AVTX

SEC source: 0001677036-26-000009 · form4-10022026_041018.xml · derivative · entry 1

Lind Kevin Robert · CIK 0001677036 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,352

Underlying: Common Stock · 1,352 shares

Expires 2036-09-30

F2 · price: The options were issued to the Reporting Person pursuant to the Issuer's Amended and Restated Non-Employee Director Compensation Plan in lieu of Board fees.

F1 · derivative.exercise_date: The options were granted on September 30, 2026, and are 100% vested.

SEC source: 0001707797-26-000017 · form4-10022026_041020.xml · derivative · entry 1

Jain Rita · CIK 0001707797 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,322

Underlying: Common Stock · 1,322 shares

Expires 2036-09-30

F2 · price: The options were issued to the Reporting Person pursuant to the Issuer's Amended and Restated Non-Employee Director Compensation Plan in lieu of Board fees.

F1 · derivative.exercise_date: The options were granted on September 30, 2026, and are 100% vested.

SEC source: 0002063957-26-000009 · form4-10022026_041016.xml · derivative · entry 1

Philip Ron M · CIK 0002063957 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,109

Underlying: Common Stock · 1,109 shares

Expires 2036-09-30

F2 · price: The options were issued to the Reporting Person pursuant to the Issuer's Amended and Restated Non-Employee Director Compensation Plan in lieu of Board fees.

F1 · derivative.exercise_date: The options were granted on September 30, 2026, and are 100% vested.

SEC source: 0001810417-26-000023 · form4-09182026_040901.xml · derivative · entry 3

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 83,848

Underlying: Common Stock · 12,394 shares

Expires 2034-08-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 18, 2026.

F3 · derivative.exercise_date: The stock option vests 25% on March 28, 2025, and 1/36 monthly thereafter, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001810417-26-000023 · form4-09182026_040901.xml · nonDerivative · entry 2

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 39,900

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 18, 2026.

F2 · price: The reported securities were sold in multiple transactions at prices ranging from $15.91 to $16.65. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range.

SEC source: 0001810417-26-000023 · form4-09182026_040901.xml · nonDerivative · entry 1

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 52,294

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 18, 2026.

SEC source: 0001810417-26-000021 · form4-09112026_040901.xml · derivative · entry 3

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 105,815

Underlying: Common Stock · 10,185 shares

Expires 2035-01-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 18, 2026.

F3 · derivative.exercise_date: The stock option vests twenty-five percent (25%) on January 28, 2026 and the remainder will vest in equal monthly installments over the following three (3) years, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001810417-26-000021 · form4-09112026_040901.xml · nonDerivative · entry 2

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 39,900

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 18, 2026.

F2 · price: The reported securities were sold in multiple transactions at prices ranging from $17.17 to $17.95. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range.

SEC source: 0001810417-26-000021 · form4-09112026_040901.xml · nonDerivative · entry 1

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 50,085

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 18, 2026.

SEC source: 0001918845-26-000031 · form4-09012026_080946.xml · derivative · entry 3

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 113,734

Underlying: Common Stock · 679 shares

Expires 2035-01-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

F2 · derivative.exercise_date: The stock option vests twenty-five percent (25%) on January 28, 2026 and the remainder will vest in equal monthly installments over the following three (3) years, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001918845-26-000031 · form4-09012026_080946.xml · nonDerivative · entry 2

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 51,776

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

SEC source: 0001918845-26-000031 · form4-09012026_080946.xml · nonDerivative · entry 1

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 52,455

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

SEC source: 0001810417-26-000019 · form4-08192026_040813.xml · derivative · entry 9

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 96,242

Underlying: Common Stock · 31,031 shares

Expires 2034-08-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The stock option vests 25% on March 28, 2025, and 1/36 monthly thereafter, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001810417-26-000019 · form4-08192026_040813.xml · nonDerivative · entry 6

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 39,900

F4 · price: The reported securities were sold in multiple transactions at prices ranging from $20.00 to $20.265. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range.

SEC source: 0001810417-26-000019 · form4-08192026_040813.xml · nonDerivative · entry 5

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 70,931

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001810417-26-000019 · form4-08192026_040813.xml · derivative · entry 8

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 127,273

Underlying: Common Stock · 2,876 shares

Expires 2034-08-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The stock option vests 25% on March 28, 2025, and 1/36 monthly thereafter, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001810417-26-000019 · form4-08192026_040813.xml · derivative · entry 7

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 130,149

Underlying: Common Stock · 37,945 shares

Expires 2034-08-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 18, 2026.

F5 · derivative.exercise_date: The stock option vests 25% on March 28, 2025, and 1/36 monthly thereafter, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001810417-26-000019 · form4-08192026_040813.xml · nonDerivative · entry 4

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 39,900

F3 · price: The reported securities were sold in multiple transactions at prices ranging from $19.70 to $20.02. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range.

SEC source: 0001810417-26-000019 · form4-08192026_040813.xml · nonDerivative · entry 3

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 43,649

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 18, 2026.

F2 · price: The reported securities were sold in multiple transactions at prices ranging from $19.16 to $20.02. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range.

SEC source: 0001810417-26-000019 · form4-08192026_040813.xml · nonDerivative · entry 2

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 81,594

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001810417-26-000019 · form4-08192026_040813.xml · nonDerivative · entry 1

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 78,718

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 18, 2026.

SEC source: 0001918845-26-000029 · form4-08192026_040810.xml · derivative · entry 3

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 123,750

Underlying: Common Stock · 1,000 shares

Expires 2034-07-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

F2 · derivative.exercise_date: The stock option vests twenty-five percent (25%) on July 15, 2025 and the remainder will vest in equal monthly installments over the following three (3) years, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001918845-26-000029 · form4-08192026_040810.xml · nonDerivative · entry 2

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 51,776

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

SEC source: 0001918845-26-000029 · form4-08192026_040810.xml · nonDerivative · entry 1

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 52,776

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

SEC source: 0002047607-26-000008 · form4-08122026_040809.xml · nonDerivative · entry 1

Riley Jennifer · CIK 0002047607 · Chief Strategy Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,041

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $19.54 to $19.65, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001918845-26-000026 · form4-08122026_040801.xml · derivative · entry 3

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 114,413

Underlying: Common Stock · 679 shares

Expires 2035-01-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

F2 · derivative.exercise_date: The stock option vests twenty-five percent (25%) on January 28, 2026 and the remainder will vest in equal monthly installments over the following three (3) years, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001918845-26-000026 · form4-08122026_040801.xml · nonDerivative · entry 2

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 51,776

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

SEC source: 0001918845-26-000026 · form4-08122026_040801.xml · nonDerivative · entry 1

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 52,455

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

SEC source: 0001918845-26-000024 · form4-07292026_040701.xml · derivative · entry 3

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 124,750

Underlying: Common Stock · 1,000 shares

Expires 2034-07-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

F2 · derivative.exercise_date: The stock option vests twenty-five percent (25%) on July 15, 2025 and the remainder will vest in equal monthly installments over the following three (3) years, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001918845-26-000024 · form4-07292026_040701.xml · nonDerivative · entry 2

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 51,776

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

SEC source: 0001918845-26-000024 · form4-07292026_040701.xml · nonDerivative · entry 1

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 52,776

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

SEC source: 0002063957-26-000007 · form4-07022026_040721.xml · derivative · entry 1

Philip Ron M · CIK 0002063957 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 69

Underlying: Common Stock · 69 shares

Expires 2036-06-30

F1 · derivative.exercise_date: The options were granted on June 30, 2026, and are 100% vested.

SEC source: 0001918845-26-000022 · form4-07022026_040722.xml · derivative · entry 5

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 115,092

Underlying: Common Stock · 1,779 shares

Expires 2035-01-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

F3 · derivative.exercise_date: The stock option vests twenty-five percent (25%) on January 28, 2026 and the remainder will vest in equal monthly installments over the following three (3) years, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001918845-26-000022 · form4-07022026_040722.xml · derivative · entry 4

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 125,750

Underlying: Common Stock · 2,875 shares

Expires 2034-07-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

F2 · derivative.exercise_date: The stock option vests twenty-five percent (25%) on July 15, 2025 and the remainder will vest in equal monthly installments over the following three (3) years, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001918845-26-000022 · form4-07022026_040722.xml · nonDerivative · entry 3

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 51,776

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

SEC source: 0001918845-26-000022 · form4-07022026_040722.xml · nonDerivative · entry 2

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 56,430

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

SEC source: 0001918845-26-000022 · form4-07022026_040722.xml · nonDerivative · entry 1

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 54,651

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

SEC source: 0001677036-26-000006 · form4-07022026_040719.xml · derivative · entry 1

Lind Kevin Robert · CIK 0001677036 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,105

Underlying: Common Stock · 1,105 shares

Expires 2036-06-30

F1 · derivative.exercise_date: The options were granted on June 30, 2026, and are 100% vested.

SEC source: 0001707797-26-000014 · form4-07022026_040717.xml · derivative · entry 1

Jain Rita · CIK 0001707797 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,080

Underlying: Common Stock · 1,080 shares

Expires 2036-06-30

F1 · derivative.exercise_date: The options were granted on June 30, 2026, and are 100% vested.

SEC source: 0002063957-26-000005 · form4-06252026_090620.xml · derivative · entry 1

Philip Ron M · CIK 0002063957 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,200

Underlying: Common Stock · 40,200 shares

Expires 2036-06-23

F1 · derivative.exercise_date: The stock option vests in three substantially equal annual installments on the first, second and third anniversary of the date of grant, subject to the Eligible Director's continued service on each such vesting date.

SEC source: 0001918845-26-000020 · form4-06252026_090648.xml · derivative · entry 3

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 116,871

Underlying: Common Stock · 1,450 shares

Expires 2035-01-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

F2 · derivative.exercise_date: The stock option vests twenty-five percent (25%) on January 28, 2026 and the remainder will vest in equal monthly installments over the following three (3) years, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001918845-26-000020 · form4-06252026_090648.xml · nonDerivative · entry 2

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 51,776

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

SEC source: 0001918845-26-000020 · form4-06252026_090648.xml · nonDerivative · entry 1

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 53,226

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 13, 2025.

SEC source: 0002047607-26-000006 · form4-06122026_080614.xml · nonDerivative · entry 1

Riley Jennifer · CIK 0002047607 · Chief Strategy Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,696

F1 · balance_after: Includes 3,429 shares acquired pursuant to the Issuer's Employee Stock Purchase Plan as a part of this reporting transaction.

SEC source: 0001810417-26-000016 · form4-06122026_080641.xml · nonDerivative · entry 1

Sullivan Christopher Ryan · CIK 0001810417 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,773

F1 · balance_after: Includes 588 shares acquired pursuant to the Issuer's Employee Stock Purchase Plan as a part of this reporting transaction.

SEC source: 0001677896-26-000008 · form4-06122026_080618.xml · nonDerivative · entry 1

VARKI PAUL · CIK 0001677896 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,576

F1 · balance_after: Includes 5,723 shares acquired pursuant to the Issuer's Employee Stock Purchase Plan as a part of this reporting transaction.

SEC source: 0001918845-26-000018 · form4-06122026_080645.xml · nonDerivative · entry 1

Doyle Mittie · CIK 0001918845 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,776

F1 · balance_after: Includes 5,738 shares acquired pursuant to the Issuer's Employee Stock Purchase Plan as a part of this reporting transaction.

SEC source: 0002017156-26-000004 · form4-06042026_040611.xml · derivative · entry 1

Truex Samantha · CIK 0002017156 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,100

Underlying: Common Stock · 20,100 shares

Expires 2036-06-02

F1 · derivative.exercise_date: The stock option vests 100% on the first anniversary of the date of grant, subject to the director's continued service on such vesting date.

SEC source: 0001862734-26-000004 · form4-06042026_040605.xml · derivative · entry 1

KANTOFF AARON · CIK 0001862734 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,100

Underlying: Common Stock · 20,100 shares

Expires 2036-06-02

F1 · derivative.exercise_date: The stock option vests 100% on the first anniversary of the date of grant, subject to the director's continued service on such vesting date.

SEC source: 0001448914-26-000004 · form4-06042026_040603.xml · derivative · entry 1

Heffernan Michael Thomas · CIK 0001448914 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,500

Underlying: Common Stock · 29,500 shares

Expires 2036-06-02

F1 · derivative.exercise_date: The stock option vests 100% on the first anniversary of the date of grant, subject to the director's continued service on such vesting date.