CRBU

SEC source: 0001209191-22-047748 · doc4.xml · derivative · entry 3

Kanner Steven · CIK 0001871131 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 73,601

Underlying: Common Stock · 43,248 shares

Expires 2029-09-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: 1/4th of the shares subject to this option vested on October 1, 2020 and an additional 1/48th of the aggregate number of shares subject to the option have vested or will vest on the corresponding day of each month thereafter, subject to the reporting person's continued services to the Issuer through the applicable vesting dates.

SEC source: 0001209191-22-047748 · doc4.xml · nonDerivative · entry 2

Kanner Steven · CIK 0001871131 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 302,059

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 24, 2022.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $10.88 to $11.37, inclusive. The reporting person undertakes to provide to Caribou Biosciences, Inc., any security holder of Caribou Biosciences, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote (2) to this Form 4.

SEC source: 0001209191-22-047748 · doc4.xml · nonDerivative · entry 1

Kanner Steven · CIK 0001871131 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 345,307

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-22-047370 · doc4.xml · derivative · entry 1

Khan Ruhi Ahmad · CIK 0001891113 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 70,000

Underlying: Common Stock · 70,000 shares

Expires 2032-08-21

F1 · derivative.exercise_date: 1/48th of the shares subject to this option will vest on September 22, 2022, and on the corresponding day of each month thereafter, subject to the reporting person's continued services to the Issuer through the applicable vesting dates.

SEC source: 0001209191-22-047368 · doc4.xml · nonDerivative · entry 1

Fischesser Ryan · CIK 0001871155 · VP of Finance and Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 120,366

F1 · shares: Represents a grant of restricted stock units ("RSUs") that vest in two equal annual installments beginning on August 22, 2023, subject to the reporting person's continued service to the Issuer through the applicable vesting dates. The RSUs will be settled in stock within 30 days after each vesting date.

SEC source: 0001209191-22-030288 · doc4.xml · derivative · entry 1

JOHNSON DAVID LEE · CIK 0001733883 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 44,000

Underlying: Common Stock · 44,000 shares

Expires 2032-05-17

F1 · derivative.exercise_date: This option becomes exercisable in three equal annual installments beginning May 18, 2023.

SEC source: 0001209191-22-029893 · doc4.xml · derivative · entry 4

Kanner Steven · CIK 0001871131 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 116,849

Underlying: Common Stock · 6,114 shares

Expires 2029-09-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Due to a rounding error, the exercise price for this stock option was inadvertently originally reported as $2.68 per share on the reporting person's Form 3 filed on July 22, 2021.

F3 · derivative.exercise_date: 1/4th of the shares subject to this option vested on October 1, 2020 and an additional 1/48th of the aggregate number of shares subject to the option have vested or will vest on the corresponding day of each month thereafter, subject to the reporting person's continued services to the Issuer through the applicable vesting dates.

SEC source: 0001209191-22-029893 · doc4.xml · derivative · entry 3

Kanner Steven · CIK 0001871131 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,534

Underlying: Common Stock · 68,306 shares

Expires 2027-07-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: 1/4th of the shares subject to this option vested on June 30, 2018 and an additional 1/48th of the aggregate number of shares subject to the option vested on the corresponding day of each month thereafter (or the last day of the month, if there was no corresponding day of the month), subject to the reporting person's continued services to the Issuer through the applicable vesting dates.

SEC source: 0001209191-22-029893 · doc4.xml · nonDerivative · entry 2

Kanner Steven · CIK 0001871131 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 302,059

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Due to a rounding error, the exercise price for this stock option was inadvertently originally reported as $2.68 per share on the reporting person's Form 3 filed on July 22, 2021.

SEC source: 0001209191-22-029893 · doc4.xml · nonDerivative · entry 1

Kanner Steven · CIK 0001871131 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 295,945

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-22-028170 · doc4.xml · derivative · entry 3

Haurwitz Rachel E. · CIK 0001670579 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 116,350

Underlying: Common Stock · 10,000 shares

Expires 2023-06-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Due to a rounding error, the exercise price for this stock option was inadvertently originally reported as $2.95 per share on the reporting person's Form 3 filed on July 22, 2021.

F3 · derivative.exercise_date: 1/4th of the shares subject to this option vested on June 12, 2019 and an additional 1/48th of the aggregate number of shares subject to this option have vested or will vest on the corresponding day of each month thereafter until the option is fully vested on June 12, 2022, subject to the reporting person's continued service to the Issuer through the applicable vesting dates.

SEC source: 0001209191-22-028170 · doc4.xml · nonDerivative · entry 1

Haurwitz Rachel E. · CIK 0001670579 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Due to a rounding error, the exercise price for this stock option was inadvertently originally reported as $2.95 per share on the reporting person's Form 3 filed on July 22, 2021.

SEC source: 0001209191-22-027696 · doc4.xml · derivative · entry 4

Fischesser Ryan · CIK 0001871155 · VP of Finance and Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,176

Underlying: Common Stock · 1,138 shares

Expires 2031-03-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: 1/4th of the shares subject to this option vested on January 1, 2022 and an additional 1/48th of the aggregate number of shares subject to the option have vested or will vest on the corresponding day of each month thereafter until the option is fully vested on January 1, 2025, subject to the reporting person's continued service to the Issuer through the applicable vesting dates. The vesting schedule for this option was inadvertently described incorrectly in the reporting person's Form 3 filed on July 23, 2021.

SEC source: 0001209191-22-027696 · doc4.xml · derivative · entry 3

Fischesser Ryan · CIK 0001871155 · VP of Finance and Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,543

Underlying: Common Stock · 1,136 shares

Expires 2029-03-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Due to a rounding error, the exercise price for this stock option was inadvertently originally reported as $2.68 per share on the reporting person's Form 3 filed on July 23, 2021.

F2 · derivative.exercise_date: 1/4th of the shares subject to this option vested on January 1, 2020 and an additional 1/48th of the aggregate number of shares subject to the option have vested or will vest on the corresponding day of each month thereafter so that the option is fully vested on January 1, 2023, subject to the reporting person's continues service to the Issuer through the applicable vesting dates.

SEC source: 0001209191-22-027696 · doc4.xml · nonDerivative · entry 2

Fischesser Ryan · CIK 0001871155 · VP of Finance and Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 115,518

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-22-027696 · doc4.xml · nonDerivative · entry 1

Fischesser Ryan · CIK 0001871155 · VP of Finance and Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 114,380

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Due to a rounding error, the exercise price for this stock option was inadvertently originally reported as $2.68 per share on the reporting person's Form 3 filed on July 23, 2021.

SEC source: 0001209191-22-019808 · doc4.xml · derivative · entry 4

Fischesser Ryan · CIK 0001871155 · VP of Finance and Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,314

Underlying: Common Stock · 1,138 shares

Expires 2031-03-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: 1/4th of the shares subject to this option vested on January 1, 2022 and an additional 1/48th of the aggregate number of shares subject to the option have vested or will vest on the corresponding day of each month thereafter until the option is fully vested on January 1, 2025, subject to the reporting person's continued service to the Issuer through the applicable vesting dates.

SEC source: 0001209191-22-019808 · doc4.xml · derivative · entry 3

Fischesser Ryan · CIK 0001871155 · VP of Finance and Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,679

Underlying: Common Stock · 1,136 shares

Expires 2029-03-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Due to a rounding error, the exercise price for this stock option was inadvertently originally reported as $2.68 per share on the reporting person's Form 3 filed on July 23, 2021.

F3 · derivative.exercise_date: 1/4th of the shares subject to this option vested on January 1, 2020 and an additional 1/48th of the aggregate number of shares subject to the option have vested or will vest on the corresponding day of each month thereafter until the option is fully vested on January 1, 2023, subject to the reporting person's continued service to the Issuer through the applicable vesting dates. The vesting schedule for this option was inadvertently described incorrectly in the reporting person's Form 3 filed on July 23, 2021.

SEC source: 0001209191-22-019808 · doc4.xml · nonDerivative · entry 2

Fischesser Ryan · CIK 0001871155 · VP of Finance and Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 113,244

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-22-019808 · doc4.xml · nonDerivative · entry 1

Fischesser Ryan · CIK 0001871155 · VP of Finance and Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 112,106

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Due to a rounding error, the exercise price for this stock option was inadvertently originally reported as $2.68 per share on the reporting person's Form 3 filed on July 23, 2021.

F2 · balance_after: Includes 1,888 shares purchased pursuant to the Issuer's 2021 Employee Stock Purchase Plan on February 15, 2022 for $9.85 per share.

SEC source: 0001209191-22-016872 · doc4.xml · derivative · entry 4

Kanner Steven · CIK 0001871131 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 230,365

Underlying: Common Stock · 1,549 shares

Expires 2031-03-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: 1/4th of the shares subject to this option vested on March 2, 2022 and an additional 1/48th of the aggregate number of shares subject to the option will vest on the corresponding day of each month thereafter until the option is fully vested, subject to the reporting person's continued service to the Issuer through the applicable vesting dates.

SEC source: 0001209191-22-016872 · doc4.xml · derivative · entry 3

Kanner Steven · CIK 0001871131 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 122,963

Underlying: Common Stock · 9,171 shares

Expires 2029-09-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Due to a rounding error, the exercise price for this stock option was inadvertently originally reported as $2.68 per share on the reporting person's Form 3 filed on July 22, 2021.

F3 · derivative.exercise_date: 1/4th of the shares subject to this option vested on October 1, 2020 and an additional 1/48th of the aggregate number of shares subject to the option have vested or will vest on the corresponding day of each month thereafter until the option is fully vested, subject to the reporting person's continued service to the Issuer through the applicable vesting dates.

SEC source: 0001209191-22-016872 · doc4.xml · nonDerivative · entry 2

Kanner Steven · CIK 0001871131 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 227,639

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-22-016872 · doc4.xml · nonDerivative · entry 1

Kanner Steven · CIK 0001871131 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 226,090

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Due to a rounding error, the exercise price for this stock option was inadvertently originally reported as $2.68 per share on the reporting person's Form 3 filed on July 22, 2021.

F2 · balance_after: Includes 1,888 shares purchased pursuant to the Issuer's 2021 Employee Stock Purchase Plan on February 15, 2022 for $9.85 per share.

SEC source: 0001209191-22-007860 · doc4.xml · derivative · entry 2

O'Byrne Jason · CIK 0001871145 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 412,865

Underlying: Common Stock · 24,336 shares

Expires 2031-03-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 1/4th of the shares subject to this option vested on February 8, 2022 and an additional 1/48th of the aggregate number of shares subject to the option will vest on the corresponding day of each month thereafter until the option is fully vested on February 8, 2025, subject to the reporting person's continued services to the Issuer through the applicable vesting dates.

SEC source: 0001209191-22-007860 · doc4.xml · nonDerivative · entry 1

O'Byrne Jason · CIK 0001871145 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,336

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-22-005222 · doc4.xml · derivative · entry 2

Haurwitz Rachel E. · CIK 0001670579 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 126,350

Underlying: Common Stock · 10,000 shares

Expires 2023-06-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Due to a rounding error, the exercise price for this stock option was inadvertently originally reported as $2.95 per share on the reporting person's Form 3 filed on July 22, 2021.

F2 · derivative.exercise_date: 1/4th of the shares subject to this option vested on June 12, 2019 and an additional 1/48th of the aggregate number of shares subject to the option have vested or will vest on the corresponding day of each month thereafter until the option is fully vested on June 12, 2022, subject to the reporting person's continued services to the Issuer through the applicable vesting dates.

SEC source: 0001209191-22-005222 · doc4.xml · nonDerivative · entry 1

Haurwitz Rachel E. · CIK 0001670579 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,359,395

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-22-028169 · doc4a.xml · derivative · entry 3

Haurwitz Rachel E. · CIK 0001670579 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 126,350

Underlying: Common Stock · 10,000 shares

Expires 2023-06-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Due to a rounding error, the exercise price for this stock option was inadvertently originally reported as $2.95 per share on the reporting person's Form 3 filed on July 22, 2021.

F4 · derivative.exercise_date: 1/4th of the shares subject to this option vested on June 12, 2019 and an additional 1/48th of the aggregate number of shares subject to this option have vested or will vest on the corresponding day of each month thereafter until the option is fully vested on June 12, 2022, subject to the reporting person's continued service to the Issuer through the applicable vesting dates.

SEC source: 0001209191-22-028169 · doc4a.xml · nonDerivative · entry 1

Haurwitz Rachel E. · CIK 0001670579 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Due to a rounding error, the exercise price for this stock option was inadvertently originally reported as $2.95 per share on the reporting person's Form 3 filed on July 22, 2021.

F2 · balance_after: This Form 4/A is being filed to correct an inadvertent error in the original Form 4 filed January 27, 2022 attributing direct ownership of 3,349,395 shares listed in column 5 to the reporting person. As described in a Form 5 filed on February 9, 2022, on September 27, 2021, these 3,349,395 shares were transferred to a trust for which the reporting person and her spouse serve as a Co-Trustees.

SEC source: 0001209191-22-004860 · doc4.xml · derivative · entry 2

Rizvi Syed Ali-aamir · CIK 0001897621 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 161,250

Underlying: Common stock · 161,250 shares

Expires 2032-01-24

F2 · derivative.exercise_date: 1/4th of the shares subject to this option will vest on January 18, 2023 and an additional 1/48th of the aggregate number of shares subject to the option will vest on the corresponding day of each month thereafter, subject to the reporting person's continued services to the Issuer through the applicable vesting dates.

SEC source: 0001209191-22-004860 · doc4.xml · nonDerivative · entry 1

Rizvi Syed Ali-aamir · CIK 0001897621 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 65,000

F1 · shares: This reflects restricted stock units ("RSUs") that vest in four equal annual installments beginning on January 18, 2023, subject to the reporting person's continued services to the Issuer through the applicable vesting dates. The RSUs will be settled in stock within 30 days after each vesting date.

SEC source: 0001209191-22-003062 · doc4.xml · derivative · entry 4

Fischesser Ryan · CIK 0001871155 · VP of Finance and Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,452

Underlying: Common Stock · 6,818 shares

Expires 2031-03-29

F4 · derivative.exercise_date: 1/4th of the shares subject to this option vested on January 1, 2022 and an additional 1/48th of the aggregate number of shares subject to the option have vested or will vest on the corresponding day of each month thereafter, subject to the reporting person's continued services to the Issuer through the applicable vesting dates.

SEC source: 0001209191-22-003062 · doc4.xml · derivative · entry 3

Fischesser Ryan · CIK 0001871155 · VP of Finance and Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,815

Underlying: Common Stock · 569 shares

Expires 2029-03-18

F2 · derivative.exercise_price: The exercise price for this stock option was incorrectly reported as $2.68 per share on the reporting person's Form 3 filed on July 23, 2021.

F3 · derivative.exercise_date: The shares subject to this option have vested or will vest in equal monthly installments until the option is fully vested on January 1, 2023, subject to the reporting person's continued service to the Issuer through the applicable vesting dates.

SEC source: 0001209191-22-003062 · doc4.xml · nonDerivative · entry 2

Fischesser Ryan · CIK 0001871155 · VP of Finance and Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 109,082

F1 · kind: These shares were acquired pursuant to the exercise of a stock option, as reported in Table II below.

SEC source: 0001209191-22-003062 · doc4.xml · nonDerivative · entry 1

Fischesser Ryan · CIK 0001871155 · VP of Finance and Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 102,264

F1 · kind: These shares were acquired pursuant to the exercise of a stock option, as reported in Table II below.

SEC source: 0001209191-21-070823 · doc4.xml · derivative · entry 1

Sacks Natalie · CIK 0001683811 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,500

Underlying: Common Stock · 27,500 shares

Expires 2031-12-19

F1 · derivative.exercise_date: One-twelfth of the shares subject to this option will vest on each monthly anniversary of the grant date such that the option will be fully vested on December 20, 2022, subject to the reporting person continuing to provide service to the Issuer through each such vesting date.

SEC source: 0001209191-21-070829 · doc4.xml · derivative · entry 1

Zheng Ran · CIK 0001885914 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,750

Underlying: Common Stock · 13,750 shares

Expires 2031-12-19

F1 · derivative.exercise_date: One-twelfth of the shares subject to this option will vest on each monthly anniversary of the grant date such that the option will be fully vested on December 20, 2022, subject to the reporting person continuing to provide service to the Issuer through each such vesting date.

SEC source: 0001209191-21-070804 · doc4.xml · derivative · entry 1

Haurwitz Rachel E. · CIK 0001670579 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 411,000

Underlying: Common Stock · 411,000 shares

Expires 2031-12-19

F1 · derivative.exercise_date: The shares subject to this option will vest in equal monthly installments starting on the first monthly anniversary of the grant date until the option is fully vested on December 20, 2025, subject to the reporting person's continued service to the Issuer through the applicable vesting dates.

SEC source: 0001209191-21-070795 · doc4.xml · derivative · entry 1

Braunstein Scott · CIK 0001643875 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,500

Underlying: Common Stock · 27,500 shares

Expires 2031-12-19

F1 · derivative.exercise_date: One-twelfth of the shares subject to this option will vest on each monthly anniversary of the grant date such that the option will be fully vested on December 20, 2022, subject to the reporting person continuing to provide services to the Issuer through each such vesting date.

SEC source: 0001209191-21-070814 · doc4.xml · derivative · entry 1

MCCLUNG BARBARA G · CIK 0001231321 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 147,000

Underlying: Common Stock · 147,000 shares

Expires 2031-12-19

F1 · derivative.exercise_date: The shares subject to this option will vest in equal monthly installments starting on the first monthly anniversary of the grant date until the option is fully vested on December 20, 2025, subject to the reporting person's continued service to the Issuer through the applicable vesting dates.

SEC source: 0001209191-21-070799 · doc4.xml · derivative · entry 1

GUGGENHIME ANDREW · CIK 0001230724 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,500

Underlying: Common Stock · 27,500 shares

Expires 2031-12-19

F1 · derivative.exercise_date: One-twelfth of the shares subject to this option will vest on each monthly anniversary of the grant date such that the option will be fully vested on December 20, 2022, subject to the reporting person continuing to provide services to the Issuer through each such vesting date.

SEC source: 0001209191-21-070825 · doc4.xml · derivative · entry 1

Whiting Nancy · CIK 0001880609 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,750

Underlying: Common Stock · 13,750 shares

Expires 2031-12-19

F1 · derivative.exercise_date: One-twelfth of the shares subject to this option will vest on each monthly anniversary of the grant date such that the option will be fully vested on December 20, 2022, subject to the reporting person continuing to provide services to the Issuer through each such vesting date.

SEC source: 0001209191-21-070819 · doc4.xml · derivative · entry 1

O'Byrne Jason · CIK 0001871145 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 147,000

Underlying: Common Stock · 147,000 shares

Expires 2031-12-19

F1 · derivative.exercise_date: The shares subject to this option will vest in equal monthly installments starting on the first monthly anniversary of the grant date until the option is fully vested on December 20, 2025, subject to the reporting person's continued service to the Issuer through the applicable vesting dates.

SEC source: 0001209191-21-070810 · doc4.xml · derivative · entry 1

Kanner Steven · CIK 0001871131 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 147,000

Underlying: Common Stock · 147,000 shares

Expires 2031-12-19

F1 · derivative.exercise_date: The shares subject to this option will vest in equal monthly installments starting on the first monthly anniversary of the grant date until the option is fully vested on December 20, 2025, subject to the reporting person's continued service to the Issuer through the applicable vesting dates.

SEC source: 0001209191-21-070797 · doc4.xml · derivative · entry 3

Fischesser Ryan · CIK 0001871155 · VP of Finance and Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2031-12-19

F4 · derivative.exercise_date: The shares subject to this option will vest in equal monthly installments starting on the first monthly anniversary of the grant date until the option is fully vested on December 20, 2025, subject to the reporting person's continued service to the Issuer through the applicable vesting dates.

SEC source: 0001209191-21-070797 · doc4.xml · derivative · entry 2

Fischesser Ryan · CIK 0001871155 · VP of Finance and Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,384

Underlying: Common Stock · 1,136 shares

Expires 2029-03-18

F2 · derivative.exercise_price: The exercise price for this stock option was incorrectly reported as $2.68 per share on the reporting person's Form 3 filed on July 23, 2021.

F3 · derivative.exercise_date: The shares subject to this option have vested or will vest in equal monthly installments until the option is fully vested on January 1, 2023, subject to the reporting person's continued service to the Issuer through the applicable vesting dates.

SEC source: 0001209191-21-070797 · doc4.xml · nonDerivative · entry 1

Fischesser Ryan · CIK 0001871155 · VP of Finance and Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 101,695

F1 · kind: These shares were acquired pursuant to the exercise of a stock option, as reported in Table II below.

F2 · price: The exercise price for this stock option was incorrectly reported as $2.68 per share on the reporting person's Form 3 filed on July 23, 2021.

SEC source: 0001209191-21-071011 · doc4a.xml · derivative · entry 1

Whiting Nancy · CIK 0001880609 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,060

Underlying: Common Stock · 13,060 shares

Expires 2031-12-19

F1 · shares: On December 21, 2021, the reporting person filed a Form 4 to report a stock option grant. Due to a clerical error, that grant was shown as covering 13,750 shares. The correct number of shares is 13,060. This amendment reports the correct number of shares.

F2 · derivative.exercise_date: The shares subject to this option will vest in equal monthly installments starting on the first monthly anniversary of the grant date until the option is fully vested on December 20, 2025, subject to the reporting person's continued service to the Issuer through the applicable vesting dates.

F1 · derivative.underlying_shares: On December 21, 2021, the reporting person filed a Form 4 to report a stock option grant. Due to a clerical error, that grant was shown as covering 13,750 shares. The correct number of shares is 13,060. This amendment reports the correct number of shares.

F1 · balance_after: On December 21, 2021, the reporting person filed a Form 4 to report a stock option grant. Due to a clerical error, that grant was shown as covering 13,750 shares. The correct number of shares is 13,060. This amendment reports the correct number of shares.

SEC source: 0001209191-21-068582 · doc4.xml · derivative · entry 4

MCCLUNG BARBARA G · CIK 0001231321 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 74,836

Underlying: Common Stock · 6,115 shares

Expires 2029-09-30

F2 · derivative.exercise_price: The exercise price for this stock option was incorrectly reported as $2.68 per share on the reporting person's Form 3 filed on July 22, 2021.

F4 · derivative.exercise_date: The shares subject to this option have vested or will vest in equal monthly installments until the option is fully vested on October 1, 2023, subject to the reporting person's continued service to the Issuer through the applicable vesting dates.