Reporting Person's holdings.

SEC source: 0001415889-24-009019 · form4-03222024_110316.xml · nonDerivative · entry 2

Ballal Rahul D. · CIK 0001805097 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,341

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on October 19, 2023.

F3 · price: This transaction was executed in multiple trades at prices ranging from $19.005 to $19.405. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-009019 · form4-03222024_110316.xml · nonDerivative · entry 1

Ballal Rahul D. · CIK 0001805097 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 35,619

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on October 19, 2023.

F2 · balance_after: The number of shares beneficially owned (i) reflects the 1-for-4 reverse stock split of the Issuer's Common Stock effected February 23, 2023 (the "Stock Split") and (ii) has been adjusted following an internal review of the Reporting Person's holdings.

SEC source: 0001415889-24-008883 · form4-03212024_100359.xml · nonDerivative · entry 1

Heyman Richard A. · CIK 0001584759 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 143,470

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on July 17, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $14.50 to $14.725. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-007457 · form4-03092024_120325.xml · nonDerivative · entry 1

Patel Anish · CIK 0001967163 · CHIEF OPERATING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,472

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 29, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $15.19 to $15.97. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-006358 · form4-03042024_100311.xml · derivative · entry 5

Lyssikatos Joseph P · CIK 0001967150 · Director · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 272,550

Underlying: Common Stock · 12,000 shares

Expires 2030-06-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F5 · derivative.exercise_date: The option, originally for 344,550 shares, is subject to an early exercise provision and is immediately exercisable. Shares subject to the option vest in 48 equal monthly installments beginning on May 3, 2020.

SEC source: 0001415889-24-006358 · form4-03042024_100311.xml · nonDerivative · entry 3

Lyssikatos Joseph P · CIK 0001967150 · Director · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F3 · price: This transaction was executed in multiple trades at prices ranging from $16.86 to $17.29. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-006358 · form4-03042024_100311.xml · nonDerivative · entry 2

Lyssikatos Joseph P · CIK 0001967150 · Director · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,805

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $15.86 to $16.85. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-006358 · form4-03042024_100311.xml · nonDerivative · entry 1

Lyssikatos Joseph P · CIK 0001967150 · Director · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

SEC source: 0001415889-24-005930 · form4-02292024_100247.xml · derivative · entry 3

Hohl Benjamin · CIK 0001882764 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 242,620

Underlying: Common Stock · 3,250 shares

Expires 2031-08-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F3 · derivative.exercise_date: The option, originally for 262,120 shares, vested as to one-fourth of the shares vests on August 2, 2022, and the remainder of the shares vest in 36 equal monthly installments thereafter.

SEC source: 0001415889-24-005930 · form4-02292024_100247.xml · nonDerivative · entry 2

Hohl Benjamin · CIK 0001882764 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $16.60 to $17.58. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-005930 · form4-02292024_100247.xml · nonDerivative · entry 1

Hohl Benjamin · CIK 0001882764 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,250

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

SEC source: 0001415889-24-005748 · form4-02282024_100201.xml · derivative · entry 7

Kintz Samuel · CIK 0001967168 · Director · PRESIDENT AND CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 272,550

Underlying: Common Stock · 12,000 shares

Expires 2030-06-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F7 · derivative.exercise_date: The option, originally for 344,550 shares, is subject to an early exercise provision and is immediately exercisable. Shares subject to the option vest in 48 equal monthly installments beginning on May 3, 2020.

SEC source: 0001415889-24-005748 · form4-02282024_100201.xml · nonDerivative · entry 3

Kintz Samuel · CIK 0001967168 · Director · PRESIDENT AND CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F3 · price: This transaction was executed in multiple trades at prices ranging from $17.00 to $17.56. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-005748 · form4-02282024_100201.xml · nonDerivative · entry 2

Kintz Samuel · CIK 0001967168 · Director · PRESIDENT AND CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,376

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $16.00 to $16.96. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-005748 · form4-02282024_100201.xml · nonDerivative · entry 1

Kintz Samuel · CIK 0001967168 · Director · PRESIDENT AND CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

SEC source: 0001415889-24-004495 · form4-02212024_120234.xml · nonDerivative · entry 1

Heyman Richard A. · CIK 0001584759 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 144,740

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on July 17, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $17.25 to $17.74. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-004111 · form4-02162024_040204.xml · nonDerivative · entry 2

5AM Partners VI, LLC · CIK 0001829051 · 10% owner

5AM Ventures VI, L.P. · CIK 0001753037 · 10% owner

5AM Opportunities I (GP), LLC · CIK 0001790778 · 10% owner

5AM Opportunities I, L.P. · CIK 0001753000 · 10% owner

PARMAR KUSH · CIK 0001664281 · 10% owner

Schwab Andrew J. · CIK 0001598549 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By 5AM Opportunities I, L.P.

Disclosed balance after: 635,341

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $14.89 to $14.93 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F3 · ownership.nature: The shares are directly held by 5AM Opportunities I, L.P. ("Opportunities"). 5AM Opportunities I (GP), LLC ("Opportunities GP") is the sole general partner of Opportunities. Andrew J. Schwab and Dr. Kush Parmar are the managing members of Opportunities GP and may be deemed to have shared voting and investment power over the shares beneficially owned by Opportunities. Each of Opportunities GP, Dr. Parmar and Mr. Schwab disclaims beneficial ownership of such shares, except to the extent of its or his respective pecuniary interest therein.

SEC source: 0001415889-24-004111 · form4-02162024_040204.xml · nonDerivative · entry 1

5AM Partners VI, LLC · CIK 0001829051 · 10% owner

5AM Ventures VI, L.P. · CIK 0001753037 · 10% owner

5AM Opportunities I (GP), LLC · CIK 0001790778 · 10% owner

5AM Opportunities I, L.P. · CIK 0001753000 · 10% owner

PARMAR KUSH · CIK 0001664281 · 10% owner

Schwab Andrew J. · CIK 0001598549 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By 5AMVentures VI, L.P.

Disclosed balance after: 3,200,634

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $14.89 to $14.93 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F2 · ownership.nature: The shares are directly held by 5AM Ventures VI, L.P. ("Ventures VI"). 5AM Partners VI, LLC ("Partners VI") is the sole general partner of Ventures VI. Dr. Kush Parmar and Andrew J. Schwab are the managing members of Partners VI and may be deemed to have shared voting and investment power over the shares beneficially owned by Ventures VI. Each of Partners VI, Dr. Parmar and Mr. Schwab disclaims beneficial ownership of such shares except to the extent of its or his respective pecuniary interest therein.

SEC source: 0001415889-24-004024 · form4-02162024_020217.xml · derivative · entry 1

Lyssikatos Joseph P · CIK 0001967150 · Director · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 185,000

Underlying: Common Stock · 185,000 shares

Expires 2034-02-12

F1 · derivative.exercise_date: 1/4th of the shares subject to the option will vest on February 13, 2025 and 1/48th of the shares subject to the option will vest each month thereafter, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001415889-24-004022 · form4-02162024_010204.xml · derivative · entry 1

Kintz Samuel · CIK 0001967168 · Director · PRESIDENT AND CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 410,000

Underlying: Common Stock · 410,000 shares

Expires 2034-02-12

F1 · derivative.exercise_date: 1/4th of the shares subject to the option will vest on February 13, 2025 and 1/48th of the shares subject to the option will vest each month thereafter, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001415889-24-004014 · form4-02162024_010234.xml · derivative · entry 1

Derynck Mika K · CIK 0001865125 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,835

Underlying: Common Stock · 16,835 shares

Expires 2034-02-12

F1 · derivative.exercise_date: 100% of the shares subject to the option will vest on the earlier of (i) the first anniversary of the 2024 annual meeting of the Issuer's stockholders or (ii) the date of the 2025 annual meeting of the Issuer's stockholders, subject to the Reporting Person continuing as a non-employee director on the applicable vesting date.

SEC source: 0001415889-24-004006 · form4-02162024_010242.xml · derivative · entry 1

Ballal Rahul D. · CIK 0001805097 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,835

Underlying: Common Stock · 16,835 shares

Expires 2034-02-12

F1 · derivative.exercise_date: 100% of the shares subject to the option will vest on the earlier of (i) the first anniversary of the 2024 annual meeting of the Issuer's stockholders or (ii) the date of the 2025 annual meeting of the Issuer's stockholders, subject to the Reporting Person continuing as a non-employee director on the applicable vesting date.

SEC source: 0001415889-24-004028 · form4-02162024_020201.xml · derivative · entry 1

Phillips Andrew John · CIK 0001921956 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,835

Underlying: Common Stock · 16,835 shares

Expires 2034-02-12

F1 · derivative.exercise_date: 100% of the shares subject to the option will vest on the earlier of (i) the first anniversary of the 2024 annual meeting of the Issuer's stockholders or (ii) the date of the 2025 annual meeting of the Issuer's stockholders, subject to the Reporting Person continuing as a non-employee director on the applicable vesting date.

SEC source: 0001415889-24-004026 · form4-02162024_020214.xml · derivative · entry 1

Patel Anish · CIK 0001967163 · CHIEF OPERATING OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 185,000

Underlying: Common Stock · 185,000 shares

Expires 2034-02-12

F1 · derivative.exercise_date: 1/4th of the shares subject to the option will vest on February 13, 2025 and 1/48th of the shares subject to the option will vest each month thereafter, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001415889-24-004020 · form4-02162024_010205.xml · derivative · entry 1

Hohl Benjamin · CIK 0001882764 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 185,000

Underlying: Common Stock · 185,000 shares

Expires 2034-02-12

F1 · derivative.exercise_date: 1/4th of the shares subject to the option will vest on February 13, 2025 and 1/48th of the shares subject to the option will vest each month thereafter, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001415889-24-004018 · form4-02162024_010226.xml · derivative · entry 1

Heyman Richard A. · CIK 0001584759 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,043

Underlying: Common Stock · 21,043 shares

Expires 2034-02-12

F1 · derivative.exercise_date: 100% of the shares subject to the option will vest on the earlier of (i) the first anniversary of the 2024 annual meeting of the Issuer's stockholders or (ii) the date of the 2025 annual meeting of the Issuer's stockholders, subject to the Reporting Person continuing as a non-employee director on the applicable vesting date.

SEC source: 0001415889-24-004016 · form4-02162024_010218.xml · derivative · entry 1

Gupta Rishi · CIK 0001537370 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,835

Underlying: Common Stock · 16,835 shares

Expires 2034-02-12

F1 · derivative.exercise_date: 100% of the shares subject to the option will vest on the earlier of (i) the first anniversary of the 2024 annual meeting of the Issuer's stockholders or (ii) the date of the 2025 annual meeting of the Issuer's stockholders, subject to the Reporting Person continuing as a non-employee director on the applicable vesting date.

SEC source: 0001415889-24-004012 · form4-02162024_010221.xml · derivative · entry 1

Collins Helen Louise · CIK 0001701247 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 185,000

Underlying: Common Stock · 185,000 shares

Expires 2034-02-12

F1 · derivative.exercise_date: 1/4th of the shares subject to the option will vest on February 13, 2025 and 1/48th of the shares subject to the option will vest each month thereafter, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001415889-24-004010 · form4-02162024_010212.xml · derivative · entry 1

Bauer Jake · CIK 0001654909 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,835

Underlying: Common Stock · 16,835 shares

Expires 2034-02-12

F1 · derivative.exercise_date: 100% of the shares subject to the option will vest on the earlier of (i) the first anniversary of the 2024 annual meeting of the Issuer's stockholders or (ii) the date of the 2025 annual meeting of the Issuer's stockholders, subject to the Reporting Person continuing as a non-employee director on the applicable vesting date.

SEC source: 0001415889-24-004486 · form4a-02212024_120231.xml · derivative · entry 1

Derynck Mika K · CIK 0001865125 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,364

Underlying: Common Stock · 23,364 shares

Expires 2034-02-13

F1 · shares: The original Form 4 filed February 15, 2024 incorrectly reported the number of shares subject to the option grant.

F2 · derivative.exercise_date: 100% of the shares subject to the option will vest on the earlier of (i) the first anniversary of the 2024 annual meeting of the Issuer's stockholders or (ii) the date of the 2025 annual meeting of the Issuer's stockholders, subject to the Reporting Person continuing as a non-employee director on the applicable vesting date.

F1 · derivative.underlying_shares: The original Form 4 filed February 15, 2024 incorrectly reported the number of shares subject to the option grant.

F1 · balance_after: The original Form 4 filed February 15, 2024 incorrectly reported the number of shares subject to the option grant.

SEC source: 0001415889-24-004482 · form4a-02212024_120256.xml · derivative · entry 1

Ballal Rahul D. · CIK 0001805097 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,364

Underlying: Common Stock · 23,364 shares

Expires 2034-02-13

F1 · shares: The original Form 4 filed February 15, 2024 incorrectly reported the number of shares subject to the option grant.

F2 · derivative.exercise_date: 100% of the shares subject to the option will vest on the earlier of (i) the first anniversary of the 2024 annual meeting of the Issuer's stockholders or (ii) the date of the 2025 annual meeting of the Issuer's stockholders, subject to the Reporting Person continuing as a non-employee director on the applicable vesting date.

F1 · derivative.underlying_shares: The original Form 4 filed February 15, 2024 incorrectly reported the number of shares subject to the option grant.

F1 · balance_after: The original Form 4 filed February 15, 2024 incorrectly reported the number of shares subject to the option grant.

SEC source: 0001415889-24-004493 · form4a-02212024_120239.xml · derivative · entry 1

Phillips Andrew John · CIK 0001921956 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,364

Underlying: Common Stock · 23,364 shares

Expires 2034-02-13

F1 · shares: The original Form 4 filed February 15, 2024 incorrectly reported the number of shares subject to the option grant.

F2 · derivative.exercise_date: 100% of the shares subject to the option will vest on the earlier of (i) the first anniversary of the 2024 annual meeting of the Issuer's stockholders or (ii) the date of the 2025 annual meeting of the Issuer's stockholders, subject to the Reporting Person continuing as a non-employee director on the applicable vesting date.

F1 · derivative.underlying_shares: The original Form 4 filed February 15, 2024 incorrectly reported the number of shares subject to the option grant.

F1 · balance_after: The original Form 4 filed February 15, 2024 incorrectly reported the number of shares subject to the option grant.

SEC source: 0001415889-24-004490 · form4a-02212024_120255.xml · derivative · entry 1

Heyman Richard A. · CIK 0001584759 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,205

Underlying: Common Stock · 29,205 shares

Expires 2034-02-13

F1 · shares: The original Form 4 filed February 15, 2024 incorrectly reported the number of shares subject to the option grant.

F2 · derivative.exercise_date: 100% of the shares subject to the option will vest on the earlier of (i) the first anniversary of the 2024 annual meeting of the Issuer's stockholders or (ii) the date of the 2025 annual meeting of the Issuer's stockholders, subject to the Reporting Person continuing as a non-employee director on the applicable vesting date.

F1 · derivative.underlying_shares: The original Form 4 filed February 15, 2024 incorrectly reported the number of shares subject to the option grant.

F1 · balance_after: The original Form 4 filed February 15, 2024 incorrectly reported the number of shares subject to the option grant.

SEC source: 0001415889-24-004488 · form4a-02212024_120247.xml · derivative · entry 1

Gupta Rishi · CIK 0001537370 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,364

Underlying: Common Stock · 23,364 shares

Expires 2034-02-13

F1 · shares: The original Form 4 filed February 15, 2024 incorrectly reported the number of shares subject to the option grant.

F2 · derivative.exercise_date: 100% of the shares subject to the option will vest on the earlier of (i) the first anniversary of the 2024 annual meeting of the Issuer's stockholders or (ii) the date of the 2025 annual meeting of the Issuer's stockholders, subject to the Reporting Person continuing as a non-employee director on the applicable vesting date.

F1 · derivative.underlying_shares: The original Form 4 filed February 15, 2024 incorrectly reported the number of shares subject to the option grant.

F1 · balance_after: The original Form 4 filed February 15, 2024 incorrectly reported the number of shares subject to the option grant.

SEC source: 0001415889-24-004484 · form4a-02212024_120202.xml · derivative · entry 1

Bauer Jake · CIK 0001654909 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,364

Underlying: Common Stock · 23,364 shares

Expires 2034-02-13

F1 · shares: The original Form 4 filed February 15, 2024 incorrectly reported the number of shares subject to the option grant.

F2 · derivative.exercise_date: 100% of the shares subject to the option will vest on the earlier of (i) the first anniversary of the 2024 annual meeting of the Issuer's stockholders or (ii) the date of the 2025 annual meeting of the Issuer's stockholders, subject to the Reporting Person continuing as a non-employee director on the applicable vesting date.

F1 · derivative.underlying_shares: The original Form 4 filed February 15, 2024 incorrectly reported the number of shares subject to the option grant.

F1 · balance_after: The original Form 4 filed February 15, 2024 incorrectly reported the number of shares subject to the option grant.

SEC source: 0001415889-24-003122 · form4-02092024_010243.xml · nonDerivative · entry 1

Patel Anish · CIK 0001967163 · CHIEF OPERATING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,347

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 29, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $15.07 to $15.11. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-002295 · form4-02022024_090230.xml · nonDerivative · entry 2

5AM Partners VI, LLC · CIK 0001829051 · 10% owner

5AM Ventures VI, L.P. · CIK 0001753037 · 10% owner

5AM Opportunities I (GP), LLC · CIK 0001790778 · 10% owner

5AM Opportunities I, L.P. · CIK 0001753000 · 10% owner

PARMAR KUSH · CIK 0001664281 · 10% owner

Schwab Andrew J. · CIK 0001598549 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By 5AM Opportunities I, L.P.

Disclosed balance after: 771,983

F2 · ownership.nature: The shares are directly held by 5AM Opportunities I, L.P. ("Opportunities"). 5AM Opportunities I (GP), LLC ("Opportunities GP") is the sole general partner of Opportunities. Andrew J. Schwab and Dr. Kush Parmar are the managing members of Opportunities GP and may be deemed to have shared voting and investment power over the shares beneficially owned by Opportunities. Each of Opportunities GP, Dr. Parmar and Mr. Schwab disclaims beneficial ownership of such shares, except to the extent of its or his respective pecuniary interest therein.

SEC source: 0001415889-24-002295 · form4-02022024_090230.xml · nonDerivative · entry 1

5AM Partners VI, LLC · CIK 0001829051 · 10% owner

5AM Ventures VI, L.P. · CIK 0001753037 · 10% owner

5AM Opportunities I (GP), LLC · CIK 0001790778 · 10% owner

5AM Opportunities I, L.P. · CIK 0001753000 · 10% owner

PARMAR KUSH · CIK 0001664281 · 10% owner

Schwab Andrew J. · CIK 0001598549 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By 5AMVentures VI, L.P.

Disclosed balance after: 3,888,992

F1 · ownership.nature: The shares are directly held by 5AM Ventures VI, L.P. ("Ventures VI"). 5AM Partners VI, LLC ("Partners VI") is the sole general partner of Ventures VI. Dr. Kush Parmar and Andrew J. Schwab are the managing members of Partners VI and may be deemed to have shared voting and investment power over the shares beneficially owned by Ventures VI. Each of Partners VI, Dr. Parmar and Mr. Schwab disclaims beneficial ownership of such shares except to the extent of its or his respective pecuniary interest therein.

SEC source: 0001415889-24-002220 · form4-02022024_010213.xml · nonDerivative · entry 1

Heyman Richard A. · CIK 0001584759 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 146,010

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on July 17, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $16.10 to $16.68. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001415889-24-002127 · form4-02012024_020241.xml · derivative · entry 4

Lyssikatos Joseph P · CIK 0001967150 · Director · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 284,550

Underlying: Common Stock · 12,000 shares

Expires 2030-06-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F4 · derivative.exercise_date: The option, originally for 344,550 shares, is subject to an early exercise provision and is immediately exercisable. Shares subject to the option vest in 48 equal monthly installments beginning on May 3, 2020.

SEC source: 0001415889-24-002127 · form4-02012024_020241.xml · nonDerivative · entry 2

Lyssikatos Joseph P · CIK 0001967150 · Director · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 26, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $15.58 to $16.375. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.