CRL

SEC source: 0001127602-22-005478 · form4.xml · nonDerivative · entry 19

FOSTER JAMES C · CIK 0001141722 · Director · Chairman, President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 218,704

F1 · kind: This sale occurred pursuant to a 10b5-1 Trading Plan.

F19 · price: This transaction was executed in multiple trades at prices ranging from $331.03 to $331.67. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-22-005478 · form4.xml · nonDerivative · entry 18

FOSTER JAMES C · CIK 0001141722 · Director · Chairman, President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 219,618

F1 · kind: This sale occurred pursuant to a 10b5-1 Trading Plan.

F18 · price: This transaction was executed in multiple trades at prices ranging from $329.835 to $330.495. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-22-005478 · form4.xml · nonDerivative · entry 17

FOSTER JAMES C · CIK 0001141722 · Director · Chairman, President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 220,083

F1 · kind: This sale occurred pursuant to a 10b5-1 Trading Plan.

F17 · price: This transaction was executed in multiple trades at prices ranging from $328.79 to $329.35. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-22-005478 · form4.xml · nonDerivative · entry 16

FOSTER JAMES C · CIK 0001141722 · Director · Chairman, President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 220,241

F1 · kind: This sale occurred pursuant to a 10b5-1 Trading Plan.

F16 · price: This transaction was executed in multiple trades at prices ranging from $328.36 to $328.7025. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-22-005478 · form4.xml · nonDerivative · entry 15

FOSTER JAMES C · CIK 0001141722 · Director · Chairman, President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 220,339

F1 · kind: This sale occurred pursuant to a 10b5-1 Trading Plan.

F15 · price: This transaction was executed in multiple trades at prices ranging from $326.825 to $327.055. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-22-005478 · form4.xml · nonDerivative · entry 14

FOSTER JAMES C · CIK 0001141722 · Director · Chairman, President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 220,518

F1 · kind: This sale occurred pursuant to a 10b5-1 Trading Plan.

F14 · price: This transaction was executed in multiple trades at prices ranging from $322.9 to $323.225. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-22-005478 · form4.xml · nonDerivative · entry 13

FOSTER JAMES C · CIK 0001141722 · Director · Chairman, President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 220,692

F1 · kind: This sale occurred pursuant to a 10b5-1 Trading Plan.

SEC source: 0001127602-22-005478 · form4.xml · nonDerivative · entry 12

FOSTER JAMES C · CIK 0001141722 · Director · Chairman, President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 220,792

F1 · kind: This sale occurred pursuant to a 10b5-1 Trading Plan.

F13 · price: This transaction was executed in multiple trades at prices ranging from $319.8175 to $320.71. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-22-005478 · form4.xml · nonDerivative · entry 11

FOSTER JAMES C · CIK 0001141722 · Director · Chairman, President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 221,212

F1 · kind: This sale occurred pursuant to a 10b5-1 Trading Plan.

F12 · price: This transaction was executed in multiple trades at prices ranging from $317.83 to $318.29. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-22-005478 · form4.xml · nonDerivative · entry 10

FOSTER JAMES C · CIK 0001141722 · Director · Chairman, President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 221,537

F1 · kind: This sale occurred pursuant to a 10b5-1 Trading Plan.

F11 · price: This transaction was executed in multiple trades at prices ranging from $316.765 to $317.48. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-22-005478 · form4.xml · nonDerivative · entry 9

FOSTER JAMES C · CIK 0001141722 · Director · Chairman, President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 222,780

F1 · kind: This sale occurred pursuant to a 10b5-1 Trading Plan.

F10 · price: This transaction was executed in multiple trades at prices ranging from $315.79 to $316.73. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-22-005478 · form4.xml · nonDerivative · entry 8

FOSTER JAMES C · CIK 0001141722 · Director · Chairman, President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 224,937

F1 · kind: This sale occurred pursuant to a 10b5-1 Trading Plan.

F9 · price: This transaction was executed in multiple trades at prices ranging from $314.78 to $315.605. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-22-005478 · form4.xml · nonDerivative · entry 7

FOSTER JAMES C · CIK 0001141722 · Director · Chairman, President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 226,753

F1 · kind: This sale occurred pursuant to a 10b5-1 Trading Plan.

F8 · price: This transaction was executed in multiple trades at prices ranging from $313.785 to $314.73. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-22-005478 · form4.xml · nonDerivative · entry 6

FOSTER JAMES C · CIK 0001141722 · Director · Chairman, President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 229,565

F1 · kind: This sale occurred pursuant to a 10b5-1 Trading Plan.

F7 · price: This transaction was executed in multiple trades at prices ranging from $312.86 to $313.745. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-22-005478 · form4.xml · nonDerivative · entry 5

FOSTER JAMES C · CIK 0001141722 · Director · Chairman, President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 231,079

F1 · kind: This sale occurred pursuant to a 10b5-1 Trading Plan.

F6 · price: This transaction was executed in multiple trades at prices ranging from $311.76 to $312.72. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-22-005478 · form4.xml · nonDerivative · entry 4

FOSTER JAMES C · CIK 0001141722 · Director · Chairman, President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 232,914

F1 · kind: This sale occurred pursuant to a 10b5-1 Trading Plan.

F5 · price: This transaction was executed in multiple trades at prices ranging from $310.8475 to $311.74. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-22-005478 · form4.xml · nonDerivative · entry 3

FOSTER JAMES C · CIK 0001141722 · Director · Chairman, President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 234,557

F1 · kind: This sale occurred pursuant to a 10b5-1 Trading Plan.

F4 · price: This transaction was executed in multiple trades at prices ranging from $309.84 to $310.735. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-22-005478 · form4.xml · nonDerivative · entry 2

FOSTER JAMES C · CIK 0001141722 · Director · Chairman, President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 237,013

F1 · kind: This sale occurred pursuant to a 10b5-1 Trading Plan.

F3 · price: This transaction was executed in multiple trades at prices ranging from $308.75 to $309.68. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-22-005478 · form4.xml · nonDerivative · entry 1

FOSTER JAMES C · CIK 0001141722 · Director · Chairman, President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 238,077

F1 · kind: This sale occurred pursuant to a 10b5-1 Trading Plan.

F2 · price: This transaction was executed in multiple trades at prices ranging from $307.75 to $308.46. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-22-006343 · form4.xml · nonDerivative · entry 1

LaPlume Joseph W · CIK 0001767215 · EVP, Corp Strategy & Develop

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,675

SEC source: 0001127602-22-006261 · form4.xml · nonDerivative · entry 2

Barbo William D · CIK 0001688104 · Corporate Executive VP & CCO

10b5-1 filing: Not disclosed

Ownership: Indirect · By Trust

Disclosed balance after: 18,090

SEC source: 0001127602-22-006261 · form4.xml · nonDerivative · entry 1

Barbo William D · CIK 0001688104 · Corporate Executive VP & CCO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,371

SEC source: 0001127602-22-002803 · form4.xml · nonDerivative · entry 3

Creamer Victoria L · CIK 0001632780 · EVP & Chief People Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,950

SEC source: 0001127602-22-002801 · form4.xml · nonDerivative · entry 2

LaPlume Joseph W · CIK 0001767215 · EVP, Corp Strategy & Develop

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,825

SEC source: 0001127602-22-002801 · form4.xml · nonDerivative · entry 1

LaPlume Joseph W · CIK 0001767215 · EVP, Corp Strategy & Develop

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,395

F1 · shares: Reflects shares of common stock issued following the achievement of performance goals set forth in performance share unit awards originally granted on February 22, 2019.

SEC source: 0001127602-22-002795 · form4.xml · nonDerivative · entry 2

Knell Michael Gunnar · CIK 0001543779 · CSVP&Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,145

SEC source: 0001127602-22-002795 · form4.xml · nonDerivative · entry 1

Knell Michael Gunnar · CIK 0001543779 · CSVP&Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,971

F1 · shares: Reflects shares of common stock issued following the achievement of performance goals set forth in performance share unit awards originally granted on February 22, 2019.

SEC source: 0001127602-22-002803 · form4.xml · nonDerivative · entry 2

Creamer Victoria L · CIK 0001632780 · EVP & Chief People Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,293

SEC source: 0001127602-22-002803 · form4.xml · nonDerivative · entry 1

Creamer Victoria L · CIK 0001632780 · EVP & Chief People Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,688

F1 · shares: Reflects shares of common stock issued following the achievement of performance goals set forth in performance share unit awards originally granted on February 22, 2019.

SEC source: 0001127602-22-002789 · form4.xml · nonDerivative · entry 3

FOSTER JAMES C · CIK 0001141722 · Director · Chairman, President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 238,402

F4 · balance_after: On 11/18/2021, the reporting person contributed 8,000 shares of CRL Common Stock to a grantor retained annuity trust for the benefit of himself and his adult children.

SEC source: 0001127602-22-002789 · form4.xml · nonDerivative · entry 2

FOSTER JAMES C · CIK 0001141722 · Director · Chairman, President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 263,510

F3 · shares: Reflects shares of common stock issued following the achievement of performance goals set forth in performance share unit awards originally granted on February 22, 2019.

F4 · balance_after: On 11/18/2021, the reporting person contributed 8,000 shares of CRL Common Stock to a grantor retained annuity trust for the benefit of himself and his adult children.

SEC source: 0001127602-22-002799 · form4.xml · nonDerivative · entry 3

Girshick Birgit · CIK 0001732091 · Corporate Executive VP & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,223

SEC source: 0001127602-22-002799 · form4.xml · nonDerivative · entry 2

Girshick Birgit · CIK 0001732091 · Corporate Executive VP & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,100

F1 · shares: Reflects shares of common stock issued following the achievement of performance goals set forth in performance share unit awards originally granted on February 22, 2019.

SEC source: 0001127602-22-002797 · form4.xml · nonDerivative · entry 3

Barbo William D · CIK 0001688104 · Corporate Executive VP & CCO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,549

SEC source: 0001127602-22-002797 · form4.xml · nonDerivative · entry 2

Barbo William D · CIK 0001688104 · Corporate Executive VP & CCO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,644

F1 · shares: Reflects shares of common stock issued following the achievement of performance goals set forth in performance share unit awards originally granted on February 22, 2019.

SEC source: 0001127602-22-002781 · form4.xml · nonDerivative · entry 2

Smith David Ross · CIK 0001650274 · Corporate Executive VP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,382

SEC source: 0001127602-22-002781 · form4.xml · nonDerivative · entry 1

Smith David Ross · CIK 0001650274 · Corporate Executive VP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,746

F1 · shares: Reflects shares of common stock issued following the achievement of performance goals set forth in performance share unit awards originally granted on February 22, 2019.

SEC source: 0001127602-22-000559 · form4.xml · nonDerivative · entry 1

MACKAY MARTIN · CIK 0001414815 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,662

F1 · shares: The grant was made in lieu of director service fees. The restricted stock units vest upon the earlier of 5/7/2022, or the business day prior to the Company's next annual meeting.

SEC source: 0001127602-21-031913 · form4.xml · nonDerivative · entry 2

LaPlume Joseph W · CIK 0001767215 · EVP, Corp Strategy & Develop

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,051

F1 · shares: Unvested restricted stock units vest as follows: 6,771 on December 25, 2026.

SEC source: 0001127602-22-002797 · form4.xml · nonDerivative · entry 1

Barbo William D · CIK 0001688104 · Corporate Executive VP & CCO

10b5-1 filing: Not disclosed

Ownership: Indirect · By Trust

Disclosed balance after: 11,912

SEC source: 0001127602-21-031913 · form4.xml · nonDerivative · entry 1

LaPlume Joseph W · CIK 0001767215 · EVP, Corp Strategy & Develop

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,280

SEC source: 0001127602-22-002789 · form4.xml · nonDerivative · entry 1

FOSTER JAMES C · CIK 0001141722 · Director · Chairman, President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · 2019 GRAT

Disclosed balance after: 0

F1 · shares: On 10/26/2021: 14,813 shares were gifted from the 2019 GRAT account to Mr. Foster's children.

F2 · ownership.nature: On 10/26/2021: 4,200 shares were transferred from the 2019 GRAT account to Direct Holdings.

SEC source: 0001127602-22-002552 · form5.xml · nonDerivative · entry 1

WALLMAN RICHARD F · CIK 0001198092 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,829

SEC source: 0001127602-22-002799 · form4.xml · nonDerivative · entry 1

Girshick Birgit · CIK 0001732091 · Corporate Executive VP & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,071

SEC source: 0001127602-21-025281 · form4.xml · nonDerivative · entry 4

Girshick Birgit · CIK 0001732091 · Corporate Executive VP

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,602

F1 · kind: This sale occurred pursuant to a 10b5-1 Trading Plan.

SEC source: 0001127602-21-025281 · form4.xml · nonDerivative · entry 3

Girshick Birgit · CIK 0001732091 · Corporate Executive VP

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,946

F1 · kind: This sale occurred pursuant to a 10b5-1 Trading Plan.

SEC source: 0001127602-21-025281 · form4.xml · nonDerivative · entry 2

Girshick Birgit · CIK 0001732091 · Corporate Executive VP

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,953

F1 · kind: This sale occurred pursuant to a 10b5-1 Trading Plan.

SEC source: 0001127602-21-025281 · form4.xml · nonDerivative · entry 1

Girshick Birgit · CIK 0001732091 · Corporate Executive VP

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,025

F1 · kind: This sale occurred pursuant to a 10b5-1 Trading Plan.

SEC source: 0001127602-21-024662 · form4.xml · derivative · entry 5

MASSARO GEORGE · CIK 0001221496 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,539 shares

Expires 2030-05-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-21-024662 · form4.xml · nonDerivative · entry 4

MASSARO GEORGE · CIK 0001221496 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,855

F2 · price: This transaction was executed in multiple trades at prices ranging from $442.725 to $443.265. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.