DNLI

SEC source: 0001209191-19-059302 · doc4.xml · nonDerivative · entry 2

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,448,059

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $18.00 to $18.07 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

SEC source: 0001209191-19-059343 · doc4.xml · derivative · entry 8

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 112,058

Underlying: Common Stock · 711 shares

Expires 2027-03-07

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: 25% of the shares subject to the option vested on March 8, 2018 and an additional 1/48 of the shares vest monthly thereafter.

SEC source: 0001209191-19-059343 · doc4.xml · nonDerivative · entry 4

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,839

F2 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $18.00 to $18.02 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-19-059343 · doc4.xml · nonDerivative · entry 3

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,550

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-19-059343 · doc4.xml · nonDerivative · entry 2

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 583,366

F2 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F3 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $18.00 to $18.04 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F4 · ownership.nature: The shares are held of record by the Schuth Family Trust, for which the Reporting Person serves as trustee.

SEC source: 0001209191-19-058147 · doc4.xml · nonDerivative · entry 5

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 584,378

F2 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F4 · ownership.nature: The shares are held of record by the Schuth Family Trust, for which the Reporting Person serves as trustee.

SEC source: 0001209191-19-058172 · doc4.xml · nonDerivative · entry 3

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,450,572

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $18.00 to $18.12 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

SEC source: 0001209191-19-058147 · doc4.xml · nonDerivative · entry 4

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 584,607

F2 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $18.00 to $18.12 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F4 · ownership.nature: The shares are held of record by the Schuth Family Trust, for which the Reporting Person serves as trustee.

SEC source: 0001209191-19-058172 · doc4.xml · nonDerivative · entry 2

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,492,757

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $18.00 to $18.01 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

SEC source: 0001209191-19-058147 · doc4.xml · nonDerivative · entry 3

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 598,732

F2 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F3 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $18.00 to $18.01 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F4 · ownership.nature: The shares are held of record by the Schuth Family Trust, for which the Reporting Person serves as trustee.

SEC source: 0001209191-19-054152 · doc4.xml · derivative · entry 4

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 112,769

Underlying: Common Stock · 5,129 shares

Expires 2027-03-07

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: 25% of the shares subject to the option vested on March 8, 2018 and an additional 1/48 of the shares vest monthly thereafter.

SEC source: 0001209191-19-054152 · doc4.xml · nonDerivative · entry 3

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,839

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-19-049178 · doc4.xml · nonDerivative · entry 2

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 610,089

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $18.00 to $18.46 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Schuth Family Trust, for which the Reporting Person serves as trustee.

SEC source: 0001209191-19-048640 · doc4.xml · nonDerivative · entry 3

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,494,057

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $18.00 to $18.29 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

SEC source: 0001209191-19-048640 · doc4.xml · nonDerivative · entry 2

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,498,904

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $18.00 to $18.04 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

SEC source: 0001209191-19-047187 · doc4.xml · nonDerivative · entry 2

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,710

F2 · kind: Shares withheld to satisfy the tax obligations by the reporting person in connection with the vesting of restricted stock units.

SEC source: 0001209191-19-047185 · doc4.xml · nonDerivative · entry 2

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 49,684

F2 · kind: Shares withheld to satisfy the tax obligations by the reporting person in connection with the vesting of restricted stock units.

SEC source: 0001209191-19-047184 · doc4.xml · nonDerivative · entry 2

Krognes Steve E. · CIK 0001666236 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,003,666

F2 · kind: Shares withheld to satisfy the tax obligations by the reporting person in connection with the vesting of restricted stock units.

SEC source: 0001209191-19-047187 · doc4.xml · derivative · entry 4

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,643

Underlying: Common Stock · 5,643 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Common Stock of the Issuer.

F4 · derivative.exercise_date: 50% of the shares subject to the option vested on August 20, 2019 and the remaining 50% shall vest on August 20, 2020, subject to the Reporting Person remaining a service provider of the Issuer through such date.

F4 · derivative.expiration_date: 50% of the shares subject to the option vested on August 20, 2019 and the remaining 50% shall vest on August 20, 2020, subject to the Reporting Person remaining a service provider of the Issuer through such date.

SEC source: 0001209191-19-047187 · doc4.xml · nonDerivative · entry 1

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,685

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of Common Stock of the Issuer.

SEC source: 0001209191-19-047185 · doc4.xml · derivative · entry 5

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,643

Underlying: Common Stock · 5,643 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Common Stock of the Issuer.

F5 · derivative.exercise_date: 50% of the shares subject to the option vested on August 20, 2019 and the remaining 50% shall vest on August 20, 2020, subject to the Reporting Person remaining a service provider of the Issuer through such date.

F5 · derivative.expiration_date: 50% of the shares subject to the option vested on August 20, 2019 and the remaining 50% shall vest on August 20, 2020, subject to the Reporting Person remaining a service provider of the Issuer through such date.

SEC source: 0001209191-19-047185 · doc4.xml · nonDerivative · entry 1

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,518

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of Common Stock of the Issuer.

SEC source: 0001209191-19-047184 · doc4.xml · derivative · entry 3

Krognes Steve E. · CIK 0001666236 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,643

Underlying: Common Stock · 5,643 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Common Stock of the Issuer.

F3 · derivative.exercise_date: 50% of the shares subject to the option vested on August 20, 2019 and the remaining 50% shall vest on August 20, 2020, subject to the Reporting Person remaining a service provider of the Issuer through such date.

F3 · derivative.expiration_date: 50% of the shares subject to the option vested on August 20, 2019 and the remaining 50% shall vest on August 20, 2020, subject to the Reporting Person remaining a service provider of the Issuer through such date.

SEC source: 0001209191-19-047184 · doc4.xml · nonDerivative · entry 1

Krognes Steve E. · CIK 0001666236 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,005,643

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of Common Stock of the Issuer.

SEC source: 0001012975-19-000552 · edgar.xml · nonDerivative · entry 2

NELSEN ROBERT · CIK 0001219042 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,030

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F4 · kind: Reflects change from indirect to direct ownership of shares previously reported as beneficially owned by the reporting person.

SEC source: 0001012975-19-000552 · edgar.xml · nonDerivative · entry 1

NELSEN ROBERT · CIK 0001219042 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by ARCH Venture Fund VIII, L.P.

Disclosed balance after: 10,668,749

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F2 · ownership.nature: Following the transactions reported herein, 10,668,749 shares of common stock held of record by ARCH Venture Fund VIII, L.P. ("ARCH Fund VIII").

F3 · ownership.nature: The sole general partner of ARCH Fund VIII is ARCH Venture Partners VIII, L.P. ("ARCH Partners VIII"). The sole general partner of ARCH Partners VIII is ARCH Venture Partners VIII, LLC ("ARCH VIII LLC"). ARCH Partners VIII may therefore be deemed to beneficially own the securities held by ARCH Fund VIII and ARCH VIII LLC may be deemed to beneficially own the securities held by ARCH Fund VIII. ARCH Partners VIII and ARCH VIII LLC disclaim beneficial ownership of such securities, except to the extent of any pecuniary interest therein. The Reporting Person is a managing director of ARCH VIII LLC and may be deemed to beneficially own the shares held by ARCH Fund VIII. Messr. Nelsen disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0001012975-19-000551 · edgar.xml · nonDerivative · entry 1

ARCH Venture Fund VIII, L.P. · CIK 0001605598 · 10% owner

ARCH Venture Partners VIII, L.P. · CIK 0001616176 · 10% owner

ARCH Venture Partners VIII, LLC · CIK 0001616165 · 10% owner

BYBEE CLINTON · CIK 0001219043 · 10% owner

CRANDELL KEITH · CIK 0001219039 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,668,749

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F2 · ownership.direct: Following the transactions reported herein, 10,668,749 shares of common stock held of record by ARCH Venture Fund VIII, L.P. ("ARCH Fund VIII").

F3 · ownership.direct: The sole general partner of ARCH Fund VIII is ARCH Venture Partners VIII, L.P. ("ARCH Partners VIII"). The sole general partner of ARCH Partners VIII is ARCH Venture Partners VIII, LLC ("ARCH VIII LLC"). ARCH Partners VIII may therefore be deemed to beneficially own the securities held by ARCH Fund VIII and ARCH VIII LLC may be deemed to beneficially own the securities held by ARCH Fund VIII. ARCH Partners VIII and ARCH VIII LLC disclaim beneficial ownership of such securities, except to the extent of any pecuniary interest therein. Keith L. Crandell and Clinton Bybee are managing directors of ARCH VIII LLC, and they may be deemed to beneficially own the shares held by ARCH Fund VIII. Messrs. Crandell and Bybee disclaim beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0001209191-19-045394 · doc4.xml · nonDerivative · entry 2

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 617,589

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $18.21 to $19.12 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Schuth Family Trust, for which the Reporting Person serves as trustee.

SEC source: 0001209191-19-041710 · doc4.xml · nonDerivative · entry 3

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 625,089

F2 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $20.87 to $20.94 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F4 · ownership.nature: The shares are held of record by the Schuth Family Trust, for which the Reporting Person serves as trustee.

SEC source: 0001209191-19-041710 · doc4.xml · nonDerivative · entry 2

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 625,489

F2 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F3 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $19.86 to $20.85 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F4 · ownership.nature: The shares are held of record by the Schuth Family Trust, for which the Reporting Person serves as trustee.

SEC source: 0001209191-19-041708 · doc4.xml · derivative · entry 10

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 78,126

Underlying: Common Stock · 3,907 shares

Expires 2027-03-07

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F11 · derivative.exercise_date: Of the total 187,500 shares granted, 25% of the shares subject to the option vested on March 8, 2018 and an additional 1/48 of the shares vest monthly thereafter.

SEC source: 0001209191-19-041708 · doc4.xml · derivative · entry 9

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 92,565

Underlying: Common Stock · 2,604 shares

Expires 2026-07-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F10 · derivative.exercise_date: Of the total 125,000 shares granted, 25% of the shares subject to the option vested on July 2, 2017 and an additional 1/48 of the shares vest monthly thereafter.

SEC source: 0001209191-19-041708 · doc4.xml · nonDerivative · entry 8

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 79,934

F4 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F9 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $20.86 to $20.93 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F8 · ownership.nature: The shares are held of record by the Rohatgi-Ho Family 2009 Revocable Trust, for which Reporting Person serves as trustee.

SEC source: 0001209191-19-041708 · doc4.xml · nonDerivative · entry 7

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 81,034

F4 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F7 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $19.86 to $20.84 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F8 · ownership.nature: The shares are held of record by the Rohatgi-Ho Family 2009 Revocable Trust, for which Reporting Person serves as trustee.

SEC source: 0001209191-19-041708 · doc4.xml · nonDerivative · entry 6

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,081

F4 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F6 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $20.05 to $20.95 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-19-041708 · doc4.xml · nonDerivative · entry 5

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,988

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-19-041708 · doc4.xml · nonDerivative · entry 4

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,081

F4 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $19.86 to $20.07 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-19-041708 · doc4.xml · nonDerivative · entry 3

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,685

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · balance_after: Includes 1,894 shares acquired on May 31, 2018, 883 shares acquired on November 30, 2018 and 1,304 shares acquired on May 31, 2019 under the Issuer's 2017 Employee Stock Purchase Plan. The shares acquired on May 31, 2018 and November 30, 2018 were inadvertently omitted from certain Forms 4 filed by the Reporting Person, and the shares held directly by the Reporting Person have been corrected on this Form 4.

SEC source: 0001209191-19-041176 · doc4.xml · nonDerivative · entry 3

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,502,638

F3 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $20.60 to $21.09 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F2 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

SEC source: 0001209191-19-036500 · doc4.xml · nonDerivative · entry 2

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 632,589

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $18.49 to $19.24 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Schuth Family Trust, for which the Reporting Person serves as trustee.

SEC source: 0001209191-19-036499 · doc4.xml · derivative · entry 9

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 82,033

Underlying: Common Stock · 3,906 shares

Expires 2027-03-07

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F9 · derivative.exercise_date: Of the total 187,500 shares granted, 25% of the shares subject to the option vested on March 8, 2018 and an additional 1/48 of the shares vest monthly thereafter.

SEC source: 0001209191-19-036499 · doc4.xml · derivative · entry 8

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 95,169

Underlying: Common Stock · 711 shares

Expires 2026-07-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · derivative.exercise_date: Of the total 125,000 shares granted, 25% of the shares subject to the option vested on July 2, 2017 and an additional 1/48 of the shares vest monthly thereafter.

SEC source: 0001209191-19-036499 · doc4.xml · nonDerivative · entry 7

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 90,923

F3 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F6 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $18.49 to $19.23 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F7 · ownership.nature: The shares are held of record by the Rohatgi-Ho Family 2009 Revocable Trust, for which Reporting Person serves as trustee.

SEC source: 0001209191-19-036499 · doc4.xml · nonDerivative · entry 6

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F3 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $18.55 to $19.15 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-19-036499 · doc4.xml · nonDerivative · entry 5

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,906

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-19-036499 · doc4.xml · nonDerivative · entry 4

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F3 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $18.60 to $18.67 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-19-036499 · doc4.xml · nonDerivative · entry 3

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 711

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-19-034830 · doc4.xml · nonDerivative · entry 2

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,560,971

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $18.87 to $19.40 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

SEC source: 0001209191-19-033735 · doc4.xml · derivative · entry 1

Cook Jennifer E. · CIK 0001754371 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,245

Underlying: Common Stock · 27,245 shares

Expires 2029-05-29

F1 · derivative.exercise_date: 100% of the shares subject to the option shall vest upon the earlier of the one year anniversary of the grant date or the day prior to the Issuer's next annual meeting of stockholders occurring after the grant date, in each case, provided that the Reporting Person continues to serve as a non-employee director through the applicable vesting date.

SEC source: 0001209191-19-033743 · doc4.xml · derivative · entry 1

SATO VICKI L · CIK 0001197020 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,245

Underlying: Common Stock · 27,245 shares

Expires 2029-05-29

F1 · derivative.exercise_date: 100% of the shares subject to the option shall vest upon the earlier of the one year anniversary of the grant date or the day prior to the Issuer's next annual meeting of stockholders occurring after the grant date, in each case, provided that the Reporting Person continues to serve as a non-employee director through the applicable vesting date.