AVTX

SEC source: 0001918845-26-000008 · form4-04082026_080437.xml · derivative · entry 3

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 210,530

Underlying: Common Stock · 3,970 shares

Expires 2034-07-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

F3 · derivative.exercise_date: The stock option vests twenty-five percent (25%) on July 15, 2025 and the remainder will vest in equal monthly installments over the following three (3) years, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001918845-26-000008 · form4-04082026_080437.xml · nonDerivative · entry 2

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,622

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

F2 · price: The reported securities were sold in multiple transactions at prices ranging from $18.00 to $18.10. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range.

SEC source: 0001918845-26-000008 · form4-04082026_080437.xml · nonDerivative · entry 1

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,592

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

SEC source: 0001810417-26-000006 · form4-04032026_070439.xml · nonDerivative · entry 4

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 17,338

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 12, 2025.

F5 · price: The reported securities were sold in multiple transactions at prices ranging from $17.39 to $17.80. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range.

SEC source: 0001810417-26-000006 · form4-04032026_070439.xml · nonDerivative · entry 3

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 19,118

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 12, 2025.

F4 · price: The reported securities were sold in multiple transactions at prices ranging from $16.385 to $17.37. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range.

SEC source: 0001810417-26-000006 · form4-04032026_070439.xml · nonDerivative · entry 2

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,318

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 12, 2025.

F3 · price: The reported securities were sold in multiple transactions at prices ranging from $16.45 to $17.38. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range.

SEC source: 0001810417-26-000006 · form4-04032026_070439.xml · nonDerivative · entry 1

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 32,797

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 12, 2025.

F2 · price: The reported securities were sold in multiple transactions at prices ranging from $15.24 to $16.21. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range.

SEC source: 0001918845-26-000006 · form4-04032026_070418.xml · derivative · entry 3

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 148,329

Underlying: Common Stock · 679 shares

Expires 2035-01-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

F2 · derivative.exercise_date: The stock option vests twenty-five percent (25%) on January 28, 2026 and the remainder will vest in equal monthly installments over the following three (3) years, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001918845-26-000006 · form4-04032026_070418.xml · nonDerivative · entry 2

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,622

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

SEC source: 0001918845-26-000006 · form4-04032026_070418.xml · nonDerivative · entry 1

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,301

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

SEC source: 0001707797-26-000003 · form4-04012026_040410.xml · derivative · entry 1

Jain Rita · CIK 0001707797 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,339

Underlying: Common Stock · 1,339 shares

Expires 2036-03-31

F1 · derivative.exercise_date: The options were granted on March 31, 2026, and are 100% vested.

SEC source: 0001677036-26-000002 · form4-04012026_040408.xml · derivative · entry 1

Lind Kevin Robert · CIK 0001677036 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,370

Underlying: Common Stock · 1,370 shares

Expires 2036-03-31

F1 · derivative.exercise_date: The options were granted on March 31, 2026, and are 100% vested.

SEC source: 0002017156-26-000002 · form4-03312026_080309.xml · derivative · entry 2

Truex Samantha · CIK 0002017156 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,167

Underlying: Common Stock · 3,166 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F2 · derivative.exercise_date: On August 13, 2024, the Reporting Person was granted 9,500 restricted stock units, vesting 1/3 on March 28, 2025, March 28, 2026, and March 28, 2027, subject to the Reporting Person's continued service on such vesting date.

F2 · derivative.expiration_date: On August 13, 2024, the Reporting Person was granted 9,500 restricted stock units, vesting 1/3 on March 28, 2025, March 28, 2026, and March 28, 2027, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0002017156-26-000002 · form4-03312026_080309.xml · nonDerivative · entry 1

Truex Samantha · CIK 0002017156 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,333

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0002013869-26-000002 · form4-03312026_080309.xml · derivative · entry 2

Goldman Jonathan · CIK 0002013869 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,167

Underlying: Common Stock · 3,166 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F2 · derivative.exercise_date: On August 13, 2024, the Reporting Person was granted 9,500 restricted stock units, vesting 1/3 on March 28, 2025, March 28, 2026, and March 28, 2027, subject to the Reporting Person's continued service on such vesting date.

F2 · derivative.expiration_date: On August 13, 2024, the Reporting Person was granted 9,500 restricted stock units, vesting 1/3 on March 28, 2025, March 28, 2026, and March 28, 2027, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0002013869-26-000002 · form4-03312026_080309.xml · nonDerivative · entry 1

Goldman Jonathan · CIK 0002013869 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,166

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001862734-26-000002 · form4-03312026_080342.xml · derivative · entry 2

KANTOFF AARON · CIK 0001862734 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,167

Underlying: Common Stock · 3,166 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F2 · derivative.exercise_date: On August 13, 2024, the Reporting Person was granted 9,500 restricted stock units, vesting 1/3 on March 28, 2025, March 28, 2026, and March 28, 2027, subject to the Reporting Person's continued service on such vesting date.

F2 · derivative.expiration_date: On August 13, 2024, the Reporting Person was granted 9,500 restricted stock units, vesting 1/3 on March 28, 2025, March 28, 2026, and March 28, 2027, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001862734-26-000002 · form4-03312026_080342.xml · nonDerivative · entry 1

KANTOFF AARON · CIK 0001862734 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,333

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001810417-26-000004 · form4-03312026_080330.xml · derivative · entry 3

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,200

Underlying: Common Stock · 24,200 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F2 · derivative.exercise_date: On August 13, 2024, the Reporting Person was granted 72,600 restricted stock units, vesting 1/3 on March 28, 2025, March 28, 2026, and March 28, 2027, subject to the Reporting Person's continued service on such vesting date.

F2 · derivative.expiration_date: On August 13, 2024, the Reporting Person was granted 72,600 restricted stock units, vesting 1/3 on March 28, 2025, March 28, 2026, and March 28, 2027, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001810417-26-000004 · form4-03312026_080330.xml · nonDerivative · entry 2

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,297

SEC source: 0001810417-26-000004 · form4-03312026_080330.xml · nonDerivative · entry 1

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 41,538

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001247024-26-000002 · form4-03312026_080359.xml · derivative · entry 2

KAPLAN GILLA · CIK 0001247024 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,167

Underlying: Common Stock · 3,166 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F2 · derivative.exercise_date: On August 13, 2024, the Reporting Person was granted 9,500 restricted stock units, vesting 1/3 on March 28, 2025, March 28, 2026, and March 28, 2027, subject to the Reporting Person's continued service on such vesting date.

F2 · derivative.expiration_date: On August 13, 2024, the Reporting Person was granted 9,500 restricted stock units, vesting 1/3 on March 28, 2025, March 28, 2026, and March 28, 2027, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001247024-26-000002 · form4-03312026_080359.xml · nonDerivative · entry 1

KAPLAN GILLA · CIK 0001247024 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,333

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001586785-26-000004 · form4-03312026_080315.xml · derivative · entry 3

NEIL GARRY ARTHUR · CIK 0001586785 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 64,867

Underlying: Common Stock · 64,866 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F2 · derivative.exercise_date: On August 13, 2024, the Reporting Person was granted 194,600 restricted stock units, vesting 1/3 on March 28, 2025, March 28, 2026, and March 28, 2027, subject to the Reporting Person's continued service on such vesting date.

F2 · derivative.expiration_date: On August 13, 2024, the Reporting Person was granted 194,600 restricted stock units, vesting 1/3 on March 28, 2025, March 28, 2026, and March 28, 2027, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001586785-26-000004 · form4-03312026_080315.xml · nonDerivative · entry 2

NEIL GARRY ARTHUR · CIK 0001586785 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 90,114

SEC source: 0001586785-26-000004 · form4-03312026_080315.xml · nonDerivative · entry 1

NEIL GARRY ARTHUR · CIK 0001586785 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 112,006

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001789335-26-000004 · form4-03312026_080349.xml · derivative · entry 2

Chan Mitchell · CIK 0001789335 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,167

Underlying: Common Stock · 3,166 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F2 · derivative.exercise_date: On August 13, 2024, the Reporting Person was granted 9,500 restricted stock units, vesting 1/3 on March 28, 2025, March 28, 2026, and March 28, 2027, subject to the Reporting Person's continued service on such vesting date.

F2 · derivative.expiration_date: On August 13, 2024, the Reporting Person was granted 9,500 restricted stock units, vesting 1/3 on March 28, 2025, March 28, 2026, and March 28, 2027, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001789335-26-000004 · form4-03312026_080349.xml · nonDerivative · entry 1

Chan Mitchell · CIK 0001789335 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,333

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001918845-26-000004 · form4-03182026_080310.xml · derivative · entry 5

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 149,008

Underlying: Common Stock · 5,992 shares

Expires 2035-01-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock option vests twenty-five percent (25%) on January 28, 2026 and the remainder will vest in equal monthly installments over the following three (3) years, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001918845-26-000004 · form4-03182026_080310.xml · derivative · entry 4

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 214,500

Underlying: Common Stock · 19,500 shares

Expires 2034-07-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock option vests twenty-five percent (25%) on July 15, 2025 and the remainder will vest in equal monthly installments over the following three (3) years, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001918845-26-000004 · form4-03182026_080310.xml · nonDerivative · entry 3

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,622

F1 · price: The reported securities were sold in multiple transactions at prices ranging from $16.00 to $16.34. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range.

SEC source: 0001918845-26-000004 · form4-03182026_080310.xml · nonDerivative · entry 2

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 29,114

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001918845-26-000004 · form4-03182026_080310.xml · nonDerivative · entry 1

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,122

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0002090172-26-000002 · form4-03022026_090334.xml · derivative · entry 1

Boyd Taylor · CIK 0002090172 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 95,000

Underlying: Common Stock · 95,000 shares

Expires 2036-02-26

F1 · derivative.exercise_date: The stock option vests twenty-five percent (25%) on February 26, 2027 and the remainder will vest in equal monthly installments over the following three (3) years, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0002047607-26-000002 · form4-03022026_090329.xml · derivative · entry 1

Riley Jennifer · CIK 0002047607 · Chief Strategy Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 95,000

Underlying: Common Stock · 95,000 shares

Expires 2036-02-26

F1 · derivative.exercise_date: The stock option vests twenty-five percent (25%) on February 26, 2027 and the remainder will vest in equal monthly installments over the following three (3) years, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001810417-26-000002 · form4-03022026_090301.xml · derivative · entry 1

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 105,000

Underlying: Common Stock · 105,000 shares

Expires 2036-02-26

F1 · derivative.exercise_date: The stock option vests twenty-five percent (25%) on February 26, 2027 and the remainder will vest in equal monthly installments over the following three (3) years, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001677896-26-000002 · form4-03022026_090313.xml · derivative · entry 1

VARKI PAUL · CIK 0001677896 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 80,000

Underlying: Common Stock · 80,000 shares

Expires 2036-02-26

F1 · derivative.exercise_date: The stock option vests twenty-five percent (25%) on February 26, 2027 and the remainder will vest in equal monthly installments over the following three (3) years, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001918845-26-000002 · form4-03022026_090303.xml · derivative · entry 1

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 105,000

Underlying: Common Stock · 105,000 shares

Expires 2036-02-26

F1 · derivative.exercise_date: The stock option vests twenty-five percent (25%) on February 26, 2027 and the remainder will vest in equal monthly installments over the following three (3) years, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001586785-26-000002 · form4-03022026_090353.xml · derivative · entry 1

NEIL GARRY ARTHUR · CIK 0001586785 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 286,000

Underlying: Common Stock · 286,000 shares

Expires 2036-02-26

F1 · derivative.exercise_date: The stock option vests twenty-five percent (25%) on February 26, 2027 and the remainder will vest in equal monthly installments over the following three (3) years, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001470831-26-000007 · form4.xml · derivative · entry 1

Lind Kevin Robert · CIK 0001677036 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 848

Underlying: Common Stock · 848 shares

Expires 2035-12-31

F1 · derivative.exercise_date: The options were granted on December 31, 2025, and are 100% vested.

SEC source: 0001470831-26-000006 · form4.xml · derivative · entry 1

Jain Rita · CIK 0001707797 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,043

Underlying: Common Stock · 1,043 shares

Expires 2035-12-31

F1 · derivative.exercise_date: The options were granted on December 31, 2025, and are 100% vested.

SEC source: 0001470831-25-000411 · form4.xml · nonDerivative · entry 1

Riley Jennifer · CIK 0002047607 · Chief Strategy Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,655

F1 · balance_after: Includes 2,655 shares acquired pursuant to the Issuer's Employee Stock Purchase Plan as a part of this reporting transaction.

SEC source: 0001470831-25-000409 · form4.xml · nonDerivative · entry 1

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,338

F1 · balance_after: Includes 417 additional shares acquired pursuant to the Issuer's Employee Stock Purchase Plan as a part of this reporting transaction.

SEC source: 0001470831-25-000412 · form4.xml · nonDerivative · entry 1

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,622

F1 · balance_after: Includes 3,622 shares acquired pursuant to the Issuer's Employee Stock Purchase Plan as a part of this reporting transaction.

SEC source: 0001470831-25-000410 · form4.xml · nonDerivative · entry 1

VARKI PAUL · CIK 0001677896 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,634

F1 · balance_after: Includes 3,634 shares acquired pursuant to the Issuer's Employee Stock Purchase Plan as a part of this reporting transaction.

SEC source: 0002013869-25-000002 · primary_doc.xml · derivative · entry 4

Goldman Jonathan · CIK 0002013869 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,400

Underlying: Common Stock · 8,200 shares

Expires 2034-08-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock option vests 1/3 on March 28, 2025, March 28, 2026 and March 28, 2027, subject to the Eligible Director's continued service on such vesting date.

SEC source: 0002013869-25-000002 · primary_doc.xml · nonDerivative · entry 3

Goldman Jonathan · CIK 0002013869 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F1 · price: The reported securities were sold in multiple transactions at prices ranging from $14.02 to $14.60. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range.

SEC source: 0002013869-25-000002 · primary_doc.xml · nonDerivative · entry 2

Goldman Jonathan · CIK 0002013869 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,200

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0002013869-25-000002 · primary_doc.xml · nonDerivative · entry 1

Goldman Jonathan · CIK 0002013869 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

SEC source: 0001677036-25-000004 · primary_doc.xml · derivative · entry 1

Lind Kevin Robert · CIK 0001677036 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,200

Underlying: Common Stock · 40,200 shares

Expires 2035-10-01

F1 · derivative.exercise_date: The stock option vests in three substantially equal installments on the first, second and third anniversary of the date of grant, subject to the Eligible Director's continued service on each such vesting date.