ATRA

SEC source: 0001209191-17-036609 · doc4.xml · nonDerivative · entry 1

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 459,528

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted March 22, 2016.

F2 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $13.10 to $14.05. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F3 · ownership.nature: Shares are held by the Isaac E. Ciechanover and Allison M. Ciechanover Family Trust dated 8/8/08, of which the Reporting Person is a trustee.

SEC source: 0001209191-17-033914 · doc4.xml · nonDerivative · entry 2

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 462,978

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted March 22, 2016.

F4 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $14.70 to $15.075. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F3 · ownership.nature: Shares are held by the Isaac E. Ciechanover and Allison M. Ciechanover Family Trust dated 8/8/08, of which the Reporting Person is a trustee.

SEC source: 0001209191-17-033914 · doc4.xml · nonDerivative · entry 1

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 465,378

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted March 22, 2016.

F2 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $14.65 to $15.05. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F3 · ownership.nature: Shares are held by the Isaac E. Ciechanover and Allison M. Ciechanover Family Trust dated 8/8/08, of which the Reporting Person is a trustee.

SEC source: 0001209191-17-033189 · doc4.xml · nonDerivative · entry 2

Clark Mitchall G. · CIK 0001612094 · EVP & Chief R & QA Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 153,000

F2 · kind: Shares sold to cover tax obligation from settlement of vested restricted stock units.

F3 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted October 12, 2016.

SEC source: 0001209191-17-033185 · doc4.xml · nonDerivative · entry 4

Soffer Gad · CIK 0001612090 · EVP & Chief Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 264,409

F4 · kind: Shares sold to cover tax liability from settlement of RSUs.

F5 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $15.00 to $15.30. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001209191-17-033208 · doc4.xml · nonDerivative · entry 4

MCGRATH JOHN · CIK 0001205442 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 117,460

F2 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted July 6, 2016.

F4 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $15.20 to $15.30. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001209191-17-033206 · doc4.xml · nonDerivative · entry 3

Gallagher Carol Giltner · CIK 0001329959 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,374

F2 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted October 14, 2016.

SEC source: 0001209191-17-033198 · doc4.xml · derivative · entry 3

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,754

Underlying: Common Stock · 5,908 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock or a cash settlement.

F4 · derivative.exercise_date: The RSUs were granted with both (a) a liquidity event-based vesting condition and (b) a service-based vesting condition, both of which conditions must be satisfied in order for the RSUs to vest. The liquidity event-based condition was satisfied upon the closing of the Issuer's initial public offering (the "IPO"). The shares that vested on the closing date of the IPO, and the shares that vested thereafter through May 15, 2015, were settled on May 15, 2015. The service-based vesting condition provides that 1/48th of the total number of shares shall vest monthly from January 10, 2014, subject to the holder's continuous service through each such date.

F5 · derivative.expiration_date: The earlier of (i) January 10, 2021 or (ii) the recipient's termination date.

SEC source: 0001209191-17-033198 · doc4.xml · nonDerivative · entry 1

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 731,859

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Shares issued upon settlement of vested restricted stock units ("RSUs").

SEC source: 0001209191-17-033189 · doc4.xml · derivative · entry 3

Clark Mitchall G. · CIK 0001612094 · EVP & Chief R & QA Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,442

Underlying: Common Stock · 7,212 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock or a cash settlement.

F5 · derivative.exercise_date: The RSUs were granted with both (a) a liquidity event-based vesting condition and (b) a service-based vesting condition, both of which conditions must be satisfied in order for the RSUs to vest. The liquidity event-based condition was satisfied upon the closing of the Issuer's initial public offering (the "IPO"). The shares that vested on the closing date of the IPO, and the shares that vested thereafter through May 15, 2015, were settled on May 15, 2015. The service-based vesting condition provides that 25% of the total number of shares on March 17, 2015 and 1/48th of the total number of shares monthly thereafter, subject to the holder's continuous service through each such date.

F6 · derivative.expiration_date: The earlier of (i) March 27, 2021 or (ii) the recepient's termination date.

SEC source: 0001209191-17-033189 · doc4.xml · nonDerivative · entry 1

Clark Mitchall G. · CIK 0001612094 · EVP & Chief R & QA Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 156,873

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Shares issued upon settlement of vested restricted stock units ("RSUs").

SEC source: 0001209191-17-033195 · doc4.xml · derivative · entry 5

Haqq Christopher · CIK 0001612095 · EVP, R&D & Chief Scientific Of

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,211

Underlying: Common Stock · 829 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock or a cash settlement.

F7 · derivative.exercise_date: The RSUs were granted with both (a) a liquidity event-based vesting condition and (b) a service-based vesting condition, both of which conditions must be satisfied in order for the RSUs to vest. The liquidity event-based condition was satisfied upon the closing of the Issuer's initial public offering (the "IPO"). The shares that vested on the closing date of the IPO, and the shares that vested thereafter through May 15, 2015, were settled on May 15, 2015. The service-based vesting condition provides that 1/48th of the total number of shares shall vest monthly from January 10, 2014, subject to the holder's continuous service through each such date.

F8 · derivative.expiration_date: The earlier of (i) January 10, 2021 or (ii) the recipient's termination date.

SEC source: 0001209191-17-033195 · doc4.xml · nonDerivative · entry 2

Haqq Christopher · CIK 0001612095 · EVP, R&D & Chief Scientific Of

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 374,080

F2 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted December 7, 2015.

F3 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $14.65 to $15.20. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001209191-17-033195 · doc4.xml · nonDerivative · entry 1

Haqq Christopher · CIK 0001612095 · EVP, R&D & Chief Scientific Of

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 381,684

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Shares issued upon settlement of vested restricted stock units ("RSUs").

SEC source: 0001209191-17-033185 · doc4.xml · derivative · entry 6

Soffer Gad · CIK 0001612090 · EVP & Chief Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,055

Underlying: Common Stock · 4,146 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock or a cash settlement.

F9 · derivative.exercise_date: The RSUs were granted with both (a) a liquidity event-based vesting condition and (b) a service-based vesting condition, both of which conditions must be satisfied in order for the RSUs to vest. The liquidity event-based condition was satisfied upon the closing of the Issuer's initial public offering (the "IPO"). The shares that vested on the closing date of the IPO, and the shares that vested thereafter through May 15, 2015, were settled on May 15, 2015. The service-based vesting condition provides that 1/48th of the total number of shares shall vest monthly from January 10, 2014, subject to the holder's continuous service through each such date.

F10 · derivative.expiration_date: The earlier of (i) January 10, 2021 or (ii) the recipient's termination date.

SEC source: 0001209191-17-033185 · doc4.xml · derivative · entry 5

Soffer Gad · CIK 0001612090 · EVP & Chief Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 6,410 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock or a cash settlement.

F7 · derivative.exercise_date: The RSUs were granted with both (a) a liquidity event-based vesting condition and (b) a service-based vesting condition, both of which conditions must be satisfied in order for the RSUs to vest. The liquidity event-based condition was satisfied upon the closing of the Issuer's initial public offering (the "IPO"). The shares that vested on the closing date of the IPO, and the shares that vested thereafter through May 15, 2015, were settled on May 15, 2015. The service-based vesting condition provides that 25% of the total number of shares on March 25, 2014 and 1/48th of the total number of shares monthly thereafter, subject to the holder's continuous service through each such date.

F8 · derivative.expiration_date: The earlier of (i) March 13, 2020 or (ii) the recipient's termination date.

SEC source: 0001209191-17-033185 · doc4.xml · nonDerivative · entry 3

Soffer Gad · CIK 0001612090 · EVP & Chief Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 270,083

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: Shares issued upon settlement of vested restricted stock units ("RSUs").

SEC source: 0001209191-17-033185 · doc4.xml · nonDerivative · entry 2

Soffer Gad · CIK 0001612090 · EVP & Chief Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 265,937

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: Shares issued upon settlement of vested restricted stock units ("RSUs").

SEC source: 0001209191-17-033185 · doc4.xml · nonDerivative · entry 1

Soffer Gad · CIK 0001612090 · EVP & Chief Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 259,527

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted September 26, 2016.

F2 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $15.00 to $15.25. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001209191-17-033208 · doc4.xml · derivative · entry 6

MCGRATH JOHN · CIK 0001205442 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 20,526

Underlying: Common Stock · 7,698 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock or a cash settlement.

F9 · derivative.exercise_date: The RSUs were granted with both (a) a liquidity event-based vesting condition and (b) a service-based vesting condition, both of which conditions must be satisfied in order for the RSUs to vest. The liquidity event-based condition was satisfied upon the closing of the Issuer's initial public offering (the "IPO"). The shares that vested on the closing date of the IPO, and the shares that vested thereafter through May 15, 2015, were settled on May 15, 2015. The service-based vesting condition provides that 25% of the total number of shares on January 6, 2015 and 1/48th of the total number of shares monthly thereafter, subject to the holder's continuous service through each such date.

F10 · derivative.expiration_date: The earlier of (i) December 12, 2020 or (ii) the recipient's termination date.

F8 · ownership.nature: The shares are held by the David B. Horowitz and John McGrath Jr. Revocable Living Trust dated 6/3/11, of which the Reporting Person is trustee.

SEC source: 0001209191-17-033208 · doc4.xml · derivative · entry 5

MCGRATH JOHN · CIK 0001205442 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 0

Underlying: Common Stock · 935 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock or a cash settlement.

F6 · derivative.exercise_date: The RSUs were granted with both (a) a liquidity event-based vesting condition and (b) a service-based vesting condition, both of which conditions must be satisfied in order for the RSUs to vest. The liquidity event-based condition was satisfied upon the closing of the Issuer's initial public offering (the "IPO"). The shares that vested on the closing date of the IPO, and the shares that vested thereafter through May 15, 2015, were settled on May 15, 2015. The service-based vesting condition provides that 25% of the total number of shares on March 13, 2014 and 1/48th of the total number of shares monthly thereafter, subject to the holder's continuous service through each such date.

F7 · derivative.expiration_date: The earlier of (i) March 13, 2020 or (ii) the recepient's termination date.

F8 · ownership.nature: The shares are held by the David B. Horowitz and John McGrath Jr. Revocable Living Trust dated 6/3/11, of which the Reporting Person is trustee.

SEC source: 0001209191-17-033208 · doc4.xml · nonDerivative · entry 3

MCGRATH JOHN · CIK 0001205442 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 119,460

F2 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted July 6, 2016.

F3 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $14.70 to $15.25. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001209191-17-033208 · doc4.xml · nonDerivative · entry 2

MCGRATH JOHN · CIK 0001205442 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 121,460

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Shares issued upon settlement of vested restricted stock units ("RSUs").

SEC source: 0001209191-17-033208 · doc4.xml · nonDerivative · entry 1

MCGRATH JOHN · CIK 0001205442 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 113,762

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Shares issued upon settlement of vested restricted stock units ("RSUs").

SEC source: 0001209191-17-033206 · doc4.xml · derivative · entry 5

Gallagher Carol Giltner · CIK 0001329959 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,997

Underlying: Common Stock · 817 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock or a cash settlement.

F6 · derivative.exercise_date: The restricted stock units ("RSUs") were granted with both (a) a liquidity event-based vesting condition and (b) a service-based vesting condition, both of which conditions must be satisfied in order for the RSUs to vest. The liquidity event-based condition was satisfied upon the closing of the Issuer's initial public offering (the "IPO"). The shares that vested on the closing date of the IPO, and the shares that vested thereafter through August 17, 2015, were settled on August 17, 2015. The service-based vesting condition provides that 1/48th of the total number of shares vest monthly from March 25, 2014, subject to the holder's continuous service through each such date.

F7 · derivative.expiration_date: The earlier of (i) March 27, 2021 or (ii) the recipient's termination date.

SEC source: 0001209191-17-033206 · doc4.xml · derivative · entry 4

Gallagher Carol Giltner · CIK 0001329959 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,645

Underlying: Common Stock · 1,549 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock or a cash settlement.

F4 · derivative.exercise_date: The restricted stock units ("RSUs") were granted with both (a) a liquidity event-based vesting condition and (b) a service-based vesting condition, both of which conditions must be satisfied in order for the RSUs to vest. The liquidity event-based condition was satisfied upon the closing of the Issuer's initial public offering (the "IPO"). The shares that vested on the closing date of the IPO, and the shares that vested thereafter through August 17, 2015, were settled on August 17, 2015. The service-based vesting condition provides that 1/48th of the total number of shares vest monthly from January 30, 2014, subject to the holder's continuous service through each such date.

F5 · derivative.expiration_date: The earlier of (i) January 30, 2021 or (ii) the second anniversary of termination date.

SEC source: 0001209191-17-033206 · doc4.xml · nonDerivative · entry 2

Gallagher Carol Giltner · CIK 0001329959 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,558

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Shares issued upon settlement of vested restricted stock units.

SEC source: 0001209191-17-033206 · doc4.xml · nonDerivative · entry 1

Gallagher Carol Giltner · CIK 0001329959 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,741

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Shares issued upon settlement of vested restricted stock units.

SEC source: 0001209191-17-033201 · doc4.xml · derivative · entry 2

Fust Matthew K · CIK 0001397266 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,342

Underlying: Common Stock · 1,602 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock or a cash settlement.

F3 · derivative.exercise_date: The restricted stock units ("RSUs") were granted with both (a) a liquidity event-based vesting condition and (b) a service-based vesting condition, both of which conditions must be satisfied in order for the RSUs to vest. The liquidity event-based condition was satisfied upon the closing of the Issuer's initial public offering (the "IPO"). The shares that vested on the closing date of the IPO, and the shares that vested thereafter through May 15, 2015, were settled on May 15, 2015. The service-based vesting condition provides that 25% of the total number of shares on March 14, 2015 and 1/48th of the total number of shares monthly thereafter, subject to the holder's continuous service through each such date.

F4 · derivative.expiration_date: The earlier of (i) March 27, 2021 or (ii) the recipient's termination date.

SEC source: 0001209191-17-033201 · doc4.xml · nonDerivative · entry 1

Fust Matthew K · CIK 0001397266 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,298

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Shares issued upon settlement of vested restricted stock units.

SEC source: 0001209191-17-031664 · doc4.xml · derivative · entry 1

Porter Derrell · CIK 0001706400 · SVP, Head of Global Commercial

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130,000

Underlying: Common Stock · 130,000 shares

Expires 2024-05-10

F1 · derivative.exercise_date: 25% of the shares subject to the option vest and become exercisable on May 10, 2018 and 1/48th of the shares subject to the stock option vest and become exercisable each full month thereafter.

SEC source: 0001209191-17-028273 · doc4.xml · nonDerivative · entry 3

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 467,778

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted March 22, 2016.

F5 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $17.50 to $17.90. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F3 · ownership.nature: Shares are held by the Isaac E. Ciechanover and Allison M. Ciechanover Family Trust dated 8/8/08, of which the Reporting Person is a trustee.

SEC source: 0001209191-17-028273 · doc4.xml · nonDerivative · entry 2

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 471,378

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted March 22, 2016.

F4 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $17.55 to $17.90. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F3 · ownership.nature: Shares are held by the Isaac E. Ciechanover and Allison M. Ciechanover Family Trust dated 8/8/08, of which the Reporting Person is a trustee.

SEC source: 0001209191-17-028273 · doc4.xml · nonDerivative · entry 1

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 472,878

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted March 22, 2016.

F2 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $16.55 to $17.45. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F3 · ownership.nature: Shares are held by the Isaac E. Ciechanover and Allison M. Ciechanover Family Trust dated 8/8/08, of which the Reporting Person is a trustee.

SEC source: 0001209191-17-027470 · doc4.xml · nonDerivative · entry 1

Haqq Christopher · CIK 0001612095 · EVP, R&D & Chief Scientific Of

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 380,855

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted September 27, 2016.

F2 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $17.00 to $17.55. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001209191-17-026678 · doc4.xml · nonDerivative · entry 2

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 474,978

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted March 22, 2016.

F4 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $16.75 to $17.15. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F3 · ownership.nature: Shares are held by the Isaac E. Ciechanover and Allison M. Ciechanover Family Trust dated 8/8/08, of which the Reporting Person is a trustee.

SEC source: 0001209191-17-026678 · doc4.xml · nonDerivative · entry 1

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 479,178

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted March 22, 2016.

F2 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $16.70 to $17.60. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F3 · ownership.nature: Shares are held by the Isaac E. Ciechanover and Allison M. Ciechanover Family Trust dated 8/8/08, of which the Reporting Person is a trustee.

SEC source: 0001209191-17-024291 · doc4.xml · derivative · entry 2

Newell Joe · CIK 0001702457 · Chief Tech. Operations Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 90,000

Underlying: Common Stock · 90,000 shares

Expires 2024-04-03

F2 · derivative.exercise_date: 25% of the shares shall vest one year from April 3, 2017, and the remaining shares shall vest in 36 equal monthly installment thereafter, subject to the reporting person's continuous service.

SEC source: 0001209191-17-024291 · doc4.xml · nonDerivative · entry 1

Newell Joe · CIK 0001702457 · Chief Tech. Operations Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,500

F1 · shares: These restricted stock units vest in four equal annual installments on each of the first, second, third and fourth anniversaries from April 3, 2017, subject to the reporting person's continuous service.

SEC source: 0001209191-17-023215 · doc4.xml · nonDerivative · entry 3

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 482,178

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted March 22, 2016.

F5 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $19.65 to $20.05. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F3 · ownership.nature: Shares are held by the Isaac E. Ciechanover and Allison M. Ciechanover Family Trust dated 8/8/08, of which the Reporting Person is a trustee.

SEC source: 0001209191-17-023215 · doc4.xml · nonDerivative · entry 2

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 482,596

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted March 22, 2016.

F4 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $18.55 to $19.525. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F3 · ownership.nature: Shares are held by the Isaac E. Ciechanover and Allison M. Ciechanover Family Trust dated 8/8/08, of which the Reporting Person is a trustee.

SEC source: 0001209191-17-023215 · doc4.xml · nonDerivative · entry 1

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 485,778

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted March 22, 2016.

F2 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $20.00 to $20.75. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F3 · ownership.nature: Shares are held by the Isaac E. Ciechanover and Allison M. Ciechanover Family Trust dated 8/8/08, of which the Reporting Person is a trustee.

SEC source: 0001209191-17-022684 · doc4.xml · nonDerivative · entry 2

MCGRATH JOHN · CIK 0001205442 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 112,827

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted July 6, 2016.

F3 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $20.80 to $21.45. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001209191-17-022684 · doc4.xml · nonDerivative · entry 1

MCGRATH JOHN · CIK 0001205442 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 119,327

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted July 6, 2016.

F2 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $20.10 to $20.50. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001209191-17-021840 · doc4.xml · nonDerivative · entry 3

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 498,178

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted March 22, 2016.

F5 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $19.20 to $20.15. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F3 · ownership.nature: Shares are held by the Isaac E. Ciechanover and Allison M. Ciechanover Family Trust dated 8/8/08, of which the Reporting Person is a trustee.

SEC source: 0001209191-17-021840 · doc4.xml · nonDerivative · entry 2

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 515,778

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted March 22, 2016.

F4 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $18.20 to $19.00. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F3 · ownership.nature: Shares are held by the Isaac E. Ciechanover and Allison M. Ciechanover Family Trust dated 8/8/08, of which the Reporting Person is a trustee.

SEC source: 0001209191-17-021840 · doc4.xml · nonDerivative · entry 1

Ciechanover Isaac E. · CIK 0001612096 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 518,178

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted March 22, 2016.

F2 · price: The price in Column 4 is a weighted average sale price. The prices actually received ranged from $18.25 to $19.10. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F3 · ownership.nature: Shares are held by the Isaac E. Ciechanover and Allison M. Ciechanover Family Trust dated 8/8/08, of which the Reporting Person is a trustee.

SEC source: 0001209191-17-021452 · doc4.xml · nonDerivative · entry 1

Haqq Christopher · CIK 0001612095 · EVP, R&D & Chief Scientific Of

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 386,855

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted December 7, 2015.

SEC source: 0001209191-17-019981 · doc4.xml · nonDerivative · entry 1

MCGRATH JOHN · CIK 0001205442 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 126,827

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted July 6, 2016.

SEC source: 0001209191-17-020262 · doc4.xml · nonDerivative · entry 1

Soffer Gad · CIK 0001612090 · EVP & Chief Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 266,527

F1 · kind: Transaction pursuant to Rule 10b5-1 Plan adopted September 26, 2016.