ATRA

SEC source: 0001209191-17-013442 · doc4.xml · nonDerivative · entry 1

MCGRATH JOHN · CIK 0001205442 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 150,827

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted July 6, 2016.

F2 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $14.90 to $15.65. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001209191-17-011765 · doc4.xml · nonDerivative · entry 2

Clark Mitchall G. · CIK 0001612094 · EVP & Chief R & QA Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 149,661

F3 · kind: Shares sold to cover tax obligation from settlement of vested restricted stock units.

F4 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted October 12, 2016.

SEC source: 0001209191-17-011763 · doc4.xml · nonDerivative · entry 3

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 348,978

F2 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted March 22, 2016.

F5 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $15.35 to $16.00. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F4 · ownership.nature: Shares are held by the Isaac E. Ciechanover and Allison M. Ciechanover Family Trust dated 8/8/08, of which the Reporting Person is a trustee.

SEC source: 0001209191-17-011766 · doc4.xml · nonDerivative · entry 4

Soffer Gad · CIK 0001612090 · EVP & Chief Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 269,027

F4 · kind: Shares sold to cover tax liability from settlement of RSUs.

F5 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $15.40 to $16.30. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001209191-17-011769 · doc4.xml · nonDerivative · entry 3

Gallagher Carol Giltner · CIK 0001329959 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 102,192

F2 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted October 14, 2016.

SEC source: 0001209191-17-011765 · doc4.xml · derivative · entry 3

Clark Mitchall G. · CIK 0001612094 · EVP & Chief R & QA Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,654

Underlying: Common Stock · 7,211 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock or a cash settlement.

F6 · derivative.exercise_date: The RSUs were granted with both (a) a liquidity event-based vesting condition and (b) a service-based vesting condition, both of which conditions must be satisfied in order for the RSUs to vest. The liquidity event-based condition was satisfied upon the closing of the Issuer's initial public offering (the "IPO"). The shares that vested on the closing date of the IPO, and the shares that vested thereafter through May 15, 2015, were settled on May 15, 2015. The service-based vesting condition provides that 25% of the total number of shares on March 17, 2015 and 1/48th of the total number of shares monthly thereafter, subject to the holder's continuous service through each such date.

F7 · derivative.expiration_date: The earlier of (i) March 27, 2021 or (ii) the recepient's termination date.

SEC source: 0001209191-17-011765 · doc4.xml · nonDerivative · entry 1

Clark Mitchall G. · CIK 0001612094 · EVP & Chief R & QA Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 152,720

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Shares issued upon settlement of vested restricted stock units ("RSUs").

F2 · balance_after: Includes 822 shares issued on November 30, 2016 pursuant to the Issuer's Employee Stock Purchase Plan.

SEC source: 0001209191-17-011763 · doc4.xml · derivative · entry 5

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,662

Underlying: Common Stock · 5,907 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock or a cash settlement.

F8 · derivative.exercise_date: The RSUs were granted with both (a) a liquidity event-based vesting condition and (b) a service-based vesting condition, both of which conditions must be satisfied in order for the RSUs to vest. The liquidity event-based condition was satisfied upon the closing of the Issuer's initial public offering (the "IPO"). The shares that vested on the closing date of the IPO, and the shares that vested thereafter through May 15, 2015, were settled on May 15, 2015. The service-based vesting condition provides that 1/48th of the total number of shares shall vest monthly from January 10, 2014, subject to the holder's continuous service through each such date.

F9 · derivative.expiration_date: The earlier of (i) January 10, 2021 or (ii) the recipient's termination date.

SEC source: 0001209191-17-011763 · doc4.xml · nonDerivative · entry 2

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 351,378

F2 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted March 22, 2016.

F3 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $15.35 to $16.00. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F4 · ownership.nature: Shares are held by the Isaac E. Ciechanover and Allison M. Ciechanover Family Trust dated 8/8/08, of which the Reporting Person is a trustee.

SEC source: 0001209191-17-011763 · doc4.xml · nonDerivative · entry 1

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 725,951

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Shares issued upon settlement of vested restricted stock units ("RSUs").

SEC source: 0001209191-17-011764 · doc4.xml · derivative · entry 5

Haqq Christopher · CIK 0001612095 · EVP, R&D & Chief Scientific Of

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,040

Underlying: Common Stock · 829 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock or a cash settlement.

F7 · derivative.exercise_date: The RSUs were granted with both (a) a liquidity event-based vesting condition and (b) a service-based vesting condition, both of which conditions must be satisfied in order for the RSUs to vest. The liquidity event-based condition was satisfied upon the closing of the Issuer's initial public offering (the "IPO"). The shares that vested on the closing date of the IPO, and the shares that vested thereafter through May 15, 2015, were settled on May 15, 2015. The service-based vesting condition provides that 1/48th of the total number of shares shall vest monthly from January 10, 2014, subject to the holder's continuous service through each such date.

F8 · derivative.expiration_date: The earlier of (i) January 10, 2021 or (ii) the recipient's termination date.

SEC source: 0001209191-17-011764 · doc4.xml · nonDerivative · entry 2

Haqq Christopher · CIK 0001612095 · EVP, R&D & Chief Scientific Of

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 392,855

F2 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted December 7, 2015.

F3 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $15.30 to $15.70. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001209191-17-011764 · doc4.xml · nonDerivative · entry 1

Haqq Christopher · CIK 0001612095 · EVP, R&D & Chief Scientific Of

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 400,459

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Shares issued upon settlement of vested restricted stock units ("RSUs").

SEC source: 0001209191-17-011766 · doc4.xml · derivative · entry 6

Soffer Gad · CIK 0001612090 · EVP & Chief Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,201

Underlying: Common Stock · 4,146 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock or a cash settlement.

F9 · derivative.exercise_date: The RSUs were granted with both (a) a liquidity event-based vesting condition and (b) a service-based vesting condition, both of which conditions must be satisfied in order for the RSUs to vest. The liquidity event-based condition was satisfied upon the closing of the Issuer's initial public offering (the "IPO"). The shares that vested on the closing date of the IPO, and the shares that vested thereafter through May 15, 2015, were settled on May 15, 2015. The service-based vesting condition provides that 1/48th of the total number of shares shall vest monthly from January 10, 2014, subject to the holder's continuous service through each such date.

F10 · derivative.expiration_date: The earlier of (i) January 10, 2021 or (ii) the recipient's termination date.

SEC source: 0001209191-17-011766 · doc4.xml · derivative · entry 5

Soffer Gad · CIK 0001612090 · EVP & Chief Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,410

Underlying: Common Stock · 9,616 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock or a cash settlement.

F7 · derivative.exercise_date: The RSUs were granted with both (a) a liquidity event-based vesting condition and (b) a service-based vesting condition, both of which conditions must be satisfied in order for the RSUs to vest. The liquidity event-based condition was satisfied upon the closing of the Issuer's initial public offering (the "IPO"). The shares that vested on the closing date of the IPO, and the shares that vested thereafter through May 15, 2015, were settled on May 15, 2015. The service-based vesting condition provides that 25% of the total number of shares on March 25, 2014 and 1/48th of the total number of shares monthly thereafter, subject to the holder's continuous service through each such date.

F8 · derivative.expiration_date: The earlier of (i) March 13, 2020 or (ii) the recipient's termination date.

SEC source: 0001209191-17-011766 · doc4.xml · nonDerivative · entry 3

Soffer Gad · CIK 0001612090 · EVP & Chief Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 276,300

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: Shares issued upon settlement of vested restricted stock units ("RSUs").

SEC source: 0001209191-17-011766 · doc4.xml · nonDerivative · entry 2

Soffer Gad · CIK 0001612090 · EVP & Chief Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 272,154

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: Shares issued upon settlement of vested restricted stock units ("RSUs").

SEC source: 0001209191-17-011768 · doc4.xml · derivative · entry 4

MCGRATH JOHN · CIK 0001205442 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 28,224

Underlying: Common Stock · 7,697 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock or a cash settlement.

F6 · derivative.exercise_date: The RSUs were granted with both (a) a liquidity event-based vesting condition and (b) a service-based vesting condition, both of which conditions must be satisfied in order for the RSUs to vest. The liquidity event-based condition was satisfied upon the closing of the Issuer's initial public offering (the "IPO"). The shares that vested on the closing date of the IPO, and the shares that vested thereafter through May 15, 2015, were settled on May 15, 2015. The service-based vesting condition provides that 25% of the total number of shares on January 6, 2015 and 1/48th of the total number of shares monthly thereafter, subject to the holder's continuous service through each such date.

F7 · derivative.expiration_date: The earlier of (i) December 12, 2020 or (ii) the recipient's termination date.

F5 · ownership.nature: The shares are held by the David B. Horowitz and John McGrath Jr. Revocable Living Trust dated 6/3/11, of which the Reporting Person is trustee.

SEC source: 0001209191-17-011768 · doc4.xml · derivative · entry 3

MCGRATH JOHN · CIK 0001205442 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 935

Underlying: Common Stock · 2,804 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock or a cash settlement.

F3 · derivative.exercise_date: The RSUs were granted with both (a) a liquidity event-based vesting condition and (b) a service-based vesting condition, both of which conditions must be satisfied in order for the RSUs to vest. The liquidity event-based condition was satisfied upon the closing of the Issuer's initial public offering (the "IPO"). The shares that vested on the closing date of the IPO, and the shares that vested thereafter through May 15, 2015, were settled on May 15, 2015. The service-based vesting condition provides that 25% of the total number of shares on March 13, 2014 and 1/48th of the total number of shares monthly thereafter, subject to the holder's continuous service through each such date.

F4 · derivative.expiration_date: The earlier of (i) March 13, 2020 or (ii) the recepient's termination date.

F5 · ownership.nature: The shares are held by the David B. Horowitz and John McGrath Jr. Revocable Living Trust dated 6/3/11, of which the Reporting Person is trustee.

SEC source: 0001209191-17-011768 · doc4.xml · nonDerivative · entry 2

MCGRATH JOHN · CIK 0001205442 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 159,827

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Shares issued upon settlement of vested restricted stock units ("RSUs").

SEC source: 0001209191-17-011768 · doc4.xml · nonDerivative · entry 1

MCGRATH JOHN · CIK 0001205442 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 152,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Shares issued upon settlement of vested restricted stock units ("RSUs").

SEC source: 0001209191-17-011769 · doc4.xml · derivative · entry 5

Gallagher Carol Giltner · CIK 0001329959 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,814

Underlying: Common Stock · 817 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock or a cash settlement.

F6 · derivative.exercise_date: The restricted stock units ("RSUs") were granted with both (a) a liquidity event-based vesting condition and (b) a service-based vesting condition, both of which conditions must be satisfied in order for the RSUs to vest. The liquidity event-based condition was satisfied upon the closing of the Issuer's initial public offering (the "IPO"). The shares that vested on the closing date of the IPO, and the shares that vested thereafter through August 17, 2015, were settled on August 17, 2015. The service-based vesting condition provides that 1/48th of the total number of shares vest monthly from March 25, 2014, subject to the holder's continuous service through each such date.

F7 · derivative.expiration_date: The earlier of (i) March 27, 2021 or (ii) the recipient's termination date.

SEC source: 0001209191-17-011769 · doc4.xml · derivative · entry 4

Gallagher Carol Giltner · CIK 0001329959 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,194

Underlying: Common Stock · 1,548 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock or a cash settlement.

F4 · derivative.exercise_date: The restricted stock units ("RSUs") were granted with both (a) a liquidity event-based vesting condition and (b) a service-based vesting condition, both of which conditions must be satisfied in order for the RSUs to vest. The liquidity event-based condition was satisfied upon the closing of the Issuer's initial public offering (the "IPO"). The shares that vested on the closing date of the IPO, and the shares that vested thereafter through August 17, 2015, were settled on August 17, 2015. The service-based vesting condition provides that 1/48th of the total number of shares vest monthly from January 30, 2014, subject to the holder's continuous service through each such date.

F5 · derivative.expiration_date: The earlier of (i) January 30, 2021 or (ii) the second anniversary of termination date.

SEC source: 0001209191-17-011769 · doc4.xml · nonDerivative · entry 2

Gallagher Carol Giltner · CIK 0001329959 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,375

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Shares issued upon settlement of vested restricted stock units.

SEC source: 0001209191-17-011769 · doc4.xml · nonDerivative · entry 1

Gallagher Carol Giltner · CIK 0001329959 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 102,558

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Shares issued upon settlement of vested restricted stock units.

SEC source: 0001209191-17-011767 · doc4.xml · derivative · entry 2

Fust Matthew K · CIK 0001397266 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,944

Underlying: Common Stock · 1,603 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock or a cash settlement.

F3 · derivative.exercise_date: The restricted stock units ("RSUs") were granted with both (a) a liquidity event-based vesting condition and (b) a service-based vesting condition, both of which conditions must be satisfied in order for the RSUs to vest. The liquidity event-based condition was satisfied upon the closing of the Issuer's initial public offering (the "IPO"). The shares that vested on the closing date of the IPO, and the shares that vested thereafter through May 15, 2015, were settled on May 15, 2015. The service-based vesting condition provides that 25% of the total number of shares on March 14, 2015 and 1/48th of the total number of shares monthly thereafter, subject to the holder's continuous service through each such date.

F4 · derivative.expiration_date: The earlier of (i) March 27, 2021 or (ii) the recipient's termination date.

SEC source: 0001209191-17-011767 · doc4.xml · nonDerivative · entry 1

Fust Matthew K · CIK 0001397266 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,696

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Shares issued upon settlement of vested restricted stock units.

SEC source: 0001209191-17-011766 · doc4.xml · nonDerivative · entry 1

Soffer Gad · CIK 0001612090 · EVP & Chief Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 262,538

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted September 26, 2016.

F2 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $15.00 to $15.65. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001209191-17-010165 · doc4.xml · nonDerivative · entry 2

Soffer Gad · CIK 0001612090 · EVP & Chief Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 269,538

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted September 26, 2016.

F2 · kind: Shares sold to cover tax liability from settlement of RSUs.

F4 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $16.00 to $16.25. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001209191-17-010165 · doc4.xml · nonDerivative · entry 1

Soffer Gad · CIK 0001612090 · EVP & Chief Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 269,938

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted September 26, 2016.

F2 · kind: Shares sold to cover tax liability from settlement of RSUs.

F3 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $15.00 to $15.90. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001209191-17-009718 · doc4.xml · nonDerivative · entry 1

Haqq Christopher · CIK 0001612095 · EVP, R&D & Chief Scientific Of

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 399,630

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted September 27, 2016.

F2 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $15.15 to $15.90. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001209191-17-009533 · doc4.xml · nonDerivative · entry 2

Turner Heather D · CIK 0001403571 · EVP, General Counsel & Sec.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 86,142

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted September 23, 2016.

F3 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $16.15 to $16.20. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001209191-17-009533 · doc4.xml · nonDerivative · entry 1

Turner Heather D · CIK 0001403571 · EVP, General Counsel & Sec.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 86,775

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted September 23, 2016.

F2 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $15.15 to $16.10. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001209191-17-008830 · doc4.xml · nonDerivative · entry 1

Haqq Christopher · CIK 0001612095 · EVP, R&D & Chief Scientific Of

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 413,605

F1 · shares: These restricted stock units vest in four equal annual installments on each of the first, second, third and fourth anniversaries of the grant date, subject to the reporting person's continuous service.

SEC source: 0001209191-17-008814 · doc4.xml · nonDerivative · entry 1

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 720,044

F1 · shares: These restricted stock units vest in four equal annual installments on each of the first, second, third and fourth anniversaries of the grant date, subject to the reporting person's continuous service.

SEC source: 0001209191-17-008810 · doc4.xml · nonDerivative · entry 1

Clark Mitchall G. · CIK 0001612094 · EVP & Chief R & QA Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 144,687

F1 · shares: These restricted stock units vest in four equal annual installments on each of the first, second, third and fourth anniversaries of the grant date, subject to the reporting person's continuous service.

SEC source: 0001209191-17-008824 · doc4.xml · nonDerivative · entry 1

Soffer Gad · CIK 0001612090 · EVP & Chief Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 275,812

F1 · shares: These restricted stock units vest in four equal annual installments on each of the first, second, third and fourth anniversaries of the grant date, subject to the reporting person's continuous service.

SEC source: 0001209191-17-008820 · doc4.xml · nonDerivative · entry 1

Turner Heather D · CIK 0001403571 · EVP, General Counsel & Sec.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 98,357

F1 · shares: These restricted stock units vest in four equal annual installments on each of the first, second, third and fourth anniversaries of the grant date, subject to the reporting person's continuous service.

SEC source: 0001209191-17-008827 · doc4.xml · nonDerivative · entry 1

MCGRATH JOHN · CIK 0001205442 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 149,326

F1 · shares: These restricted stock units vest in four equal annual installments on each of the first, second, third and fourth anniversaries of the grant date, subject to the reporting person's continuous service.

SEC source: 0001209191-17-008079 · doc4.xml · nonDerivative · entry 2

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 353,778

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted March 22, 2016.

F4 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $13.35 to $14.20. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F3 · ownership.nature: Shares are held by the Isaac E. Ciechanover and Allison M. Ciechanover Family Trust dated 8/8/08, of which the Reporting Person is a trustee.

SEC source: 0001209191-17-008079 · doc4.xml · nonDerivative · entry 1

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 356,178

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted March 22, 2016.

F2 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $13.35 to $13.80. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F3 · ownership.nature: Shares are held by the Isaac E. Ciechanover and Allison M. Ciechanover Family Trust dated 8/8/08, of which the Reporting Person is a trustee.

SEC source: 0001209191-17-004502 · doc4.xml · nonDerivative · entry 2

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 358,578

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted March 22, 2016.

F4 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $14.25 to $14.60. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F3 · ownership.nature: Shares are held by the Isaac E. Ciechanover and Allison M. Ciechanover Family Trust dated 8/8/08, of which the Reporting Person is a trustee.

SEC source: 0001209191-17-004333 · doc4.xml · nonDerivative · entry 1

Haqq Christopher · CIK 0001612095 · EVP, R&D & Chief Scientific Of

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 364,105

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted September 27, 2016.

F2 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $14.00 to $14.55. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001209191-17-004502 · doc4.xml · nonDerivative · entry 1

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 360,978

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted March 22, 2016.

F2 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $13.975 to $14.20. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F3 · ownership.nature: Shares are held by the Isaac E. Ciechanover and Allison M. Ciechanover Family Trust dated 8/8/08, of which the Reporting Person is a trustee.

SEC source: 0001209191-17-002930 · doc4.xml · nonDerivative · entry 2

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 364,578

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted March 22, 2016.

F4 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $16.80 to $17.50. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F3 · ownership.nature: Shares are held by the Isaac E. Ciechanover and Allison M. Ciechanover Family Trust dated 8/8/08, of which the Reporting Person is a trustee.

SEC source: 0001209191-17-002930 · doc4.xml · nonDerivative · entry 1

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 370,578

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted March 22, 2016.

F2 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $16.10 to $16.675. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F3 · ownership.nature: Shares are held by the Isaac E. Ciechanover and Allison M. Ciechanover Family Trust dated 8/8/08, of which the Reporting Person is a trustee.

SEC source: 0001209191-17-002279 · doc4.xml · derivative · entry 6

SEIDENBERG BETH C · CIK 0001184592 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,500

Underlying: Common Stock · 5,500 shares

Expires 2024-01-03

F6 · derivative.exercise_date: The option shall vest on June 8, 2017, the date of the Company's annual stockholder meeting, subject to the Reporting Person's continuous service.

SEC source: 0001209191-17-002279 · doc4.xml · nonDerivative · entry 1

SEIDENBERG BETH C · CIK 0001184592 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,689

F1 · shares: These restricted stock units shall vest on June 8, 2017, the date of the Company's annual stockholder meeting, subject to the Reporting Person's continuous service.

SEC source: 0001209191-17-002040 · doc4.xml · derivative · entry 2

DOBMEIER ERIC · CIK 0001202785 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,500

Underlying: Common Stock · 5,500 shares

Expires 2024-01-03

F2 · derivative.exercise_date: The option shall vest on June 8, 2017, the date of the Company's annual stockholder meeting, subject to the Reporting Person's continuous service.

SEC source: 0001209191-17-002040 · doc4.xml · nonDerivative · entry 1

DOBMEIER ERIC · CIK 0001202785 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,500

F1 · shares: These restricted stock units shall vest on June 8, 2017, the date of the Company's annual stockholder meeting, subject to the Reporting Person's continuous service.