CTXR

SEC source: 0001213900-25-075035 · ownership.xml · derivative · entry 5

HOLUBIAK MYRON Z · CIK 0001199080 · Director · Vice Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,344

Underlying: Common Stock · 22,344 shares

Expires 2026-09-27

F4 · security: The options are held by the Reporting Person's daughter. The Reporting Person disclaims beneficial ownership in these shares.

F2 · kind: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2025 to September 27, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

F2 · price: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2025 to September 27, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

F2 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2025 to September 27, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

SEC source: 0001213900-25-075035 · ownership.xml · derivative · entry 4

HOLUBIAK MYRON Z · CIK 0001199080 · Director · Vice Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 22,344 shares

Expires 2025-09-27

F2 · security: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2025 to September 27, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

F2 · kind: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2025 to September 27, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

F2 · price: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2025 to September 27, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

F2 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2025 to September 27, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

SEC source: 0001213900-25-075035 · ownership.xml · derivative · entry 3

HOLUBIAK MYRON Z · CIK 0001199080 · Director · Vice Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,373

Underlying: Common Stock · 31,373 shares

Expires 2026-08-14

F1 · security: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2025 to August 14, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

F1 · kind: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2025 to August 14, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

F1 · price: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2025 to August 14, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

F1 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2025 to August 14, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

SEC source: 0001213900-25-075035 · ownership.xml · derivative · entry 2

HOLUBIAK MYRON Z · CIK 0001199080 · Director · Vice Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 31,373 shares

Expires 2025-08-14

F1 · security: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2025 to August 14, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

F1 · kind: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2025 to August 14, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

F1 · price: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2025 to August 14, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

F1 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2025 to August 14, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

SEC source: 0001213900-25-090602 · ownership.xml · derivative · entry 5

Mazur Leonard L · CIK 0001463414 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 89,388

Underlying: Common Stock · 89,388 shares

Expires 2026-09-27

F2 · security: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2025 to September 27, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

F2 · kind: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2025 to September 27, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

F2 · price: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2025 to September 27, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

F2 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2025 to September 27, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

SEC source: 0001213900-25-090602 · ownership.xml · derivative · entry 4

Mazur Leonard L · CIK 0001463414 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 89,388 shares

Expires 2025-09-27

F2 · security: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2025 to September 27, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

F2 · kind: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2025 to September 27, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

F2 · price: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2025 to September 27, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

F2 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2025 to September 27, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

SEC source: 0001213900-25-090602 · ownership.xml · derivative · entry 3

Mazur Leonard L · CIK 0001463414 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 125,490

Underlying: Common Stock · 125,490 shares

Expires 2026-08-14

F1 · security: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2025 to August 14, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

F1 · kind: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2025 to August 14, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

F1 · price: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2025 to August 14, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

F1 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2025 to August 14, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

SEC source: 0001213900-25-090602 · ownership.xml · derivative · entry 2

Mazur Leonard L · CIK 0001463414 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 125,490 shares

Expires 2025-08-14

F1 · security: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2025 to August 14, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

F1 · kind: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2025 to August 14, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

F1 · price: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2025 to August 14, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

F1 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2025 to August 14, 2026, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

SEC source: 0001213900-24-096894 · ownership.xml · derivative · entry 1

Smith Robert Joseph · CIK 0002008764 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires 2034-11-07

F1 · derivative.exercise_date: The options were granted on November 7, 2024. The options will vest 100% on the one-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of the vesting date.

SEC source: 0001213900-24-096891 · ownership.xml · derivative · entry 1

Czuczman Myron · CIK 0001817716 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 300,000

Underlying: Common Stock · 300,000 shares

Expires 2034-11-07

F1 · derivative.exercise_date: The options were granted on November 7, 2024. The options will vest 1/3 on each of the one-year, two-year and three-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of each such vesting date.

SEC source: 0001213900-24-096895 · ownership.xml · derivative · entry 2

Webb Carol · CIK 0001671111 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires 2034-11-07

F1 · derivative.exercise_date: The options were granted on November 7, 2024. The options will vest 100% on the one-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of the vesting date.

SEC source: 0001213900-24-096892 · ownership.xml · derivative · entry 2

Mazur Leonard L · CIK 0001463414 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 600,000

Underlying: Common Stock · 600,000 shares

Expires 2034-11-07

F1 · derivative.exercise_date: The options were granted on November 7, 2024. The options vest 1/3 on each of the one-year, two-year and three-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of each such vesting date.

SEC source: 0001213900-24-096889 · ownership.xml · derivative · entry 1

MCGRATH DENNIS M · CIK 0001269340 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires 2034-11-07

F1 · derivative.exercise_date: The options were granted on November 7, 2024. The options will vest 100% on the one-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of the vesting date.

SEC source: 0001213900-24-096888 · ownership.xml · derivative · entry 3

HOLUBIAK MYRON Z · CIK 0001199080 · Director · Vice Chairman

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2034-11-07

F2 · derivative.exercise_date: The options are held by the Reporting Person's daughter. The Reporting Person disclaims beneficial ownership in these shares.

F2 · ownership.nature: The options are held by the Reporting Person's daughter. The Reporting Person disclaims beneficial ownership in these shares.

SEC source: 0001213900-24-096888 · ownership.xml · derivative · entry 2

HOLUBIAK MYRON Z · CIK 0001199080 · Director · Vice Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 350,000

Underlying: Common Stock · 350,000 shares

Expires 2034-11-07

F1 · derivative.exercise_date: The options were granted on November 7, 2024. The options will vest 1/3 on each of the one-year, two-year and three-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of each such vesting date.

SEC source: 0001213900-24-096893 · ownership.xml · derivative · entry 2

Bartushak Jaime · CIK 0001725077 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 350,000

Underlying: Common Stock · 350,000 shares

Expires 2034-11-07

F1 · derivative.exercise_date: The options were granted on November 7, 2024. The options will vest 1/3 on each of the one-year, two-year and three-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company on each such vesting date

SEC source: 0001213900-24-096890 · ownership.xml · derivative · entry 1

Dutia Suren G · CIK 0001514063 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires 2034-11-07

F1 · derivative.exercise_date: The options were granted on November 7, 2024. The options will vest 100% on the one-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of the vesting date.

SEC source: 0001213900-24-096887 · ownership.xml · derivative · entry 2

Holuka Eugene Myron · CIK 0001678292 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires 2034-11-07

F1 · derivative.exercise_date: The options were granted on November 7, 2024. The options will vest 100% on the one-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of the vesting date.

SEC source: 0001213900-24-082812 · ownership.xml · derivative · entry 5

Mazur Leonard L · CIK 0001463414 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,234,700

Underlying: Common Stock · 2,234,700 shares

Expires 2025-09-27

F2 · security: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2024 to September 27, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

F2 · kind: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2024 to September 27, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

F2 · price: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2024 to September 27, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

F2 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2024 to September 27, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

SEC source: 0001213900-24-082812 · ownership.xml · derivative · entry 4

Mazur Leonard L · CIK 0001463414 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,234,700 shares

Expires 2024-09-27

F2 · security: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2024 to September 27, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

F2 · kind: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2024 to September 27, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

F2 · price: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2024 to September 27, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

F2 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2024 to September 27, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

SEC source: 0001213900-24-082813 · ownership.xml · derivative · entry 5

HOLUBIAK MYRON Z · CIK 0001199080 · Director · Vice Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 558,597

Underlying: Common Stock · 558,597 shares

Expires 2025-09-27

F2 · security: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2024 to September 27, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

F2 · kind: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2024 to September 27, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

F2 · price: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2024 to September 27, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

F2 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2024 to September 27, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

SEC source: 0001213900-24-082813 · ownership.xml · derivative · entry 4

HOLUBIAK MYRON Z · CIK 0001199080 · Director · Vice Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 558,597 shares

Expires 2024-09-27

F2 · security: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2024 to September 27, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

F2 · kind: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2024 to September 27, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

F2 · price: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2024 to September 27, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

F2 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from September 27, 2024 to September 27, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on September 27, 2019 and was exercisable immediately.

SEC source: 0001213900-24-082812 · ownership.xml · derivative · entry 3

Mazur Leonard L · CIK 0001463414 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,137,255

Underlying: Common Stock · 3,137,255 shares

Expires 2025-08-14

F1 · security: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2024 to August 14, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

F1 · kind: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2024 to August 14, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

F1 · price: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2024 to August 14, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

F1 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2024 to August 14, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

SEC source: 0001213900-24-082812 · ownership.xml · derivative · entry 2

Mazur Leonard L · CIK 0001463414 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,137,255 shares

Expires 2024-08-14

F1 · security: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2024 to August 14, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

F1 · kind: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2024 to August 14, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

F1 · price: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2024 to August 14, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

F1 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2024 to August 14, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

SEC source: 0001213900-24-082813 · ownership.xml · derivative · entry 3

HOLUBIAK MYRON Z · CIK 0001199080 · Director · Vice Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 784,314

Underlying: Common Stock · 784,314 shares

Expires 2025-08-14

F1 · security: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2024 to August 14, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

F1 · kind: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2024 to August 14, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

F1 · price: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2024 to August 14, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

F1 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2024 to August 14, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

SEC source: 0001213900-24-082813 · ownership.xml · derivative · entry 2

HOLUBIAK MYRON Z · CIK 0001199080 · Director · Vice Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 784,314 shares

Expires 2024-08-14

F1 · security: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2024 to August 14, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

F1 · kind: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2024 to August 14, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

F1 · price: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2024 to August 14, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

F1 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from August 14, 2024 to August 14, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on August 13, 2018 and was exercisable immediately.

SEC source: 0001213900-24-030811 · ownership.xml · derivative · entry 3

Mazur Leonard L · CIK 0001463414 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,165,048

Underlying: Common Stock · 1,165,048 shares

Expires 2025-04-05

F1 · security: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from April 5, 2024 to April 5, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on April 3, 2019 and was exercisable immediately.

F1 · kind: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from April 5, 2024 to April 5, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on April 3, 2019 and was exercisable immediately.

F1 · price: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from April 5, 2024 to April 5, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on April 3, 2019 and was exercisable immediately.

F1 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from April 5, 2024 to April 5, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on April 3, 2019 and was exercisable immediately.

SEC source: 0001213900-24-030811 · ownership.xml · derivative · entry 2

Mazur Leonard L · CIK 0001463414 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,165,048 shares

Expires 2024-04-05

F1 · security: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from April 5, 2024 to April 5, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on April 3, 2019 and was exercisable immediately.

F1 · kind: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from April 5, 2024 to April 5, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on April 3, 2019 and was exercisable immediately.

F1 · price: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from April 5, 2024 to April 5, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on April 3, 2019 and was exercisable immediately.

F1 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from April 5, 2024 to April 5, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on April 3, 2019 and was exercisable immediately.

SEC source: 0001213900-24-030812 · ownership.xml · derivative · entry 3

HOLUBIAK MYRON Z · CIK 0001199080 · Director · Vice Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 129,450

Underlying: Common Stock · 129,450 shares

Expires 2025-04-05

F1 · security: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from April 5, 2024 to April 5, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on April 3, 2019 and was exercisable immediately.

F1 · kind: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from April 5, 2024 to April 5, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on April 3, 2019 and was exercisable immediately.

F1 · price: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from April 5, 2024 to April 5, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on April 3, 2019 and was exercisable immediately.

F1 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from April 5, 2024 to April 5, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on April 3, 2019 and was exercisable immediately.

SEC source: 0001213900-24-030812 · ownership.xml · derivative · entry 2

HOLUBIAK MYRON Z · CIK 0001199080 · Director · Vice Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 129,450 shares

Expires 2024-04-05

F1 · security: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from April 5, 2024 to April 5, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on April 3, 2019 and was exercisable immediately.

F1 · kind: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from April 5, 2024 to April 5, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on April 3, 2019 and was exercisable immediately.

F1 · price: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from April 5, 2024 to April 5, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on April 3, 2019 and was exercisable immediately.

F1 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding warrant to extend the termination date from April 5, 2024 to April 5, 2025, which resulted in the cancellation of the "old" warrant and the grant of a replacement warrant. The warrant was originally issued on April 3, 2019 and was exercisable immediately.

SEC source: 0001213900-24-023487 · ownership.xml · derivative · entry 1

Smith Robert Joseph · CIK 0002008764 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2034-03-12

F1 · derivative.exercise_date: The options were granted on March 14, 2024, with a Vesting Commencement Date of March 12, 2024, the date of the Optionee's election to the Board of the Company. The options will vest 100% on the one-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of the vesting date.

SEC source: 0001213900-24-074506 · ownership.xml · derivative · entry 3

Holuka Eugene Myron · CIK 0001678292 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,415 shares

Expires 2024-04-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001213900-24-074506 · ownership.xml · nonDerivative · entry 2

Holuka Eugene Myron · CIK 0001678292 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,367

SEC source: 0001213900-24-074506 · ownership.xml · nonDerivative · entry 1

Holuka Eugene Myron · CIK 0001678292 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,415

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001213900-24-074505 · ownership.xml · derivative · entry 3

Webb Carol · CIK 0001671111 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 12,071 shares

Expires 2024-03-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001213900-24-074505 · ownership.xml · nonDerivative · entry 2

Webb Carol · CIK 0001671111 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,835

SEC source: 0001213900-24-074505 · ownership.xml · nonDerivative · entry 1

Webb Carol · CIK 0001671111 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,071

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001013762-23-003534 · ownership.xml · derivative · entry 1

Czuczman Myron · CIK 0001817716 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 300,000

Underlying: Common Stock · 300,000 shares

Expires 2033-10-10

F1 · derivative.exercise_date: The options were granted on October 10, 2023. The options will vest 1/3 on each of the one-year, two-year and three-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of each such vesting date.

SEC source: 0001013762-23-003535 · ownership.xml · derivative · entry 1

Webb Carol · CIK 0001671111 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2033-10-10

F1 · security: The options were granted on October 10, 2023. The options will vest 100% on the one-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of the vesting date.

F1 · derivative.exercise_date: The options were granted on October 10, 2023. The options will vest 100% on the one-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of the vesting date.

SEC source: 0001013762-23-003528 · ownership.xml · derivative · entry 13

Mazur Leonard L · CIK 0001463414 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 550,000

Underlying: Common Stock · 550,000 shares

Expires 2033-10-10

F10 · security: The options were granted on October 10, 2023. The options will vest 1/3 on each of the one-year, two-year and three-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of each such vesting date.

F10 · derivative.exercise_date: The options were granted on October 10, 2023. The options will vest 1/3 on each of the one-year, two-year and three-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of each such vesting date.

SEC source: 0001013762-23-003529 · ownership.xml · derivative · entry 1

MCGRATH DENNIS M · CIK 0001269340 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2033-10-10

F1 · security: The options were granted on October 10, 2023. The options will vest 100% on the one-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of the vesting date.

F1 · derivative.exercise_date: The options were granted on October 10, 2023. The options will vest 100% on the one-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of the vesting date.

SEC source: 0001013762-23-003533 · ownership.xml · derivative · entry 15

HOLUBIAK MYRON Z · CIK 0001199080 · Director · Vice Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 400,000

Underlying: Common Stock · 400,000 shares

Expires 2033-10-10

F11 · security: The options were granted on October 10, 2023. The options will vest 1/3 on each of the one-year, two-year and three-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of each such vesting date.

F11 · derivative.exercise_date: The options were granted on October 10, 2023. The options will vest 1/3 on each of the one-year, two-year and three-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of each such vesting date.

SEC source: 0001013762-23-003532 · ownership.xml · derivative · entry 1

Holuka Eugene Myron · CIK 0001678292 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2033-10-10

F1 · security: The options were granted on October 10, 2023. The options will vest 100% on the one-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of the vesting date.

F1 · derivative.exercise_date: The options were granted on October 10, 2023. The options will vest 100% on the one-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of the vesting date.

SEC source: 0001013762-23-003531 · ownership.xml · derivative · entry 1

Dutia Suren G · CIK 0001514063 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2033-10-10

F1 · security: The options were granted on October 10, 2023. The options will vest 100% on the one-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of the vesting date.

F1 · derivative.exercise_date: The options were granted on October 10, 2023. The options will vest 100% on the one-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of the vesting date.

SEC source: 0001013762-23-003530 · ownership.xml · derivative · entry 2

Bartushak Jaime · CIK 0001725077 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 300,000

Underlying: Common Stock · 300,000 shares

Expires 2033-10-10

F1 · security: The options were granted on October 10, 2023. The options will vest 1/3 on each of the one-year, two-year and three-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company on each such vesting date.

F1 · derivative.exercise_date: The options were granted on October 10, 2023. The options will vest 1/3 on each of the one-year, two-year and three-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company on each such vesting date.

SEC source: 0001213900-23-009756 · ownership.xml · derivative · entry 1

MCGRATH DENNIS M · CIK 0001269340 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2033-02-07

F1 · security: The options were granted on February 7, 2023. The options will vest 100% on the one-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of the vesting date.

F1 · derivative.exercise_date: The options were granted on February 7, 2023. The options will vest 100% on the one-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of the vesting date.

SEC source: 0001213900-22-062472 · ownership.xml · derivative · entry 1

Czuczman Myron · CIK 0001817716 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 300,000

Underlying: Common Stock · 300,000 shares

Expires 2032-10-04

F1 · derivative.exercise_date: The options were granted on October 4, 2022. The options will vest 1/3 on each of the one-year, two-year and three-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of each such vesting date.

SEC source: 0001213900-22-062485 · ownership.xml · derivative · entry 1

Kane William · CIK 0001671585 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2032-10-04

F1 · security: The options were granted on October 4, 2022. The options will vest 100% on the one-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of the vesting date.

F1 · derivative.exercise_date: The options were granted on October 4, 2022. The options will vest 100% on the one-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of the vesting date.

SEC source: 0001213900-22-062475 · ownership.xml · derivative · entry 1

Webb Carol · CIK 0001671111 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2032-10-04

F1 · security: The options were granted on October 4, 2022. The options will vest 100% on the one-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of the vesting date.

F1 · derivative.exercise_date: The options were granted on October 4, 2022. The options will vest 100% on the one-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of the vesting date.

SEC source: 0001213900-22-062481 · ownership.xml · derivative · entry 16

Mazur Leonard L · CIK 0001463414 · Director · Executive Chairman · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 550,000

Underlying: Common Stock · 550,000 shares

Expires 2032-10-04

F9 · security: The options were granted on October 4, 2022. The options will vest 1/3 on each of the one-year, two-year and three-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of each such vesting date.

F9 · derivative.exercise_date: The options were granted on October 4, 2022. The options will vest 1/3 on each of the one-year, two-year and three-year anniversary of the Vesting Commencement Date, provided that the Optionee provides Continuous Service to the Company as of each such vesting date.