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Nasdaq · USD

DNLI

Denali Therapeutics Inc.

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1735
SEC CIK
0001714899
Parsed reports
436

Last 12 months

Inside the activity.

0 purchase rows · 7 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 202500
Dec 202500
Jan 202602
Feb 202600
Mar 202600
Apr 202600
May 202600
Jun 202600
Jul 202600
Aug 202601
Sep 202604
Oct 202600

Latest available

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
May 26, 2021 Filed May 28, 2021 20:03 UTC
SATO VICKI LDirector
SaleCommon Stock 732 $65.88 $48,220.50
Disclosure

SEC source: 0001209191-21-036513 · doc4.xml · nonDerivative · entry 2

SATO VICKI L · CIK 0001197020 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 134,129

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares ranging from $65.60 to $66.53 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · balance_after: Includes 3,253 restricted stock units.

Read SEC document
May 26, 2021 Filed May 28, 2021 20:03 UTC
SATO VICKI LDirector
SaleCommon Stock 894 $64.90 $58,022.39
Disclosure

SEC source: 0001209191-21-036513 · doc4.xml · nonDerivative · entry 1

SATO VICKI L · CIK 0001197020 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 134,861

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares ranging from $64.58 to $65.57 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · balance_after: Includes 3,253 restricted stock units.

Read SEC document
May 24, 2021 Filed May 25, 2021 00:05 UTC SaleCommon Stock 8,806 $60.03 $528,580.15
Disclosure

SEC source: 0001209191-21-035548 · doc4.xml · nonDerivative · entry 2

Tessier-Lavigne Marc · CIK 0001437435 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,542,296

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $60.00 to $60.135 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · balance_after: Includes 3,253 restricted stock units.

Read SEC document
May 21, 2021 Filed May 25, 2021 00:05 UTC SaleCommon Stock 37,957 $60.13 $2,282,468.28
Disclosure

SEC source: 0001209191-21-035548 · doc4.xml · nonDerivative · entry 1

Tessier-Lavigne Marc · CIK 0001437435 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,551,102

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $60.00 to $60.67 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · balance_after: Includes 3,253 restricted stock units.

Read SEC document
May 12, 2021 Filed Jun 4, 2021 00:55 UTC OtherCommon Stock 2,537 $0.00 $0.00
Disclosure

SEC source: 0001209191-21-038043 · doc4.xml · nonDerivative · entry 4

NELSEN ROBERT · CIK 0001219042 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,105

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F2 · kind: Reflects change from indirect to direct ownership of shares previously reported as beneficially owned by the Reporting Person.

Read SEC document
May 12, 2021 Filed Jun 4, 2021 00:55 UTC OtherCommon Stock 500,000 $0.00 $0.00
Disclosure

SEC source: 0001209191-21-038043 · doc4.xml · nonDerivative · entry 2

NELSEN ROBERT · CIK 0001219042 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by ARCH Venture Fund VIII, L.P.

Disclosed balance after: 9,668,749

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F2 · kind: Reflects change from indirect to direct ownership of shares previously reported as beneficially owned by the Reporting Person.

F3 · ownership.nature: The sole general partner of ARCH Venture Fund VIII, L.P. ("ARCH Fund VIII") is ARCH Venture Partners VIII, L.P. ("ARCH Partners VIII"). The sole general partner of ARCH Partners VIII is ARCH Venture Partners VIII, LLC ("ARCH VIII LLC"). ARCH Partners VIII may therefore be deemed to beneficially own the securities held by ARCH Fund VIII and ARCH VIII LLC may be deemed to beneficially own the securities held by ARCH Fund VIII. ARCH Partners VIII and ARCH VIII LLC disclaim beneficial ownership of such securities, except to the extent of any pecuniary interest therein. The Reporting Person is a managing director of ARCH VIII LLC and may be deemed to beneficially own the shares held by ARCH Fund VIII. Mr. Nelsen disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

F5 · ownership.nature: Following the reported transactions, 9,668,749 shares of common stock were held of record by ARCH Fund VIII.

Read SEC document
May 04, 2021 Filed May 6, 2021 22:50 UTC
Schuth Alexander O.COO and Secretary
SaleCommon Stock 445 $57.39 $25,538.55
Disclosure

SEC source: 0001209191-21-030724 · doc4.xml · nonDerivative · entry 3

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 511,582

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $56.80 to $57.54 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by The Schuth Family Trust U/A DTD 06/05/2017, for which the Reporting Person serves as trustee.

Read SEC document
May 04, 2021 Filed May 6, 2021 22:50 UTC
Schuth Alexander O.COO and Secretary
SaleCommon Stock 3,557 $55.92 $198,889.66
Disclosure

SEC source: 0001209191-21-030724 · doc4.xml · nonDerivative · entry 2

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 512,027

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $55.55 to $56.41 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by The Schuth Family Trust U/A DTD 06/05/2017, for which the Reporting Person serves as trustee.

Read SEC document
May 04, 2021 Filed May 6, 2021 22:50 UTC
Schuth Alexander O.COO and Secretary
SaleCommon Stock 5,998 $55.09 $330,435.82
Disclosure

SEC source: 0001209191-21-030724 · doc4.xml · nonDerivative · entry 1

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 515,584

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $54.52 to $55.50 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by The Schuth Family Trust U/A DTD 06/05/2017, for which the Reporting Person serves as trustee.

Read SEC document
May 03, 2021 Filed May 5, 2021 20:13 UTC
Watts Ryan J.Director · President and CEO
SaleCommon Stock 851 $59.92 $50,989.37
Disclosure

SEC source: 0001209191-21-030300 · doc4.xml · nonDerivative · entry 3

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,229,075

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $59.79 to $60.00 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

Read SEC document
May 03, 2021 Filed May 5, 2021 20:13 UTC
Watts Ryan J.Director · President and CEO
SaleCommon Stock 3,485 $59.12 $206,029.72
Disclosure

SEC source: 0001209191-21-030300 · doc4.xml · nonDerivative · entry 2

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,229,926

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $58.765 to $59.63 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

Read SEC document
May 03, 2021 Filed May 5, 2021 20:13 UTC
Watts Ryan J.Director · President and CEO
SaleCommon Stock 13,997 $58.45 $818,082.66
Disclosure

SEC source: 0001209191-21-030300 · doc4.xml · nonDerivative · entry 1

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,233,411

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $57.76 to $58.755 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

Read SEC document
May 03, 2021 Filed May 5, 2021 20:14 UTC SaleCommon Stock 98 $61.20 $5,997.60
Disclosure

SEC source: 0001209191-21-030304 · doc4.xml · nonDerivative · entry 2

Tessier-Lavigne Marc · CIK 0001437435 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,589,059

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F3 · balance_after: Includes 3,253 restricted stock units.

Read SEC document
May 03, 2021 Filed May 5, 2021 20:14 UTC SaleCommon Stock 3,139 $60.08 $188,591.12
Disclosure

SEC source: 0001209191-21-030304 · doc4.xml · nonDerivative · entry 1

Tessier-Lavigne Marc · CIK 0001437435 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,589,157

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $60.00 to $60.45 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · balance_after: Includes 3,253 restricted stock units.

Read SEC document
April 28, 2021 Filed Apr 30, 2021 21:07 UTC
SATO VICKI LDirector
SaleCommon Stock 688 $63.03 $43,367.39
Disclosure

SEC source: 0001209191-21-029337 · doc4.xml · nonDerivative · entry 3

SATO VICKI L · CIK 0001197020 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 135,755

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares ranging from $62.73 to 63.27 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · balance_after: Includes 3,253 restricted stock units.

Read SEC document
April 28, 2021 Filed Apr 30, 2021 21:07 UTC
SATO VICKI LDirector
SaleCommon Stock 597 $62.05 $37,042.06
Disclosure

SEC source: 0001209191-21-029337 · doc4.xml · nonDerivative · entry 2

SATO VICKI L · CIK 0001197020 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 136,443

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares ranging from $61.47 to $62.405 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · balance_after: Includes 3,253 restricted stock units.

Read SEC document
April 28, 2021 Filed Apr 30, 2021 21:07 UTC
SATO VICKI LDirector
SaleCommon Stock 381 $60.71 $23,128.99
Disclosure

SEC source: 0001209191-21-029337 · doc4.xml · nonDerivative · entry 1

SATO VICKI L · CIK 0001197020 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 137,040

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares ranging from $60.36 to $60.985 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · balance_after: Includes 3,253 restricted stock units.

Read SEC document
April 05, 2021 Filed Apr 7, 2021 00:39 UTC
Schuth Alexander O.COO and Secretary
SaleCommon Stock 700 $57.44 $40,205.90
Disclosure

SEC source: 0001209191-21-025768 · doc4.xml · nonDerivative · entry 3

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 521,582

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $57.11 to $57.86 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by The Schuth Family Trust U/A DTD 06/05/2017, for which the Reporting Person serves as trustee.

Read SEC document
April 05, 2021 Filed Apr 7, 2021 00:39 UTC
Schuth Alexander O.COO and Secretary
SaleCommon Stock 4,156 $56.47 $234,668.54
Disclosure

SEC source: 0001209191-21-025768 · doc4.xml · nonDerivative · entry 2

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 522,282

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $56.10 to $57.02 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by The Schuth Family Trust U/A DTD 06/05/2017, for which the Reporting Person serves as trustee.

Read SEC document
April 05, 2021 Filed Apr 7, 2021 00:39 UTC
Schuth Alexander O.COO and Secretary
SaleCommon Stock 5,144 $55.60 $286,026.98
Disclosure

SEC source: 0001209191-21-025768 · doc4.xml · nonDerivative · entry 1

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 526,438

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $55.10 to $56.09 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by The Schuth Family Trust U/A DTD 06/05/2017, for which the Reporting Person serves as trustee.

Read SEC document
April 01, 2021 Filed Apr 5, 2021 20:09 UTC
Watts Ryan J.Director · President and CEO
SaleCommon Stock 4,586 $57.31 $262,842.00
Disclosure

SEC source: 0001209191-21-025115 · doc4.xml · nonDerivative · entry 4

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,247,408

F2 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $57.038 to $58.02 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F1 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

Read SEC document
April 01, 2021 Filed Apr 5, 2021 20:09 UTC
Watts Ryan J.Director · President and CEO
SaleCommon Stock 8,516 $56.88 $484,356.02
Disclosure

SEC source: 0001209191-21-025115 · doc4.xml · nonDerivative · entry 3

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,251,994

F2 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $56.32 to $57.03 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F1 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

Read SEC document
April 01, 2021 Filed Apr 5, 2021 20:09 UTC
Watts Ryan J.Director · President and CEO
SaleCommon Stock 5,232 $55.52 $290,485.87
Disclosure

SEC source: 0001209191-21-025115 · doc4.xml · nonDerivative · entry 2

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,260,510

F2 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F3 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $55.245 to $56.235 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F1 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

Read SEC document
April 01, 2021 Filed Apr 5, 2021 20:10 UTC SaleCommon Stock 6,184 $57.60 $356,167.48
Disclosure

SEC source: 0001209191-21-025119 · doc4.xml · nonDerivative · entry 3

Tessier-Lavigne Marc · CIK 0001437435 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,592,296

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $57.23 to $58.095 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · balance_after: Includes 3,253 restricted stock units.

Read SEC document
April 01, 2021 Filed Apr 5, 2021 20:10 UTC SaleCommon Stock 29,593 $56.91 $1,684,019.26
Disclosure

SEC source: 0001209191-21-025119 · doc4.xml · nonDerivative · entry 2

Tessier-Lavigne Marc · CIK 0001437435 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,598,480

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $56.23 to $57.22 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · balance_after: Includes 3,253 restricted stock units.

Read SEC document
April 01, 2021 Filed Apr 5, 2021 20:10 UTC SaleCommon Stock 14,223 $55.61 $790,884.14
Disclosure

SEC source: 0001209191-21-025119 · doc4.xml · nonDerivative · entry 1

Tessier-Lavigne Marc · CIK 0001437435 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,628,073

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $55.22 to $56.21 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · balance_after: Includes 3,253 restricted stock units.

Read SEC document
March 31, 2021 Filed Apr 1, 2021 20:47 UTC
SATO VICKI LDirector
SaleCommon Stock 136 $57.61 $7,834.42
Disclosure

SEC source: 0001209191-21-024126 · doc4.xml · nonDerivative · entry 4

SATO VICKI L · CIK 0001197020 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 137,421

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $57.525 to $57.68 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F2 · balance_after: Includes 3,253 restricted stock units.

Read SEC document
March 31, 2021 Filed Apr 1, 2021 20:47 UTC
SATO VICKI LDirector
SaleCommon Stock 635 $56.92 $36,144.84
Disclosure

SEC source: 0001209191-21-024126 · doc4.xml · nonDerivative · entry 3

SATO VICKI L · CIK 0001197020 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 137,557

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $56.52 to $57.405 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F2 · balance_after: Includes 3,253 restricted stock units.

Read SEC document
March 31, 2021 Filed Apr 1, 2021 20:47 UTC
SATO VICKI LDirector
SaleCommon Stock 877 $55.91 $49,033.95
Disclosure

SEC source: 0001209191-21-024126 · doc4.xml · nonDerivative · entry 2

SATO VICKI L · CIK 0001197020 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 138,192

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F3 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $55.485 to $56.34 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F2 · balance_after: Includes 3,253 restricted stock units.

Read SEC document
March 31, 2021 Filed Apr 1, 2021 20:47 UTC
SATO VICKI LDirector
SaleCommon Stock 18 $54.38 $978.84
Disclosure

SEC source: 0001209191-21-024126 · doc4.xml · nonDerivative · entry 1

SATO VICKI L · CIK 0001197020 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 139,069

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · balance_after: Includes 3,253 restricted stock units.

Read SEC document
March 29, 2021 Filed Mar 31, 2021 22:30 UTC
Ho CaroleChief Medical Officer
SaleCommon Stock 2,822 $54.62 $154,126.35
Disclosure

SEC source: 0001209191-21-023846 · doc4.xml · nonDerivative · entry 1

Ho Carole · CIK 0001724605 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 162,319

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $54.08 to $54.93 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Rohatgi-Ho Family 2009 Revocable Trust, for which Reporting Person serves as trustee.

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March 22, 2021 Filed Jun 4, 2021 00:55 UTC OtherCommon Stock 2,538 $0.00 $0.00
Disclosure

SEC source: 0001209191-21-038043 · doc4.xml · nonDerivative · entry 3

NELSEN ROBERT · CIK 0001219042 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,568

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F2 · kind: Reflects change from indirect to direct ownership of shares previously reported as beneficially owned by the Reporting Person.

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March 22, 2021 Filed Jun 4, 2021 00:55 UTC OtherCommon Stock 500,000 $0.00 $0.00
Disclosure

SEC source: 0001209191-21-038043 · doc4.xml · nonDerivative · entry 1

NELSEN ROBERT · CIK 0001219042 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by ARCH Venture Fund VIII, L.P.

Disclosed balance after: 10,168,749

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F2 · kind: Reflects change from indirect to direct ownership of shares previously reported as beneficially owned by the Reporting Person.

F3 · ownership.nature: The sole general partner of ARCH Venture Fund VIII, L.P. ("ARCH Fund VIII") is ARCH Venture Partners VIII, L.P. ("ARCH Partners VIII"). The sole general partner of ARCH Partners VIII is ARCH Venture Partners VIII, LLC ("ARCH VIII LLC"). ARCH Partners VIII may therefore be deemed to beneficially own the securities held by ARCH Fund VIII and ARCH VIII LLC may be deemed to beneficially own the securities held by ARCH Fund VIII. ARCH Partners VIII and ARCH VIII LLC disclaim beneficial ownership of such securities, except to the extent of any pecuniary interest therein. The Reporting Person is a managing director of ARCH VIII LLC and may be deemed to beneficially own the shares held by ARCH Fund VIII. Mr. Nelsen disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

F4 · ownership.nature: Following the reported transactions, 10,168,749 shares of common stock were held of record by ARCH Fund VIII.

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March 15, 2021 Filed Mar 16, 2021 23:16 UTC
Krognes Steve E.CFO and Treasurer
SaleCommon Stock 1,158 $63.67 $73,729.86
Disclosure

SEC source: 0001209191-21-021122 · doc4.xml · nonDerivative · entry 4

Krognes Steve E. · CIK 0001666236 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 850,000

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F6 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $63.67 to $63.69 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by The Steve Edward Krognes Revocable Trust U/A DTD 01/25/2016, for which the Reporting Person serves as trustee.

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March 15, 2021 Filed Mar 16, 2021 23:16 UTC
Krognes Steve E.CFO and Treasurer
SaleCommon Stock 3,258 $62.71 $204,318.95
Disclosure

SEC source: 0001209191-21-021122 · doc4.xml · nonDerivative · entry 3

Krognes Steve E. · CIK 0001666236 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 851,158

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $62.52 to $63.03 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by The Steve Edward Krognes Revocable Trust U/A DTD 01/25/2016, for which the Reporting Person serves as trustee.

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March 15, 2021 Filed Mar 16, 2021 23:16 UTC
Krognes Steve E.CFO and Treasurer
SaleCommon Stock 32,326 $62.04 $2,005,602.02
Disclosure

SEC source: 0001209191-21-021122 · doc4.xml · nonDerivative · entry 2

Krognes Steve E. · CIK 0001666236 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 854,416

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $61.52 to $62.50 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by The Steve Edward Krognes Revocable Trust U/A DTD 01/25/2016, for which the Reporting Person serves as trustee.

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March 15, 2021 Filed Mar 16, 2021 23:16 UTC
Krognes Steve E.CFO and Treasurer
SaleCommon Stock 13,258 $61.16 $810,912.31
Disclosure

SEC source: 0001209191-21-021122 · doc4.xml · nonDerivative · entry 1

Krognes Steve E. · CIK 0001666236 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 886,742

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $60.52 to $61.515 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by The Steve Edward Krognes Revocable Trust U/A DTD 01/25/2016, for which the Reporting Person serves as trustee.

Read SEC document
March 09, 2021 Filed Apr 5, 2021 20:09 UTC
Watts Ryan J.Director · President and CEO
GiftCommon Stock 40,000 $0.00 $0.00
Disclosure

SEC source: 0001209191-21-025115 · doc4.xml · nonDerivative · entry 1

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,265,742

F1 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

Read SEC document
March 04, 2021 Filed Mar 4, 2021 23:38 UTC
Schuth Alexander O.COO and Secretary
SaleCommon Stock 1,878 $61.58 $115,647.24
Disclosure

SEC source: 0001209191-21-017983 · doc4.xml · nonDerivative · entry 2

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 531,582

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $61.375 to $62.02 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by The Schuth Family Trust U/A DTD 06/05/2017, for which the Reporting Person serves as trustee.

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March 04, 2021 Filed Mar 4, 2021 23:38 UTC
Schuth Alexander O.COO and Secretary
SaleCommon Stock 8,122 $60.89 $494,524.21
Disclosure

SEC source: 0001209191-21-017983 · doc4.xml · nonDerivative · entry 1

Schuth Alexander O. · CIK 0001724311 · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 533,460

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $60.37 to $61.325 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by The Schuth Family Trust U/A DTD 06/05/2017, for which the Reporting Person serves as trustee.

Read SEC document
March 03, 2021 Filed Mar 4, 2021 23:04 UTC
SATO VICKI LDirector
SaleCommon Stock 115 $63.37 $7,286.98
Disclosure

SEC source: 0001209191-21-017970 · doc4.xml · nonDerivative · entry 4

SATO VICKI L · CIK 0001197020 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 139,087

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

Read SEC document
March 03, 2021 Filed Mar 4, 2021 23:04 UTC
SATO VICKI LDirector
SaleCommon Stock 266 $62.29 $16,569.14
Disclosure

SEC source: 0001209191-21-017970 · doc4.xml · nonDerivative · entry 3

SATO VICKI L · CIK 0001197020 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 139,202

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $62.18 to $63.10 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

Read SEC document
March 03, 2021 Filed Mar 4, 2021 23:04 UTC
SATO VICKI LDirector
SaleCommon Stock 1,050 $61.52 $64,600.20
Disclosure

SEC source: 0001209191-21-017970 · doc4.xml · nonDerivative · entry 2

SATO VICKI L · CIK 0001197020 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 139,468

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $61.14 to $61.97 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

Read SEC document
March 03, 2021 Filed Mar 4, 2021 23:04 UTC
SATO VICKI LDirector
SaleCommon Stock 235 $60.36 $14,184.60
Disclosure

SEC source: 0001209191-21-017970 · doc4.xml · nonDerivative · entry 1

SATO VICKI L · CIK 0001197020 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 140,518

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $60.02 to $60.72 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · balance_after: The Reporting Person reported a prior award of restricted stock units in Table II of Form 4. This total reported in Column 5 includes 3,253 previously reported restricted stock units.

Read SEC document
March 01, 2021 Filed Mar 3, 2021 21:19 UTC
Watts Ryan J.Director · President and CEO
SaleCommon Stock 68 $70.92 $4,822.83
Disclosure

SEC source: 0001209191-21-016854 · doc4.xml · nonDerivative · entry 7

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,305,742

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F9 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $70.90 to $70.95 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

Read SEC document
March 01, 2021 Filed Mar 3, 2021 21:19 UTC
Watts Ryan J.Director · President and CEO
SaleCommon Stock 594 $69.65 $41,370.91
Disclosure

SEC source: 0001209191-21-016854 · doc4.xml · nonDerivative · entry 6

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,305,810

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F8 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $69.28 to $69.96 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

Read SEC document
March 01, 2021 Filed Mar 3, 2021 21:19 UTC
Watts Ryan J.Director · President and CEO
SaleCommon Stock 1,625 $68.46 $111,245.88
Disclosure

SEC source: 0001209191-21-016854 · doc4.xml · nonDerivative · entry 5

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,306,404

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F7 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $68.155 to $69.11 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

Read SEC document
March 01, 2021 Filed Mar 3, 2021 21:19 UTC
Watts Ryan J.Director · President and CEO
SaleCommon Stock 3,339 $67.69 $226,016.91
Disclosure

SEC source: 0001209191-21-016854 · doc4.xml · nonDerivative · entry 4

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,308,029

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F6 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $67.15 to $68.135 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

Read SEC document
March 01, 2021 Filed Mar 3, 2021 21:19 UTC
Watts Ryan J.Director · President and CEO
SaleCommon Stock 3,453 $66.55 $229,779.89
Disclosure

SEC source: 0001209191-21-016854 · doc4.xml · nonDerivative · entry 3

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,311,368

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F5 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $66.15 to $67.105 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

Read SEC document
March 01, 2021 Filed Mar 3, 2021 21:19 UTC
Watts Ryan J.Director · President and CEO
SaleCommon Stock 5,885 $65.63 $386,209.01
Disclosure

SEC source: 0001209191-21-016854 · doc4.xml · nonDerivative · entry 2

Watts Ryan J. · CIK 0001724310 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,314,821

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F4 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $65.15 to $66.13 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: The shares are held of record by the Watts Family 2015 Trust dated July 7, 2015, for which the Reporting Person serves as trustee.

Read SEC document

Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.