AWHL

SEC source: 0000905148-17-000783 · form4.xml · derivative · entry 3

SCHULER JACK W · CIK 0001021412 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 773,003 shares

Expires 2017-08-31

F1 · ownership.nature: These shares of common stock are directly owned by the Jack W. Schuler Living Trust. Jack W. Schuler is the sole trustee of the Jack W. Schuler Living Trust.

SEC source: 0000905148-17-000783 · form4.xml · nonDerivative · entry 1

SCHULER JACK W · CIK 0001021412 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 3,905,223

F1 · ownership.nature: These shares of common stock are directly owned by the Jack W. Schuler Living Trust. Jack W. Schuler is the sole trustee of the Jack W. Schuler Living Trust.

SEC source: 0000905148-17-000775 · form4.xml · derivative · entry 17

Schuler Henri George · CIK 0001629151 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Schuler Grandchildren LLC

Disclosed balance after: 113,332

Underlying: Common Stock · 113,332 shares

Expires 2017-08-31

F9 · derivative.exercise_price: To the extent that any part of this warrant is not exercised by August 31, 2017, the exercise price of the warrant will revert to $2.00 per share and the warrant will expire on December 23, 2017.

F8 · kind: The reported transactions involved an amendment of an outstanding warrant to reduce the exercise price from $2.00 to $1.00 per share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new warrant.

F8 · price: The reported transactions involved an amendment of an outstanding warrant to reduce the exercise price from $2.00 to $1.00 per share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new warrant.

F9 · derivative.expiration_date: To the extent that any part of this warrant is not exercised by August 31, 2017, the exercise price of the warrant will revert to $2.00 per share and the warrant will expire on December 23, 2017.

F5 · ownership.nature: These Shares and Warrants are directly owned by the Schuler Grandchildren LLC. H. George Schuler is the manager of the Schuler Grandchildren LLC.

F7 · ownership.nature: The reporting person disclaims beneficial ownership of these Shares and Warrants except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that he is the beneficial owner of the Shares and Warrants for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

SEC source: 0000905148-17-000775 · form4.xml · derivative · entry 16

Schuler Henri George · CIK 0001629151 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Schuler Grandchildren LLC

Disclosed balance after: 0

Underlying: Common Stock · 113,332 shares

Expires 2017-12-23

F8 · kind: The reported transactions involved an amendment of an outstanding warrant to reduce the exercise price from $2.00 to $1.00 per share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new warrant.

F8 · price: The reported transactions involved an amendment of an outstanding warrant to reduce the exercise price from $2.00 to $1.00 per share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new warrant.

F5 · ownership.nature: These Shares and Warrants are directly owned by the Schuler Grandchildren LLC. H. George Schuler is the manager of the Schuler Grandchildren LLC.

F7 · ownership.nature: The reporting person disclaims beneficial ownership of these Shares and Warrants except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that he is the beneficial owner of the Shares and Warrants for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

SEC source: 0000905148-17-000775 · form4.xml · derivative · entry 15

Schuler Henri George · CIK 0001629151 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Schuler GC 2010 Continuation Trust

Disclosed balance after: 113,332

Underlying: Common Stock · 113,332 shares

Expires 2017-08-31

F9 · derivative.exercise_price: To the extent that any part of this warrant is not exercised by August 31, 2017, the exercise price of the warrant will revert to $2.00 per share and the warrant will expire on December 23, 2017.

F8 · kind: The reported transactions involved an amendment of an outstanding warrant to reduce the exercise price from $2.00 to $1.00 per share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new warrant.

F8 · price: The reported transactions involved an amendment of an outstanding warrant to reduce the exercise price from $2.00 to $1.00 per share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new warrant.

F9 · derivative.expiration_date: To the extent that any part of this warrant is not exercised by August 31, 2017, the exercise price of the warrant will revert to $2.00 per share and the warrant will expire on December 23, 2017.

F4 · ownership.nature: These Shares and Warrants are directly owned by the Schuler GC 2010 Continuation Trust. H. George Schuler is the sole trustee of the Schuler GC 2010 Continuation Trust.

F7 · ownership.nature: The reporting person disclaims beneficial ownership of these Shares and Warrants except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that he is the beneficial owner of the Shares and Warrants for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

SEC source: 0000905148-17-000775 · form4.xml · derivative · entry 14

Schuler Henri George · CIK 0001629151 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Schuler GC 2010 Continuation Trust

Disclosed balance after: 0

Underlying: Common Stock · 113,332 shares

Expires 2017-12-23

F8 · kind: The reported transactions involved an amendment of an outstanding warrant to reduce the exercise price from $2.00 to $1.00 per share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new warrant.

F8 · price: The reported transactions involved an amendment of an outstanding warrant to reduce the exercise price from $2.00 to $1.00 per share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new warrant.

F4 · ownership.nature: These Shares and Warrants are directly owned by the Schuler GC 2010 Continuation Trust. H. George Schuler is the sole trustee of the Schuler GC 2010 Continuation Trust.

F7 · ownership.nature: The reporting person disclaims beneficial ownership of these Shares and Warrants except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that he is the beneficial owner of the Shares and Warrants for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

SEC source: 0000905148-17-000775 · form4.xml · derivative · entry 13

Schuler Henri George · CIK 0001629151 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Therese Heidi Schuler Trust

Disclosed balance after: 571,702

Underlying: Common Stock · 571,702 shares

Expires 2017-08-31

F9 · derivative.exercise_price: To the extent that any part of this warrant is not exercised by August 31, 2017, the exercise price of the warrant will revert to $2.00 per share and the warrant will expire on December 23, 2017.

F8 · kind: The reported transactions involved an amendment of an outstanding warrant to reduce the exercise price from $2.00 to $1.00 per share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new warrant.

F8 · price: The reported transactions involved an amendment of an outstanding warrant to reduce the exercise price from $2.00 to $1.00 per share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new warrant.

F9 · derivative.expiration_date: To the extent that any part of this warrant is not exercised by August 31, 2017, the exercise price of the warrant will revert to $2.00 per share and the warrant will expire on December 23, 2017.

F3 · ownership.nature: These Shares and Warrants are directly owned by the Therese Heidi Schuler Trust. H. George Schuler is the sole trustee of the Therese Heidi Schuler Trust.

F7 · ownership.nature: The reporting person disclaims beneficial ownership of these Shares and Warrants except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that he is the beneficial owner of the Shares and Warrants for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

SEC source: 0000905148-17-000775 · form4.xml · derivative · entry 12

Schuler Henri George · CIK 0001629151 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Therese Heidi Schuler Trust

Disclosed balance after: 0

Underlying: Common Stock · 571,702 shares

Expires 2017-12-23

F8 · kind: The reported transactions involved an amendment of an outstanding warrant to reduce the exercise price from $2.00 to $1.00 per share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new warrant.

F8 · price: The reported transactions involved an amendment of an outstanding warrant to reduce the exercise price from $2.00 to $1.00 per share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new warrant.

F3 · ownership.nature: These Shares and Warrants are directly owned by the Therese Heidi Schuler Trust. H. George Schuler is the sole trustee of the Therese Heidi Schuler Trust.

F7 · ownership.nature: The reporting person disclaims beneficial ownership of these Shares and Warrants except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that he is the beneficial owner of the Shares and Warrants for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

SEC source: 0000905148-17-000775 · form4.xml · derivative · entry 11

Schuler Henri George · CIK 0001629151 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Tanya Eva Schuler Trust

Disclosed balance after: 571,702

Underlying: Common Stock · 571,702 shares

Expires 2017-08-31

F9 · derivative.exercise_price: To the extent that any part of this warrant is not exercised by August 31, 2017, the exercise price of the warrant will revert to $2.00 per share and the warrant will expire on December 23, 2017.

F8 · kind: The reported transactions involved an amendment of an outstanding warrant to reduce the exercise price from $2.00 to $1.00 per share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new warrant.

F8 · price: The reported transactions involved an amendment of an outstanding warrant to reduce the exercise price from $2.00 to $1.00 per share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new warrant.

F9 · derivative.expiration_date: To the extent that any part of this warrant is not exercised by August 31, 2017, the exercise price of the warrant will revert to $2.00 per share and the warrant will expire on December 23, 2017.

F2 · ownership.nature: These Shares and Warrants are directly owned by the Tanya Eva Schuler Trust. H. George Schuler is the sole trustee of the Tanya Eva Schuler Trust.

F7 · ownership.nature: The reporting person disclaims beneficial ownership of these Shares and Warrants except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that he is the beneficial owner of the Shares and Warrants for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

SEC source: 0000905148-17-000775 · form4.xml · derivative · entry 10

Schuler Henri George · CIK 0001629151 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Tanya Eva Schuler Trust

Disclosed balance after: 0

Underlying: Common Stock · 571,702 shares

Expires 2017-12-23

F8 · kind: The reported transactions involved an amendment of an outstanding warrant to reduce the exercise price from $2.00 to $1.00 per share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new warrant.

F8 · price: The reported transactions involved an amendment of an outstanding warrant to reduce the exercise price from $2.00 to $1.00 per share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new warrant.

F2 · ownership.nature: These Shares and Warrants are directly owned by the Tanya Eva Schuler Trust. H. George Schuler is the sole trustee of the Tanya Eva Schuler Trust.

F7 · ownership.nature: The reporting person disclaims beneficial ownership of these Shares and Warrants except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that he is the beneficial owner of the Shares and Warrants for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

SEC source: 0000905148-17-000775 · form4.xml · derivative · entry 9

Schuler Henri George · CIK 0001629151 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Tino Hans Schuler Trust

Disclosed balance after: 571,702

Underlying: Common Stock · 571,702 shares

Expires 2017-08-31

F9 · derivative.exercise_price: To the extent that any part of this warrant is not exercised by August 31, 2017, the exercise price of the warrant will revert to $2.00 per share and the warrant will expire on December 23, 2017.

F8 · kind: The reported transactions involved an amendment of an outstanding warrant to reduce the exercise price from $2.00 to $1.00 per share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new warrant.

F8 · price: The reported transactions involved an amendment of an outstanding warrant to reduce the exercise price from $2.00 to $1.00 per share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new warrant.

F9 · derivative.expiration_date: To the extent that any part of this warrant is not exercised by August 31, 2017, the exercise price of the warrant will revert to $2.00 per share and the warrant will expire on December 23, 2017.

F1 · ownership.nature: These shares of Common Stock ("Shares") and Warrants to acquire Common Stock ("Warrants") are directly owned by the Tino Hans Schuler Trust. H. George Schuler is the sole trustee of the Tino Hans Schuler Trust.

F7 · ownership.nature: The reporting person disclaims beneficial ownership of these Shares and Warrants except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that he is the beneficial owner of the Shares and Warrants for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

SEC source: 0000905148-17-000775 · form4.xml · derivative · entry 8

Schuler Henri George · CIK 0001629151 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Tino Hans Schuler Trust

Disclosed balance after: 0

Underlying: Common Stock · 571,702 shares

Expires 2017-12-23

F8 · kind: The reported transactions involved an amendment of an outstanding warrant to reduce the exercise price from $2.00 to $1.00 per share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new warrant.

F8 · price: The reported transactions involved an amendment of an outstanding warrant to reduce the exercise price from $2.00 to $1.00 per share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new warrant.

F1 · ownership.nature: These shares of Common Stock ("Shares") and Warrants to acquire Common Stock ("Warrants") are directly owned by the Tino Hans Schuler Trust. H. George Schuler is the sole trustee of the Tino Hans Schuler Trust.

F7 · ownership.nature: The reporting person disclaims beneficial ownership of these Shares and Warrants except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that he is the beneficial owner of the Shares and Warrants for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

SEC source: 0000905148-17-000774 · form4.xml · derivative · entry 4

SCHULER JACK W · CIK 0001021412 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 773,003

Underlying: Common Stock · 773,003 shares

Expires 2017-08-31

F3 · derivative.exercise_price: To the extent that any part of this warrant is not exercised by August 31, 2017, the exercise price of the warrant will revert to $2.00 per share and the warrant will expire on December 23, 2017.

F2 · kind: The two reported transactions involved an amendment of an outstanding warrant to reduce the exercise price from $2.00 to $1.00 per share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new warrant.

F2 · price: The two reported transactions involved an amendment of an outstanding warrant to reduce the exercise price from $2.00 to $1.00 per share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new warrant.

F3 · derivative.expiration_date: To the extent that any part of this warrant is not exercised by August 31, 2017, the exercise price of the warrant will revert to $2.00 per share and the warrant will expire on December 23, 2017.

F1 · ownership.nature: These shares of Common Stock and Warrants to acquire Common Stock are directly owned by the Jack W. Schuler Living Trust. Jack W. Schuler is the sole trustee of the Jack W. Schuler Living Trust.

SEC source: 0000905148-17-000774 · form4.xml · derivative · entry 3

SCHULER JACK W · CIK 0001021412 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 773,003 shares

Expires 2017-12-23

F2 · kind: The two reported transactions involved an amendment of an outstanding warrant to reduce the exercise price from $2.00 to $1.00 per share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new warrant.

F2 · price: The two reported transactions involved an amendment of an outstanding warrant to reduce the exercise price from $2.00 to $1.00 per share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new warrant.

F1 · ownership.nature: These shares of Common Stock and Warrants to acquire Common Stock are directly owned by the Jack W. Schuler Living Trust. Jack W. Schuler is the sole trustee of the Jack W. Schuler Living Trust.

SEC source: 0001140361-17-033837 · doc1.xml · derivative · entry 2

FEINBERG LARRY N · CIK 0000926475 · 10% owner · * See Remarks

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner · * See Remarks

Oracle Ten Fund Master, LP · CIK 0001577258 · 10% owner · * See Remarks

ORACLE INSTITUTIONAL PARTNERS L P · CIK 0000924141 · 10% owner · * See Remarks

Oracle Associates LLC · CIK 0001317217 · 10% owner · * See Remarks

ORACLE INVESTMENT MANAGEMENT INC · CIK 0001012622 · 10% owner · * See Remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 583,333

Underlying: Common Stock · 583,333 shares

Expires 2017-08-31

F3 · derivative.exercise_price: See Exhibit 99.1, Note 3.

F2 · kind: See Exhibit 99.1, Note 2.

F2 · price: See Exhibit 99.1, Note 2.

F3 · derivative.expiration_date: See Exhibit 99.1, Note 3.

F1 · ownership.nature: See Exhibit 99.1, Note1.

SEC source: 0001140361-17-033837 · doc1.xml · derivative · entry 1

FEINBERG LARRY N · CIK 0000926475 · 10% owner · * See Remarks

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner · * See Remarks

Oracle Ten Fund Master, LP · CIK 0001577258 · 10% owner · * See Remarks

ORACLE INSTITUTIONAL PARTNERS L P · CIK 0000924141 · 10% owner · * See Remarks

Oracle Associates LLC · CIK 0001317217 · 10% owner · * See Remarks

ORACLE INVESTMENT MANAGEMENT INC · CIK 0001012622 · 10% owner · * See Remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 583,333 shares

Expires 2017-12-23

F2 · kind: See Exhibit 99.1, Note 2.

F2 · price: See Exhibit 99.1, Note 2.

F1 · ownership.nature: See Exhibit 99.1, Note1.

SEC source: 0001623017-17-000006 · primary_doc.xml · nonDerivative · entry 1

Palmieri Valerie Barber · CIK 0001623017 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 59,865

F1 · shares: The purchase reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 25, 2017.

SEC source: 0001623017-17-000005 · primary_doc.xml · nonDerivative · entry 1

Palmieri Valerie Barber · CIK 0001623017 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 59,097

SEC source: 0001637904-17-000002 · primary_doc.xml · derivative · entry 1

FERRARA FRED · CIK 0001637904 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2027-03-23

F1 · derivative.exercise_date: The option vests in four equal annual installments beginning on March 23, 2018.

SEC source: 0001623017-17-000004 · primary_doc.xml · derivative · entry 1

Palmieri Valerie Barber · CIK 0001623017 · Director · President and Chief Executive

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 450,000

Underlying: Common Stock · 450,000 shares

Expires 2027-03-23

F1 · derivative.exercise_date: The option vests in four equal annual installments beginning on March 23, 2018.

SEC source: 0001255627-17-000001 · primary_doc.xml · nonDerivative · entry 1

SCHREIBER DAVID · CIK 0001255627 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 88,205

F1 · shares: The shares of common stock represent restricted stock units with contingent right to receive one share of common stock of Vermillion, Inc. for each restricted stock unit. 50% of the restricted stock units will vest on June 1, 2017, 25% of the restricted stock units will vest on September 1, 2017 and 25% of the restricted stock units will vest on December 1, 2017.

SEC source: 0001532303-17-000002 · primary_doc.xml · derivative · entry 1

Schoen Eric · CIK 0001532303 · SVP Finance & CAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2027-03-23

F1 · derivative.exercise_date: The option vests in four equal annual installments beginning on March 23, 2018.

SEC source: 0001488364-17-000001 · primary_doc.xml · nonDerivative · entry 1

Severinghaus Carl · CIK 0001488364 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 212,296

F1 · shares: The shares of common stock represent restricted stock units with contingent right to receive one share of common stock of Vermillion, Inc. for each restricted stock unit. 50% of the restricted stock units will vest on June 1, 2017, 25% of the restricted stock units will vest on September 1, 2017 and 25% of the restricted stock units will vest on December 1, 2017.

SEC source: 0001162956-17-000002 · primary_doc.xml · nonDerivative · entry 1

LAFRANCE JAMES T · CIK 0001162956 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 225,418

F1 · shares: The shares of common stock represent restricted stock units with contingent right to receive one share of common stock of Vermillion, Inc. for each restricted stock unit. 50% of the restricted stock units will vest on June 1, 2017, 25% of the restricted stock units will vest on September 1, 2017 and 25% of the restricted stock units will vest on December 1, 2017.

SEC source: 0000926617-17-000019 · certent-form4.xml · nonDerivative · entry 1

Jordan Veronica GH · CIK 0001381123 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 95,917

F1 · shares: The shares of common stock represent restricted stock units with contingent right to receive one share of common stock of Vermillion, Inc. for each restricted stock unit. 50% of the restricted stock units will vest on June 1, 2017, 25% of the restricted stock units will vest on September 1, 2017 and 25% of the restricted stock units will vest on December 1, 2017.

SEC source: 0001294046-17-000002 · primary_doc.xml · nonDerivative · entry 1

Burns James S · CIK 0001294046 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 288,607

F1 · shares: The shares of common stock represent restricted stock units with contingent right to receive one share of common stock of Vermillion, Inc. for each restricted stock unit. 50% of the restricted stock units will vest on June 1, 2017, 25% of the restricted stock units will vest on September 1, 2017 and 25% of the restricted stock units will vest on December 1, 2017.

SEC source: 0001140361-17-008151 · doc1.xml · derivative · entry 2

FEINBERG LARRY N · CIK 0000926475 · 10% owner · * See Remarks

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Oracle Ten Fund Master, LP · CIK 0001577258 · 10% owner

ORACLE INSTITUTIONAL PARTNERS L P · CIK 0000924141 · 10% owner

Oracle Associates LLC · CIK 0001317217 · 10% owner

ORACLE INVESTMENT MANAGEMENT INC · CIK 0001012622 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 583,333 shares

Expires 2022-02-13

F2 · derivative.exercise_price: See Exhibit 99.1, Note 2.

F3 · price: See Exhibit 99.1, Note 3.

F1 · ownership.nature: See Exhibit 99.1, Note 1.

SEC source: 0001140361-17-008151 · doc1.xml · nonDerivative · entry 1

FEINBERG LARRY N · CIK 0000926475 · 10% owner · * See Remarks

ORACLE PARTNERS LP · CIK 0000941901 · 10% owner

Oracle Ten Fund Master, LP · CIK 0001577258 · 10% owner

ORACLE INSTITUTIONAL PARTNERS L P · CIK 0000924141 · 10% owner

Oracle Associates LLC · CIK 0001317217 · 10% owner

ORACLE INVESTMENT MANAGEMENT INC · CIK 0001012622 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 9,825,289

F1 · price: See Exhibit 99.1, Note 1.

F1 · ownership.nature: See Exhibit 99.1, Note 1.

SEC source: 0000905148-17-000363 · form4.xml · derivative · entry 11

Schuler Henri George · CIK 0001629151 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Schuler GC 2010 Continuation Trust

Disclosed balance after: 365,072

Underlying: Common Stock · 365,072 shares

Expires 2022-02-17

F4 · ownership.nature: These Shares are directly owned by the Schuler GC 2010 Continuation Trust. H. George Schuler is the sole trustee of the Schuler GC 2010 Continuation Trust.

F7 · ownership.nature: The reporting person disclaims beneficial ownership of these Shares except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that he is the beneficial owner of the Shares for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

SEC source: 0000905148-17-000363 · form4.xml · derivative · entry 10

Schuler Henri George · CIK 0001629151 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Therese Heidi Schuler Trust

Disclosed balance after: 365,072

Underlying: Common Stock · 365,072 shares

Expires 2022-02-17

F3 · ownership.nature: These Shares are directly owned by the Therese Heidi Schuler Trust. H. George Schuler is the sole trustee of the Therese Heidi Schuler Trust.

F7 · ownership.nature: The reporting person disclaims beneficial ownership of these Shares except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that he is the beneficial owner of the Shares for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

SEC source: 0000905148-17-000363 · form4.xml · derivative · entry 9

Schuler Henri George · CIK 0001629151 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Tanya Eve Schuler Trust

Disclosed balance after: 365,072

Underlying: Common Stock · 365,072 shares

Expires 2022-02-17

F2 · ownership.nature: These Shares are directly owned by the Tanya Eve Schuler Trust. H. George Schuler is the sole trustee of the Tanya Eve Schuler Trust.

F7 · ownership.nature: The reporting person disclaims beneficial ownership of these Shares except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that he is the beneficial owner of the Shares for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

SEC source: 0000905148-17-000363 · form4.xml · derivative · entry 8

Schuler Henri George · CIK 0001629151 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Tino Hans Schuler Trust

Disclosed balance after: 365,072

Underlying: Common Stock · 365,072 shares

Expires 2022-02-17

F1 · ownership.nature: These shares of common stock ("Shares") are directly owned by the Tino Hans Schuler Trust. H. George Schuler is the sole trustee of the Tino Hans Schuler Trust.

F7 · ownership.nature: The reporting person disclaims beneficial ownership of these Shares except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that he is the beneficial owner of the Shares for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

SEC source: 0000905148-17-000363 · form4.xml · nonDerivative · entry 4

Schuler Henri George · CIK 0001629151 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Schuler GC 2010 Continuation Trust

Disclosed balance after: 726,671

F4 · ownership.nature: These Shares are directly owned by the Schuler GC 2010 Continuation Trust. H. George Schuler is the sole trustee of the Schuler GC 2010 Continuation Trust.

F7 · ownership.nature: The reporting person disclaims beneficial ownership of these Shares except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that he is the beneficial owner of the Shares for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

SEC source: 0000905148-17-000363 · form4.xml · nonDerivative · entry 3

Schuler Henri George · CIK 0001629151 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Therese Heidi Schuler Trust

Disclosed balance after: 2,325,319

F3 · ownership.nature: These Shares are directly owned by the Therese Heidi Schuler Trust. H. George Schuler is the sole trustee of the Therese Heidi Schuler Trust.

F7 · ownership.nature: The reporting person disclaims beneficial ownership of these Shares except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that he is the beneficial owner of the Shares for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

SEC source: 0000905148-17-000363 · form4.xml · nonDerivative · entry 2

Schuler Henri George · CIK 0001629151 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Tanya Eve Schuler Trust

Disclosed balance after: 2,325,319

F2 · ownership.nature: These Shares are directly owned by the Tanya Eve Schuler Trust. H. George Schuler is the sole trustee of the Tanya Eve Schuler Trust.

F7 · ownership.nature: The reporting person disclaims beneficial ownership of these Shares except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that he is the beneficial owner of the Shares for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

SEC source: 0000905148-17-000363 · form4.xml · nonDerivative · entry 1

Schuler Henri George · CIK 0001629151 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Tino Hans Schuler Trust

Disclosed balance after: 2,325,319

F1 · ownership.nature: These shares of common stock ("Shares") are directly owned by the Tino Hans Schuler Trust. H. George Schuler is the sole trustee of the Tino Hans Schuler Trust.

F7 · ownership.nature: The reporting person disclaims beneficial ownership of these Shares except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that he is the beneficial owner of the Shares for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

SEC source: 0000905148-17-000362 · form4.xml · derivative · entry 3

SCHULER JACK W · CIK 0001021412 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 730,560

Underlying: Common Stock · 730,560 shares

Expires 2022-02-17

F1 · ownership.nature: These shares of common stock are directly owned by the Jack W. Schuler Living Trust. Jack W. Schuler is the sole trustee of the Jack W. Schuler Living Trust.

SEC source: 0000905148-17-000362 · form4.xml · nonDerivative · entry 1

SCHULER JACK W · CIK 0001021412 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 3,132,220

F1 · ownership.nature: These shares of common stock are directly owned by the Jack W. Schuler Living Trust. Jack W. Schuler is the sole trustee of the Jack W. Schuler Living Trust.

SEC source: 0000926617-17-000008 · certent-form4.xml · derivative · entry 2

Jordan Veronica GH · CIK 0001381123 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,021

Underlying: Common Stock · 5,021 shares

Expires 2022-02-17

SEC source: 0000926617-17-000008 · certent-form4.xml · nonDerivative · entry 1

Jordan Veronica GH · CIK 0001381123 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 70,315

SEC source: 0001637904-17-000001 · primary_doc.xml · derivative · entry 2

FERRARA FRED · CIK 0001637904 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,021

Underlying: Common Stock · 5,021 shares

Expires 2022-02-17

SEC source: 0001637904-17-000001 · primary_doc.xml · nonDerivative · entry 1

FERRARA FRED · CIK 0001637904 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,695

SEC source: 0001623017-17-000003 · primary_doc.xml · derivative · entry 2

Palmieri Valerie Barber · CIK 0001623017 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,531

Underlying: Common Stock · 7,531 shares

Expires 2022-02-17

SEC source: 0001623017-17-000003 · primary_doc.xml · nonDerivative · entry 1

Palmieri Valerie Barber · CIK 0001623017 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 58,542

SEC source: 0001532303-17-000001 · primary_doc.xml · derivative · entry 2

Schoen Eric · CIK 0001532303 · Sr VP Finance & CAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,510

Underlying: Common Stock · 2,510 shares

Expires 2022-02-17

SEC source: 0001532303-17-000001 · primary_doc.xml · nonDerivative · entry 1

Schoen Eric · CIK 0001532303 · Sr VP Finance & CAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,872

SEC source: 0001294046-17-000001 · primary_doc.xml · derivative · entry 2

Burns James S · CIK 0001294046 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,250

Underlying: Common Stock · 11,250 shares

Expires 2022-02-17

SEC source: 0001294046-17-000001 · primary_doc.xml · nonDerivative · entry 1

Burns James S · CIK 0001294046 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 265,922

SEC source: 0001162956-17-000001 · primary_doc.xml · derivative · entry 2

LAFRANCE JAMES T · CIK 0001162956 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,021

Underlying: Common Stock · 5,021 shares

Expires 2022-02-17

SEC source: 0001162956-17-000001 · primary_doc.xml · nonDerivative · entry 1

LAFRANCE JAMES T · CIK 0001162956 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 190,094