DNLI

SEC source: 0001209191-21-016854 · doc4.xml · nonDerivative · entry 1

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,320,706

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $64.12 to $65.10 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

SEC source: 0001209191-21-016857 · doc4.xml · nonDerivative · entry 7

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 165,141

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F3 · ownership.nature: The shares are held of record by the Rohatgi-Ho Family 2009 Revocable Trust, for which Reporting Person serves as trustee.

SEC source: 0001209191-21-016857 · doc4.xml · nonDerivative · entry 6

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 165,209

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F7 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $70.03 to $70.32 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Rohatgi-Ho Family 2009 Revocable Trust, for which Reporting Person serves as trustee.

SEC source: 0001209191-21-016857 · doc4.xml · nonDerivative · entry 5

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 165,334

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F3 · ownership.nature: The shares are held of record by the Rohatgi-Ho Family 2009 Revocable Trust, for which Reporting Person serves as trustee.

SEC source: 0001209191-21-016857 · doc4.xml · nonDerivative · entry 4

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 165,542

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F6 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $67.45 to $68.335 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Rohatgi-Ho Family 2009 Revocable Trust, for which Reporting Person serves as trustee.

SEC source: 0001209191-21-016857 · doc4.xml · nonDerivative · entry 3

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 166,862

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $66.375 to $67.35 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Rohatgi-Ho Family 2009 Revocable Trust, for which Reporting Person serves as trustee.

SEC source: 0001209191-21-016857 · doc4.xml · nonDerivative · entry 2

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 168,035

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $65.26 to $66.21 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Rohatgi-Ho Family 2009 Revocable Trust, for which Reporting Person serves as trustee.

SEC source: 0001209191-21-016857 · doc4.xml · nonDerivative · entry 1

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 170,906

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $64.20 to $65.155 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Rohatgi-Ho Family 2009 Revocable Trust, for which Reporting Person serves as trustee.

SEC source: 0001209191-21-016855 · doc4.xml · nonDerivative · entry 7

Tessier-Lavigne Marc · CIK 0001437435 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,642,296

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F9 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $70.68 to $71.55 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-21-016855 · doc4.xml · nonDerivative · entry 6

Tessier-Lavigne Marc · CIK 0001437435 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,643,327

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F8 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $69.23 to $69.96 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-21-016855 · doc4.xml · nonDerivative · entry 5

Tessier-Lavigne Marc · CIK 0001437435 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,646,809

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F7 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $68.155 to $69.10 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-21-016855 · doc4.xml · nonDerivative · entry 4

Tessier-Lavigne Marc · CIK 0001437435 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,652,820

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F6 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $67.155 to $68.14 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-21-016855 · doc4.xml · nonDerivative · entry 3

Tessier-Lavigne Marc · CIK 0001437435 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,667,765

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $66.155 to $67.15 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-21-016855 · doc4.xml · nonDerivative · entry 2

Tessier-Lavigne Marc · CIK 0001437435 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,686,081

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $65.145 to $66.14 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-21-016855 · doc4.xml · nonDerivative · entry 1

Tessier-Lavigne Marc · CIK 0001437435 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,723,526

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $64.08 to $65.05 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · balance_after: The Reporting Person reported a prior award of restricted stock units in Table II of Form 4. This total reported in Column 5 includes 3,253 previously reported restricted stock units.

SEC source: 0001209191-21-012052 · doc4.xml · nonDerivative · entry 4

Krognes Steve E. · CIK 0001666236 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 900,000

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F6 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $66.66 to $67.075 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by The Steve Edward Krognes Revocable Trust U/A DTD 01/25/2016, for which the Reporting Person serves as trustee.

SEC source: 0001209191-21-012052 · doc4.xml · nonDerivative · entry 3

Krognes Steve E. · CIK 0001666236 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 900,501

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $65.64 to $66.60 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by The Steve Edward Krognes Revocable Trust U/A DTD 01/25/2016, for which the Reporting Person serves as trustee.

SEC source: 0001209191-21-012052 · doc4.xml · nonDerivative · entry 2

Krognes Steve E. · CIK 0001666236 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 917,117

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $64.63 to $65.57 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by The Steve Edward Krognes Revocable Trust U/A DTD 01/25/2016, for which the Reporting Person serves as trustee.

SEC source: 0001209191-21-012052 · doc4.xml · nonDerivative · entry 1

Krognes Steve E. · CIK 0001666236 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 927,316

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $63.63 to $64.625 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by The Steve Edward Krognes Revocable Trust U/A DTD 01/25/2016, for which the Reporting Person serves as trustee.

SEC source: 0000899243-21-007016 · doc4.xml · nonDerivative · entry 1

BRATTON DOUGLAS K · CIK 0001281933 · 10% owner

AKDL, L.P. · CIK 0001716958 · 10% owner

Crestline SI (GP), L.P. · CIK 0001626597 · 10% owner

Crestline Investors, Inc. · CIK 0001626596 · 10% owner

Crestline Management, LP · CIK 0001536054 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By AKDL, L.P.

Disclosed balance after: 9,984,836

F1 · ownership.nature: These shares of common stock of Denali Therapeutics Inc. (the "Issuer") are held directly by AKDL, L.P. ("AKDL"). The general partner of AKDL is Crestline SI (GP), L.P. ("Crestline SI") and the investment manager of AKDL is Crestline Management, L.P. ("Crestline Management"). Crestline Investors, Inc. ("Crestline") is the general partner of both Crestline SI and Crestline Management. Douglas K. Bratton is the sole director of Crestline. AKDL is ultimately controlled by Mr. Bratton and Mr. Bratton has voting and investment power over all securities held by AKDL. In addition, Crestline SI, Crestline and Mr. Bratton may be deemed to have a pecuniary interest in a portion of the securities held by AKDL through direct or indirect limited partner interests, including limited partner profit interests, and/or general partner interests in AKDL. Crestline SI, Crestline Management, Crestline and Mr. Bratton may each be deemed to beneficially own the securities held by AKDL.

F2 · ownership.nature: (Continued from footnote 1) Each such entity and Mr. Bratton disclaims beneficial ownership of such securities except to the extent of its or his respective pecuniary interest therein.

SEC source: 0001209191-21-011004 · doc4.xml · nonDerivative · entry 2

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,324,076

F1 · kind: Shares sold to satisfy the tax obligations by the reporting person in connection with the settlement of previously vested restricted stock units.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $71.03 to $71.90 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · balance_after: Includes 19,696 shares acquired pursuant to vesting of restricted stock units and issued directly to the Watts Family 2015 Trust dated July 7, 2015.

F4 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

SEC source: 0001209191-21-011004 · doc4.xml · nonDerivative · entry 1

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,325,036

F1 · kind: Shares sold to satisfy the tax obligations by the reporting person in connection with the settlement of previously vested restricted stock units.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $69.71 to $70.66 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · balance_after: Includes 19,696 shares acquired pursuant to vesting of restricted stock units and issued directly to the Watts Family 2015 Trust dated July 7, 2015.

F4 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

SEC source: 0001209191-21-011008 · doc4.xml · nonDerivative · entry 2

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 541,582

F1 · kind: Shares sold to satisfy the tax obligations by the reporting person in connection with the settlement of previously vested restricted stock units.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $70.87 to $71.74 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · balance_after: Includes 7,285 shares acquired pursuant to vesting of restricted stock units and issued directly to the Schuth Family Trust U/A DTD 06/05/2017.

F4 · ownership.nature: The shares are held of record by The Schuth Family Trust U/A DTD 06/05/2017, for which the Reporting Person serves as trustee.

SEC source: 0001209191-21-011008 · doc4.xml · nonDerivative · entry 1

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 542,015

F1 · kind: Shares sold to satisfy the tax obligations by the reporting person in connection with the settlement of previously vested restricted stock units.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $69.80 to $70.69 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · balance_after: Includes 7,285 shares acquired pursuant to vesting of restricted stock units and issued directly to the Schuth Family Trust U/A DTD 06/05/2017.

F4 · ownership.nature: The shares are held of record by The Schuth Family Trust U/A DTD 06/05/2017, for which the Reporting Person serves as trustee.

SEC source: 0001209191-21-011006 · doc4.xml · nonDerivative · entry 2

Krognes Steve E. · CIK 0001666236 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 97,587

F1 · kind: Shares sold to satisfy the tax obligations by the reporting person in connection with the settlement of previously vested restricted stock units.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $71.06 to $71.72 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · balance_after: The Reporting Person has reported prior awards of restricted stock units in Table II of Form 4. This total reported in Column 5 includes 80,358 previously reported restricted stock units and 7,285 shares acquired pursuant to vesting of restricted stock units.

SEC source: 0001209191-21-011006 · doc4.xml · nonDerivative · entry 1

Krognes Steve E. · CIK 0001666236 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 97,987

F1 · kind: Shares sold to satisfy the tax obligations by the reporting person in connection with the settlement of previously vested restricted stock units.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $69.675 to $70.64 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · balance_after: The Reporting Person has reported prior awards of restricted stock units in Table II of Form 4. This total reported in Column 5 includes 80,358 previously reported restricted stock units and 7,285 shares acquired pursuant to vesting of restricted stock units.

SEC source: 0001209191-21-011010 · doc4.xml · nonDerivative · entry 2

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 172,233

F1 · kind: Shares sold to satisfy the tax obligations by the Reporting Person in connection with the settlement of previously vested restricted stock units.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $71.01 to $71.705 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · balance_after: Includes 7,468 shares acquired pursuant to vesting of restricted stock units and issued directly to the Rohatgi-Ho Family 2009 Revocable Trust.

F4 · ownership.nature: The shares are held of record by the Rohatgi-Ho Family 2009 Revocable Trust, for which Reporting Person serves as trustee.

SEC source: 0001209191-21-011010 · doc4.xml · nonDerivative · entry 1

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 172,633

F1 · kind: Shares sold to satisfy the tax obligations by the Reporting Person in connection with the settlement of previously vested restricted stock units.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $69.79 to $70.74 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · balance_after: Includes 7,468 shares acquired pursuant to vesting of restricted stock units and issued directly to the Rohatgi-Ho Family 2009 Revocable Trust.

F4 · ownership.nature: The shares are held of record by the Rohatgi-Ho Family 2009 Revocable Trust, for which Reporting Person serves as trustee.

SEC source: 0001209191-21-009455 · doc4.xml · nonDerivative · entry 5

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,313,853

F3 · kind: Shares sold to satisfy the tax obligations by the reporting person in connection with the settlement of previously vested restricted stock units.

F6 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $74.79 to $75.195 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F2 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

SEC source: 0001209191-21-009455 · doc4.xml · nonDerivative · entry 4

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,314,664

F3 · kind: Shares sold to satisfy the tax obligations by the reporting person in connection with the settlement of previously vested restricted stock units.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $73.62 to $74.50 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F2 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

SEC source: 0001209191-21-009455 · doc4.xml · nonDerivative · entry 3

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,316,298

F3 · kind: Shares sold to satisfy the tax obligations by the reporting person in connection with the settlement of previously vested restricted stock units.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $72.61 to $73.58 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F2 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

SEC source: 0001209191-21-009892 · doc4.xml · nonDerivative · entry 3

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 537,344

F3 · kind: Shares sold to satisfy the tax obligations by the reporting person in connection with the settlement of previously vested restricted stock units.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $75.22 to $76.17 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F2 · ownership.nature: The shares are held of record by The Schuth Family Trust U/A DTD 06/05/2017, for which the Reporting Person serves as trustee.

SEC source: 0001209191-21-009892 · doc4.xml · nonDerivative · entry 2

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 537,550

F3 · kind: Shares sold to satisfy the tax obligations by the reporting person in connection with the settlement of previously vested restricted stock units.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $74.17 to $75.16 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F2 · ownership.nature: The shares are held of record by The Schuth Family Trust U/A DTD 06/05/2017, for which the Reporting Person serves as trustee.

SEC source: 0001209191-21-009890 · doc4.xml · nonDerivative · entry 3

Krognes Steve E. · CIK 0001666236 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,979

F2 · kind: Shares sold to satisfy the tax obligations by the reporting person in connection with the settlement of previously vested restricted stock units.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $75.09 to $76.075 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-21-009890 · doc4.xml · nonDerivative · entry 2

Krognes Steve E. · CIK 0001666236 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,405

F2 · kind: Shares sold to satisfy the tax obligations by the reporting person in connection with the settlement of previously vested restricted stock units.

F3 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $73.91 to $74.77 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-21-009888 · doc4.xml · nonDerivative · entry 4

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 167,921

F3 · kind: Shares sold to satisfy the tax obligations by the reporting person in connection with the settlement of previously vested restricted stock units.

F2 · ownership.nature: The shares are held of record by the Rohatgi-Ho Family 2009 Revocable Trust, for which Reporting Person serves as trustee.

SEC source: 0001209191-21-009888 · doc4.xml · nonDerivative · entry 3

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 168,021

F3 · kind: Shares sold to satisfy the tax obligations by the reporting person in connection with the settlement of previously vested restricted stock units.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $74.96 to $75.21 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F2 · ownership.nature: The shares are held of record by the Rohatgi-Ho Family 2009 Revocable Trust, for which Reporting Person serves as trustee.

SEC source: 0001209191-21-009888 · doc4.xml · nonDerivative · entry 2

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 168,385

F3 · kind: Shares sold to satisfy the tax obligations by the reporting person in connection with the settlement of previously vested restricted stock units.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $73.96 to $74.75 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F2 · ownership.nature: The shares are held of record by the Rohatgi-Ho Family 2009 Revocable Trust, for which Reporting Person serves as trustee.

SEC source: 0001209191-21-009455 · doc4.xml · derivative · entry 7

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,600

Underlying: Common Stock · 8,800 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer.

F8 · derivative.exercise_date: 25% of the restricted stock units vested on February 8, 2020 (the "Vesting Commencement Date") and an additional 25% of the restricted stock units shall vest on each annual anniversary of the Vesting Commencement Date thereafter, subject to the Reporting Person remaining a service provider of the Issuer through each such date.

F8 · derivative.expiration_date: 25% of the restricted stock units vested on February 8, 2020 (the "Vesting Commencement Date") and an additional 25% of the restricted stock units shall vest on each annual anniversary of the Vesting Commencement Date thereafter, subject to the Reporting Person remaining a service provider of the Issuer through each such date.

SEC source: 0001209191-21-009455 · doc4.xml · derivative · entry 6

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 5,516 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer.

F7 · derivative.exercise_date: 50% of the restricted stock units vested on February 8, 2020 and the remaining 50% of the restricted stock units vested on February 8, 2021, subject to the Reporting Person remaining a service provider of the Issuer through each such date.

F7 · derivative.expiration_date: 50% of the restricted stock units vested on February 8, 2020 and the remaining 50% of the restricted stock units vested on February 8, 2021, subject to the Reporting Person remaining a service provider of the Issuer through each such date.

SEC source: 0001209191-21-009455 · doc4.xml · nonDerivative · entry 2

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,318,965

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer.

F2 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

SEC source: 0001209191-21-009455 · doc4.xml · nonDerivative · entry 1

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,310,165

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer.

F2 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

SEC source: 0001209191-21-009892 · doc4.xml · derivative · entry 5

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,500

Underlying: Common Stock · 4,250 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer.

F6 · derivative.exercise_date: 25% of the restricted stock units vested on February 7, 2020 (the "Vesting Commencement Date") and an additional 25% of the restricted stock units shall vest on each annual anniversary of the Vesting Commencement Date thereafter, subject to the Reporting Person remaining a service provider of the Issuer through each such date.

F6 · derivative.expiration_date: 25% of the restricted stock units vested on February 7, 2020 (the "Vesting Commencement Date") and an additional 25% of the restricted stock units shall vest on each annual anniversary of the Vesting Commencement Date thereafter, subject to the Reporting Person remaining a service provider of the Issuer through each such date.

SEC source: 0001209191-21-009892 · doc4.xml · nonDerivative · entry 1

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 538,812

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer.

F2 · ownership.nature: The shares are held of record by The Schuth Family Trust U/A DTD 06/05/2017, for which the Reporting Person serves as trustee.

SEC source: 0001209191-21-009890 · doc4.xml · derivative · entry 5

Krognes Steve E. · CIK 0001666236 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,500

Underlying: Common Stock · 4,250 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer.

F6 · derivative.exercise_date: 25% of the restricted stock units vested on February 7, 2020 (the "Vesting Commencement Date") and an additional 25% of the restricted stock units shall vest on each annual anniversary of the Vesting Commencement Date thereafter, subject to the Reporting Person remaining a service provider of the Issuer through each such date.

F6 · derivative.expiration_date: 25% of the restricted stock units vested on February 7, 2020 (the "Vesting Commencement Date") and an additional 25% of the restricted stock units shall vest on each annual anniversary of the Vesting Commencement Date thereafter, subject to the Reporting Person remaining a service provider of the Issuer through each such date.

SEC source: 0001209191-21-009890 · doc4.xml · nonDerivative · entry 1

Krognes Steve E. · CIK 0001666236 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,427

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer.

SEC source: 0001209191-21-009888 · doc4.xml · derivative · entry 7

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,500

Underlying: Common Stock · 4,250 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer.

F7 · derivative.exercise_date: 25% of the restricted stock units vested on February 7, 2020 (the "Vesting Commencement Date") and an additional 25% of the restricted stock units shall vest on each annual anniversary of the Vesting Commencement Date thereafter, subject to the Reporting Person remaining a service provider of the Issuer through each such date.

F7 · derivative.expiration_date: 25% of the restricted stock units vested on February 7, 2020 (the "Vesting Commencement Date") and an additional 25% of the restricted stock units shall vest on each annual anniversary of the Vesting Commencement Date thereafter, subject to the Reporting Person remaining a service provider of the Issuer through each such date.

SEC source: 0001209191-21-009888 · doc4.xml · nonDerivative · entry 1

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 169,391

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer.

F2 · ownership.nature: The shares are held of record by the Rohatgi-Ho Family 2009 Revocable Trust, for which Reporting Person serves as trustee.

SEC source: 0001209191-21-008103 · doc4.xml · nonDerivative · entry 3

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 534,562

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $68.44 to $68.90 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by The Schuth Family Trust U/A DTD 06/05/2017, for which the Reporting Person serves as trustee.

SEC source: 0001209191-21-008103 · doc4.xml · nonDerivative · entry 2

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 536,474

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $67.32 to $68.31 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by The Schuth Family Trust U/A DTD 06/05/2017, for which the Reporting Person serves as trustee.