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Nasdaq · USD

CRSP

CRISPR Therapeutics AG

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Tapewire entity
3852
SEC CIK
0001674416
Parsed reports
491

Last 12 months

Inside the activity.

0 purchase rows · 27 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 202500
Dec 202503
Jan 202607
Feb 202602
Mar 2026010
Apr 202600
May 202601
Jun 202600
Jul 202600
Aug 202600
Sep 202602
Oct 202602

Latest available

Insider transactions

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
January 15, 2021 Filed Jan 20, 2021 23:07 UTC SaleCommon Shares 700 $214.60 $150,220.00
Disclosure

SEC source: 0001209191-21-004458 · doc4.xml · nonDerivative · entry 11

Klein Lawrence Otto · CIK 0001762583 · CBO & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,200

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F10 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $214.60 to $214.60, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

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January 15, 2021 Filed Jan 20, 2021 23:07 UTC SaleCommon Shares 2,800 $213.64 $598,192.00
Disclosure

SEC source: 0001209191-21-004458 · doc4.xml · nonDerivative · entry 10

Klein Lawrence Otto · CIK 0001762583 · CBO & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,900

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F9 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $213.48 to $214.31, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

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January 15, 2021 Filed Jan 20, 2021 23:07 UTC SaleCommon Shares 634 $212.20 $134,534.80
Disclosure

SEC source: 0001209191-21-004458 · doc4.xml · nonDerivative · entry 9

Klein Lawrence Otto · CIK 0001762583 · CBO & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,700

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F8 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $212.01 to $212.79, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

Read SEC document
January 15, 2021 Filed Jan 20, 2021 23:07 UTC Exercise / conversionCommon Shares 16,344 $14.43 $235,843.92
Disclosure

SEC source: 0001209191-21-004458 · doc4.xml · nonDerivative · entry 8

Klein Lawrence Otto · CIK 0001762583 · CBO & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,334

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 15, 2021 Filed Jan 20, 2021 23:07 UTC SaleCommon Shares 200 $217.45 $43,490.00
Disclosure

SEC source: 0001209191-21-004458 · doc4.xml · nonDerivative · entry 7

Klein Lawrence Otto · CIK 0001762583 · CBO & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F7 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $217.42 to $217.47, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

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January 15, 2021 Filed Jan 20, 2021 23:07 UTC SaleCommon Shares 400 $216.24 $86,496.00
Disclosure

SEC source: 0001209191-21-004458 · doc4.xml · nonDerivative · entry 6

Klein Lawrence Otto · CIK 0001762583 · CBO & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,200

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F6 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $216.15 to $216.43, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

Read SEC document
January 15, 2021 Filed Jan 20, 2021 23:07 UTC SaleCommon Shares 1,400 $214.46 $300,244.00
Disclosure

SEC source: 0001209191-21-004458 · doc4.xml · nonDerivative · entry 5

Klein Lawrence Otto · CIK 0001762583 · CBO & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,600

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $214.125 to $214.75, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

Read SEC document
January 15, 2021 Filed Jan 20, 2021 23:07 UTC SaleCommon Shares 1,200 $213.71 $256,452.00
Disclosure

SEC source: 0001209191-21-004458 · doc4.xml · nonDerivative · entry 4

Klein Lawrence Otto · CIK 0001762583 · CBO & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,000

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $213.10 to $214.09, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

Read SEC document
January 15, 2021 Filed Jan 20, 2021 23:07 UTC SaleCommon Shares 2,555 $212.54 $543,039.70
Disclosure

SEC source: 0001209191-21-004458 · doc4.xml · nonDerivative · entry 3

Klein Lawrence Otto · CIK 0001762583 · CBO & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,200

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $212.01 to $212.98, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

Read SEC document
January 15, 2021 Filed Jan 20, 2021 23:07 UTC SaleCommon Shares 2,911 $211.44 $615,501.84
Disclosure

SEC source: 0001209191-21-004458 · doc4.xml · nonDerivative · entry 2

Klein Lawrence Otto · CIK 0001762583 · CBO & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,755

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $211.01 to $212.00, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

Read SEC document
January 15, 2021 Filed Jan 20, 2021 23:07 UTC Exercise / conversionCommon Shares 8,666 $12.57 $108,931.62
Disclosure

SEC source: 0001209191-21-004458 · doc4.xml · nonDerivative · entry 1

Klein Lawrence Otto · CIK 0001762583 · CBO & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,666

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 15, 2021 Filed Mar 12, 2021 22:37 UTC Amendment Exercise / conversionCommon Shares 16,334 $14.43 $235,699.62
Disclosure

SEC source: 0001209191-21-020248 · doc4a.xml · nonDerivative · entry 1

Klein Lawrence Otto · CIK 0001762583 · CBO & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,942

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: This amended Form 4 is being filed to correct the number of shares acquired on January 15, 2021.

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January 02, 2021 Filed Jan 4, 2021 21:12 UTC Tax withholdingCommon Shares 9,392 $153.11 $1,438,009.12
Disclosure

SEC source: 0001209191-21-000256 · doc4.xml · nonDerivative · entry 1

Klein Lawrence Otto · CIK 0001762583 · CBO & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,608

F1 · kind: On January 2, 2019, the reporting person was granted 20,000 restricted stock units. The restricted stock units vested in full on January 2, 2021. Amount reported represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of these restricted stock units. This sale is mandated by the Company's RSU Settlement Policy to fund the tax withholding obligation and does not represent a discretionary trade by the reporting person.

Read SEC document
December 29, 2020 Filed Dec 30, 2020 21:02 UTC
Kulkarni SamarthDirector · Chief Executive Officer
Exercise / conversionStock Option (right to buy) · Derivative 13,800 $0.00 Strike: $1.81 $0.00
Disclosure

SEC source: 0001209191-20-065501 · doc4.xml · derivative · entry 2

Kulkarni Samarth · CIK 0001682019 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 128,983

Underlying: Common Shares · 13,800 shares

Expires 2025-09-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: This option was granted on September 10, 2015 with respect to 321,712 Common Shares with 120,640 of the shares vested on August 1, 2016, the first anniversary of employment commencement, and the remainder vest in equal 36 monthly installments thereafter.

Read SEC document
December 29, 2020 Filed Dec 30, 2020 21:02 UTC
Kulkarni SamarthDirector · Chief Executive Officer
Exercise / conversionCommon Shares 13,800 $1.81 $24,978.00
Disclosure

SEC source: 0001209191-20-065501 · doc4.xml · nonDerivative · entry 1

Kulkarni Samarth · CIK 0001682019 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 182,989

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 21, 2020 Filed Dec 22, 2020 21:55 UTC
Ho Tony WExecutive VP, Head of R&D
Exercise / conversionStock Option (right to buy) · Derivative 23,551 $0.00 Strike: $16.90 $0.00
Disclosure

SEC source: 0001209191-20-064857 · doc4.xml · derivative · entry 11

Ho Tony W · CIK 0001713637 · Executive VP, Head of R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 236,449

Underlying: Common Shares · 23,551 shares

Expires 2027-08-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F12 · derivative.exercise_date: This option was granted on August 1, 2017 with respect to 260,000 Common Shares of which 25% vested on 8/1/2018 and the remaining 75% vest in 36 equal monthly installments on the final day of each succeeding calendar month.

Read SEC document
December 21, 2020 Filed Dec 22, 2020 21:55 UTC
Ho Tony WExecutive VP, Head of R&D
SaleCommon Shares 2,951 $150.61 $444,450.11
Disclosure

SEC source: 0001209191-20-064857 · doc4.xml · nonDerivative · entry 10

Ho Tony W · CIK 0001713637 · Executive VP, Head of R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,964

F2 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F11 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $150.44 to $151.03, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

Read SEC document
December 21, 2020 Filed Dec 22, 2020 21:55 UTC
Ho Tony WExecutive VP, Head of R&D
SaleCommon Shares 5,000 $149.73 $748,650.00
Disclosure

SEC source: 0001209191-20-064857 · doc4.xml · nonDerivative · entry 9

Ho Tony W · CIK 0001713637 · Executive VP, Head of R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,915

F2 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F10 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $149.20 to $150.195, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

Read SEC document
December 21, 2020 Filed Dec 22, 2020 21:55 UTC
Ho Tony WExecutive VP, Head of R&D
SaleCommon Shares 8,400 $148.38 $1,246,392.00
Disclosure

SEC source: 0001209191-20-064857 · doc4.xml · nonDerivative · entry 8

Ho Tony W · CIK 0001713637 · Executive VP, Head of R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,915

F2 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F9 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $148.19 to $149.17, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

Read SEC document
December 21, 2020 Filed Dec 22, 2020 21:55 UTC
Ho Tony WExecutive VP, Head of R&D
SaleCommon Shares 1,400 $147.05 $205,870.00
Disclosure

SEC source: 0001209191-20-064857 · doc4.xml · nonDerivative · entry 7

Ho Tony W · CIK 0001713637 · Executive VP, Head of R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,315

F2 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F8 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $147.00 to $147.125, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

Read SEC document
December 21, 2020 Filed Dec 22, 2020 21:55 UTC
Ho Tony WExecutive VP, Head of R&D
SaleCommon Shares 500 $152.41 $76,205.00
Disclosure

SEC source: 0001209191-20-064857 · doc4.xml · nonDerivative · entry 6

Ho Tony W · CIK 0001713637 · Executive VP, Head of R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 51,715

F2 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F7 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $152.04 to $152.60, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

Read SEC document
December 21, 2020 Filed Dec 22, 2020 21:55 UTC
Ho Tony WExecutive VP, Head of R&D
SaleCommon Shares 1,100 $151.58 $166,738.00
Disclosure

SEC source: 0001209191-20-064857 · doc4.xml · nonDerivative · entry 5

Ho Tony W · CIK 0001713637 · Executive VP, Head of R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,215

F2 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F6 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $151.00 to $151.97, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

Read SEC document
December 21, 2020 Filed Dec 22, 2020 21:55 UTC
Ho Tony WExecutive VP, Head of R&D
SaleCommon Shares 1,600 $150.16 $240,256.00
Disclosure

SEC source: 0001209191-20-064857 · doc4.xml · nonDerivative · entry 4

Ho Tony W · CIK 0001713637 · Executive VP, Head of R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,315

F2 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $149.755 to $150.73, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

Read SEC document
December 21, 2020 Filed Dec 22, 2020 21:55 UTC
Ho Tony WExecutive VP, Head of R&D
SaleCommon Shares 900 $149.18 $134,262.00
Disclosure

SEC source: 0001209191-20-064857 · doc4.xml · nonDerivative · entry 3

Ho Tony W · CIK 0001713637 · Executive VP, Head of R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 54,915

F2 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $148.69 to $149.59, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

Read SEC document
December 21, 2020 Filed Dec 22, 2020 21:55 UTC
Ho Tony WExecutive VP, Head of R&D
SaleCommon Shares 1,700 $148.11 $251,787.00
Disclosure

SEC source: 0001209191-20-064857 · doc4.xml · nonDerivative · entry 2

Ho Tony W · CIK 0001713637 · Executive VP, Head of R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 55,815

F2 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $147.44 to $148.29, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

Read SEC document
December 21, 2020 Filed Dec 22, 2020 21:55 UTC
Ho Tony WExecutive VP, Head of R&D
Exercise / conversionCommon Shares 23,551 $16.90 $398,011.90
Disclosure

SEC source: 0001209191-20-064857 · doc4.xml · nonDerivative · entry 1

Ho Tony W · CIK 0001713637 · Executive VP, Head of R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 57,515

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 217 shares acquired under the CRISPR Therapeutics AG 2016 Employee Stock Purchase Plan.

Read SEC document
December 16, 2020 Filed Dec 19, 2020 00:12 UTC SaleCommon Shares 931 $151.05 $140,625.13
Disclosure

SEC source: 0000899243-20-034537 · doc4.xml · nonDerivative · entry 10

Bolzon Bradley J PhD · CIK 0001354345 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 339,834

F1 · kind: The sale of these shares was effected pursuant to Rule 10b5-1 trading plans adopted by each of the Reporting Person and Versant Venture Management, LLC ("VVM LLC"), respectively.

F3 · shares: These securities are held of record by VVM LLC, for the benefit of the Reporting Person, pursuant to an agreement between VVM LLC and the Reporting Person.

F8 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $150.79 to $151.36, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (8) to this Form 4.

F4 · ownership.nature: These securities are held of record by VVM LLC. The Reporting Person is a managing member of VVM LLC and the Reporting Person may be deemed to indirectly beneficially own the securities through his interest in VVM LLC. The Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein, if any.

Read SEC document
December 16, 2020 Filed Dec 19, 2020 00:12 UTC SaleCommon Shares 969 $151.05 $146,364.93
Disclosure

SEC source: 0000899243-20-034537 · doc4.xml · nonDerivative · entry 9

Bolzon Bradley J PhD · CIK 0001354345 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The sale of these shares was effected pursuant to Rule 10b5-1 trading plans adopted by each of the Reporting Person and Versant Venture Management, LLC ("VVM LLC"), respectively.

F8 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $150.79 to $151.36, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (8) to this Form 4.

Read SEC document
December 16, 2020 Filed Dec 19, 2020 00:12 UTC SaleCommon Shares 958 $150.14 $143,837.19
Disclosure

SEC source: 0000899243-20-034537 · doc4.xml · nonDerivative · entry 8

Bolzon Bradley J PhD · CIK 0001354345 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 340,765

F1 · kind: The sale of these shares was effected pursuant to Rule 10b5-1 trading plans adopted by each of the Reporting Person and Versant Venture Management, LLC ("VVM LLC"), respectively.

F3 · shares: These securities are held of record by VVM LLC, for the benefit of the Reporting Person, pursuant to an agreement between VVM LLC and the Reporting Person.

F7 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $149.77 to $150.61, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (7) to this Form 4.

F4 · ownership.nature: These securities are held of record by VVM LLC. The Reporting Person is a managing member of VVM LLC and the Reporting Person may be deemed to indirectly beneficially own the securities through his interest in VVM LLC. The Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein, if any.

Read SEC document
December 16, 2020 Filed Dec 19, 2020 00:12 UTC SaleCommon Shares 995 $150.14 $149,392.48
Disclosure

SEC source: 0000899243-20-034537 · doc4.xml · nonDerivative · entry 7

Bolzon Bradley J PhD · CIK 0001354345 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 969

F1 · kind: The sale of these shares was effected pursuant to Rule 10b5-1 trading plans adopted by each of the Reporting Person and Versant Venture Management, LLC ("VVM LLC"), respectively.

F7 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $149.77 to $150.61, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (7) to this Form 4.

Read SEC document
December 16, 2020 Filed Dec 19, 2020 00:12 UTC SaleCommon Shares 2,009 $149.12 $299,586.50
Disclosure

SEC source: 0000899243-20-034537 · doc4.xml · nonDerivative · entry 6

Bolzon Bradley J PhD · CIK 0001354345 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 341,723

F1 · kind: The sale of these shares was effected pursuant to Rule 10b5-1 trading plans adopted by each of the Reporting Person and Versant Venture Management, LLC ("VVM LLC"), respectively.

F3 · shares: These securities are held of record by VVM LLC, for the benefit of the Reporting Person, pursuant to an agreement between VVM LLC and the Reporting Person.

F6 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $148.72 to $149.60, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (6) to this Form 4.

F4 · ownership.nature: These securities are held of record by VVM LLC. The Reporting Person is a managing member of VVM LLC and the Reporting Person may be deemed to indirectly beneficially own the securities through his interest in VVM LLC. The Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein, if any.

Read SEC document
December 16, 2020 Filed Dec 19, 2020 00:12 UTC SaleCommon Shares 2,091 $149.12 $311,814.52
Disclosure

SEC source: 0000899243-20-034537 · doc4.xml · nonDerivative · entry 5

Bolzon Bradley J PhD · CIK 0001354345 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,964

F1 · kind: The sale of these shares was effected pursuant to Rule 10b5-1 trading plans adopted by each of the Reporting Person and Versant Venture Management, LLC ("VVM LLC"), respectively.

F6 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $148.72 to $149.60, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (6) to this Form 4.

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December 16, 2020 Filed Dec 19, 2020 00:12 UTC SaleCommon Shares 2,576 $148.28 $381,972.11
Disclosure

SEC source: 0000899243-20-034537 · doc4.xml · nonDerivative · entry 4

Bolzon Bradley J PhD · CIK 0001354345 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 343,732

F1 · kind: The sale of these shares was effected pursuant to Rule 10b5-1 trading plans adopted by each of the Reporting Person and Versant Venture Management, LLC ("VVM LLC"), respectively.

F3 · shares: These securities are held of record by VVM LLC, for the benefit of the Reporting Person, pursuant to an agreement between VVM LLC and the Reporting Person.

F5 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $147.67 to $148.66, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (5) to this Form 4.

F4 · ownership.nature: These securities are held of record by VVM LLC. The Reporting Person is a managing member of VVM LLC and the Reporting Person may be deemed to indirectly beneficially own the securities through his interest in VVM LLC. The Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein, if any.

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December 16, 2020 Filed Dec 19, 2020 00:12 UTC SaleCommon Shares 2,679 $148.28 $397,245.07
Disclosure

SEC source: 0000899243-20-034537 · doc4.xml · nonDerivative · entry 3

Bolzon Bradley J PhD · CIK 0001354345 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,055

F1 · kind: The sale of these shares was effected pursuant to Rule 10b5-1 trading plans adopted by each of the Reporting Person and Versant Venture Management, LLC ("VVM LLC"), respectively.

F5 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $147.67 to $148.66, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (5) to this Form 4.

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December 16, 2020 Filed Dec 19, 2020 00:12 UTC SaleCommon Shares 878 $147.00 $129,067.76
Disclosure

SEC source: 0000899243-20-034537 · doc4.xml · nonDerivative · entry 2

Bolzon Bradley J PhD · CIK 0001354345 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 346,308

F1 · kind: The sale of these shares was effected pursuant to Rule 10b5-1 trading plans adopted by each of the Reporting Person and Versant Venture Management, LLC ("VVM LLC"), respectively.

F3 · shares: These securities are held of record by VVM LLC, for the benefit of the Reporting Person, pursuant to an agreement between VVM LLC and the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $146.67 to $147.59, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

F4 · ownership.nature: These securities are held of record by VVM LLC. The Reporting Person is a managing member of VVM LLC and the Reporting Person may be deemed to indirectly beneficially own the securities through his interest in VVM LLC. The Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein, if any.

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December 16, 2020 Filed Dec 19, 2020 00:12 UTC SaleCommon Shares 914 $147.00 $134,359.83
Disclosure

SEC source: 0000899243-20-034537 · doc4.xml · nonDerivative · entry 1

Bolzon Bradley J PhD · CIK 0001354345 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,734

F1 · kind: The sale of these shares was effected pursuant to Rule 10b5-1 trading plans adopted by each of the Reporting Person and Versant Venture Management, LLC ("VVM LLC"), respectively.

F2 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $146.67 to $147.59, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

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December 10, 2020 Filed Dec 18, 2020 00:14 UTC Amendment SaleCommon Shares 15,900 $144.85 $2,303,154.75
Disclosure

SEC source: 0000899243-20-034324 · doc4a.xml · nonDerivative · entry 5

Bolzon Bradley J PhD · CIK 0001354345 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,648

F1 · kind: The sale of these shares was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F6 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $144.04 to $144.99, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (6) to this Form 4.

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December 10, 2020 Filed Dec 18, 2020 00:14 UTC Amendment SaleCommon Shares 2,223 $143.26 $318,462.31
Disclosure

SEC source: 0000899243-20-034324 · doc4a.xml · nonDerivative · entry 4

Bolzon Bradley J PhD · CIK 0001354345 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,548

F1 · kind: The sale of these shares was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F5 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $143.00 to $143.64, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (5) to this Form 4.

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December 10, 2020 Filed Dec 18, 2020 00:14 UTC Amendment SaleCommon Shares 5,958 $142.42 $848,562.19
Disclosure

SEC source: 0000899243-20-034324 · doc4a.xml · nonDerivative · entry 3

Bolzon Bradley J PhD · CIK 0001354345 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,771

F1 · kind: The sale of these shares was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $142.00 to $142.94, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (4) to this Form 4.

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December 10, 2020 Filed Dec 18, 2020 00:14 UTC Amendment SaleCommon Shares 6,648 $141.53 $940,923.35
Disclosure

SEC source: 0000899243-20-034324 · doc4a.xml · nonDerivative · entry 2

Bolzon Bradley J PhD · CIK 0001354345 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,729

F1 · kind: The sale of these shares was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $141.10 to $141.98, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (3) to this Form 4.

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December 10, 2020 Filed Dec 18, 2020 00:14 UTC Amendment SaleCommon Shares 2,271 $140.62 $319,345.29
Disclosure

SEC source: 0000899243-20-034324 · doc4a.xml · nonDerivative · entry 1

Bolzon Bradley J PhD · CIK 0001354345 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,377

F1 · kind: The sale of these shares was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $140.20 to $140.91, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

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December 10, 2020 Filed Dec 11, 2020 21:05 UTC
Kulkarni SamarthDirector · Chief Executive Officer
Exercise / conversionStock Option (Right to Buy) · Derivative 20,000 $0.00 Strike: $1.81 $0.00
Disclosure

SEC source: 0001209191-20-062919 · doc4.xml · derivative · entry 7

Kulkarni Samarth · CIK 0001682019 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 142,783

Underlying: Common Shares · 20,000 shares

Expires 2025-09-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · derivative.exercise_date: This option was granted on September 10, 2015 with respect to 321,712 Common Shares with 120,640 of the shares vested on August 1, 2016, the first anniversary of employment commencement, and the remainder vest in equal 36 monthly installments thereafter.

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December 10, 2020 Filed Dec 11, 2020 21:05 UTC
Kulkarni SamarthDirector · Chief Executive Officer
SaleCommon Shares 600 $144.97 $86,982.00
Disclosure

SEC source: 0001209191-20-062919 · doc4.xml · nonDerivative · entry 6

Kulkarni Samarth · CIK 0001682019 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 169,189

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F6 · price: he price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $144.95 to $145.05, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

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December 10, 2020 Filed Dec 11, 2020 21:05 UTC
Kulkarni SamarthDirector · Chief Executive Officer
SaleCommon Shares 2,100 $143.71 $301,791.00
Disclosure

SEC source: 0001209191-20-062919 · doc4.xml · nonDerivative · entry 5

Kulkarni Samarth · CIK 0001682019 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 169,789

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $143.63 to $144.11, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

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December 10, 2020 Filed Dec 11, 2020 21:05 UTC
Kulkarni SamarthDirector · Chief Executive Officer
SaleCommon Shares 6,766 $142.75 $965,846.50
Disclosure

SEC source: 0001209191-20-062919 · doc4.xml · nonDerivative · entry 4

Kulkarni Samarth · CIK 0001682019 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 171,889

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $142.61.00 to $143.21, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

Read SEC document
December 10, 2020 Filed Dec 11, 2020 21:05 UTC
Kulkarni SamarthDirector · Chief Executive Officer
SaleCommon Shares 5,034 $141.98 $714,727.32
Disclosure

SEC source: 0001209191-20-062919 · doc4.xml · nonDerivative · entry 3

Kulkarni Samarth · CIK 0001682019 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 178,655

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $141.54 to $142.42, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

Read SEC document
December 10, 2020 Filed Dec 11, 2020 21:05 UTC
Kulkarni SamarthDirector · Chief Executive Officer
SaleCommon Shares 5,500 $141.17 $776,435.00
Disclosure

SEC source: 0001209191-20-062919 · doc4.xml · nonDerivative · entry 2

Kulkarni Samarth · CIK 0001682019 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 183,689

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $140.53 to $141.51, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

Read SEC document
December 10, 2020 Filed Dec 11, 2020 21:05 UTC
Kulkarni SamarthDirector · Chief Executive Officer
Exercise / conversionCommon Shares 20,000 $1.81 $36,200.00
Disclosure

SEC source: 0001209191-20-062919 · doc4.xml · nonDerivative · entry 1

Kulkarni Samarth · CIK 0001682019 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 189,189

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 10, 2020 Filed Dec 15, 2020 00:11 UTC SaleCommon Shares 15,900 $144.85 $2,303,154.75
Disclosure

SEC source: 0000899243-20-033783 · doc4.xml · nonDerivative · entry 5

Bolzon Bradley J PhD · CIK 0001354345 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 314,186

F1 · kind: The sale of these shares was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · shares: These securities are held of record by Versant Venture Management, LLC ("VVM LLC"), for the benefit of the Reporting Person, pursuant to an agreement between VVM LLC and the Reporting Person.

F8 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $144.04 to $144.99, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (8) to this Form 4.

F4 · ownership.nature: These securities are held of record by VVM LLC. The Reporting Person is a managing member of VVM LLC and the Reporting Person may be deemed to indirectly beneficially own the securities through his interest in VVM LLC. The Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein, if any.

Read SEC document
December 10, 2020 Filed Dec 15, 2020 00:11 UTC SaleCommon Shares 2,223 $143.26 $318,462.31
Disclosure

SEC source: 0000899243-20-033783 · doc4.xml · nonDerivative · entry 4

Bolzon Bradley J PhD · CIK 0001354345 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 330,086

F1 · kind: The sale of these shares was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · shares: These securities are held of record by Versant Venture Management, LLC ("VVM LLC"), for the benefit of the Reporting Person, pursuant to an agreement between VVM LLC and the Reporting Person.

F7 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $143.00 to $143.64, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (7) to this Form 4.

F4 · ownership.nature: These securities are held of record by VVM LLC. The Reporting Person is a managing member of VVM LLC and the Reporting Person may be deemed to indirectly beneficially own the securities through his interest in VVM LLC. The Reporting Person disclaims beneficial ownership of these securities, except to the extent of his pecuniary interest therein, if any.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.