CGEM

SEC source: 0001193125-25-328909 · ownership.xml · nonDerivative · entry 1

Michaelson Jennifer · CIK 0001838061 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 132,635

F1 · kind: Transaction effected pursuant to a plan established pursuant to Rule 10b5-1 on August 7, 2025.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $9.99 to $10.09. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001193125-25-327033 · ownership.xml · nonDerivative · entry 1

SUMER JACQUELYN L · CIK 0001844824 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 135,432

F1 · kind: Sale of shares to cover personal income tax obligations upon vesting of restricted stock units.

F2 · balance_after: Includes 2,017 shares of common stock that the Reporting Person purchased pursuant to the Issuer's 2021 Employee Stock Purchase Plan for the purchase period of January 1, 2025 through June 30, 2025 that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001193125-25-327030 · ownership.xml · nonDerivative · entry 1

Jones Jeffrey Alan · CIK 0001914647 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 169,532

F1 · kind: Sale of shares to cover personal income tax obligations upon vesting of restricted stock units.

SEC source: 0001193125-25-327027 · ownership.xml · nonDerivative · entry 1

Michaelson Jennifer · CIK 0001838061 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 133,980

F1 · kind: Sale of shares to cover personal income tax obligations upon vesting of restricted stock units.

SEC source: 0001193125-25-321122 · ownership.xml · nonDerivative · entry 2

Michaelson Jennifer · CIK 0001838061 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 136,878

F3 · kind: Transaction effected pursuant to a plan established pursuant to Rule 10b5-1 on August 7, 2025.

SEC source: 0001193125-25-321122 · ownership.xml · nonDerivative · entry 1

Michaelson Jennifer · CIK 0001838061 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 137,873

F1 · kind: Sale of shares to cover personal income tax obligations upon vesting of restricted stock units.

F2 · balance_after: Includes 2,017 shares of common stock that the Reporting Person purchased pursuant to the Issuer's 2021 Employee Stock Purchase Plan for the purchase period of January 1, 2025 through June 30, 2025 that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001193125-25-297549 · ownership.xml · nonDerivative · entry 1

Michaelson Jennifer · CIK 0001838061 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 138,004

F1 · kind: Transaction effected pursuant to a plan established pursuant to Rule 10b5-1 on August 7, 2025.

SEC source: 0000902664-25-004662 · ownership.xml · nonDerivative · entry 1

Lynx1 Capital Management LP · CIK 0001910456 · 10% owner

Nichols Weston · CIK 0001746376 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 8,963,500

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $8.035 to $8.50 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth herein.

F2 · ownership.nature: The securities to which this filing relates are held directly by Lynx1 Master Fund LP to which Lynx1 Capital Management LP (the "Investment Manager") serves as investment manager. Weston Nichols ("Mr. Nichols") is the sole member of Lynx1 Capital Management GP LLC, the general partner of the Investment Manager. Each of the Investment Manager and Mr. Nichols disclaims beneficial ownership of the securities to which this filing relates for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except to the extent of his or its pecuniary interest therein, if any.

SEC source: 0000902664-25-004499 · ownership.xml · nonDerivative · entry 4

Lynx1 Capital Management LP · CIK 0001910456 · 10% owner

Nichols Weston · CIK 0001746376 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 8,797,833

F5 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $7.78 to $7.85 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares purchased at each separate price within the range set forth herein.

F2 · ownership.nature: The securities to which this filing relates are held directly by Lynx1 Master Fund LP to which Lynx1 Capital Management LP (the "Investment Manager") serves as investment manager. Weston Nichols ("Mr. Nichols") is the sole member of Lynx1 Capital Management GP LLC, the general partner of the Investment Manager. Each of the Investment Manager and Mr. Nichols disclaims beneficial ownership of the securities to which this filing relates for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except to the extent of his or its pecuniary interest therein, if any.

SEC source: 0000902664-25-004499 · ownership.xml · nonDerivative · entry 3

Lynx1 Capital Management LP · CIK 0001910456 · 10% owner

Nichols Weston · CIK 0001746376 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 8,765,616

F4 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $8.68 to $9.22 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares purchased at each separate price within the range set forth herein.

F2 · ownership.nature: The securities to which this filing relates are held directly by Lynx1 Master Fund LP to which Lynx1 Capital Management LP (the "Investment Manager") serves as investment manager. Weston Nichols ("Mr. Nichols") is the sole member of Lynx1 Capital Management GP LLC, the general partner of the Investment Manager. Each of the Investment Manager and Mr. Nichols disclaims beneficial ownership of the securities to which this filing relates for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except to the extent of his or its pecuniary interest therein, if any.

SEC source: 0000902664-25-004499 · ownership.xml · nonDerivative · entry 2

Lynx1 Capital Management LP · CIK 0001910456 · 10% owner

Nichols Weston · CIK 0001746376 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 8,615,616

F3 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $7.88 to $8.00 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares purchased at each separate price within the range set forth herein.

F2 · ownership.nature: The securities to which this filing relates are held directly by Lynx1 Master Fund LP to which Lynx1 Capital Management LP (the "Investment Manager") serves as investment manager. Weston Nichols ("Mr. Nichols") is the sole member of Lynx1 Capital Management GP LLC, the general partner of the Investment Manager. Each of the Investment Manager and Mr. Nichols disclaims beneficial ownership of the securities to which this filing relates for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except to the extent of his or its pecuniary interest therein, if any.

SEC source: 0000902664-25-004499 · ownership.xml · nonDerivative · entry 1

Lynx1 Capital Management LP · CIK 0001910456 · 10% owner

Nichols Weston · CIK 0001746376 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 8,564,116

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $7.50 to $7.68 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares purchased at each separate price within the range set forth herein.

F2 · ownership.nature: The securities to which this filing relates are held directly by Lynx1 Master Fund LP to which Lynx1 Capital Management LP (the "Investment Manager") serves as investment manager. Weston Nichols ("Mr. Nichols") is the sole member of Lynx1 Capital Management GP LLC, the general partner of the Investment Manager. Each of the Investment Manager and Mr. Nichols disclaims beneficial ownership of the securities to which this filing relates for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except to the extent of his or its pecuniary interest therein, if any.

SEC source: 0000902664-25-004379 · ownership.xml · nonDerivative · entry 3

Lynx1 Capital Management LP · CIK 0001910456 · 10% owner

Nichols Weston · CIK 0001746376 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 8,549,084

F4 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $6.87 to $7.46 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares purchased at each separate price within the range set forth herein.

F2 · ownership.nature: The securities to which this filing relates are held directly by Lynx1 Master Fund LP to which Lynx1 Capital Management LP (the "Investment Manager") serves as investment manager. Weston Nichols ("Mr. Nichols") is the sole member of Lynx1 Capital Management GP LLC, the general partner of the Investment Manager. Each of the Investment Manager and Mr. Nichols disclaims beneficial ownership of the securities to which this filing relates for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except to the extent of his or its pecuniary interest therein, if any.

SEC source: 0000902664-25-004379 · ownership.xml · nonDerivative · entry 2

Lynx1 Capital Management LP · CIK 0001910456 · 10% owner

Nichols Weston · CIK 0001746376 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 8,271,786

F3 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $6.60 to $6.90 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares purchased at each separate price within the range set forth herein.

F2 · ownership.nature: The securities to which this filing relates are held directly by Lynx1 Master Fund LP to which Lynx1 Capital Management LP (the "Investment Manager") serves as investment manager. Weston Nichols ("Mr. Nichols") is the sole member of Lynx1 Capital Management GP LLC, the general partner of the Investment Manager. Each of the Investment Manager and Mr. Nichols disclaims beneficial ownership of the securities to which this filing relates for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except to the extent of his or its pecuniary interest therein, if any.

SEC source: 0000902664-25-004379 · ownership.xml · nonDerivative · entry 1

Lynx1 Capital Management LP · CIK 0001910456 · 10% owner

Nichols Weston · CIK 0001746376 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 7,645,743

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $6.40 to $6.60 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares purchased at each separate price within the range set forth herein.

F2 · ownership.nature: The securities to which this filing relates are held directly by Lynx1 Master Fund LP to which Lynx1 Capital Management LP (the "Investment Manager") serves as investment manager. Weston Nichols ("Mr. Nichols") is the sole member of Lynx1 Capital Management GP LLC, the general partner of the Investment Manager. Each of the Investment Manager and Mr. Nichols disclaims beneficial ownership of the securities to which this filing relates for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except to the extent of his or its pecuniary interest therein, if any.

SEC source: 0000950170-25-106029 · ownership.xml · derivative · entry 1

Allen Andrew R · CIK 0001374539 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 79,456

Underlying: Common Stock · 79,456 shares

Expires 2035-08-07

F1 · derivative.exercise_date: The option represents a right to purchase a total of 79,456 shares of the Issuer's common stock, which shall vest as to one-third of the shares underlying the option on each of the first, second and third anniversaries of the grant date of the award, subject to the Reporting Person's continued service as a director on each such vesting date.

SEC source: 0000950170-25-106028 · ownership.xml · derivative · entry 1

Doyle Mittie · CIK 0001918845 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 79,456

Underlying: Common Stock · 79,456 shares

Expires 2035-08-07

F1 · derivative.exercise_date: The option represents a right to purchase a total of 79,456 shares of the Issuer's common stock, which shall vest as to one-third of the shares underlying the option on each of the first, second and third anniversaries of the grant date of the award, subject to the Reporting Person's continued service as a director on each such vesting date.

SEC source: 0000950170-25-086732 · ownership.xml · derivative · entry 1

Rosenberg Anthony · CIK 0001466175 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 38,513

Underlying: Common Stock · 38,513 shares

Expires 2035-06-12

F1 · derivative.exercise_date: The option represents a right to purchase a total of 38,513 shares of the Issuer's Common Stock, which shall vest in full on the earlier of (i) June 12, 2026 or (ii) the date of the Issuer's next annual meeting, subject to the Reporting Person's continued service as a director on such vesting date

SEC source: 0000950170-25-086726 · ownership.xml · derivative · entry 1

Webster Stephen W · CIK 0001438421 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 38,513

Underlying: Common Stock · 38,513 shares

Expires 2035-06-12

F1 · derivative.exercise_date: The option represents a right to purchase a total of 38,513 shares of the Issuer's Common Stock, which shall vest in full on the earlier of (i) June 12, 2026 or (ii) the date of the Issuer's next annual meeting, subject to the Reporting Person's continued service as a director on such vesting date

SEC source: 0000950170-25-086721 · ownership.xml · derivative · entry 1

Meek David D. · CIK 0001555337 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 38,513

Underlying: Common Stock · 38,513 shares

Expires 2035-06-12

F1 · derivative.exercise_date: The option represents a right to purchase a total of 38,513 shares of the Issuer's Common Stock, which shall vest in full on the earlier of (i) June 12, 2026 or (ii) the date of the Issuer's next annual meeting, subject to the Reporting Person's continued service as a director on such vesting date

SEC source: 0000950170-25-086737 · ownership.xml · derivative · entry 1

Ryan David P. · CIK 0001951490 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 38,513

Underlying: Common Stock · 38,513 shares

Expires 2035-06-12

F1 · derivative.exercise_date: The option represents a right to purchase a total of 38,513 shares of the Issuer's Common Stock, which shall vest in full on the earlier of (i) June 12, 2026 or (ii) the date of the Issuer's next annual meeting, subject to the Reporting Person's continued service as a director on such vesting date

SEC source: 0000950170-25-086718 · ownership.xml · derivative · entry 1

Martin Anne-Marie · CIK 0001914495 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 38,513

Underlying: Common Stock · 38,513 shares

Expires 2035-06-12

F1 · derivative.exercise_date: The option represents a right to purchase a total of 38,513 shares of the Issuer's Common Stock, which shall vest in full on the earlier of (i) June 12, 2026 or (ii) the date of the Issuer's next annual meeting, subject to the Reporting Person's continued service as a director on such vesting date

SEC source: 0000950170-25-029199 · ownership.xml · nonDerivative · entry 1

AHMED NADIM · CIK 0001731193 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 430,621

F1 · shares: Sale of shares to cover personal income tax obligations upon vesting of restricted stock units.

SEC source: 0000950170-25-029201 · ownership.xml · nonDerivative · entry 1

Jones Jeffrey Alan · CIK 0001914647 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 174,164

F1 · shares: Sale of shares to cover personal income tax obligations upon vesting of restricted stock units.

SEC source: 0000950170-25-029200 · ownership.xml · nonDerivative · entry 1

Michaelson Jennifer · CIK 0001838061 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 142,004

F1 · shares: Sale of shares to cover personal income tax obligations upon vesting of restricted stock units.

SEC source: 0000950170-25-029197 · ownership.xml · nonDerivative · entry 1

SUMER JACQUELYN L · CIK 0001844824 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 136,895

F1 · shares: Sale of shares to cover personal income tax obligations upon vesting of restricted stock units.

SEC source: 0000950170-25-025027 · ownership.xml · derivative · entry 2

Fenton Mary Kay · CIK 0001378589 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 120,000

Underlying: Common Stock · 120,000 shares

Expires 2035-02-19

F2 · derivative.exercise_date: The shares underlying the option vest over four years, with one forty-eighth (1/48th) of the shares vesting in equal monthly installments until the fourth anniversary of the grant date.

SEC source: 0000950170-25-025027 · ownership.xml · nonDerivative · entry 1

Fenton Mary Kay · CIK 0001378589 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 60,000

F1 · shares: The shares underlying the restricted stock unit vest on an annual basis over four years.

SEC source: 0000950170-25-025029 · ownership.xml · derivative · entry 2

AHMED NADIM · CIK 0001731193 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 360,000

Underlying: Common Stock · 360,000 shares

Expires 2035-02-19

F2 · derivative.exercise_date: The shares underlying the option vest over four years, with one forty-eighth (1/48th) of the shares vesting in equal monthly installments until the fourth anniversary of the grant date.

SEC source: 0000950170-25-025029 · ownership.xml · nonDerivative · entry 1

AHMED NADIM · CIK 0001731193 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 443,150

F1 · shares: The shares underlying the restricted stock unit vest on an annual basis over four years.

SEC source: 0000950170-25-025030 · ownership.xml · derivative · entry 2

SUMER JACQUELYN L · CIK 0001844824 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2035-02-19

F2 · derivative.exercise_date: The shares underlying the option vest over four years, with one forty-eighth (1/48th) of the shares vesting in equal monthly installments until the fourth anniversary of the grant date.

SEC source: 0000950170-25-025030 · ownership.xml · nonDerivative · entry 1

SUMER JACQUELYN L · CIK 0001844824 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 140,651

F1 · shares: The shares underlying the restricted stock unit vest on an annual basis over four years.

SEC source: 0000950170-25-025032 · ownership.xml · derivative · entry 2

Michaelson Jennifer · CIK 0001838061 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2035-02-19

F2 · derivative.exercise_date: The shares underlying the option vest over four years, with one forty-eighth (1/48th) of the shares vesting in equal monthly installments until the fourth anniversary of the grant date.

SEC source: 0000950170-25-025032 · ownership.xml · nonDerivative · entry 1

Michaelson Jennifer · CIK 0001838061 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 145,760

F1 · shares: The shares underlying the restricted stock unit vest on an annual basis over four years.

SEC source: 0000950170-25-025031 · ownership.xml · derivative · entry 2

Savill Corrine · CIK 0001837524 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2035-02-19

F2 · derivative.exercise_date: The shares underlying the option vest over four years, with one forty-eighth (1/48th) of the shares vesting in equal monthly installments until the fourth anniversary of the grant date.

SEC source: 0000950170-25-025031 · ownership.xml · nonDerivative · entry 1

Savill Corrine · CIK 0001837524 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 240,990

F1 · shares: The shares underlying the restricted stock unit vest on an annual basis over four years.

SEC source: 0000950170-25-025028 · ownership.xml · derivative · entry 2

Jones Jeffrey Alan · CIK 0001914647 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 130,000

Underlying: Common Stock · 130,000 shares

Expires 2035-02-19

F2 · derivative.exercise_date: The shares underlying the option vest over four years, with one forty-eighth (1/48th) of the shares vesting in equal monthly installments until the fourth anniversary of the grant date.

SEC source: 0000950170-25-025028 · ownership.xml · nonDerivative · entry 1

Jones Jeffrey Alan · CIK 0001914647 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 179,059

F1 · shares: The shares underlying the restricted stock unit vest on an annual basis over four years.

SEC source: 0000950170-25-002946 · ownership.xml · nonDerivative · entry 1

Michaelson Jennifer · CIK 0001838061 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 95,760

F1 · kind: Transaction effected pursuant to a plan established pursuant to Rule 10b5-1 on January 5, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $12.32 to $12.62. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in the footnote.

SEC source: 0000950170-24-140856 · ownership.xml · nonDerivative · entry 1

AHMED NADIM · CIK 0001731193 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 263,150

F1 · shares: Sale of shares to cover personal income tax obligations upon vesting of restricted stock units.

SEC source: 0000950170-24-139125 · ownership.xml · nonDerivative · entry 1

Michaelson Jennifer · CIK 0001838061 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 99,760

F1 · shares: Sale of shares to cover personal income tax obligations upon vesting of restricted stock units.

SEC source: 0000950170-24-139124 · ownership.xml · nonDerivative · entry 1

Jones Jeffrey Alan · CIK 0001914647 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 114,059

F1 · shares: Sale of shares to cover personal income tax obligations upon vesting of restricted stock units.

SEC source: 0000950170-24-139123 · ownership.xml · nonDerivative · entry 1

SUMER JACQUELYN L · CIK 0001844824 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 90,651

F1 · shares: Sale of shares to cover personal income tax obligations upon vesting of restricted stock units.

SEC source: 0000950170-24-136726 · ownership.xml · nonDerivative · entry 1

Michaelson Jennifer · CIK 0001838061 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 104,453

F1 · kind: Sale of shares to cover personal income tax obligations upon vesting of restricted stock units.

SEC source: 0000950170-24-123538 · ownership.xml · nonDerivative · entry 1

Michaelson Jennifer · CIK 0001838061 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 107,942

F1 · kind: Transaction effected pursuant to a plan established pursuant to Rule 10b5-1 on January 5, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $15.25 to $15.98. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000950170-24-104820 · ownership.xml · nonDerivative · entry 1

Michaelson Jennifer · CIK 0001838061 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 115,942

F1 · kind: Transaction effected pursuant to a plan established pursuant to Rule 10b5-1 on January 5, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $17.79 to $18.55. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000950170-24-094861 · ownership.xml · derivative · entry 1

Thistle Mary · CIK 0001317917 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,743

Underlying: Common Stock · 25,743 shares

Expires 2034-08-08

F1 · derivative.exercise_date: The option represents a right to purchase a total of 25,743 shares of the Issuer's common stock, which shall vest as to one-third of the shares underlying the option on each of the first, second and third anniversaries of the grant date of the award, subject to the Reporting Person's continued service as a director on each such vesting date.

SEC source: 0000950170-24-082485 · ownership.xml · nonDerivative · entry 1

Michaelson Jennifer · CIK 0001838061 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 123,942

F1 · kind: Transaction effected pursuant to a plan established pursuant to Rule 10b5-1 on January 5, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $15.97 to $16.77. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000950170-24-080961 · ownership.xml · nonDerivative · entry 1

Michaelson Jennifer · CIK 0001838061 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 131,942

F2 · price: In accordance with the ESPP, the shares were purchased based on 85% of the closing price of the Issuer's common stock on January 2, 2024.

F1 · acquired: The reporting person is voluntarily reporting the acquisition of shares of the Issuer's common stock pursuant to the Issuer's 2021 Employee Stock Purchase Plan (the "ESPP"), for the purchase period of January 1, 2024 through June 30, 2024. This transaction is also exempt under Rule 16b-3(c).

SEC source: 0000950170-24-078677 · ownership.xml · derivative · entry 1

Rosenberg Anthony · CIK 0001466175 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,806

Underlying: Common Stock · 15,806 shares

Expires 2034-06-26

F1 · derivative.exercise_date: The option represents a right to purchase a total of 15,806 shares of the Issuer's Common Stock, which shall vest in full on the earlier of (i) June 26, 2025 or (ii) the date of the Issuer's next annual meeting, subject to the Reporting Person's continued service as a director on such vesting date.