CRBU

SEC source: 0001209191-21-068582 · doc4.xml · derivative · entry 3

MCCLUNG BARBARA G · CIK 0001231321 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 77

Underlying: Common Stock · 12 shares

Expires 2028-06-11

F2 · derivative.exercise_price: The exercise price for this stock option was incorrectly reported as $2.68 per share on the reporting person's Form 3 filed on July 22, 2021.

F3 · derivative.exercise_date: The shares subject to this option have vested or will vest in equal monthly installments until the option is fully vested on June 12, 2022, subject to the reporting person's continued service to the Issuer through the applicable vesting dates.

SEC source: 0001209191-21-068582 · doc4.xml · nonDerivative · entry 2

MCCLUNG BARBARA G · CIK 0001231321 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 348,971

F1 · kind: These shares were acquired pursuant to the exercise of a stock option, as reported in Table II below.

F2 · price: The exercise price for this stock option was incorrectly reported as $2.68 per share on the reporting person's Form 3 filed on July 22, 2021.

SEC source: 0001209191-21-068582 · doc4.xml · nonDerivative · entry 1

MCCLUNG BARBARA G · CIK 0001231321 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 342,856

F1 · kind: These shares were acquired pursuant to the exercise of a stock option, as reported in Table II below.

F2 · price: The exercise price for this stock option was incorrectly reported as $2.68 per share on the reporting person's Form 3 filed on July 22, 2021.

SEC source: 0001209191-21-064866 · doc4.xml · derivative · entry 1

Khan Ruhi Ahmad · CIK 0001891113 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 225,000

Underlying: Common Stock · 225,000 shares

Expires 2031-11-14

F1 · derivative.exercise_date: 25% of the shares subject to the option shall vest on November 8, 2022, and the remaining shares subject to the option shall vest monthly thereafter (1/48 of the shares per month for the 36 months following the one-year cliff), subject to the reporting person's continued service to the Issuer through the applicable vesting dates.

SEC source: 0001209191-21-064491 · doc4.xml · derivative · entry 1

Richardson-Heron Dara · CIK 0001893193 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 44,000

Underlying: Common Stock · 44,000 shares

Expires 2031-11-10

F1 · derivative.exercise_date: The option becomes exercisable in three equal annual installments beginning November 11, 2022.

SEC source: 0001209191-21-061294 · doc4.xml · derivative · entry 4

MCCLUNG BARBARA G · CIK 0001231321 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 89

Underlying: Common Stock · 43 shares

Expires 2028-06-11

F2 · derivative.exercise_price: The exercise price for this stock option was incorrectly reported as $2.68 per share on the reporting person's Form 3 filed on July 22, 2021.

F5 · derivative.exercise_date: The shares subject to this option have vested or will vest in equal monthly installments until the option is fully vested on June 12, 2022, subject to the reporting person's continued service to the Issuer through the applicable vesting dates.

SEC source: 0001209191-21-061294 · doc4.xml · derivative · entry 3

MCCLUNG BARBARA G · CIK 0001231321 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,951

Underlying: Common Stock · 9,176 shares

Expires 2029-09-30

F2 · derivative.exercise_price: The exercise price for this stock option was incorrectly reported as $2.68 per share on the reporting person's Form 3 filed on July 22, 2021.

F4 · derivative.exercise_date: The shares subject to this option have vested or will vest in equal monthly installments until the option is fully vested on October 1, 2023, subject to the reporting person's continued service to the Issuer through the applicable vesting dates.

SEC source: 0001209191-21-061294 · doc4.xml · nonDerivative · entry 2

MCCLUNG BARBARA G · CIK 0001231321 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 342,844

F1 · kind: These shares were acquired pursuant to the exercise of a stock option, as reported in Table II below.

F2 · price: The exercise price for this stock option was incorrectly reported as $2.68 per share on the reporting person's Form 3 filed on July 22, 2021.

SEC source: 0001209191-21-061294 · doc4.xml · nonDerivative · entry 1

MCCLUNG BARBARA G · CIK 0001231321 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 342,801

F1 · kind: These shares were acquired pursuant to the exercise of a stock option, as reported in Table II below.

F2 · price: The exercise price for this stock option was incorrectly reported as $2.68 per share on the reporting person's Form 3 filed on July 22, 2021.

F3 · balance_after: The amount of securities beneficially owned was incorrectly reported as 333,626 shares on the reporting person's Form 3 filed on July 22, 2021. The correct number is 333,625.

SEC source: 0001209191-21-060424 · doc4.xml · derivative · entry 6

Kanner Steven · CIK 0001871131 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 132,134

Underlying: Common Stock · 14,614 shares

Expires 2029-09-30

F2 · derivative.exercise_price: The exercise price for this stock option was incorrectly reported as $2.68 per share on the reporting person's Form 3 filed on July 22, 2021.

F4 · derivative.exercise_date: 1/4th of the shares subject to this option vested on October 1, 2020 and an additional 1/48th of the aggregate number of shares subject to the option have vested or will vest on the corresponding day of each month thereafter, subject to the reporting person's continued services to the Issuer through the applicable vesting dates.

SEC source: 0001209191-21-060424 · doc4.xml · derivative · entry 5

Kanner Steven · CIK 0001871131 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,879

Underlying: Common Stock · 698 shares

Expires 2028-03-07

F3 · derivative.exercise_date: This option became fully exercisable on June 30, 2021.

SEC source: 0001209191-21-060424 · doc4.xml · derivative · entry 4

Kanner Steven · CIK 0001871131 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 71,840

Underlying: Common Stock · 99,548 shares

Expires 2027-07-11

F3 · derivative.exercise_date: This option became fully exercisable on June 30, 2021.

SEC source: 0001209191-21-060424 · doc4.xml · nonDerivative · entry 3

Kanner Steven · CIK 0001871131 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 215,031

F1 · kind: These shares were acquired pursuant to the exercise of a stock option, as reported in Table II below.

F2 · price: The exercise price for this stock option was incorrectly reported as $2.68 per share on the reporting person's Form 3 filed on July 22, 2021.

SEC source: 0001209191-21-060424 · doc4.xml · nonDerivative · entry 2

Kanner Steven · CIK 0001871131 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 200,417

F1 · kind: These shares were acquired pursuant to the exercise of a stock option, as reported in Table II below.

SEC source: 0001209191-21-060424 · doc4.xml · nonDerivative · entry 1

Kanner Steven · CIK 0001871131 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 199,719

F1 · kind: These shares were acquired pursuant to the exercise of a stock option, as reported in Table II below.

SEC source: 0001209191-21-060289 · doc4.xml · derivative · entry 2

Fischesser Ryan · CIK 0001871155 · VP of Finance and Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,520

Underlying: Common Stock · 1,746 shares

Expires 2029-03-18

F2 · derivative.exercise_price: The exercise price for this stock option was incorrectly reported as $2.68 per share on the reporting person's Form 3 filed on July 23, 2021.

F3 · derivative.exercise_date: The shares subject to this option have vested or will vest in equal monthly installments until the option is fully vested on January 1, 2023, subject to the reporting person's continued service to the Issuer through the applicable vesting dates.

SEC source: 0001209191-21-060289 · doc4.xml · nonDerivative · entry 1

Fischesser Ryan · CIK 0001871155 · VP of Finance and Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,559

F1 · kind: These shares were acquired pursuant to the exercise of a stock option, as reported in Table II below.

F2 · price: The exercise price for this stock option was incorrectly reported as $2.68 per share on the reporting person's Form 3 filed on July 23, 2021.

SEC source: 0001209191-21-058926 · doc4.xml · derivative · entry 1

Zheng Ran · CIK 0001885914 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 44,000

Underlying: Common Stock · 44,000 shares

Expires 2031-09-30

F1 · derivative.exercise_date: The option becomes exercisable in three equal annual installments beginning October 1, 2022.

SEC source: 0001209191-22-008027 · doc5.xml · nonDerivative · entry 2

Haurwitz Rachel E. · CIK 0001670579 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By Trust

Disclosed balance after: 3,349,395

F1 · shares: Represents transfer of shares to The City Canyon Family Trust dated May 31, 2021, of which the Reporting Person is a Co-Trustee with her spouse.

F2 · ownership.nature: Shares are held by The City Canyon Family Trust dated May 31, 2021, of which the Reporting Person is a Co-Trustee with her spouse.

SEC source: 0001209191-22-008027 · doc5.xml · nonDerivative · entry 1

Haurwitz Rachel E. · CIK 0001670579 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · shares: Represents transfer of shares to The City Canyon Family Trust dated May 31, 2021, of which the Reporting Person is a Co-Trustee with her spouse.

SEC source: 0001209191-21-055280 · doc4.xml · derivative · entry 1

Whiting Nancy · CIK 0001880609 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 44,000

Underlying: Common Stock · 44,000 shares

Expires 2031-09-07

F1 · derivative.exercise_date: The option becomes exercisable in three equal annual installments beginning September 8, 2022.

SEC source: 0000315066-21-001645 · primary_doc.xml · derivative · entry 8

FMR LLC · CIK 0000315066 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · Impresa Fund III Limited Partnership

Disclosed balance after: 0

Underlying: Common Stock · 1,464,775 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: On July 27, 2021 , in connection with the completion of the issuer's initial public offering, each share of Series A-1 and Series B Preferred Stock converted into 1.818 share of Common Stock.

F1 · price: On July 27, 2021 , in connection with the completion of the issuer's initial public offering, each share of Series A-1 and Series B Preferred Stock converted into 1.818 share of Common Stock.

F1 · derivative.exercise_date: On July 27, 2021 , in connection with the completion of the issuer's initial public offering, each share of Series A-1 and Series B Preferred Stock converted into 1.818 share of Common Stock.

F1 · derivative.expiration_date: On July 27, 2021 , in connection with the completion of the issuer's initial public offering, each share of Series A-1 and Series B Preferred Stock converted into 1.818 share of Common Stock.

SEC source: 0000315066-21-001645 · primary_doc.xml · derivative · entry 7

FMR LLC · CIK 0000315066 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · F-Prime Capital Partners Healthcare Advisors Fund IV LP

Disclosed balance after: 0

Underlying: Common Stock · 17,572 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: On July 27, 2021 , in connection with the completion of the issuer's initial public offering, each share of Series A-1 and Series B Preferred Stock converted into 1.818 share of Common Stock.

F1 · price: On July 27, 2021 , in connection with the completion of the issuer's initial public offering, each share of Series A-1 and Series B Preferred Stock converted into 1.818 share of Common Stock.

F1 · derivative.exercise_date: On July 27, 2021 , in connection with the completion of the issuer's initial public offering, each share of Series A-1 and Series B Preferred Stock converted into 1.818 share of Common Stock.

F1 · derivative.expiration_date: On July 27, 2021 , in connection with the completion of the issuer's initial public offering, each share of Series A-1 and Series B Preferred Stock converted into 1.818 share of Common Stock.

SEC source: 0000315066-21-001645 · primary_doc.xml · derivative · entry 6

FMR LLC · CIK 0000315066 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · F-Prime Capital Partners Healthcare Fund IV LP

Disclosed balance after: 0

Underlying: Common Stock · 1,070,427 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: On July 27, 2021 , in connection with the completion of the issuer's initial public offering, each share of Series A-1 and Series B Preferred Stock converted into 1.818 share of Common Stock.

F1 · price: On July 27, 2021 , in connection with the completion of the issuer's initial public offering, each share of Series A-1 and Series B Preferred Stock converted into 1.818 share of Common Stock.

F1 · derivative.exercise_date: On July 27, 2021 , in connection with the completion of the issuer's initial public offering, each share of Series A-1 and Series B Preferred Stock converted into 1.818 share of Common Stock.

F1 · derivative.expiration_date: On July 27, 2021 , in connection with the completion of the issuer's initial public offering, each share of Series A-1 and Series B Preferred Stock converted into 1.818 share of Common Stock.

SEC source: 0000315066-21-001645 · primary_doc.xml · derivative · entry 5

FMR LLC · CIK 0000315066 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · F-Prime Capital Partners Healthcare Fund IV LP

Disclosed balance after: 0

Underlying: Common Stock · 770,510 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: On July 27, 2021 , in connection with the completion of the issuer's initial public offering, each share of Series A-1 and Series B Preferred Stock converted into 1.818 share of Common Stock.

F1 · price: On July 27, 2021 , in connection with the completion of the issuer's initial public offering, each share of Series A-1 and Series B Preferred Stock converted into 1.818 share of Common Stock.

F1 · derivative.exercise_date: On July 27, 2021 , in connection with the completion of the issuer's initial public offering, each share of Series A-1 and Series B Preferred Stock converted into 1.818 share of Common Stock.

F1 · derivative.expiration_date: On July 27, 2021 , in connection with the completion of the issuer's initial public offering, each share of Series A-1 and Series B Preferred Stock converted into 1.818 share of Common Stock.

SEC source: 0000315066-21-001645 · primary_doc.xml · nonDerivative · entry 4

FMR LLC · CIK 0000315066 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · Impresa Fund III Limited Partnership

Disclosed balance after: 1,464,775

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: On July 27, 2021 , in connection with the completion of the issuer's initial public offering, each share of Series A-1 and Series B Preferred Stock converted into 1.818 share of Common Stock.

SEC source: 0000315066-21-001645 · primary_doc.xml · nonDerivative · entry 3

FMR LLC · CIK 0000315066 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · F-Prime Capital Partners Healthcare Advisors Fund IV LP

Disclosed balance after: 17,572

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: On July 27, 2021 , in connection with the completion of the issuer's initial public offering, each share of Series A-1 and Series B Preferred Stock converted into 1.818 share of Common Stock.

SEC source: 0000315066-21-001645 · primary_doc.xml · nonDerivative · entry 2

FMR LLC · CIK 0000315066 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · F-Prime Capital Partners Healthcare Fund IV LP

Disclosed balance after: 1,840,937

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: On July 27, 2021 , in connection with the completion of the issuer's initial public offering, each share of Series A-1 and Series B Preferred Stock converted into 1.818 share of Common Stock.

SEC source: 0000315066-21-001645 · primary_doc.xml · nonDerivative · entry 1

FMR LLC · CIK 0000315066 · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · F-Prime Capital Partners Healthcare Fund IV LP

Disclosed balance after: 770,510

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: On July 27, 2021 , in connection with the completion of the issuer's initial public offering, each share of Series A-1 and Series B Preferred Stock converted into 1.818 share of Common Stock.