BLFS

SEC source: 0001437749-21-021860 · rdgdoc.xml · nonDerivative · entry 4

Rice Michael · CIK 0001389512 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 265,462

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person effective as of November 12, 2020.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $52.24 to $53.22, inclusive. The reporting person undertakes to provide to the registrant, any security holder of the registrant, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001437749-21-021860 · rdgdoc.xml · nonDerivative · entry 3

Rice Michael · CIK 0001389512 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 276,923

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001437749-21-021860 · rdgdoc.xml · derivative · entry 5

Rice Michael · CIK 0001389512 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,230

Underlying: Common Stock · 11,461 shares

Expires 2021-12-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option vested in two equal annual installments based on the registrant's satisfaction of certain performance criteria for the fiscal year ending December 2017. The performance criteria for 2017 were met, resulting in vesting of the option as follows: 114,613 shares vested on March 8, 2018 and 114,613 shares vested on March 8, 2019.

SEC source: 0001437749-21-021860 · rdgdoc.xml · nonDerivative · entry 2

Rice Michael · CIK 0001389512 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 265,462

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person effective as of November 12, 2020.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $50.91 to $53.32, inclusive. The reporting person undertakes to provide to the registrant, any security holder of the registrant, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001437749-21-021860 · rdgdoc.xml · nonDerivative · entry 1

Rice Michael · CIK 0001389512 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 276,923

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000919574-21-006570 · ownership.xml · nonDerivative · entry 1

Casdin Partners Master Fund, L.P. · CIK 0001534265 · 10% owner

Casdin Capital, LLC · CIK 0001534261 · 10% owner

Casdin Partners GP, LLC · CIK 0001534260 · 10% owner

Casdin Eli · CIK 0001534264 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,566,292

F1 · kind: The reported securities were received by Casdin Partners Master Fund, L.P. (the "Master Fund") upon closing of the merger between Sexton Biotechnologies, Inc. ("Sexton") and the Issuer with approximately 10% of the amount deposited into an escrow account for indemnification and post-closing purchase price adjustments. The foregoing description of the merger does not purport to be complete and is subject to and qualified in its entirety by reference to the Issuer's 8-K filed on September 8, 2021, which is incorporated by reference.

F1 · price: The reported securities were received by Casdin Partners Master Fund, L.P. (the "Master Fund") upon closing of the merger between Sexton Biotechnologies, Inc. ("Sexton") and the Issuer with approximately 10% of the amount deposited into an escrow account for indemnification and post-closing purchase price adjustments. The foregoing description of the merger does not purport to be complete and is subject to and qualified in its entirety by reference to the Issuer's 8-K filed on September 8, 2021, which is incorporated by reference.

F2 · ownership.direct: The securities are owned directly by the Master Fund and may be deemed to be indirectly beneficially owned by (i) Casdin Capital, LLC, the investment adviser to the Master Fund, (ii) Casdin Partners GP, LLC, the general partner of the Master Fund, and (iii) Eli Casdin, the managing member of Casdin Capital, LLC and Casdin Partners GP, LLC.

SEC source: 0000919574-23-003420 · ownership.xml · nonDerivative · entry 1

Casdin Partners Master Fund, L.P. · CIK 0001534265 · 10% owner

Casdin Capital, LLC · CIK 0001534261 · 10% owner

Casdin Partners GP, LLC · CIK 0001534260 · 10% owner

Casdin Eli · CIK 0001534264 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,571,535

F1 · kind: The reported securities were received by Casdin Partners Master Fund, L.P. (the "Master Fund") upon closing of the merger between Sexton Biotechnologies, Inc. ("Sexton") and the Issuer with approximately 10% of the amount deposited into an escrow account for indemnification and post-closing purchase price adjustments. The foregoing description of the merger does not purport to be complete and is subject to and qualified in its entirety by reference to the Issuer's 8-K filed on September 8, 2021, which is incorporated by reference.

F1 · price: The reported securities were received by Casdin Partners Master Fund, L.P. (the "Master Fund") upon closing of the merger between Sexton Biotechnologies, Inc. ("Sexton") and the Issuer with approximately 10% of the amount deposited into an escrow account for indemnification and post-closing purchase price adjustments. The foregoing description of the merger does not purport to be complete and is subject to and qualified in its entirety by reference to the Issuer's 8-K filed on September 8, 2021, which is incorporated by reference.

F2 · ownership.direct: The securities are owned directly by the Master Fund and may be deemed to be indirectly beneficially owned by (i) Casdin Capital, LLC, the investment adviser to the Master Fund, (ii) Casdin Partners GP, LLC, the general partner of the Master Fund, and (iii) Eli Casdin, the managing member of Casdin Capital, LLC and Casdin Partners GP, LLC.

SEC source: 0001437749-21-021221 · rdgdoc.xml · nonDerivative · entry 1

Mathew Aby J. · CIK 0001556355 · Exec VP & Chief Scientific Off

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 209,190

F1 · kind: The sale reported herein was made by the issuer to satisfy tax withholding obligations in connection with the vesting of shares of restricted stock.

SEC source: 0001437749-21-021219 · rdgdoc.xml · nonDerivative · entry 1

Rice Michael · CIK 0001389512 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 265,462

F1 · kind: The sale reported herein was made by the issuer to satisfy tax withholding obligations in connection with the vesting of shares of restricted stock.

SEC source: 0001437749-21-021220 · rdgdoc.xml · nonDerivative · entry 1

Foster Karen A. · CIK 0001683151 · Chief Quality Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 72,452

F1 · kind: The sale reported herein was made by the issuer to satisfy tax withholding obligations in connection with the vesting of shares of restricted stock.

SEC source: 0001437749-21-021017 · rdgdoc.xml · nonDerivative · entry 4

Mathew Aby J. · CIK 0001556355 · Exec VP & Chief Scientific Off

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 209,589

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person effective as of November 12, 2020.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $49.19 to $54.83, inclusive. The reporting person undertakes to provide to the registrant, any security holder of the registrant, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001437749-21-021017 · rdgdoc.xml · nonDerivative · entry 3

Mathew Aby J. · CIK 0001556355 · Exec VP & Chief Scientific Off

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 219,589

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001437749-21-021108 · rdgdoc.xml · nonDerivative · entry 1

Schick Joseph C · CIK 0001592238 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,875

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $52.53 to $52.58, inclusive. The reporting person undertakes to provide to the registrant, any security holder of the registrant, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001437749-21-021017 · rdgdoc.xml · derivative · entry 6

Mathew Aby J. · CIK 0001556355 · Exec VP & Chief Scientific Off

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 78,853

Underlying: Common Stock · 10,000 shares

Expires 2021-12-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: On December 20, 2016, the reporting person was granted an option to purchase 197,707 shares of common stock which vested in two equal annual installments on March 8, 2018 and March 8, 2019.

SEC source: 0001437749-21-021017 · rdgdoc.xml · derivative · entry 5

Mathew Aby J. · CIK 0001556355 · Exec VP & Chief Scientific Off

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 88,853

Underlying: Common Stock · 10,000 shares

Expires 2021-12-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: On December 20, 2016, the reporting person was granted an option to purchase 197,707 shares of common stock which vested in two equal annual installments on March 8, 2018 and March 8, 2019.

SEC source: 0001437749-21-021017 · rdgdoc.xml · nonDerivative · entry 2

Mathew Aby J. · CIK 0001556355 · Exec VP & Chief Scientific Off

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 209,589

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person effective as of November 12, 2020.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $45.4 to $47.02, inclusive. The reporting person undertakes to provide to the registrant, any security holder of the registrant, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001437749-21-021017 · rdgdoc.xml · nonDerivative · entry 1

Mathew Aby J. · CIK 0001556355 · Exec VP & Chief Scientific Off

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 219,589

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001437749-21-021016 · rdgdoc.xml · derivative · entry 3

Foster Karen A. · CIK 0001683151 · Chief Quality Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,996

Underlying: Common Stock · 16,332 shares

Expires 2021-12-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: On December 20, 2016, the reporting person was granted an option to purchase 163,323 shares of common stock which vested in two equal installments on March 8, 2018 and March 8, 2019.

SEC source: 0001437749-21-021016 · rdgdoc.xml · nonDerivative · entry 2

Foster Karen A. · CIK 0001683151 · Chief Quality Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 72,777

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 12, 2020.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $45.4 to $47.02 per share, inclusive. The reporting person undertakes to provide to the registrant, any security holder of the registrant, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001437749-21-021016 · rdgdoc.xml · nonDerivative · entry 1

Foster Karen A. · CIK 0001683151 · Chief Quality Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 89,109

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001437749-21-020556 · rdgdoc.xml · nonDerivative · entry 4

DE GREEF RODERICK · CIK 0001241181 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 128,614

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person effective as of May 20, 2021.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $44 to $45.97, inclusive. The reporting person undertakes to provide to the registrant, any security holder of the registrant, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001437749-21-020557 · rdgdoc.xml · nonDerivative · entry 1

Schick Joseph C · CIK 0001592238 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,750

SEC source: 0001437749-21-020556 · rdgdoc.xml · nonDerivative · entry 3

DE GREEF RODERICK · CIK 0001241181 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 140,614

F4 · kind: The sale reported herein was made by the issuer to satisfy tax withholding obligations in connection with the vesting of shares of restricted stock.

SEC source: 0001437749-21-020556 · rdgdoc.xml · nonDerivative · entry 2

DE GREEF RODERICK · CIK 0001241181 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 150,853

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person effective as of May 20, 2021.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $44.48 to $45.26, inclusive. The reporting person undertakes to provide to the registrant, any security holder of the registrant, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001437749-21-020458 · rdgdoc.xml · derivative · entry 6

Berard Todd · CIK 0001633186 · Chief Marketing Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,960

Underlying: Common Stock · 6,160 shares

Expires 2021-12-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: On December 20, 2016, the reporting person was granted an option to purchase 123,209 shares of common stock which vested in two equal annual installments on March 8, 2018 and March 8, 2019.

SEC source: 0001437749-21-020458 · rdgdoc.xml · nonDerivative · entry 4

Berard Todd · CIK 0001633186 · Chief Marketing Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 79,064

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 12, 2020.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $44.25 to $45.68 per share, inclusive. The reporting person undertakes to provide to the registrant, any security holder of the registrant, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001437749-21-020458 · rdgdoc.xml · nonDerivative · entry 3

Berard Todd · CIK 0001633186 · Chief Marketing Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 85,224

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001437749-21-020556 · rdgdoc.xml · nonDerivative · entry 1

DE GREEF RODERICK · CIK 0001241181 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 162,853

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person effective as of May 20, 2021.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $44.26 to $45.68, inclusive. The reporting person undertakes to provide to the registrant, any security holder of the registrant, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001437749-21-020458 · rdgdoc.xml · derivative · entry 5

Berard Todd · CIK 0001633186 · Chief Marketing Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 43,120

Underlying: Common Stock · 6,160 shares

Expires 2021-12-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: On December 20, 2016, the reporting person was granted an option to purchase 123,209 shares of common stock which vested in two equal annual installments on March 8, 2018 and March 8, 2019.

SEC source: 0001437749-21-020458 · rdgdoc.xml · nonDerivative · entry 2

Berard Todd · CIK 0001633186 · Chief Marketing Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 79,064

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 12, 2020.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $45.50 to $46.83 per share, inclusive. The reporting person undertakes to provide to the registrant, any security holder of the registrant, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001437749-21-020458 · rdgdoc.xml · nonDerivative · entry 1

Berard Todd · CIK 0001633186 · Chief Marketing Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 85,224

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001437749-21-020457 · rdgdoc.xml · nonDerivative · entry 1

Hinson Andrew G · CIK 0001389410 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,675

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person effective as of November 12, 2020.

SEC source: 0001437749-21-018816 · rdgdoc.xml · derivative · entry 6

Rice Michael · CIK 0001389512 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 91,691

Underlying: Common Stock · 11,461 shares

Expires 2021-12-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option vested in two equal annual installments based on the registrant's satisfaction of certain performance criteria for the fiscal year ending December 2017. The performance criteria for 2017 were met, resulting in vesting of the option as follows: 114,613 shares vested on March 8, 2018 and 114,613 shares vested on March 8, 2019.

SEC source: 0001437749-21-018816 · rdgdoc.xml · nonDerivative · entry 4

Rice Michael · CIK 0001389512 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 266,310

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person effective as of November 12, 2020.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $47.8 to $48.66, inclusive. The reporting person undertakes to provide to the registrant, any security holder of the registrant, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001437749-21-018816 · rdgdoc.xml · nonDerivative · entry 3

Rice Michael · CIK 0001389512 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 277,771

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001437749-21-018816 · rdgdoc.xml · derivative · entry 5

Rice Michael · CIK 0001389512 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,152

Underlying: Common Stock · 11,461 shares

Expires 2021-12-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option vested in two equal annual installments based on the registrant's satisfaction of certain performance criteria for the fiscal year ending December 2017. The performance criteria for 2017 were met, resulting in vesting of the option as follows: 114,613 shares vested on March 8, 2018 and 114,613 shares vested on March 8, 2019.

SEC source: 0001437749-21-018816 · rdgdoc.xml · nonDerivative · entry 2

Rice Michael · CIK 0001389512 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 266,310

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person effective as of November 12, 2020.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $47.93 to $48.75, inclusive. The reporting person undertakes to provide to the registrant, any security holder of the registrant, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001437749-21-018816 · rdgdoc.xml · nonDerivative · entry 1

Rice Michael · CIK 0001389512 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 277,771

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001437749-21-018182 · rdgdoc.xml · nonDerivative · entry 1

Rice Michael · CIK 0001389512 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 266,310

F1 · kind: This transaction represents a charitable donation to a third party. No value was received for the gifted shares.

SEC source: 0001437749-21-017793 · rdgdoc.xml · derivative · entry 3

Foster Karen A. · CIK 0001683151 · Chief Quality Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 65,328

Underlying: Common Stock · 16,333 shares

Expires 2021-12-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: On December 20, 2016, the reporting person was granted an option to purchase 163,323 shares of common stock which vested in two equal installments on March 8, 2018 and March 8, 2019.

SEC source: 0001437749-21-017793 · rdgdoc.xml · nonDerivative · entry 2

Foster Karen A. · CIK 0001683151 · Chief Quality Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 72,777

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 12, 2020.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $44.76 to $46.5 per share, inclusive. The reporting person undertakes to provide to the registrant, any security holder of the registrant, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001437749-21-017793 · rdgdoc.xml · nonDerivative · entry 1

Foster Karen A. · CIK 0001683151 · Chief Quality Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 89,110

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001437749-21-017792 · rdgdoc.xml · nonDerivative · entry 2

Schulz Marcus · CIK 0001812702 · Chief Revenue Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,447

F1 · shares: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person effective as of November 12, 2020.

SEC source: 0001437749-21-017792 · rdgdoc.xml · nonDerivative · entry 1

Schulz Marcus · CIK 0001812702 · Chief Revenue Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,097

F1 · shares: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person effective as of November 12, 2020.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $44.76 to $46.42, inclusive. The reporting person undertakes to provide to the registrant, any security holder of the registrant, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001437749-21-017325 · rdgdoc.xml · derivative · entry 6

Mathew Aby J. · CIK 0001556355 · Exec VP & Chief Scientific Off

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 98,853

Underlying: Common Stock · 8,854 shares

Expires 2021-12-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: On December 20, 2016, the reporting person was granted an option to purchase 197,707 shares of common stock which vested in two equal annual installments on March 8, 2018 and March 8, 2019.

SEC source: 0001437749-21-017325 · rdgdoc.xml · nonDerivative · entry 4

Mathew Aby J. · CIK 0001556355 · Exec VP & Chief Scientific Off

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 209,589

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person effective as of November 12, 2020.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $45.14 to $46.03, inclusive. The reporting person undertakes to provide to the registrant, any security holder of the registrant, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001437749-21-017325 · rdgdoc.xml · nonDerivative · entry 3

Mathew Aby J. · CIK 0001556355 · Exec VP & Chief Scientific Off

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 218,443

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001437749-21-017395 · rdgdoc.xml · nonDerivative · entry 1

Schulz Marcus · CIK 0001812702 · Chief Revenue Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,366

F1 · shares: The sales reported herein was made by the issuer to satisfy tax withholding obligations in connection with the vesting of shares of restricted stock.

SEC source: 0001437749-21-017394 · rdgdoc.xml · nonDerivative · entry 1

Aebersold Sarah · CIK 0001837756 · VP, Global Human Resources

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,840

F1 · shares: The sales reported herein was made by the issuer to satisfy tax withholding obligations in connection with the vesting of shares of restricted stock.

SEC source: 0001437749-21-017325 · rdgdoc.xml · derivative · entry 5

Mathew Aby J. · CIK 0001556355 · Exec VP & Chief Scientific Off

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 107,707

Underlying: Common Stock · 10,000 shares

Expires 2021-12-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: On December 20, 2016, the reporting person was granted an option to purchase 197,707 shares of common stock which vested in two equal annual installments on March 8, 2018 and March 8, 2019.