CYTK

SEC source: 0001061983-21-000062 · edgardoc.xml · derivative · entry 2

Wong Robert · CIK 0001777562 · VP, Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,908

Underlying: Common Stock · 6,908 shares

Expires 2031-03-01

F3 · derivative.exercise_date: This option shall vest and become exercisable over 4 years, with shares divided into equal monthly installments, such that the option shall be 100% vested four years from the date of grant.

SEC source: 0001061983-21-000062 · edgardoc.xml · nonDerivative · entry 1

Wong Robert · CIK 0001777562 · VP, Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,238

F1 · kind: Comprised of restricted stock units that will vest over 3 years, with 40% vesting on the 1-year anniversary of the grant, an additional 40% vesting on the 2-year anniversary of the grant, and the final 20% vesting on the 3-year anniversary of the grant.

F2 · balance_after: Includes up to 5,238 shares of common stock purchased pursuant to the Cytokinetics, Incorporated Employee Stock Purchase Plan.

SEC source: 0001061983-21-000060 · edgardoc.xml · derivative · entry 3

Malik Fady Ibraham · CIK 0001551778 · EVP Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 49,694

Underlying: Common Stock · 49,694 shares

Expires 2031-03-01

F3 · derivative.exercise_date: This option shall vest and become exercisable over 4 years, with shares divided into equal monthly installments, such that the option shall be 100% vested four years from the date of grant.

SEC source: 0001061983-21-000060 · edgardoc.xml · derivative · entry 2

Malik Fady Ibraham · CIK 0001551778 · EVP Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,306

Underlying: Common Stock · 10,306 shares

Expires 2031-03-01

F3 · derivative.exercise_date: This option shall vest and become exercisable over 4 years, with shares divided into equal monthly installments, such that the option shall be 100% vested four years from the date of grant.

SEC source: 0001061983-21-000060 · edgardoc.xml · nonDerivative · entry 1

Malik Fady Ibraham · CIK 0001551778 · EVP Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 173,982

F1 · kind: Comprised of restricted stock units that will vest over 3 years, with 40% vesting on the 1-year anniversary of the grant, an additional 40% vesting on the 2-year anniversary of the grant, and the final 20% vesting on the 3-year anniversary of the grant.

F2 · balance_after: Includes 1,470 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000059 · edgardoc.xml · derivative · entry 3

Jaw Ching · CIK 0001710875 · SVP Finance & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,879

Underlying: Common Stock · 34,879 shares

Expires 2031-03-01

F3 · derivative.exercise_date: This option shall vest and become exercisable over 4 years, with shares divided into equal monthly installments, such that the option shall be 100% vested four years from the date of grant.

SEC source: 0001061983-21-000059 · edgardoc.xml · derivative · entry 2

Jaw Ching · CIK 0001710875 · SVP Finance & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,121

Underlying: Common Stock · 10,121 shares

Expires 2031-03-01

F3 · derivative.exercise_date: This option shall vest and become exercisable over 4 years, with shares divided into equal monthly installments, such that the option shall be 100% vested four years from the date of grant.

SEC source: 0001061983-21-000059 · edgardoc.xml · nonDerivative · entry 1

Jaw Ching · CIK 0001710875 · SVP Finance & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 92,642

F1 · kind: Comprised of restricted stock units that will vest over 3 years, with 40% vesting on the 1-year anniversary of the grant, an additional 40% vesting on the 2-year anniversary of the grant, and the final 20% vesting on the 3-year anniversary of the grant.

F2 · balance_after: Includes 727 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000058 · edgardoc.xml · derivative · entry 3

Cragg David · CIK 0001316459 · SVP Human Resources

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,879

Underlying: Common Stock · 34,879 shares

Expires 2031-03-01

F3 · derivative.exercise_date: This option shall vest and become exercisable over 4 years, with shares divided into equal monthly installments, such that the option shall be 100% vested four years from the date of grant.

SEC source: 0001061983-21-000058 · edgardoc.xml · derivative · entry 2

Cragg David · CIK 0001316459 · SVP Human Resources

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,121

Underlying: Common Stock · 10,121 shares

Expires 2031-03-01

F3 · derivative.exercise_date: This option shall vest and become exercisable over 4 years, with shares divided into equal monthly installments, such that the option shall be 100% vested four years from the date of grant.

SEC source: 0001061983-21-000058 · edgardoc.xml · nonDerivative · entry 1

Cragg David · CIK 0001316459 · SVP Human Resources

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 164,775

F1 · kind: Comprised of restricted stock units that will vest over 3 years, with 40% vesting on the 1-year anniversary of the grant, an additional 40% vesting on the 2-year anniversary of the grant, and the final 20% vesting on the 3-year anniversary of the grant.

F2 · balance_after: Includes up to 13,132 shares of common stock purchased pursuant to the Cytokinetics, Incorporated Employee Stock Purchase Plan.

SEC source: 0001061983-21-000057 · edgardoc.xml · derivative · entry 5

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 155,111

Underlying: Common Stock · 155,111 shares

Expires 2031-03-01

F5 · derivative.exercise_date: This option shall vest and become exercisable over 4 years, with shares divided into equal monthly installments, such that the option shall be 100% vested four years from the date of grant.

SEC source: 0001061983-21-000057 · edgardoc.xml · derivative · entry 4

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,889

Underlying: Common Stock · 9,889 shares

Expires 2031-03-01

F5 · derivative.exercise_date: This option shall vest and become exercisable over 4 years, with shares divided into equal monthly installments, such that the option shall be 100% vested four years from the date of grant.

SEC source: 0001061983-21-000057 · edgardoc.xml · nonDerivative · entry 1

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 380,658

F1 · kind: Comprised of restricted stock units that will vest over 3 years, with 40% vesting on the 1-year anniversary of the grant, an additional 40% vesting on the 2-year anniversary of the grant, and the final 20% vesting on the 3-year anniversary of the grant.

F2 · balance_after: Includes 4,991 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000050 · edgardoc.xml · nonDerivative · entry 1

Malik Fady Ibraham · CIK 0001551778 · EVP Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 138,982

F1 · kind: The reporting person is reporting the withholding of shares of common stock to satisfy the reporting persons withholding obligations in connection with the vesting of Restricted Stock Units vested on 03/01/2021 and does not represent a sale by the reporting person.

F2 · balance_after: Includes 1,470 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000048 · edgardoc.xml · nonDerivative · entry 1

Cragg David · CIK 0001316459 · SVP Human Resources

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 139,775

F1 · kind: The reporting person is reporting the withholding of shares of common stock to satisfy the reporting persons withholding obligations in connection with the vesting of Restricted Stock Units vested on 03/01/2021 and does not represent a sale by the reporting person.

F2 · balance_after: Includes up to 13,132 shares of common stock purchased pursuant to the Cytokinetics, Incorporated Employee Stock Purchase Plan.

SEC source: 0001061983-21-000049 · edgardoc.xml · nonDerivative · entry 1

Jaw Ching · CIK 0001710875 · SVP Finance & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 67,642

F1 · kind: The reporting person is reporting the withholding of shares of common stock to satisfy the reporting persons withholding obligations in connection with the vesting of Restricted Stock Units vested on 03/01/2021 and does not represent a sale by the reporting person.

F2 · balance_after: Includes 727 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000047 · edgardoc.xml · nonDerivative · entry 1

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 300,658

F1 · kind: The reporting person is reporting the withholding of shares of common stock to satisfy the reporting persons withholding obligations in connection with the vesting of Restricted Stock Units vested on 03/01/2021 and does not represent a sale by the reporting person.

F2 · balance_after: Includes 4,991 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000034 · edgardoc.xml · derivative · entry 5

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,434

Underlying: Common Stock · 5,000 shares

Expires 2023-03-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

SEC source: 0001061983-21-000034 · edgardoc.xml · nonDerivative · entry 2

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 334,373

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 4,991 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000034 · edgardoc.xml · nonDerivative · entry 1

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 339,373

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 4,991 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000042 · edgardoc.xml · nonDerivative · entry 1

Malik Fady Ibraham · CIK 0001551778 · EVP Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 141,749

F1 · kind: The reporting person is reporting the withholding of shares of common stock to satisfy the reporting persons withholding obligations in connection with the vesting of Restricted Stock Units vested on 02/26/2021 and does not represent a sale by the reporting person.

F2 · balance_after: Includes 1,470 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000041 · edgardoc.xml · nonDerivative · entry 1

Jaw Ching · CIK 0001710875 · SVP Finance & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 69,026

F1 · kind: The reporting person is reporting the withholding of shares of common stock to satisfy the reporting persons withholding obligations in connection with the vesting of Restricted Stock Units vested on 02/26/2021 and does not represent a sale by the reporting person.

F2 · balance_after: Includes 727 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000040 · edgardoc.xml · nonDerivative · entry 1

Cragg David · CIK 0001316459 · SVP Human Resources

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 141,850

F1 · kind: The reporting person is reporting the withholding of shares of common stock to satisfy the reporting persons withholding obligations in connection with the vesting of Restricted Stock Units vested on 02/26/2021 and does not represent a sale by the reporting person.

F2 · balance_after: Includes up to 13,132 shares of common stock purchased pursuant to the Cytokinetics, Incorporated Employee Stock Purchase Plan.

SEC source: 0001061983-21-000039 · edgardoc.xml · nonDerivative · entry 1

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 310,574

F1 · kind: The reporting person is reporting the withholding of shares of common stock to satisfy the reporting persons withholding obligations in connection with the vesting of Restricted Stock Units vested on 02/26/2021 and does not represent a sale by the reporting person.

F2 · balance_after: Includes 4,991 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000032 · edgardoc.xml · derivative · entry 10

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 72,923 shares

Expires 2021-02-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001061983-21-000032 · edgardoc.xml · derivative · entry 9

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 72,923

Underlying: Common Stock · 10,409 shares

Expires 2021-02-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001061983-21-000032 · edgardoc.xml · derivative · entry 8

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 83,332

Underlying: Common Stock · 10,409 shares

Expires 2021-02-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · kind: Incentive stock options granted on 2/28/2011 to purchase 10,409 shares at an exercise price of $9.42 per share converted to non-qualified stock options to purchase 10,409 shares at an exercise price of $9.42 per share as a result of a modification to the original grant to permit a "net exercise" of the stock options. Conversion transaction is permitted pursuant to the Issuer's Amended and Restated 2004 Equity Incentive Plan and the prior resolution of the Issuer's Compensation and Talent Committee of the Board of Directors.

SEC source: 0001061983-21-000032 · edgardoc.xml · derivative · entry 7

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 10,409 shares

Expires 2021-02-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · kind: Incentive stock options granted on 2/28/2011 to purchase 10,409 shares at an exercise price of $9.42 per share converted to non-qualified stock options to purchase 10,409 shares at an exercise price of $9.42 per share as a result of a modification to the original grant to permit a "net exercise" of the stock options. Conversion transaction is permitted pursuant to the Issuer's Amended and Restated 2004 Equity Incentive Plan and the prior resolution of the Issuer's Compensation and Talent Committee of the Board of Directors.

SEC source: 0001061983-21-000032 · edgardoc.xml · nonDerivative · entry 4

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 334,373

F2 · kind: Transaction represents a "net exercise" of 72,923 outstanding non-qualified stock options granted on 2/28/2011 and 10,409 outstanding non-qualified stock options that result from the conversion on 2/18/2021 of incentive stock options granted on 2/28/2011. The Reporting Person received 28,784 shares of Common Stock on the net exercise of a stock options to purchase an aggregate of 83,332 shares of Common Stock, with a remaining payable by Reporting Person to the Issuer of $18.24. The Issuer withheld 54,548 shares of Common Stock underlying the stock options for payment of the exercise price and tax withholding using a stock price on 2/18/2021 of $21.01. In addition to the withholding of 54,548 shares of Common Stock, the Reporting Person will pay $18.24 in cash to the Issuer for the remainder of his exercise price and tax liability.

F1 · balance_after: Includes 4,991 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000032 · edgardoc.xml · nonDerivative · entry 3

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 382,269

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 4,991 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000032 · edgardoc.xml · nonDerivative · entry 2

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 309,346

F2 · kind: Transaction represents a "net exercise" of 72,923 outstanding non-qualified stock options granted on 2/28/2011 and 10,409 outstanding non-qualified stock options that result from the conversion on 2/18/2021 of incentive stock options granted on 2/28/2011. The Reporting Person received 28,784 shares of Common Stock on the net exercise of a stock options to purchase an aggregate of 83,332 shares of Common Stock, with a remaining payable by Reporting Person to the Issuer of $18.24. The Issuer withheld 54,548 shares of Common Stock underlying the stock options for payment of the exercise price and tax withholding using a stock price on 2/18/2021 of $21.01. In addition to the withholding of 54,548 shares of Common Stock, the Reporting Person will pay $18.24 in cash to the Issuer for the remainder of his exercise price and tax liability.

F1 · balance_after: Includes 4,991 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000032 · edgardoc.xml · nonDerivative · entry 1

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 315,998

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 4,991 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000030 · edgardoc.xml · derivative · entry 1

Bhanji Muna · CIK 0001846905 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,000

Underlying: Common Stock · 35,000 shares

Expires 2031-02-17

F1 · derivative.exercise_date: Options shall vest and become exercisable in 36 equal monthly installments as from the date of the grant.

SEC source: 0001061983-21-000028 · edgardoc.xml · nonDerivative · entry 1

Malik Fady Ibraham · CIK 0001551778 · EVP Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 148,809

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 1,470 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000027 · edgardoc.xml · derivative · entry 5

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,434

Underlying: Common Stock · 5,000 shares

Expires 2023-03-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

SEC source: 0001061983-21-000027 · edgardoc.xml · nonDerivative · entry 2

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 305,589

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 4,991 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000027 · edgardoc.xml · nonDerivative · entry 1

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 310,589

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 4,991 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000024 · edgardoc.xml · derivative · entry 5

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,434

Underlying: Common Stock · 5,000 shares

Expires 2023-03-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

SEC source: 0001061983-21-000024 · edgardoc.xml · nonDerivative · entry 2

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 305,589

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 4,991 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000024 · edgardoc.xml · nonDerivative · entry 1

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 310,589

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 4,991 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000022 · edgardoc.xml · derivative · entry 5

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,434

Underlying: Common Stock · 5,000 shares

Expires 2023-03-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

SEC source: 0001061983-21-000022 · edgardoc.xml · nonDerivative · entry 2

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 305,589

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 4,991 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000022 · edgardoc.xml · nonDerivative · entry 1

Blum Robert I · CIK 0001288859 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 310,589

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 4,991 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000020 · edgardoc.xml · derivative · entry 6

Malik Fady Ibraham · CIK 0001551778 · EVP Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 617 shares

Expires 2021-02-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

SEC source: 0001061983-21-000020 · edgardoc.xml · derivative · entry 5

Malik Fady Ibraham · CIK 0001551778 · EVP Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 11,883 shares

Expires 2021-02-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

SEC source: 0001061983-21-000020 · edgardoc.xml · nonDerivative · entry 4

Malik Fady Ibraham · CIK 0001551778 · EVP Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 150,441

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 1,470 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000020 · edgardoc.xml · nonDerivative · entry 3

Malik Fady Ibraham · CIK 0001551778 · EVP Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 162,324

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 1,470 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000020 · edgardoc.xml · nonDerivative · entry 2

Malik Fady Ibraham · CIK 0001551778 · EVP Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 150,441

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 1,470 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).

SEC source: 0001061983-21-000020 · edgardoc.xml · nonDerivative · entry 1

Malik Fady Ibraham · CIK 0001551778 · EVP Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 151,058

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction effected pursuant to a 10b5-1 plan entered into by the Reporting Person on March 31, 2020.

F2 · balance_after: Includes 1,470 shares of common stock purchased pursuant to the Issuer's 2015 Employee Stock Purchase Plan (ESPP).