CERT

SEC source: 0001415889-25-009967 · form4-04032025_080412.xml · derivative · entry 11

Feehery William F · CIK 0001543193 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 83,186

Underlying: Common Stock · 41,593 shares

Expires 2027-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each RSU was granted on April 1, 2024, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2025. The remaining two-thirds of the RSUs will vest and settle in equal parts on April 1, 2026 and April 1, 2027.

F5 · derivative.exercise_date: Each RSU was granted on April 1, 2024, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2025. The remaining two-thirds of the RSUs will vest and settle in equal parts on April 1, 2026 and April 1, 2027.

SEC source: 0001415889-25-009967 · form4-04032025_080412.xml · derivative · entry 10

Feehery William F · CIK 0001543193 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,220

Underlying: Common Stock · 33,220 shares

Expires 2026-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. One-third of the RSUs vested and were settled on April 1, 2025. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2026.

F4 · derivative.exercise_date: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. One-third of the RSUs vested and were settled on April 1, 2025. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2026.

SEC source: 0001415889-25-009967 · form4-04032025_080412.xml · derivative · entry 9

Feehery William F · CIK 0001543193 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 36,580 shares

Expires 2025-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on March 31, 2023. One-third of the RSUs vested and were settled on April 1, 2024. The remaining one-third of the RSUs vested and settled on April 1, 2025.

F3 · derivative.exercise_date: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on March 31, 2023. One-third of the RSUs vested and were settled on April 1, 2024. The remaining one-third of the RSUs vested and settled on April 1, 2025.

SEC source: 0001415889-25-009967 · form4-04032025_080412.xml · nonDerivative · entry 8

Feehery William F · CIK 0001543193 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,336,673

F2 · shares: Represents shares of Certara withheld to satisfy tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") and PSUs described in footnotes 1, 3, 4, and 5, exempt under Rule 16b-3.

F5 · price: Each RSU was granted on April 1, 2024, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2025. The remaining two-thirds of the RSUs will vest and settle in equal parts on April 1, 2026 and April 1, 2027.

SEC source: 0001415889-25-009967 · form4-04032025_080412.xml · nonDerivative · entry 7

Feehery William F · CIK 0001543193 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,354,346

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · price: Each RSU was granted on April 1, 2024, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2025. The remaining two-thirds of the RSUs will vest and settle in equal parts on April 1, 2026 and April 1, 2027.

SEC source: 0001415889-25-009967 · form4-04032025_080412.xml · nonDerivative · entry 6

Feehery William F · CIK 0001543193 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,312,753

F2 · shares: Represents shares of Certara withheld to satisfy tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") and PSUs described in footnotes 1, 3, 4, and 5, exempt under Rule 16b-3.

F4 · price: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. One-third of the RSUs vested and were settled on April 1, 2025. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2026.

SEC source: 0001415889-25-009967 · form4-04032025_080412.xml · nonDerivative · entry 5

Feehery William F · CIK 0001543193 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,326,869

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · price: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. One-third of the RSUs vested and were settled on April 1, 2025. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2026.

SEC source: 0001415889-25-009967 · form4-04032025_080412.xml · nonDerivative · entry 4

Feehery William F · CIK 0001543193 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,293,649

F2 · shares: Represents shares of Certara withheld to satisfy tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") and PSUs described in footnotes 1, 3, 4, and 5, exempt under Rule 16b-3.

F3 · price: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on March 31, 2023. One-third of the RSUs vested and were settled on April 1, 2024. The remaining one-third of the RSUs vested and settled on April 1, 2025.

SEC source: 0001415889-25-009967 · form4-04032025_080412.xml · nonDerivative · entry 3

Feehery William F · CIK 0001543193 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,307,456

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on March 31, 2023. One-third of the RSUs vested and were settled on April 1, 2024. The remaining one-third of the RSUs vested and settled on April 1, 2025.

SEC source: 0001415889-25-009967 · form4-04032025_080412.xml · nonDerivative · entry 2

Feehery William F · CIK 0001543193 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,270,876

F2 · shares: Represents shares of Certara withheld to satisfy tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") and PSUs described in footnotes 1, 3, 4, and 5, exempt under Rule 16b-3.

F1 · price: Each performance stock unit ("PSU") was granted on April 1, 2022, under the Certara, Inc. ("Certara") 2020 Incentive Plan (the "2020 Incentive Plan") and represents a right to receive one share of common stock. The PSUs were subject to the achievement of certain performance objectives over a three-year period from January 1, 2022, to December 31, 2024. The PSUs were vested and settled on April 1, 2025.

SEC source: 0001415889-25-009967 · form4-04032025_080412.xml · nonDerivative · entry 1

Feehery William F · CIK 0001543193 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,279,114

F1 · price: Each performance stock unit ("PSU") was granted on April 1, 2022, under the Certara, Inc. ("Certara") 2020 Incentive Plan (the "2020 Incentive Plan") and represents a right to receive one share of common stock. The PSUs were subject to the achievement of certain performance objectives over a three-year period from January 1, 2022, to December 31, 2024. The PSUs were vested and settled on April 1, 2025.

SEC source: 0001415889-25-009982 · form4-04032025_080421.xml · derivative · entry 11

Pedersen Leif E · CIK 0001559712 · PRESIDENT, CHIEF COMMERCAL OFF

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,254

Underlying: Common Stock · 10,127 shares

Expires 2027-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each RSU was granted on April 1, 2024, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2025. The remaining two-thirds of the RSUs will vest and settle in equal parts on April 1, 2026 and April 1, 2027.

F5 · derivative.exercise_date: Each RSU was granted on April 1, 2024, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2025. The remaining two-thirds of the RSUs will vest and settle in equal parts on April 1, 2026 and April 1, 2027.

SEC source: 0001415889-25-009982 · form4-04032025_080421.xml · derivative · entry 10

Pedersen Leif E · CIK 0001559712 · PRESIDENT, CHIEF COMMERCAL OFF

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,852

Underlying: Common Stock · 7,852 shares

Expires 2026-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. One-third of the RSUs vested and were settled on April 1, 2025. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2026.

F4 · derivative.exercise_date: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. One-third of the RSUs vested and were settled on April 1, 2025. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2026.

SEC source: 0001415889-25-009982 · form4-04032025_080421.xml · derivative · entry 9

Pedersen Leif E · CIK 0001559712 · PRESIDENT, CHIEF COMMERCAL OFF

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 8,647 shares

Expires 2025-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on March 31, 2023. One-third of the RSUs vested and were settled on April 1, 2024. The remaining one-third of the RSUs vested and settled on April 1, 2025.

F3 · derivative.exercise_date: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on March 31, 2023. One-third of the RSUs vested and were settled on April 1, 2024. The remaining one-third of the RSUs vested and settled on April 1, 2025.

SEC source: 0001415889-25-009982 · form4-04032025_080421.xml · nonDerivative · entry 8

Pedersen Leif E · CIK 0001559712 · PRESIDENT, CHIEF COMMERCAL OFF

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 125,203

F2 · shares: Represents shares of Certara withheld to satisfy tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") and PSUs described in footnotes 1, 3, 4, and 5, exempt under Rule 16b-3.

F5 · price: Each RSU was granted on April 1, 2024, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2025. The remaining two-thirds of the RSUs will vest and settle in equal parts on April 1, 2026 and April 1, 2027.

SEC source: 0001415889-25-009982 · form4-04032025_080421.xml · nonDerivative · entry 7

Pedersen Leif E · CIK 0001559712 · PRESIDENT, CHIEF COMMERCAL OFF

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 127,669

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · price: Each RSU was granted on April 1, 2024, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2025. The remaining two-thirds of the RSUs will vest and settle in equal parts on April 1, 2026 and April 1, 2027.

SEC source: 0001415889-25-009982 · form4-04032025_080421.xml · nonDerivative · entry 6

Pedersen Leif E · CIK 0001559712 · PRESIDENT, CHIEF COMMERCAL OFF

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 117,542

F2 · shares: Represents shares of Certara withheld to satisfy tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") and PSUs described in footnotes 1, 3, 4, and 5, exempt under Rule 16b-3.

F4 · price: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. One-third of the RSUs vested and were settled on April 1, 2025. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2026.

SEC source: 0001415889-25-009982 · form4-04032025_080421.xml · nonDerivative · entry 5

Pedersen Leif E · CIK 0001559712 · PRESIDENT, CHIEF COMMERCAL OFF

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 119,454

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · price: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. One-third of the RSUs vested and were settled on April 1, 2025. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2026.

SEC source: 0001415889-25-009982 · form4-04032025_080421.xml · nonDerivative · entry 4

Pedersen Leif E · CIK 0001559712 · PRESIDENT, CHIEF COMMERCAL OFF

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 111,602

F2 · shares: Represents shares of Certara withheld to satisfy tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") and PSUs described in footnotes 1, 3, 4, and 5, exempt under Rule 16b-3.

F3 · price: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on March 31, 2023. One-third of the RSUs vested and were settled on April 1, 2024. The remaining one-third of the RSUs vested and settled on April 1, 2025.

SEC source: 0001415889-25-009982 · form4-04032025_080421.xml · nonDerivative · entry 3

Pedersen Leif E · CIK 0001559712 · PRESIDENT, CHIEF COMMERCAL OFF

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 113,708

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on March 31, 2023. One-third of the RSUs vested and were settled on April 1, 2024. The remaining one-third of the RSUs vested and settled on April 1, 2025.

SEC source: 0001415889-25-009982 · form4-04032025_080421.xml · nonDerivative · entry 2

Pedersen Leif E · CIK 0001559712 · PRESIDENT, CHIEF COMMERCAL OFF

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 105,061

F2 · shares: Represents shares of Certara withheld to satisfy tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") and PSUs described in footnotes 1, 3, 4, and 5, exempt under Rule 16b-3.

F1 · price: Each performance stock unit ("PSU") was granted on April 1, 2022, under the Certara, Inc. ("Certara") 2020 Incentive Plan (the "2020 Incentive Plan") and represents a right to receive one share of common stock. The PSUs were subject to the achievement of certain performance objectives over a three-year period from January 1, 2022, to December 31, 2024. The PSUs were vested and settled on April 1, 2025.

SEC source: 0001415889-25-009982 · form4-04032025_080421.xml · nonDerivative · entry 1

Pedersen Leif E · CIK 0001559712 · PRESIDENT, CHIEF COMMERCAL OFF

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 106,786

F1 · price: Each performance stock unit ("PSU") was granted on April 1, 2022, under the Certara, Inc. ("Certara") 2020 Incentive Plan (the "2020 Incentive Plan") and represents a right to receive one share of common stock. The PSUs were subject to the achievement of certain performance objectives over a three-year period from January 1, 2022, to December 31, 2024. The PSUs were vested and settled on April 1, 2025.

SEC source: 0001415889-25-009978 · form4-04032025_080427.xml · derivative · entry 9

Gallagher John E · CIK 0001628991 · PRESIDENT, CHIEF COMMERCAL OFF

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,381

Underlying: Common Stock · 15,190 shares

Expires 2027-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU was granted on April 1, 2024, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2025. The remaining two-thirds of the RSUs will vest and settle in equal parts on April 1, 2026 and April 1, 2027.

F4 · derivative.exercise_date: Each RSU was granted on April 1, 2024, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2025. The remaining two-thirds of the RSUs will vest and settle in equal parts on April 1, 2026 and April 1, 2027.

SEC source: 0001415889-25-009978 · form4-04032025_080427.xml · derivative · entry 8

Gallagher John E · CIK 0001628991 · PRESIDENT, CHIEF COMMERCAL OFF

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,633

Underlying: Common Stock · 12,633 shares

Expires 2026-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. One-third of the RSUs vested and were settled on April 1, 2025. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2026.

F3 · derivative.exercise_date: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. One-third of the RSUs vested and were settled on April 1, 2025. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2026.

SEC source: 0001415889-25-009978 · form4-04032025_080427.xml · derivative · entry 7

Gallagher John E · CIK 0001628991 · PRESIDENT, CHIEF COMMERCAL OFF

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 14,663 shares

Expires 2025-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") was granted on April 1, 2023, under the Certara, Inc. ("Certara") 2020 Incentive Plan ("2020 Incentive Plan") and represents a right to receive one share of common stock or the cash equivalent. One-half of the RSUs vested and were settled on April 1, 2024. The remaining RSUs vested and settled on April 1, 2025.

F1 · derivative.exercise_date: Each restricted stock unit ("RSU") was granted on April 1, 2023, under the Certara, Inc. ("Certara") 2020 Incentive Plan ("2020 Incentive Plan") and represents a right to receive one share of common stock or the cash equivalent. One-half of the RSUs vested and were settled on April 1, 2024. The remaining RSUs vested and settled on April 1, 2025.

SEC source: 0001415889-25-009978 · form4-04032025_080427.xml · nonDerivative · entry 6

Gallagher John E · CIK 0001628991 · PRESIDENT, CHIEF COMMERCAL OFF

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 46,528

F2 · shares: Represents shares of Certara withheld to satisfy tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") and PSUs described in footnotes 1, 3, and 4, exempt under Rule 16b-3.

F4 · price: Each RSU was granted on April 1, 2024, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2025. The remaining two-thirds of the RSUs will vest and settle in equal parts on April 1, 2026 and April 1, 2027.

SEC source: 0001415889-25-009978 · form4-04032025_080427.xml · nonDerivative · entry 5

Gallagher John E · CIK 0001628991 · PRESIDENT, CHIEF COMMERCAL OFF

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,731

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · price: Each RSU was granted on April 1, 2024, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2025. The remaining two-thirds of the RSUs will vest and settle in equal parts on April 1, 2026 and April 1, 2027.

SEC source: 0001415889-25-009978 · form4-04032025_080427.xml · nonDerivative · entry 4

Gallagher John E · CIK 0001628991 · PRESIDENT, CHIEF COMMERCAL OFF

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,541

F2 · shares: Represents shares of Certara withheld to satisfy tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") and PSUs described in footnotes 1, 3, and 4, exempt under Rule 16b-3.

F3 · price: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. One-third of the RSUs vested and were settled on April 1, 2025. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2026.

SEC source: 0001415889-25-009978 · form4-04032025_080427.xml · nonDerivative · entry 3

Gallagher John E · CIK 0001628991 · PRESIDENT, CHIEF COMMERCAL OFF

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,868

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. One-third of the RSUs vested and were settled on April 1, 2025. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2026.

SEC source: 0001415889-25-009978 · form4-04032025_080427.xml · nonDerivative · entry 2

Gallagher John E · CIK 0001628991 · PRESIDENT, CHIEF COMMERCAL OFF

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,235

F2 · shares: Represents shares of Certara withheld to satisfy tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") and PSUs described in footnotes 1, 3, and 4, exempt under Rule 16b-3.

F1 · price: Each restricted stock unit ("RSU") was granted on April 1, 2023, under the Certara, Inc. ("Certara") 2020 Incentive Plan ("2020 Incentive Plan") and represents a right to receive one share of common stock or the cash equivalent. One-half of the RSUs vested and were settled on April 1, 2024. The remaining RSUs vested and settled on April 1, 2025.

SEC source: 0001415889-25-009978 · form4-04032025_080427.xml · nonDerivative · entry 1

Gallagher John E · CIK 0001628991 · PRESIDENT, CHIEF COMMERCAL OFF

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,881

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") was granted on April 1, 2023, under the Certara, Inc. ("Certara") 2020 Incentive Plan ("2020 Incentive Plan") and represents a right to receive one share of common stock or the cash equivalent. One-half of the RSUs vested and were settled on April 1, 2024. The remaining RSUs vested and settled on April 1, 2025.

SEC source: 0001415889-25-009987 · form4-04032025_080435.xml · derivative · entry 11

Aspbury Robert · CIK 0001834221 · PRESIDENT, PREDICTIVE TECH

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,254

Underlying: Common Stock · 10,127 shares

Expires 2027-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each RSU was granted on April 1, 2024, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2025. The remaining two-thirds of the RSUs will vest and settle in equal parts on April 1, 2026 and April 1, 2027.

F5 · derivative.exercise_date: Each RSU was granted on April 1, 2024, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2025. The remaining two-thirds of the RSUs will vest and settle in equal parts on April 1, 2026 and April 1, 2027.

SEC source: 0001415889-25-009987 · form4-04032025_080435.xml · derivative · entry 10

Aspbury Robert · CIK 0001834221 · PRESIDENT, PREDICTIVE TECH

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,852

Underlying: Common Stock · 7,852 shares

Expires 2026-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. One-third of the RSUs vested and were settled on April 1, 2025. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2026.

F4 · derivative.exercise_date: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. One-third of the RSUs vested and were settled on April 1, 2025. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2026.

SEC source: 0001415889-25-009987 · form4-04032025_080435.xml · derivative · entry 9

Aspbury Robert · CIK 0001834221 · PRESIDENT, PREDICTIVE TECH

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 8,647 shares

Expires 2025-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on March 31, 2023. One-third of the RSUs vested and were settled on April 1, 2024. The remaining one-third of the RSUs vested and settled on April 1, 2025.

F3 · derivative.exercise_date: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on March 31, 2023. One-third of the RSUs vested and were settled on April 1, 2024. The remaining one-third of the RSUs vested and settled on April 1, 2025.

SEC source: 0001415889-25-009987 · form4-04032025_080435.xml · nonDerivative · entry 8

Aspbury Robert · CIK 0001834221 · PRESIDENT, PREDICTIVE TECH

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 307,176

F2 · shares: Represents shares of Certara withheld to satisfy tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") and PSUs described in footnotes 1, 3, 4, and 5, exempt under Rule 16b-3.

F5 · price: Each RSU was granted on April 1, 2024, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2025. The remaining two-thirds of the RSUs will vest and settle in equal parts on April 1, 2026 and April 1, 2027.

SEC source: 0001415889-25-009987 · form4-04032025_080435.xml · nonDerivative · entry 7

Aspbury Robert · CIK 0001834221 · PRESIDENT, PREDICTIVE TECH

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 311,936

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · price: Each RSU was granted on April 1, 2024, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2025. The remaining two-thirds of the RSUs will vest and settle in equal parts on April 1, 2026 and April 1, 2027.

SEC source: 0001415889-25-009987 · form4-04032025_080435.xml · nonDerivative · entry 6

Aspbury Robert · CIK 0001834221 · PRESIDENT, PREDICTIVE TECH

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 301,809

F2 · shares: Represents shares of Certara withheld to satisfy tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") and PSUs described in footnotes 1, 3, 4, and 5, exempt under Rule 16b-3.

F4 · price: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. One-third of the RSUs vested and were settled on April 1, 2025. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2026.

SEC source: 0001415889-25-009987 · form4-04032025_080435.xml · nonDerivative · entry 5

Aspbury Robert · CIK 0001834221 · PRESIDENT, PREDICTIVE TECH

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 305,500

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · price: Each RSU was granted on April 1, 2023, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on April 1, 2024. One-third of the RSUs vested and were settled on April 1, 2025. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2026.

SEC source: 0001415889-25-009987 · form4-04032025_080435.xml · nonDerivative · entry 4

Aspbury Robert · CIK 0001834221 · PRESIDENT, PREDICTIVE TECH

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 297,648

F2 · shares: Represents shares of Certara withheld to satisfy tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") and PSUs described in footnotes 1, 3, 4, and 5, exempt under Rule 16b-3.

F3 · price: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on March 31, 2023. One-third of the RSUs vested and were settled on April 1, 2024. The remaining one-third of the RSUs vested and settled on April 1, 2025.

SEC source: 0001415889-25-009987 · form4-04032025_080435.xml · nonDerivative · entry 3

Aspbury Robert · CIK 0001834221 · PRESIDENT, PREDICTIVE TECH

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 301,713

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on March 31, 2023. One-third of the RSUs vested and were settled on April 1, 2024. The remaining one-third of the RSUs vested and settled on April 1, 2025.

SEC source: 0001415889-25-009987 · form4-04032025_080435.xml · nonDerivative · entry 2

Aspbury Robert · CIK 0001834221 · PRESIDENT, PREDICTIVE TECH

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 293,066

F2 · shares: Represents shares of Certara withheld to satisfy tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") and PSUs described in footnotes 1, 3, 4, and 5, exempt under Rule 16b-3.

F1 · price: Each performance stock unit ("PSU") was granted on April 1, 2022, under the Certara, Inc. ("Certara") 2020 Incentive Plan (the "2020 Incentive Plan") and represents a right to receive one share of common stock. The PSUs were subject to the achievement of certain performance objectives over a three-year period from January 1, 2022, to December 31, 2024. The PSUs were vested and settled on April 1, 2025.

SEC source: 0001415889-25-009987 · form4-04032025_080435.xml · nonDerivative · entry 1

Aspbury Robert · CIK 0001834221 · PRESIDENT, PREDICTIVE TECH

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 296,396

F1 · price: Each performance stock unit ("PSU") was granted on April 1, 2022, under the Certara, Inc. ("Certara") 2020 Incentive Plan (the "2020 Incentive Plan") and represents a right to receive one share of common stock. The PSUs were subject to the achievement of certain performance objectives over a three-year period from January 1, 2022, to December 31, 2024. The PSUs were vested and settled on April 1, 2025.

SEC source: 0001415889-24-025422 · form4-10182024_081035.xml · derivative · entry 1

Reynders John V W · CIK 0002039811 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,709

Underlying: Common Stock · 10,709 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") was granted on October 16, 2024, under the Certara, Inc. 2020 Incentive Plan entitling the reporting person to receive one share of the issuer's common stock per RSU. The RSUs vest on the earlier of the one-year anniversary of the date of grant or the date of the issuer's next annual meeting.

F1 · derivative.exercise_date: Each restricted stock unit ("RSU") was granted on October 16, 2024, under the Certara, Inc. 2020 Incentive Plan entitling the reporting person to receive one share of the issuer's common stock per RSU. The RSUs vest on the earlier of the one-year anniversary of the date of grant or the date of the issuer's next annual meeting.

F1 · derivative.expiration_date: Each restricted stock unit ("RSU") was granted on October 16, 2024, under the Certara, Inc. 2020 Incentive Plan entitling the reporting person to receive one share of the issuer's common stock per RSU. The RSUs vest on the earlier of the one-year anniversary of the date of grant or the date of the issuer's next annual meeting.

SEC source: 0001415889-24-024874 · form4-10082024_081013.xml · nonDerivative · entry 1

SMITH PATRICK F · CIK 0001890360 · PRESIDENT, DRUG DEV SOLUTIONS

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 50,091

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 9, 2024.

SEC source: 0001415889-24-024816 · form4-10072024_081059.xml · derivative · entry 3

SMITH PATRICK F · CIK 0001890360 · PRESIDENT, DRUG DEV SOLUTIONS

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,303

Underlying: Common Stock · 7,151 shares

Expires 2026-10-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") was granted on October 5, 2023, under the Certara, Inc. ("Certara") 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on October 4, 2024. The remaining two-thirds of the RSUs are scheduled to vest and settle in equal parts on October 5, 2025, and October 5, 2026.

F1 · derivative.exercise_date: Each restricted stock unit ("RSU") was granted on October 5, 2023, under the Certara, Inc. ("Certara") 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on October 4, 2024. The remaining two-thirds of the RSUs are scheduled to vest and settle in equal parts on October 5, 2025, and October 5, 2026.

SEC source: 0001415889-24-024816 · form4-10072024_081059.xml · nonDerivative · entry 2

SMITH PATRICK F · CIK 0001890360 · PRESIDENT, DRUG DEV SOLUTIONS

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,500

F2 · shares: Represents RSUs of Certara withheld to satisfy tax withholding obligations in connection with the vesting of RSUs described in footnote 1, exempt under Rule 16b-3.

SEC source: 0001415889-24-024816 · form4-10072024_081059.xml · nonDerivative · entry 1

SMITH PATRICK F · CIK 0001890360 · PRESIDENT, DRUG DEV SOLUTIONS

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 57,242

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") was granted on October 5, 2023, under the Certara, Inc. ("Certara") 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. One-third of the RSUs vested and were settled on October 4, 2024. The remaining two-thirds of the RSUs are scheduled to vest and settle in equal parts on October 5, 2025, and October 5, 2026.

SEC source: 0001415889-24-023151 · form4-09102024_090936.xml · nonDerivative · entry 1

Pedersen Leif E · CIK 0001559712 · PRESIDENT, CHIEF COMMERCAL OFF

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 99,704

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 9, 2024.

F2 · price: This transaction was executed in multiple trades at prices ranging from $10.94 to $11.56. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-018891 · form4-07022024_080752.xml · nonDerivative · entry 1

Aspbury Robert · CIK 0001834221 · PRESIDENT, SCIENTIFIC SOFTWARE

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 289,314

F1 · shares: Represents restricted stock units ("RSU") withheld to satisfy tax withholding obligations in connection with the vesting and settlement of 1,832 RSUs, previously granted to the reporting person on July 1, 2021.

SEC source: 0001415889-24-015160 · form4-06032024_080612.xml · derivative · entry 2

Corcoran Daniel · CIK 0002025227 · SVP and General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,777

Underlying: Common Stock · 29,777 shares

Expires not disclosed

F2 · derivative.exercise_price: Each RSU was granted on June 1, 2024, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent thereof. The RSUs will vest and settle in two equal installments on June1, 2025 and June1, 2026.

F2 · derivative.exercise_date: Each RSU was granted on June 1, 2024, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent thereof. The RSUs will vest and settle in two equal installments on June1, 2025 and June1, 2026.

F2 · derivative.expiration_date: Each RSU was granted on June 1, 2024, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent thereof. The RSUs will vest and settle in two equal installments on June1, 2025 and June1, 2026.