BOLT

SEC source: 0000950170-25-063848 · ownership.xml · derivative · entry 1

Yonehiro Grant · CIK 0001428666 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 350,000

Underlying: Common Stock · 350,000 shares

Expires 2035-04-30

F1 · derivative.exercise_date: For so long as the Reporting Person continuously provides services to the Issuer this option will vest with respect to the shares as follows: 1/36th of the Shares will vest upon the Reporting Person completing each month of continuous service following January 1, 2025.

SEC source: 0000950170-25-063846 · ownership.xml · nonDerivative · entry 1

Nemec Sarah · CIK 0002023538 · Senior VP, Finance and PAO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,633

F1 · kind: and therefore exempt under Rule 16b-3(c)

F2 · shares: Shares acquired under the issuer's Employee Stock Purchase Plan.

SEC source: 0000950170-25-063840 · ownership.xml · nonDerivative · entry 1

Quinn William P. · CIK 0001724190 · Director · President, CEO and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 41,272

F1 · kind: and therefore exempt under Rule 16b-3(c)

F2 · shares: Shares acquired under the issuer's Employee Stock Purchase Plan.

SEC source: 0001415889-24-023005 · form4-09062024_040947.xml · derivative · entry 2

Dupont Jakob · CIK 0001553335 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,984

Underlying: Common Stock · 16,984 shares

Expires 2034-09-02

F2 · derivative.exercise_date: The shares subject to this option shall vest in full on the date immediately preceding the date of the Issuer's next annual stockholder meeting for so long as the Reporting Person is serving as a director of the Issuer on such date; provided, however that the option will vest in full upon a change in control.

SEC source: 0001415889-24-023005 · form4-09062024_040947.xml · derivative · entry 1

Dupont Jakob · CIK 0001553335 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2034-09-02

F1 · derivative.exercise_date: For so long as the Reporting Person continuously provides services to the Issuer this option will vest with respect to the shares as follows: 1/36th of the shares will vest upon the Reporting Person completing each month of continuous service following September 3, 2024; provided, however that the option will vest in full upon a change in control.

SEC source: 0000950170-24-086136 · ownership.xml · derivative · entry 2

Nemec Sarah · CIK 0002023538 · VP, Finance and PAO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 90,000

Underlying: Common Stock · 90,000 shares

Expires 2034-07-22

F2 · derivative.exercise_date: For so long as the Reporting Person continuously provides services to the Issuer this option will vest on July 15, 2025.

SEC source: 0000950170-24-086136 · ownership.xml · derivative · entry 1

Nemec Sarah · CIK 0002023538 · VP, Finance and PAO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2034-07-22

F1 · derivative.exercise_date: For so long as the Reporting Person continuously provides services to the Issuer this option will vest with respect to the shares as follows: 1/36th of the Shares will vest upon the Reporting Person completing each month of continuous service following July 15, 2024.

SEC source: 0000950170-24-086146 · ownership.xml · derivative · entry 1

Quinn William P. · CIK 0001724190 · Director · President, CEO and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 440,000

Underlying: Common Stock · 440,000 shares

Expires 2034-07-22

F1 · derivative.exercise_date: For so long as the Reporting Person continuously provides services to the Issuer this option will vest with respect to the shares as follows: 1/36th of the Shares will vest upon the Reporting Person completing each month of continuous service following July 15, 2024.

SEC source: 0000950170-24-086153 · ownership.xml · derivative · entry 1

Yonehiro Grant · CIK 0001428666 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 155,000

Underlying: Common Stock · 155,000 shares

Expires 2034-07-22

F1 · derivative.exercise_date: For so long as the Reporting Person continuously provides services to the Issuer this option will vest with respect to the shares as follows: 1/36th of the Shares will vest upon the Reporting Person completing each month of continuous service following July 15, 2024.

SEC source: 0000950170-24-073889 · ownership.xml · derivative · entry 1

LAPORTE KATHLEEN · CIK 0001196201 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,000

Underlying: Common Stock · 22,000 shares

Expires 2034-06-11

F1 · derivative.exercise_date: The shares subject to the option will vest on the earlier of June 12, 2025 or the day immediately prior to the next annual meeting of stockholders, subject to the Reporting Person's continuous service through such date; provided, however that the option will vest in full upon a change in control of the Issuer.

SEC source: 0000950170-24-073918 · ownership.xml · derivative · entry 1

SHAH MAHENDRA · CIK 0001255449 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,000

Underlying: Common Stock · 22,000 shares

Expires 2034-06-11

F1 · derivative.exercise_date: The shares subject to the option will vest on the earlier of June 12, 2025 or the day immediately prior to the next annual meeting of stockholders, subject to the Reporting Person's continuous service through such date; provided, however that the option will vest in full upon a change in control of the Issuer.

SEC source: 0000950170-24-073906 · ownership.xml · derivative · entry 1

ONETTO NICOLE · CIK 0001220049 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,000

Underlying: Common Stock · 22,000 shares

Expires 2034-06-11

F1 · derivative.exercise_date: The shares subject to the option will vest on the earlier of June 12, 2025 or the day immediately prior to the next annual meeting of stockholders, subject to the Reporting Person's continuous service through such date; provided, however that the option will vest in full upon a change in control of the Issuer.

SEC source: 0000950170-24-073898 · ownership.xml · derivative · entry 1

O'CALLAGHAN BRIAN · CIK 0001415015 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,000

Underlying: Common Stock · 22,000 shares

Expires 2034-06-11

F1 · derivative.exercise_date: The shares subject to the option will vest on the earlier of June 12, 2025 or the day immediately prior to the next annual meeting of stockholders, subject to the Reporting Person's continuous service through such date; provided, however that the option will vest in full upon a change in control of the Issuer.

SEC source: 0000950170-24-073892 · ownership.xml · derivative · entry 1

Lee Frank D. · CIK 0001814686 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,000

Underlying: Common Stock · 22,000 shares

Expires 2034-06-11

F1 · derivative.exercise_date: The shares subject to the option will vest on the earlier of June 12, 2025 or the day immediately prior to the next annual meeting of stockholders, subject to the Reporting Person's continuous service through such date; provided, however that the option will vest in full upon a change in control of the Issuer.

SEC source: 0000950170-24-073879 · ownership.xml · derivative · entry 1

Berner Laura · CIK 0001958382 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,000

Underlying: Common Stock · 22,000 shares

Expires 2034-06-11

F1 · derivative.exercise_date: The shares subject to the option will vest on the earlier of June 12, 2025 or the day immediately prior to the next annual meeting of stockholders, subject to the Reporting Person's continuous service through such date; provided, however that the option will vest in full upon a change in control of the Issuer.

SEC source: 0000950170-24-073882 · ownership.xml · derivative · entry 1

HEALY JAMES · CIK 0001245624 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,000

Underlying: Common Stock · 22,000 shares

Expires 2034-06-11

F1 · derivative.exercise_date: The shares subject to the option will vest on the earlier of June 12, 2025 or the day immediately prior to the next annual meeting of stockholders, subject to the Reporting Person's continuous service through such date; provided, however that the option will vest in full upon a change in control of the Issuer.

SEC source: 0000950170-25-063846 · ownership.xml · nonDerivative · entry 2

Nemec Sarah · CIK 0002023538 · Senior VP, Finance and PAO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,863

F1 · kind: and therefore exempt under Rule 16b-3(c)

F2 · shares: Shares acquired under the issuer's Employee Stock Purchase Plan.

SEC source: 0000950170-25-063840 · ownership.xml · nonDerivative · entry 2

Quinn William P. · CIK 0001724190 · Director · President, CEO and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 38,772

F1 · kind: and therefore exempt under Rule 16b-3(c)

F2 · shares: Shares acquired under the issuer's Employee Stock Purchase Plan.

SEC source: 0000950170-24-026996 · ownership.xml · derivative · entry 1

Quinn William P. · CIK 0001724190 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 235,000

Underlying: Common Stock · 235,000 shares

Expires 2034-03-03

F1 · derivative.exercise_date: For so long as the Reporting Person continuously provides services to the Issuer this option will vest with respect to the shares as follows: 1/36th of the Shares will vest upon the Reporting Person completing each month of continuous service following January 1, 2024.

SEC source: 0000950170-24-026999 · ownership.xml · derivative · entry 1

Yonehiro Grant · CIK 0001428666 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 235,000

Underlying: Common Stock · 235,000 shares

Expires 2034-03-03

F1 · derivative.exercise_date: For so long as the Reporting Person continuously provides services to the Issuer this option will vest with respect to the shares as follows: 1/36th of the Shares will vest upon the Reporting Person completing each month of continuous service following January 1, 2024.

SEC source: 0000950170-24-026998 · ownership.xml · derivative · entry 1

Perez Edith A. · CIK 0001821419 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 235,000

Underlying: Common Stock · 235,000 shares

Expires 2034-03-03

F1 · derivative.exercise_date: For so long as the Reporting Person continuously provides services to the Issuer this option will vest with respect to the shares as follows: 1/36th of the Shares will vest upon the Reporting Person completing each month of continuous service following January 1, 2024.

SEC source: 0000950170-24-026997 · ownership.xml · derivative · entry 1

Schatzman Randall C · CIK 0001604763 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 235,000

Underlying: Common Stock · 654,000 shares

Expires 2034-03-03

F1 · derivative.exercise_date: For so long as the Reporting Person continuously provides services to the Issuer this option will vest with respect to the shares as follows: 1/36th of the Shares will vest upon the Reporting Person completing each month of continuous service following January 1, 2024.

SEC source: 0001209191-23-058458 · doc4.xml · nonDerivative · entry 3

Quinn William P. · CIK 0001724190 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,272

SEC source: 0001209191-23-058458 · doc4.xml · nonDerivative · entry 2

Quinn William P. · CIK 0001724190 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,772

F1 · shares: Shares acquired under the issuer's Employee Stock Purchase Plan.

SEC source: 0001209191-24-002901 · doc5.xml · nonDerivative · entry 1

Yonehiro Grant · CIK 0001428666 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,918

F1 · shares: Shares acquired under the issuer's Employee Stock Purchase Plan.

SEC source: 0001209191-24-002899 · doc5.xml · nonDerivative · entry 2

Perez Edith A. · CIK 0001821419 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 46,612

F1 · shares: Shares acquired under the issuer's Employee Stock Purchase Plan.

SEC source: 0001209191-24-002897 · doc5.xml · nonDerivative · entry 2

Schatzman Randall C · CIK 0001604763 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,859

F1 · shares: Shares acquired under the issuer's Employee Stock Purchase Plan.

SEC source: 0001209191-23-057049 · doc4.xml · nonDerivative · entry 4

ENGLEMAN EDGAR · CIK 0001227162 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Vivo Capital Surplus Fund VIII, L.P.

Disclosed balance after: 251,522

F3 · price: The price reported herein is a weighted average price. These shares were sold on the open market in multiple transactions at prices ranging from $0.85 to $0.9261, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4.

F4 · ownership.nature: The securities reported herein are held of record by Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the general partner of Vivo Capital Surplus Fund VIII, L.P. The Reporting Person is one of the voting members of Vivo Capital VIII, LLC and may be deemed to have shared voting and dispositive power over the shares held by Vivo Capital Surplus Fund VIII, L.P. The Reporting Person disclaims beneficial ownership over such shares except to the extent of his pecuniary interest therein.

SEC source: 0001209191-23-057049 · doc4.xml · nonDerivative · entry 2

ENGLEMAN EDGAR · CIK 0001227162 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Vivo Capital Fund VIII, L.P.

Disclosed balance after: 1,821,483

F3 · price: The price reported herein is a weighted average price. These shares were sold on the open market in multiple transactions at prices ranging from $0.85 to $0.9261, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4.

F2 · ownership.nature: The securities reported herein are held of record by Vivo Capital Fund VIII, L.P. Vivo Capital VIII, LLC is the general partner of Vivo Capital Fund VIII, L.P. The Reporting Person is one of the voting members of Vivo Capital VIII, LLC and may be deemed to have shared voting and dispositive power over the shares held by Vivo Capital Fund VIII, L.P. The Reporting Person disclaims beneficial ownership over such shares except to the extent of his pecuniary interest therein.

SEC source: 0001209191-23-057049 · doc4.xml · nonDerivative · entry 3

ENGLEMAN EDGAR · CIK 0001227162 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Vivo Capital Surplus Fund VIII, L.P.

Disclosed balance after: 266,456

F1 · price: The price reported herein is a weighted average price. These shares were sold on the open market in multiple transactions at prices ranging from $0.90 to $0.94, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (6) to this Form 4.

F4 · ownership.nature: The securities reported herein are held of record by Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the general partner of Vivo Capital Surplus Fund VIII, L.P. The Reporting Person is one of the voting members of Vivo Capital VIII, LLC and may be deemed to have shared voting and dispositive power over the shares held by Vivo Capital Surplus Fund VIII, L.P. The Reporting Person disclaims beneficial ownership over such shares except to the extent of his pecuniary interest therein.

SEC source: 0001209191-23-057049 · doc4.xml · nonDerivative · entry 1

ENGLEMAN EDGAR · CIK 0001227162 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Vivo Capital Fund VIII, L.P.

Disclosed balance after: 1,929,628

F1 · price: The price reported herein is a weighted average price. These shares were sold on the open market in multiple transactions at prices ranging from $0.90 to $0.94, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (6) to this Form 4.

F2 · ownership.nature: The securities reported herein are held of record by Vivo Capital Fund VIII, L.P. Vivo Capital VIII, LLC is the general partner of Vivo Capital Fund VIII, L.P. The Reporting Person is one of the voting members of Vivo Capital VIII, LLC and may be deemed to have shared voting and dispositive power over the shares held by Vivo Capital Fund VIII, L.P. The Reporting Person disclaims beneficial ownership over such shares except to the extent of his pecuniary interest therein.

SEC source: 0001213900-23-089692 · ownership.xml · nonDerivative · entry 3

Vivo Capital VIII, LLC · CIK 0001618789 · 10% owner

Vivo Capital Fund VIII, L.P. · CIK 0001618788 · 10% owner

Vivo Capital Surplus Fund VIII, L.P. · CIK 0001628048 · 10% owner

Vivo Opportunity, LLC · CIK 0001728970 · 10% owner

Vivo Opportunity Fund Holdings, L.P. · CIK 0001930214 · 10% owner

Vivo Panda, LLC · CIK 0001843847 · 10% owner

Vivo Panda Fund, L.P. · CIK 0001675490 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By: Vivo Opportunity Fund Holdings, L.P.

Disclosed balance after: 111,662

F4 · price: The price reported herein is a weighted average price. These shares were sold on the open market in multiple transactions at prices ranging from $0.90 to $0.90, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4.

F3 · ownership.nature: The shares are held of record by Vivo Opportunity Fund Holdings, L.P. Vivo Opportunity, LLC is the General Partner of Vivo Opportunity Holdings, L.P. Vivo Opportunity, LLC disclaims beneficial ownership over such securities except to the extent of its pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purposes.

SEC source: 0001213900-23-089692 · ownership.xml · nonDerivative · entry 2

Vivo Capital VIII, LLC · CIK 0001618789 · 10% owner

Vivo Capital Fund VIII, L.P. · CIK 0001618788 · 10% owner

Vivo Capital Surplus Fund VIII, L.P. · CIK 0001628048 · 10% owner

Vivo Opportunity, LLC · CIK 0001728970 · 10% owner

Vivo Opportunity Fund Holdings, L.P. · CIK 0001930214 · 10% owner

Vivo Panda, LLC · CIK 0001843847 · 10% owner

Vivo Panda Fund, L.P. · CIK 0001675490 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By: Vivo Capital Surplus Fund VIII, L.P.

Disclosed balance after: 269,587

F4 · price: The price reported herein is a weighted average price. These shares were sold on the open market in multiple transactions at prices ranging from $0.90 to $0.90, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4.

F2 · ownership.nature: The shares are held of record by Vivo Capital Surplus Fund VIII, L.P. Capital VIII, LLC is the General Partner of Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC disclaims beneficial ownership over such securities except to the extent of its pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purposes.

SEC source: 0001213900-23-089692 · ownership.xml · nonDerivative · entry 1

Vivo Capital VIII, LLC · CIK 0001618789 · 10% owner

Vivo Capital Fund VIII, L.P. · CIK 0001618788 · 10% owner

Vivo Capital Surplus Fund VIII, L.P. · CIK 0001628048 · 10% owner

Vivo Opportunity, LLC · CIK 0001728970 · 10% owner

Vivo Opportunity Fund Holdings, L.P. · CIK 0001930214 · 10% owner

Vivo Panda, LLC · CIK 0001843847 · 10% owner

Vivo Panda Fund, L.P. · CIK 0001675490 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By: Vivo Capital Fund VIII, L.P.

Disclosed balance after: 1,952,302

F4 · price: The price reported herein is a weighted average price. These shares were sold on the open market in multiple transactions at prices ranging from $0.90 to $0.90, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4.

F1 · ownership.nature: The shares are held of record by Vivo Capital Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. Vivo Capital VIII, LLC disclaims beneficial ownership over such securities except to the extent of its pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purposes.

SEC source: 0001209191-23-056548 · doc4.xml · nonDerivative · entry 2

ENGLEMAN EDGAR · CIK 0001227162 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Vivo Capital Surplus Fund VIII, L.P.

Disclosed balance after: 269,587

F1 · price: The price reported herein is a weighted average price. These shares were sold on the open market in multiple transactions at prices ranging from $0.90 to $0.903, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (6) to this Form 4.

F3 · ownership.nature: The securities reported herein are held of record by Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the general partner of Vivo Capital Surplus Fund VIII, L.P. The Reporting Person is one of the voting members of Vivo Capital VIII, LLC and may be deemed to have shared voting and dispositive power over the shares held by Vivo Capital Surplus Fund VIII, L.P. The Reporting Person disclaims beneficial ownership over such shares except to the extent of his pecuniary interest therein.

SEC source: 0001209191-23-056548 · doc4.xml · nonDerivative · entry 1

ENGLEMAN EDGAR · CIK 0001227162 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Vivo Capital Fund VIII, L.P.

Disclosed balance after: 1,952,302

F1 · price: The price reported herein is a weighted average price. These shares were sold on the open market in multiple transactions at prices ranging from $0.90 to $0.903, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (6) to this Form 4.

F2 · ownership.nature: The securities reported herein are held of record by Vivo Capital Fund VIII, L.P. Vivo Capital VIII, LLC is the general partner of Vivo Capital Fund VIII, L.P. The Reporting Person is one of the voting members of Vivo Capital VIII, LLC and may be deemed to have shared voting and dispositive power over the shares held by Vivo Capital Fund VIII, L.P. The Reporting Person disclaims beneficial ownership over such shares except to the extent of his pecuniary interest therein.

SEC source: 0001213900-23-088909 · ownership.xml · nonDerivative · entry 9

Vivo Capital VIII, LLC · CIK 0001618789 · 10% owner

Vivo Capital Fund VIII, L.P. · CIK 0001618788 · 10% owner

Vivo Capital Surplus Fund VIII, L.P. · CIK 0001628048 · 10% owner

Vivo Opportunity, LLC · CIK 0001728970 · 10% owner

Vivo Opportunity Fund Holdings, L.P. · CIK 0001930214 · 10% owner

Vivo Panda, LLC · CIK 0001843847 · 10% owner

Vivo Panda Fund, L.P. · CIK 0001675490 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By: Vivo Opportunity Fund Holdings, L.P.

Disclosed balance after: 113,119

F6 · price: The price reported herein is a weighted average price. These shares were sold on the open market in multiple transactions at prices ranging from $0.92 to $0.98, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (6) to this Form 4.

F3 · ownership.nature: The shares are held of record by Vivo Opportunity Fund Holdings, L.P. Vivo Opportunity, LLC is the General Partner of Vivo Opportunity Holdings, L.P. Vivo Opportunity, LLC disclaims beneficial ownership over such securities except to the extent of its pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purposes.

SEC source: 0001213900-23-088909 · ownership.xml · nonDerivative · entry 8

Vivo Capital VIII, LLC · CIK 0001618789 · 10% owner

Vivo Capital Fund VIII, L.P. · CIK 0001618788 · 10% owner

Vivo Capital Surplus Fund VIII, L.P. · CIK 0001628048 · 10% owner

Vivo Opportunity, LLC · CIK 0001728970 · 10% owner

Vivo Opportunity Fund Holdings, L.P. · CIK 0001930214 · 10% owner

Vivo Panda, LLC · CIK 0001843847 · 10% owner

Vivo Panda Fund, L.P. · CIK 0001675490 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By: Vivo Capital Surplus Fund VIII, L.P.

Disclosed balance after: 269,823

F6 · price: The price reported herein is a weighted average price. These shares were sold on the open market in multiple transactions at prices ranging from $0.92 to $0.98, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (6) to this Form 4.

F2 · ownership.nature: The shares are held of record by Vivo Capital Surplus Fund VIII, L.P. Capital VIII, LLC is the General Partner of Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC disclaims beneficial ownership over such securities except to the extent of its pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purposes.

SEC source: 0001213900-23-088909 · ownership.xml · nonDerivative · entry 7

Vivo Capital VIII, LLC · CIK 0001618789 · 10% owner

Vivo Capital Fund VIII, L.P. · CIK 0001618788 · 10% owner

Vivo Capital Surplus Fund VIII, L.P. · CIK 0001628048 · 10% owner

Vivo Opportunity, LLC · CIK 0001728970 · 10% owner

Vivo Opportunity Fund Holdings, L.P. · CIK 0001930214 · 10% owner

Vivo Panda, LLC · CIK 0001843847 · 10% owner

Vivo Panda Fund, L.P. · CIK 0001675490 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · Vivo Capital Fund VIII, L.P.

Disclosed balance after: 1,954,009

F6 · price: The price reported herein is a weighted average price. These shares were sold on the open market in multiple transactions at prices ranging from $0.92 to $0.98, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (6) to this Form 4.

F1 · ownership.nature: The shares are held of record by Vivo Capital Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. Vivo Capital VIII, LLC disclaims beneficial ownership over such securities except to the extent of its pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purposes.

SEC source: 0001209191-23-056185 · doc4.xml · nonDerivative · entry 6

ENGLEMAN EDGAR · CIK 0001227162 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Vivo Capital Surplus Fund VIII, L.P.

Disclosed balance after: 269,823

F4 · price: The price reported herein is a weighted average price. These shares were sold on the open market in multiple transactions at prices ranging from $0.92 to $0.98, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (6) to this Form 4.

F5 · ownership.nature: The securities reported herein are held of record by Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the general partner of Vivo Capital Surplus Fund VIII, L.P. The Reporting Person is one of the voting members of Vivo Capital VIII, LLC and may be deemed to have shared voting and dispositive power over the shares held by Vivo Capital Surplus Fund VIII, L.P. The Reporting Person disclaims beneficial ownership over such shares except to the extent of his pecuniary interest therein.

SEC source: 0001209191-23-056185 · doc4.xml · nonDerivative · entry 3

ENGLEMAN EDGAR · CIK 0001227162 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Vivo Capital Fund VIII, L.P.

Disclosed balance after: 1,954,009

F4 · price: The price reported herein is a weighted average price. These shares were sold on the open market in multiple transactions at prices ranging from $0.92 to $0.98, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (6) to this Form 4.

F2 · ownership.nature: The securities reported herein are held of record by Vivo Capital Fund VIII, L.P. Vivo Capital VIII, LLC is the general partner of Vivo Capital Fund VIII, L.P. The Reporting Person is one of the voting members of Vivo Capital VIII, LLC and may be deemed to have shared voting and dispositive power over the shares held by Vivo Capital Fund VIII, L.P. The Reporting Person disclaims beneficial ownership over such shares except to the extent of his pecuniary interest therein.

SEC source: 0001213900-23-088909 · ownership.xml · nonDerivative · entry 6

Vivo Capital VIII, LLC · CIK 0001618789 · 10% owner

Vivo Capital Fund VIII, L.P. · CIK 0001618788 · 10% owner

Vivo Capital Surplus Fund VIII, L.P. · CIK 0001628048 · 10% owner

Vivo Opportunity, LLC · CIK 0001728970 · 10% owner

Vivo Opportunity Fund Holdings, L.P. · CIK 0001930214 · 10% owner

Vivo Panda, LLC · CIK 0001843847 · 10% owner

Vivo Panda Fund, L.P. · CIK 0001675490 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By: Vivo Opportunity Fund Holdings, L.P.

Disclosed balance after: 136,562

F5 · price: The price reported herein is a weighted average price. These shares were sold on the open market in multiple transactions at prices ranging from $0.93 to $0.95, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4.

F3 · ownership.nature: The shares are held of record by Vivo Opportunity Fund Holdings, L.P. Vivo Opportunity, LLC is the General Partner of Vivo Opportunity Holdings, L.P. Vivo Opportunity, LLC disclaims beneficial ownership over such securities except to the extent of its pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purposes.

SEC source: 0001213900-23-088909 · ownership.xml · nonDerivative · entry 5

Vivo Capital VIII, LLC · CIK 0001618789 · 10% owner

Vivo Capital Fund VIII, L.P. · CIK 0001618788 · 10% owner

Vivo Capital Surplus Fund VIII, L.P. · CIK 0001628048 · 10% owner

Vivo Opportunity, LLC · CIK 0001728970 · 10% owner

Vivo Opportunity Fund Holdings, L.P. · CIK 0001930214 · 10% owner

Vivo Panda, LLC · CIK 0001843847 · 10% owner

Vivo Panda Fund, L.P. · CIK 0001675490 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By: Vivo Capital Surplus Fund VIII, L.P.

Disclosed balance after: 273,615

F5 · price: The price reported herein is a weighted average price. These shares were sold on the open market in multiple transactions at prices ranging from $0.93 to $0.95, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4.

F2 · ownership.nature: The shares are held of record by Vivo Capital Surplus Fund VIII, L.P. Capital VIII, LLC is the General Partner of Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC disclaims beneficial ownership over such securities except to the extent of its pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purposes.

SEC source: 0001213900-23-088909 · ownership.xml · nonDerivative · entry 4

Vivo Capital VIII, LLC · CIK 0001618789 · 10% owner

Vivo Capital Fund VIII, L.P. · CIK 0001618788 · 10% owner

Vivo Capital Surplus Fund VIII, L.P. · CIK 0001628048 · 10% owner

Vivo Opportunity, LLC · CIK 0001728970 · 10% owner

Vivo Opportunity Fund Holdings, L.P. · CIK 0001930214 · 10% owner

Vivo Panda, LLC · CIK 0001843847 · 10% owner

Vivo Panda Fund, L.P. · CIK 0001675490 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By: Vivo Capital Fund VIII, L.P.

Disclosed balance after: 1,981,474

F5 · price: The price reported herein is a weighted average price. These shares were sold on the open market in multiple transactions at prices ranging from $0.93 to $0.95, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4.

F1 · ownership.nature: The shares are held of record by Vivo Capital Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. Vivo Capital VIII, LLC disclaims beneficial ownership over such securities except to the extent of its pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purposes.

SEC source: 0001209191-23-056185 · doc4.xml · nonDerivative · entry 5

ENGLEMAN EDGAR · CIK 0001227162 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Vivo Capital Surplus Fund VIII, L.P.

Disclosed balance after: 273,615

F3 · price: The price reported herein is a weighted average price. These shares were sold on the open market in multiple transactions at prices ranging from $0.93 to $0.95, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4.

F5 · ownership.nature: The securities reported herein are held of record by Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the general partner of Vivo Capital Surplus Fund VIII, L.P. The Reporting Person is one of the voting members of Vivo Capital VIII, LLC and may be deemed to have shared voting and dispositive power over the shares held by Vivo Capital Surplus Fund VIII, L.P. The Reporting Person disclaims beneficial ownership over such shares except to the extent of his pecuniary interest therein.

SEC source: 0001209191-23-056185 · doc4.xml · nonDerivative · entry 2

ENGLEMAN EDGAR · CIK 0001227162 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Vivo Capital Fund VIII, L.P.

Disclosed balance after: 1,981,474

F3 · price: The price reported herein is a weighted average price. These shares were sold on the open market in multiple transactions at prices ranging from $0.93 to $0.95, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (5) to this Form 4.

F2 · ownership.nature: The securities reported herein are held of record by Vivo Capital Fund VIII, L.P. Vivo Capital VIII, LLC is the general partner of Vivo Capital Fund VIII, L.P. The Reporting Person is one of the voting members of Vivo Capital VIII, LLC and may be deemed to have shared voting and dispositive power over the shares held by Vivo Capital Fund VIII, L.P. The Reporting Person disclaims beneficial ownership over such shares except to the extent of his pecuniary interest therein.

SEC source: 0001213900-23-088909 · ownership.xml · nonDerivative · entry 3

Vivo Capital VIII, LLC · CIK 0001618789 · 10% owner

Vivo Capital Fund VIII, L.P. · CIK 0001618788 · 10% owner

Vivo Capital Surplus Fund VIII, L.P. · CIK 0001628048 · 10% owner

Vivo Opportunity, LLC · CIK 0001728970 · 10% owner

Vivo Opportunity Fund Holdings, L.P. · CIK 0001930214 · 10% owner

Vivo Panda, LLC · CIK 0001843847 · 10% owner

Vivo Panda Fund, L.P. · CIK 0001675490 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By: Vivo Opportunity Fund Holdings, L.P.

Disclosed balance after: 143,571

F4 · price: The price reported herein is a weighted average price. These shares were sold on the open market in multiple transactions at prices ranging from $0.95 to $0.98, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4

F3 · ownership.nature: The shares are held of record by Vivo Opportunity Fund Holdings, L.P. Vivo Opportunity, LLC is the General Partner of Vivo Opportunity Holdings, L.P. Vivo Opportunity, LLC disclaims beneficial ownership over such securities except to the extent of its pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purposes.

SEC source: 0001213900-23-088909 · ownership.xml · nonDerivative · entry 2

Vivo Capital VIII, LLC · CIK 0001618789 · 10% owner

Vivo Capital Fund VIII, L.P. · CIK 0001618788 · 10% owner

Vivo Capital Surplus Fund VIII, L.P. · CIK 0001628048 · 10% owner

Vivo Opportunity, LLC · CIK 0001728970 · 10% owner

Vivo Opportunity Fund Holdings, L.P. · CIK 0001930214 · 10% owner

Vivo Panda, LLC · CIK 0001843847 · 10% owner

Vivo Panda Fund, L.P. · CIK 0001675490 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By: Vivo Capital Surplus Fund VIII, L.P.

Disclosed balance after: 274,749

F4 · price: The price reported herein is a weighted average price. These shares were sold on the open market in multiple transactions at prices ranging from $0.95 to $0.98, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4

F2 · ownership.nature: The shares are held of record by Vivo Capital Surplus Fund VIII, L.P. Capital VIII, LLC is the General Partner of Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC disclaims beneficial ownership over such securities except to the extent of its pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purposes.

SEC source: 0001213900-23-088909 · ownership.xml · nonDerivative · entry 1

Vivo Capital VIII, LLC · CIK 0001618789 · 10% owner

Vivo Capital Fund VIII, L.P. · CIK 0001618788 · 10% owner

Vivo Capital Surplus Fund VIII, L.P. · CIK 0001628048 · 10% owner

Vivo Opportunity, LLC · CIK 0001728970 · 10% owner

Vivo Opportunity Fund Holdings, L.P. · CIK 0001930214 · 10% owner

Vivo Panda, LLC · CIK 0001843847 · 10% owner

Vivo Panda Fund, L.P. · CIK 0001675490 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By: Vivo Capital Fund VIII, L.P.

Disclosed balance after: 1,989,685

F4 · price: The price reported herein is a weighted average price. These shares were sold on the open market in multiple transactions at prices ranging from $0.95 to $0.98, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4

F1 · ownership.nature: The shares are held of record by Vivo Capital Fund VIII, L.P. Vivo Capital VIII, LLC is the General Partner of Vivo Capital Fund VIII, L.P. Vivo Capital VIII, LLC disclaims beneficial ownership over such securities except to the extent of its pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purposes.

SEC source: 0001209191-23-056185 · doc4.xml · nonDerivative · entry 4

ENGLEMAN EDGAR · CIK 0001227162 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Vivo Capital Surplus Fund VIII, L.P.

Disclosed balance after: 274,749

F1 · price: The price reported herein is a weighted average price. These shares were sold on the open market in multiple transactions at prices ranging from $0.95 to $0.98, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in footnote (4) to this Form 4.

F5 · ownership.nature: The securities reported herein are held of record by Vivo Capital Surplus Fund VIII, L.P. Vivo Capital VIII, LLC is the general partner of Vivo Capital Surplus Fund VIII, L.P. The Reporting Person is one of the voting members of Vivo Capital VIII, LLC and may be deemed to have shared voting and dispositive power over the shares held by Vivo Capital Surplus Fund VIII, L.P. The Reporting Person disclaims beneficial ownership over such shares except to the extent of his pecuniary interest therein.