CRNX

SEC source: 0001628280-26-059883 · wk-form4_1788296002.xml · nonDerivative · entry 2

Schilke Tobin · CIK 0001678984 · Chief Financial & Infra. Ofcr.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F2 · price: The transaction reported on this line reflects the cancellation in the Merger of restricted stock units of the Company (each, a "Company RSU"), each of which represented a contingent right to receive one share of the Issuer's Common Stock. Immediately prior to the Effective Time, each Company RSU that was then outstanding but not vested became immediately vested in full. At the Effective Time, each outstanding Company RSU was canceled and converted into the right to receive an amount in cash equal to the Merger Consideration, less any applicable tax withholding.

SEC source: 0001628280-26-059883 · wk-form4_1788296002.xml · nonDerivative · entry 1

Schilke Tobin · CIK 0001678984 · Chief Financial & Infra. Ofcr.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 71,471

F1 · price: Pursuant to the Agreement and Plan of Merger, dated as of July 6, 2026 (the "Merger Agreement"), by and among Crinetics Pharmaceuticals, Inc., a Delaware corporation (the "Company"), Vertex Pharmaceuticals Incorporated, a Massachusetts corporation ("Parent"), and Clark Merger Sub, Inc., a Delaware corporation and a wholly owned subsidiary of Parent ("Merger Sub"), Merger Sub merged with and into the Company, with the Company surviving as a wholly owned subsidiary of Parent (the "Merger"), effective as of September 1, 2026 (the "Effective Time"). At the Effective Time, each share of common stock of the Company, par value $0.001 per share (the "Company Common Stock"), issued and outstanding immediately prior to the Effective Time, except as provided in the Merger Agreement, was canceled and automatically converted into the right to receive $85.00 per share in cash, without interest and subject to any applicable tax withholdings (the "Merger Consideration").

SEC source: 0001628280-26-058664 · wk-form4_1787604750.xml · nonDerivative · entry 1

Schilke Tobin · CIK 0001678984 · Chief Financial & Infra. Ofcr.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 79,427

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 25% vesting annually beginning on September 1, 2027.

F2 · balance_after: Includes 835 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001628280-26-055700 · wk-form4_1786479075.xml · derivative · entry 18

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 244,205

Underlying: Common Stock · 4,995 shares

Expires 2032-02-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: 1/48th of the shares subject to the option vested on March 31, 2022, and 1/48th of the shares subject to the option vested monthly thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001628280-26-055700 · wk-form4_1786479075.xml · derivative · entry 17

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 259,058

Underlying: Common Stock · 6,542 shares

Expires 2031-02-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: 1/48th of the shares subject to the option vested on March 26, 2021, and 1/48th of the shares subject to the option vested monthly thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001628280-26-055700 · wk-form4_1786479075.xml · derivative · entry 16

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 195,578

Underlying: Common Stock · 4,422 shares

Expires 2030-02-24

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: 1/48th of the shares subject to the option vested on March 24, 2020, and 1/48th of the shares subject to the option vested monthly thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001628280-26-055700 · wk-form4_1786479075.xml · derivative · entry 15

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 172,281

Underlying: Common Stock · 3,969 shares

Expires 2029-03-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vested monthly.

SEC source: 0001628280-26-055700 · wk-form4_1786479075.xml · nonDerivative · entry 4

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 424,706

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-26-055700 · wk-form4_1786479075.xml · nonDerivative · entry 3

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 419,711

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-26-055700 · wk-form4_1786479075.xml · nonDerivative · entry 2

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 413,169

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-26-055700 · wk-form4_1786479075.xml · nonDerivative · entry 1

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 408,747

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-26-047507 · wk-form4_1783456224.xml · nonDerivative · entry 1

Vivaldi Coelho Rogerio · CIK 0001610381 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 19,225

F1 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 11, 2025.

F2 · price: The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a sale price of $40.00 per share.

SEC source: 0001628280-26-044717 · wk-form4_1782162344.xml · derivative · entry 2

Fust Matthew K · CIK 0001397266 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,730

Underlying: Common Stock · 9,730 shares

Expires 2036-06-18

F2 · derivative.exercise_date: The stock option shall vest and become exercisable on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0001628280-26-044717 · wk-form4_1782162344.xml · nonDerivative · entry 1

Fust Matthew K · CIK 0001397266 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,761

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 100% vesting on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0001628280-26-044721 · wk-form4_1782162592.xml · derivative · entry 2

Deardorf Caren · CIK 0001871152 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,730

Underlying: Common Stock · 9,730 shares

Expires 2036-06-18

F2 · derivative.exercise_date: The stock option shall vest and become exercisable on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0001628280-26-044721 · wk-form4_1782162592.xml · nonDerivative · entry 1

Deardorf Caren · CIK 0001871152 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,225

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 100% vesting on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0001628280-26-044715 · wk-form4_1782162264.xml · derivative · entry 2

Nichols Weston · CIK 0001746376 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,730

Underlying: Common Stock · 9,730 shares

Expires 2036-06-18

F2 · derivative.exercise_date: The stock option shall vest and become exercisable on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0001628280-26-044715 · wk-form4_1782162264.xml · nonDerivative · entry 1

Nichols Weston · CIK 0001746376 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,225

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 100% vesting on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0001628280-26-044714 · wk-form4_1782162210.xml · derivative · entry 2

Vivaldi Coelho Rogerio · CIK 0001610381 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,730

Underlying: Common Stock · 9,730 shares

Expires 2036-06-18

F2 · derivative.exercise_date: The stock option shall vest and become exercisable on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0001628280-26-044714 · wk-form4_1782162210.xml · nonDerivative · entry 1

Vivaldi Coelho Rogerio · CIK 0001610381 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,225

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 100% vesting on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0001628280-26-044712 · wk-form4_1782162151.xml · derivative · entry 2

Bedrosian Camille L · CIK 0001326969 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,730

Underlying: Common Stock · 9,730 shares

Expires 2036-06-18

F2 · derivative.exercise_date: The stock option shall vest and become exercisable on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0001628280-26-044712 · wk-form4_1782162151.xml · nonDerivative · entry 1

Bedrosian Camille L · CIK 0001326969 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,225

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 100% vesting on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0001628280-26-044710 · wk-form4_1782162098.xml · derivative · entry 2

WIERENGA WENDELL · CIK 0001239956 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,730

Underlying: Common Stock · 9,730 shares

Expires 2036-06-18

F2 · derivative.exercise_date: The stock option shall vest and become exercisable on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0001628280-26-044710 · wk-form4_1782162098.xml · nonDerivative · entry 1

WIERENGA WENDELL · CIK 0001239956 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 122,071

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 100% vesting on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0001628280-26-044708 · wk-form4_1782161999.xml · derivative · entry 2

Okey Stephanie · CIK 0001742616 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,730

Underlying: Common Stock · 9,730 shares

Expires 2036-06-18

F2 · derivative.exercise_date: The stock option shall vest and become exercisable on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0001628280-26-044708 · wk-form4_1782161999.xml · nonDerivative · entry 1

Okey Stephanie · CIK 0001742616 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,325

F1 · price: The transaction reported on this line involves the receipt of restricted stock units, which represent the right to receive shares of the Issuer's Common Stock, with 100% vesting on the earlier of (a) the first anniversary of the grant date or (b) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continued service on the board of directors of the Issuer through such vesting date.

SEC source: 0001628280-26-044419 · wk-form4_1781817823.xml · nonDerivative · entry 2

Okey Stephanie · CIK 0001742616 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,400

F1 · shares: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 19, 2025.

F3 · price: The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a volume weighted average sale price of $36.22 per share. The range of sale prices on the transaction date was $36.19 to $36.29. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

SEC source: 0001628280-26-044419 · wk-form4_1781817823.xml · nonDerivative · entry 1

Okey Stephanie · CIK 0001742616 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,008

F1 · shares: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 19, 2025.

F2 · price: The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a volume weighted average sale price of $35.62 per share. The range of sale prices on the transaction date was $35.19 to $36.06. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

SEC source: 0001628280-26-039784 · wk-form4_1780430656.xml · nonDerivative · entry 14

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · By Family Trust 8

Disclosed balance after: 111,100

F3 · kind: (3) Represents contributions of shares by the Reporting Person's spouse to (a) the Iowa Descendants Trust ("Family Trust 7") and (b) the RSS Dynasty Trust ("Family Trust 8"), each of which is an irrevocable trust with an independent trustee of which the Reporting Person and his family members are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by Family Trust 5 and Family Trust 6 except to the extent of his pecuniary interest therein.

SEC source: 0001628280-26-039784 · wk-form4_1780430656.xml · nonDerivative · entry 13

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · By Family Trust 7

Disclosed balance after: 111,100

F3 · kind: (3) Represents contributions of shares by the Reporting Person's spouse to (a) the Iowa Descendants Trust ("Family Trust 7") and (b) the RSS Dynasty Trust ("Family Trust 8"), each of which is an irrevocable trust with an independent trustee of which the Reporting Person and his family members are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by Family Trust 5 and Family Trust 6 except to the extent of his pecuniary interest therein.

SEC source: 0001628280-26-039784 · wk-form4_1780430656.xml · nonDerivative · entry 12

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse

Disclosed balance after: 1,000

F3 · kind: (3) Represents contributions of shares by the Reporting Person's spouse to (a) the Iowa Descendants Trust ("Family Trust 7") and (b) the RSS Dynasty Trust ("Family Trust 8"), each of which is an irrevocable trust with an independent trustee of which the Reporting Person and his family members are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by Family Trust 5 and Family Trust 6 except to the extent of his pecuniary interest therein.

SEC source: 0001628280-26-039784 · wk-form4_1780430656.xml · nonDerivative · entry 11

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse

Disclosed balance after: 112,100

F3 · kind: (3) Represents contributions of shares by the Reporting Person's spouse to (a) the Iowa Descendants Trust ("Family Trust 7") and (b) the RSS Dynasty Trust ("Family Trust 8"), each of which is an irrevocable trust with an independent trustee of which the Reporting Person and his family members are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by Family Trust 5 and Family Trust 6 except to the extent of his pecuniary interest therein.

SEC source: 0001628280-26-039784 · wk-form4_1780430656.xml · nonDerivative · entry 10

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · By Family Trust 6

Disclosed balance after: 111,100

F2 · kind: (2) Represents contributions of shares by the Reporting Person to (a) the GMS Dynasty Trust ("Family Trust 5") and (b) the JSS Dynasty Trust ("Family Trust 6"), each of which is an irrevocable trust with an independent trustee of which the Reporting Person's spouse and her family members, and the Reporting Person's spouse, respectively, are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by Family Trust 5 and Family Trust 6 except to the extent of his pecuniary interest therein.

SEC source: 0001628280-26-039784 · wk-form4_1780430656.xml · nonDerivative · entry 9

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · By Family Trust 5

Disclosed balance after: 111,100

F2 · kind: (2) Represents contributions of shares by the Reporting Person to (a) the GMS Dynasty Trust ("Family Trust 5") and (b) the JSS Dynasty Trust ("Family Trust 6"), each of which is an irrevocable trust with an independent trustee of which the Reporting Person's spouse and her family members, and the Reporting Person's spouse, respectively, are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by Family Trust 5 and Family Trust 6 except to the extent of his pecuniary interest therein.

SEC source: 0001628280-26-039784 · wk-form4_1780430656.xml · nonDerivative · entry 8

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 404,778

F2 · kind: (2) Represents contributions of shares by the Reporting Person to (a) the GMS Dynasty Trust ("Family Trust 5") and (b) the JSS Dynasty Trust ("Family Trust 6"), each of which is an irrevocable trust with an independent trustee of which the Reporting Person's spouse and her family members, and the Reporting Person's spouse, respectively, are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by Family Trust 5 and Family Trust 6 except to the extent of his pecuniary interest therein.

SEC source: 0001628280-26-039784 · wk-form4_1780430656.xml · nonDerivative · entry 7

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 515,878

F2 · kind: (2) Represents contributions of shares by the Reporting Person to (a) the GMS Dynasty Trust ("Family Trust 5") and (b) the JSS Dynasty Trust ("Family Trust 6"), each of which is an irrevocable trust with an independent trustee of which the Reporting Person's spouse and her family members, and the Reporting Person's spouse, respectively, are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by Family Trust 5 and Family Trust 6 except to the extent of his pecuniary interest therein.

SEC source: 0001628280-26-039784 · wk-form4_1780430656.xml · nonDerivative · entry 6

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · By Charitable Trust

Disclosed balance after: 80,000

F1 · kind: (1) Represents gifts of shares by the Struthers Family Trust ("Family Trust 1"), of which the Reporting Person is the trustee and the Reporting Person and his spouse are beneficiaries, to (a) the Reporting Person, (b) the Reporting Person's spouse and (c) the Struthers Family Charitable Remainder Trust (the "Charitable Trust"), a charitable remainder trust of which the Reporting Person is the trustee and of which the Reporting Person and his spouse are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by the Charitable Trust except to the extent of his pecuniary interest therein.

SEC source: 0001628280-26-039784 · wk-form4_1780430656.xml · nonDerivative · entry 5

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse

Disclosed balance after: 223,200

F1 · kind: (1) Represents gifts of shares by the Struthers Family Trust ("Family Trust 1"), of which the Reporting Person is the trustee and the Reporting Person and his spouse are beneficiaries, to (a) the Reporting Person, (b) the Reporting Person's spouse and (c) the Struthers Family Charitable Remainder Trust (the "Charitable Trust"), a charitable remainder trust of which the Reporting Person is the trustee and of which the Reporting Person and his spouse are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by the Charitable Trust except to the extent of his pecuniary interest therein.

SEC source: 0001628280-26-039784 · wk-form4_1780430656.xml · nonDerivative · entry 4

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 626,978

F1 · kind: (1) Represents gifts of shares by the Struthers Family Trust ("Family Trust 1"), of which the Reporting Person is the trustee and the Reporting Person and his spouse are beneficiaries, to (a) the Reporting Person, (b) the Reporting Person's spouse and (c) the Struthers Family Charitable Remainder Trust (the "Charitable Trust"), a charitable remainder trust of which the Reporting Person is the trustee and of which the Reporting Person and his spouse are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by the Charitable Trust except to the extent of his pecuniary interest therein.

SEC source: 0001628280-26-039784 · wk-form4_1780430656.xml · nonDerivative · entry 3

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · By Family Trust 1

Disclosed balance after: 136,805

F1 · kind: (1) Represents gifts of shares by the Struthers Family Trust ("Family Trust 1"), of which the Reporting Person is the trustee and the Reporting Person and his spouse are beneficiaries, to (a) the Reporting Person, (b) the Reporting Person's spouse and (c) the Struthers Family Charitable Remainder Trust (the "Charitable Trust"), a charitable remainder trust of which the Reporting Person is the trustee and of which the Reporting Person and his spouse are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by the Charitable Trust except to the extent of his pecuniary interest therein.

SEC source: 0001628280-26-039784 · wk-form4_1780430656.xml · nonDerivative · entry 2

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · By Family Trust 1

Disclosed balance after: 216,805

F1 · kind: (1) Represents gifts of shares by the Struthers Family Trust ("Family Trust 1"), of which the Reporting Person is the trustee and the Reporting Person and his spouse are beneficiaries, to (a) the Reporting Person, (b) the Reporting Person's spouse and (c) the Struthers Family Charitable Remainder Trust (the "Charitable Trust"), a charitable remainder trust of which the Reporting Person is the trustee and of which the Reporting Person and his spouse are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by the Charitable Trust except to the extent of his pecuniary interest therein.

SEC source: 0001628280-26-039784 · wk-form4_1780430656.xml · nonDerivative · entry 1

Struthers Richard Scott · CIK 0001746298 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · By Family Trust 1

Disclosed balance after: 439,005

F1 · kind: (1) Represents gifts of shares by the Struthers Family Trust ("Family Trust 1"), of which the Reporting Person is the trustee and the Reporting Person and his spouse are beneficiaries, to (a) the Reporting Person, (b) the Reporting Person's spouse and (c) the Struthers Family Charitable Remainder Trust (the "Charitable Trust"), a charitable remainder trust of which the Reporting Person is the trustee and of which the Reporting Person and his spouse are beneficiaries. The Reporting Person disclaims beneficial ownership of the shares held by the Charitable Trust except to the extent of his pecuniary interest therein.

SEC source: 0001628280-26-024716 · wk-form4_1775853233.xml · derivative · entry 7

Knight Jeff E. · CIK 0001881007 · Chief Dev. & Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 65,977

Underlying: Common Stock · 19,336 shares

Expires 2033-03-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The option is exercisable as follows: 1/48th of the shares subject to the option vest monthly measured from the vesting commencement date of March 1, 2023, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001628280-26-024716 · wk-form4_1775853233.xml · derivative · entry 6

Knight Jeff E. · CIK 0001881007 · Chief Dev. & Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,589

Underlying: Common Stock · 9,624 shares

Expires 2032-02-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: 1/48th of the shares subject to the option vested monthly measured from the vesting commencement date of February 28, 2022.

SEC source: 0001628280-26-024716 · wk-form4_1775853233.xml · derivative · entry 5

Knight Jeff E. · CIK 0001881007 · Chief Dev. & Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 63,027

Underlying: Common Stock · 49,474 shares

Expires 2031-09-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: 25% of the shares subject to the option vested on August 30, 2022, and the remaining number of shares subject to the option vested monthly thereafter in thirty-six equal installments.

SEC source: 0001628280-26-024716 · wk-form4_1775853233.xml · nonDerivative · entry 4

Knight Jeff E. · CIK 0001881007 · Chief Dev. & Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 105,289

F1 · kind: The sale reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 12, 2025.

F2 · price: The common stock was sold by the Reporting Person in open market transactions on the transaction date, with a volume weighted average sale price of $40.10 per share. The range of sale prices on the transaction date was $40.00 to $40.34. Detailed information on the exact number of shares can be obtained from the Issuer upon request.

SEC source: 0001628280-26-024716 · wk-form4_1775853233.xml · nonDerivative · entry 3

Knight Jeff E. · CIK 0001881007 · Chief Dev. & Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 190,452

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-26-024716 · wk-form4_1775853233.xml · nonDerivative · entry 2

Knight Jeff E. · CIK 0001881007 · Chief Dev. & Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 171,116

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-26-024716 · wk-form4_1775853233.xml · nonDerivative · entry 1

Knight Jeff E. · CIK 0001881007 · Chief Dev. & Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 161,492

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-26-019498 · wk-form4_1773868275.xml · nonDerivative · entry 2

Betz Stephen F. · CIK 0001886575 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 137,101

F1 · kind: Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on February 28, 2022, March 1, 2023, March 4, 2024, and February 20, 2025. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $37.77 per share. The range of sales prices on the transaction date was $37.42 to $38.23 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request.