APRE

SEC source: 0001567619-21-012874 · doc1.xml · nonDerivative · entry 1

Kelly Michael Aaron · CIK 0001769668 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,610

F1 · shares: These shares represent restricted stock units which were granted on June 30, 2021, and which will vest and be settled in common stock on June 30, 2022, subject to the reporting person's continued service on the Issuer's board of directors through and including the applicable vesting date and subject to acceleration under certain conditions.

SEC source: 0001567619-21-012872 · doc1.xml · derivative · entry 2

Seizinger Bernd R. · CIK 0001789042 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,750

Underlying: Common Stock · 22,750 shares

Expires 2031-06-30

F2 · derivative.exercise_date: The option vests in full on June 30, 2022, subject to the reporting person's continued service on the Issuer's board of directors through and including the applicable vesting date and subject to acceleration under certain conditions.

SEC source: 0001567619-21-012872 · doc1.xml · nonDerivative · entry 1

Seizinger Bernd R. · CIK 0001789042 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 268,580

F1 · shares: These shares represent restricted stock units which were granted on June 30, 2021, and which will vest and be settled in common stock on June 30, 2022, subject to the reporting person's continued service on the Issuer's board of directors through and including the applicable vesting date and subject to acceleration under certain conditions.

SEC source: 0000905148-21-000282 · form4.xml · nonDerivative · entry 1

Korbel Gregory Alan · CIK 0001789032 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,500

F1 · shares: These shares represent restricted stock units which were granted on March 10, 2021, and which will vest and be settled in common stock as follows: (i) 5,000 shares on September 10, 2021, (ii) 5,000 shares on March 10, 2022 and (iii) 5,000 shares on September 10, 2022, subject to the reporting person's continued employment through and including the applicable vesting dates and subject to acceleration under certain conditions.

SEC source: 0001140361-21-006730 · form4.xml · derivative · entry 10

SCHADE CHRISTIAN S · CIK 0001214496 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 329,000

Underlying: Common Stock · 329,000 shares

Expires 2031-02-25

F3 · derivative.exercise_date: Twenty-five percent of these options vest on February 25, 2022, with the remaining options vesting ratably over the following 36 months, subject to the reporting person's continued employment through and including the applicable vesting date and subject to acceleration under certain conditions.

SEC source: 0001140361-21-006730 · form4.xml · nonDerivative · entry 2

SCHADE CHRISTIAN S · CIK 0001214496 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 176,660

F2 · shares: These shares represent restricted stock units which were granted on February 25, 2021, and which will vest and be settled in common stock as follows: (i) 29,500 shares on August 25, 2021, (ii) 29,500 shares on February 25, 2022 and (iii) 29,500 shares on August 25, 2022, subject to the reporting person's continued employment through and including the applicable vesting dates and subject to acceleration under certain conditions.

SEC source: 0001140361-21-006730 · form4.xml · nonDerivative · entry 1

SCHADE CHRISTIAN S · CIK 0001214496 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 77,160

F1 · shares: These shares represent restricted stock units which were granted on February 25, 2021, and which will vest and be settled in common stock as follows: (i) 25,666 shares on February 25, 2022, (ii) 25,667 shares on February 25, 2023 and (iii) 25,667 shares on February 25, 2024, subject to the reporting person's continued employment through and including the applicable vesting dates and subject to acceleration under certain conditions.

SEC source: 0001140361-21-006728 · form4.xml · derivative · entry 3

Coiante Scott M · CIK 0001608536 · SVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 143,000

Underlying: Common Stock · 143,000 shares

Expires 2031-02-25

F3 · derivative.exercise_date: Twenty-five percent of these options vest on February 25, 2022, with the remaining options vesting ratably over the following 36 months, subject to the reporting person's continued employment through and including the applicable vesting date and subject to acceleration under certain conditions.

SEC source: 0001140361-21-006728 · form4.xml · nonDerivative · entry 2

Coiante Scott M · CIK 0001608536 · SVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 99,000

F2 · shares: These shares represent restricted stock units which were granted on February 25, 2021, and which will vest and be settled in common stock as follows: (i) 21,166 shares on August 25, 2021, (ii) 21,167 shares on February 25, 2022 and (iii) 21,167 shares on August 25, 2022, subject to the reporting person's continued employment through and including the applicable vesting dates and subject to acceleration under certain conditions.

SEC source: 0001140361-21-006728 · form4.xml · nonDerivative · entry 1

Coiante Scott M · CIK 0001608536 · SVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,500

F1 · shares: These shares represent restricted stock units which were granted on February 25, 2021, and which will vest and be settled in common stock as follows: (i) 11,000 shares on February 25, 2022, (ii) 11,000 shares on February 25, 2023 and (iii) 11,000 shares on February 25, 2024, subject to the reporting person's continued employment through and including the applicable vesting dates and subject to acceleration under certain conditions.

SEC source: 0001140361-21-006738 · form4.xml · derivative · entry 5

Attar Eyal C. · CIK 0001789076 · SVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 143,000

Underlying: Common Stock · 143,000 shares

Expires 2031-02-25

F3 · derivative.exercise_date: Twenty-five percent of these options vest on February 25, 2022, with the remaining options vesting ratably over the following 36 months, subject to the reporting person's continued employment through and including the applicable vesting date and subject to acceleration under certain conditions.

SEC source: 0001140361-21-006738 · form4.xml · nonDerivative · entry 2

Attar Eyal C. · CIK 0001789076 · SVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 108,000

F2 · shares: These shares represent restricted stock units which were granted on February 25, 2021, and which will vest and be settled in common stock as follows: (i) 25,000 shares on August 25, 2021, (ii) 25,000 shares on February 25, 2022 and (iii) 25,000 shares on August 25, 2022, subject to the reporting person's continued employment through and including the applicable vesting dates and subject to acceleration under certain conditions.

SEC source: 0001140361-21-006738 · form4.xml · nonDerivative · entry 1

Attar Eyal C. · CIK 0001789076 · SVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,000

F1 · shares: These shares represent restricted stock units which were granted on February 25, 2021, and which will vest and be settled in common stock as follows: (i) 11,000 shares on February 25, 2022, (ii) 11,000 shares on February 25, 2023 and (iii) 11,000 shares on February 25, 2024, subject to the reporting person's continued employment through and including the applicable vesting dates and subject to acceleration under certain conditions.

SEC source: 0001140361-21-006735 · form4.xml · derivative · entry 2

Wessels Gregory S. · CIK 0001824615 · SVP, Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 66,000

Underlying: Common Stock · 66,000 shares

Expires 2031-02-25

F2 · derivative.exercise_date: Twenty-five percent of these options vest on February 25, 2022, with the remaining options vesting ratably over the following 36 months, subject to the reporting person's continued employment through and including the applicable vesting date and subject to acceleration under certain conditions.

SEC source: 0001140361-21-006735 · form4.xml · nonDerivative · entry 1

Wessels Gregory S. · CIK 0001824615 · SVP, Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,000

F1 · shares: These shares represent restricted stock units which were granted on February 25, 2021, and which will vest and be settled in common stock as follows: (i) 5,333 shares on February 25, 2022, (ii) 5,333 shares on February 25, 2023 and 5,334 shares on February 25, 2024, subject to the reporting person's continued employment through and including the applicable vesting dates and subject to acceleration under certain conditions.

SEC source: 0001140361-21-006732 · form4.xml · derivative · entry 2

Abrahmsen Lars B. · CIK 0001789039 · SVP, Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 82,000

Underlying: Common Stock · 82,000 shares

Expires 2031-02-25

F2 · derivative.exercise_date: Twenty-five percent of these options vest on February 25, 2022, with the remaining options vesting ratably over the following 36 months, subject to the reporting person's continued employment through and including the applicable vesting date and subject to acceleration under certain conditions.

SEC source: 0001140361-21-006732 · form4.xml · nonDerivative · entry 1

Abrahmsen Lars B. · CIK 0001789039 · SVP, Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,000

F1 · shares: These shares represent restricted stock units which were granted on February 25, 2021, and which will vest and be settled in common stock as follows: (i) 6,333 shares on February 25, 2022, (ii) 6,333 shares on February 25, 2023 and (iii) 6,334 shares on February 25, 2024, subject to the reporting person's continued employment through and including the applicable vesting dates and subject to acceleration under certain conditions.

SEC source: 0001140361-21-006726 · form4.xml · derivative · entry 2

Korbel Gregory Alan · CIK 0001789032 · VP of Business Dev't

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,100

Underlying: Common Stock · 41,100 shares

Expires 2031-02-25

F2 · derivative.exercise_date: Twenty-five percent of these options vest on February 25, 2022, with the remaining options vesting ratably over the following 36 months, subject to the reporting person's continued employment through and including the applicable vesting date and subject to acceleration under certain conditions.

SEC source: 0001140361-21-006726 · form4.xml · nonDerivative · entry 1

Korbel Gregory Alan · CIK 0001789032 · VP of Business Dev't

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,500

F1 · shares: These shares represent restricted stock units which were granted on February 25, 2021, and which will vest and be settled in common stock as follows: (i) 3,333 shares on August 25, 2021, (ii) 3,333 shares on February 25, 2022 and (iii) 3,334 shares on August 25, 2022, subject to the reporting person's continued employment through and including the applicable vesting dates and subject to acceleration under certain conditions.

SEC source: 0001104659-21-023991 · tm215825-38_4seq1.xml · nonDerivative · entry 2

Redmile Group, LLC · CIK 0001425738 · 10% owner

Green Jeremy · CIK 0001650527 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,768,718

F1 · ownership.nature: These securities are directly owned by certain private investment vehicles managed by Redmile Group, LLC ("Redmile") and may be deemed beneficially owned by Redmile as investment manager of such private investment vehicles. The reported securities may also be deemed beneficially owned by Jeremy Green as the principal of Redmile. The Reporting Persons disclaim beneficial ownership of the reported securities except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

SEC source: 0001104659-21-023991 · tm215825-38_4seq1.xml · nonDerivative · entry 1

Redmile Group, LLC · CIK 0001425738 · 10% owner

Green Jeremy · CIK 0001650527 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,774,581

F1 · ownership.nature: These securities are directly owned by certain private investment vehicles managed by Redmile Group, LLC ("Redmile") and may be deemed beneficially owned by Redmile as investment manager of such private investment vehicles. The reported securities may also be deemed beneficially owned by Jeremy Green as the principal of Redmile. The Reporting Persons disclaim beneficial ownership of the reported securities except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

SEC source: 0001104659-20-113186 · a4.xml · nonDerivative · entry 1

5AM Ventures IV, L.P. · CIK 0001589315 · Former 10% holder

5AM Co-Investors IV, L.P. · CIK 0001593361 · Former 10% holder

5AM Partners IV, LLC · CIK 0001589314 · Former 10% holder

5AM Opportunities I, L.P. · CIK 0001753000 · Former 10% holder

5AM Opportunities I (GP), LLC · CIK 0001790778 · Former 10% holder

DIEKMAN JOHN D · CIK 0001240357 · Former 10% holder

Schwab Andrew J. · CIK 0001598549 · Former 10% holder

PARMAR KUSH · CIK 0001664281 · Former 10% holder

ROCKLAGE SCOTT M · CIK 0001219014 · Former 10% holder

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 138,497

F1 · ownership.direct: Shares are held directly by 5AM Opportunities I, L.P. ("Opportunities"), which is under common control with the 5AM IV Funds. The 5AM IV Funds and Opportunities expressly disclaim status as a "group" for purposes of this Form 4.

F2 · ownership.direct: 5AM Opportunities I (GP), LLC ("Opportunities GP") is the sole general partner of Opportunities. Andrew J. Schwab and Dr. Kush Parmar are managing members of Opportunities GP and may be deemed to have shared voting and investment power over the shares beneficially owned by Opportunities. Each of Opportunities GP, Mr. Schwab and Dr. Parmar disclaims beneficial ownership of the shares of Common Stock held directly by Opportunities, except to the extent of its or his pecuniary interest therein.

F1 · ownership.nature: Shares are held directly by 5AM Opportunities I, L.P. ("Opportunities"), which is under common control with the 5AM IV Funds. The 5AM IV Funds and Opportunities expressly disclaim status as a "group" for purposes of this Form 4.

F2 · ownership.nature: 5AM Opportunities I (GP), LLC ("Opportunities GP") is the sole general partner of Opportunities. Andrew J. Schwab and Dr. Kush Parmar are managing members of Opportunities GP and may be deemed to have shared voting and investment power over the shares beneficially owned by Opportunities. Each of Opportunities GP, Mr. Schwab and Dr. Parmar disclaims beneficial ownership of the shares of Common Stock held directly by Opportunities, except to the extent of its or his pecuniary interest therein.

SEC source: 0000905148-20-001049 · form4.xml · derivative · entry 1

Kelly Michael Aaron · CIK 0001769668 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,000

Underlying: Common Stock · 12,000 shares

Expires 2030-09-28

F1 · derivative.exercise_date: The option vests in three equal annual installments beginning on September 28, 2021 subject to the reporting person's continued service on the Issuer's board of directors through and including the applicable vesting date and subject to acceleration under certain conditions.

SEC source: 0000905148-20-001030 · form4.xml · derivative · entry 1

Wessels Gregory S. · CIK 0001824615 · SVP, Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,700

Underlying: Common Stock · 14,700 shares

Expires 2030-09-16

F1 · derivative.exercise_date: Twenty-five percent of these options vest on September 16, 2021, with the remaining options vesting ratably over the following 36 months, subject to the reporting person's continued employment through and including the applicable vesting date and subject to acceleration under certain conditions.

SEC source: 0001123292-20-000973 · edgar.xml · nonDerivative · entry 1

KDev Investments AB · CIK 0001789888 · 10% owner

Karolinska Development AB · CIK 0001789932 · 10% owner

KCIF Co-Investment Fund KB · CIK 0001789966 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 1,992,586

F1 · security: The amount of securities of Aprea Therapeutics, Inc. (the "Issuer") reported as beneficially owned includes shares held of record by: KDev Investments AB, Karolinska Development AB and KCIF Co-Investment Fund KB (collectively, the "Reporting Persons").

F2 · ownership.nature: Karolinska Development AB ("Karolinska") is the majority owner and co-manager of KDev Investments AB and a limited partner of KCIF Co-Investment Fund KB. Karolinska and each of the other Reporting Persons disclaim beneficial ownership of any shares of the Issuer's Common Stock owned of record by any of the other Reporting Persons except to the extent of any pecuniary interest therein, and this report shall not be deemed an admission that any such entity is the beneficial owner of, or has any pecuniary interest in, such securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose. The address of each of (i) KDev Investments AB, (ii) Karolinska Development AB, and (iii) KCIF Co-Investment Fund KB is Tomtebodavagen 23A, SE 171 65 Solna, Sweden.

SEC source: 0000905148-20-000749 · form4.xml · derivative · entry 1

Christenson Johan · CIK 0001488771 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,600

Underlying: Common Stock · 5,600 shares

Expires 2030-06-30

F1 · derivative.exercise_date: The option vests in full on June 30, 2021 subject to the reporting person's continued service on the Issuer's board of directors through and including the applicable vesting date and subject to acceleration under certain conditions.

SEC source: 0000905148-20-000752 · form4.xml · derivative · entry 1

HENNEMAN JOHN B III · CIK 0001187572 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,600

Underlying: Common Stock · 5,600 shares

Expires 2030-06-30

F1 · derivative.exercise_date: The option vests in full on June 30, 2021 subject to the reporting person's continued service on the Issuer's board of directors through and including the applicable vesting date and subject to acceleration under certain conditions.

SEC source: 0000905148-20-000747 · form4.xml · derivative · entry 1

ROCKLAGE SCOTT M · CIK 0001219014 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,600

Underlying: Common Stock · 5,600 shares

Expires 2030-06-30

F1 · derivative.exercise_date: The option vests in full on June 30, 2021 subject to the reporting person's continued service on the Issuer's board of directors through and including the applicable vesting date and subject to acceleration under certain conditions.

SEC source: 0000905148-20-000750 · form4.xml · derivative · entry 1

Hepple Jonathan · CIK 0001789045 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,600

Underlying: Common Stock · 5,600 shares

Expires 2030-06-30

F1 · derivative.exercise_date: The option vests in full on June 30, 2021 subject to the reporting person's continued service on the Issuer's board of directors through and including the applicable vesting date and subject to acceleration under certain conditions.

SEC source: 0000905148-20-000751 · form4.xml · derivative · entry 1

Seizinger Bernd R. · CIK 0001789042 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,600

Underlying: Common Stock · 5,600 shares

Expires 2030-06-30

F1 · derivative.exercise_date: The option vests in full on June 30, 2021 subject to the reporting person's continued service on the Issuer's board of directors through and including the applicable vesting date and subject to acceleration under certain conditions.

SEC source: 0000905148-20-000733 · form4.xml · derivative · entry 1

Namouni Fouad · CIK 0001815851 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,000

Underlying: Common Stock · 7,000 shares

Expires 2030-06-26

F1 · derivative.exercise_date: The option vests in three equal annual installments beginning on June 26, 2021 subject to the reporting person's continued service on the Issuer's board of directors through and including the applicable vesting date and subject to acceleration under certain conditions.

SEC source: 0000905148-20-000732 · form4.xml · derivative · entry 1

Peters Richard · CIK 0001697628 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,000

Underlying: Common Stock · 7,000 shares

Expires 2030-06-26

F1 · derivative.exercise_date: The option vests in three equal annual installments beginning on June 26, 2021 subject to the reporting person's continued service on the Issuer's board of directors through and including the applicable vesting date and subject to acceleration under certain conditions.

SEC source: 0001209191-20-037714 · doc4.xml · nonDerivative · entry 3

5AM Ventures IV, L.P. · CIK 0001589315 · 10% owner

5AM Co-Investors IV, L.P. · CIK 0001593361 · 10% owner

5AM Partners IV, LLC · CIK 0001589314 · 10% owner

DIEKMAN JOHN D · CIK 0001240357 · 10% owner

Schwab Andrew J. · CIK 0001598549 · 10% owner

5AM Opportunities I, L.P. · CIK 0001753000 · 10% owner

5AM Opportunities I (GP), LLC · CIK 0001790778 · 10% owner

PARMAR KUSH · CIK 0001664281 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 313,497

F4 · ownership.direct: Shares are held directly by 5AM Opportunities I, L.P. ("Opportunities"), which is under common control with the 5AM IV Funds. The 5AM IV Funds and Opportunities expressly disclaim status as a "group" for purposes of this Form 4.

F5 · ownership.direct: 5AM Opportunities I (GP), LLC ("Opportunities GP") is the sole general partner of Opportunities. Andrew J. Schwab and Dr. Kush Parmar are managing members of Opportunities GP and may be deemed to have shared voting and investment power over the shares beneficially owned by Opportunities. Each of Opportunities GP, Mr. Schwab and Dr. Parmar disclaims beneficial ownership of the shares of Common Stock held directly by Opportunities, except to the extent of its or his pecuniary interest therein.

F4 · ownership.nature: Shares are held directly by 5AM Opportunities I, L.P. ("Opportunities"), which is under common control with the 5AM IV Funds. The 5AM IV Funds and Opportunities expressly disclaim status as a "group" for purposes of this Form 4.

F5 · ownership.nature: 5AM Opportunities I (GP), LLC ("Opportunities GP") is the sole general partner of Opportunities. Andrew J. Schwab and Dr. Kush Parmar are managing members of Opportunities GP and may be deemed to have shared voting and investment power over the shares beneficially owned by Opportunities. Each of Opportunities GP, Mr. Schwab and Dr. Parmar disclaims beneficial ownership of the shares of Common Stock held directly by Opportunities, except to the extent of its or his pecuniary interest therein.

SEC source: 0001209191-20-037714 · doc4.xml · nonDerivative · entry 2

5AM Ventures IV, L.P. · CIK 0001589315 · 10% owner

5AM Co-Investors IV, L.P. · CIK 0001593361 · 10% owner

5AM Partners IV, LLC · CIK 0001589314 · 10% owner

DIEKMAN JOHN D · CIK 0001240357 · 10% owner

Schwab Andrew J. · CIK 0001598549 · 10% owner

5AM Opportunities I, L.P. · CIK 0001753000 · 10% owner

5AM Opportunities I (GP), LLC · CIK 0001790778 · 10% owner

PARMAR KUSH · CIK 0001664281 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 75,965

F2 · ownership.direct: 5AM Partners IV, LLC is the sole general partner of each of 5AM Ventures IV, L.P. and 5AM Co-Investors IV, L.P. (collectively, the "5AM IV Funds"). Dr. John D. Diekman, Andrew J. Schwab and Dr. Scott M. Rocklage are managing members of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM IV Funds. Each of 5AM Partners IV, LLC, Dr. Diekman, Mr. Schwab and Dr. Rocklage disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM IV Funds, except to the extent of its or his pecuniary interest therein.

F3 · ownership.direct: Shares are held directly by 5AM Co-Investors IV, L.P.

F2 · ownership.nature: 5AM Partners IV, LLC is the sole general partner of each of 5AM Ventures IV, L.P. and 5AM Co-Investors IV, L.P. (collectively, the "5AM IV Funds"). Dr. John D. Diekman, Andrew J. Schwab and Dr. Scott M. Rocklage are managing members of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM IV Funds. Each of 5AM Partners IV, LLC, Dr. Diekman, Mr. Schwab and Dr. Rocklage disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM IV Funds, except to the extent of its or his pecuniary interest therein.

F3 · ownership.nature: Shares are held directly by 5AM Co-Investors IV, L.P.

SEC source: 0001209191-20-037714 · doc4.xml · nonDerivative · entry 1

5AM Ventures IV, L.P. · CIK 0001589315 · 10% owner

5AM Co-Investors IV, L.P. · CIK 0001593361 · 10% owner

5AM Partners IV, LLC · CIK 0001589314 · 10% owner

DIEKMAN JOHN D · CIK 0001240357 · 10% owner

Schwab Andrew J. · CIK 0001598549 · 10% owner

5AM Opportunities I, L.P. · CIK 0001753000 · 10% owner

5AM Opportunities I (GP), LLC · CIK 0001790778 · 10% owner

PARMAR KUSH · CIK 0001664281 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 1,823,192

F1 · ownership.direct: Shares are held directly by 5AM Ventures IV, L.P.

F2 · ownership.direct: 5AM Partners IV, LLC is the sole general partner of each of 5AM Ventures IV, L.P. and 5AM Co-Investors IV, L.P. (collectively, the "5AM IV Funds"). Dr. John D. Diekman, Andrew J. Schwab and Dr. Scott M. Rocklage are managing members of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM IV Funds. Each of 5AM Partners IV, LLC, Dr. Diekman, Mr. Schwab and Dr. Rocklage disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM IV Funds, except to the extent of its or his pecuniary interest therein.

F1 · ownership.nature: Shares are held directly by 5AM Ventures IV, L.P.

F2 · ownership.nature: 5AM Partners IV, LLC is the sole general partner of each of 5AM Ventures IV, L.P. and 5AM Co-Investors IV, L.P. (collectively, the "5AM IV Funds"). Dr. John D. Diekman, Andrew J. Schwab and Dr. Scott M. Rocklage are managing members of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM IV Funds. Each of 5AM Partners IV, LLC, Dr. Diekman, Mr. Schwab and Dr. Rocklage disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM IV Funds, except to the extent of its or his pecuniary interest therein.

SEC source: 0001209191-20-037715 · doc4.xml · nonDerivative · entry 2

ROCKLAGE SCOTT M · CIK 0001219014 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · see footnotes

Disclosed balance after: 75,965

F2 · ownership.direct: The reporting person is a managing member of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM Funds. The reporting person disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM Funds, except to the extent of his pecuniary interest therein.

F3 · ownership.direct: Shares are held directly by 5AM Co-Investors IV, L.P

F2 · ownership.nature: The reporting person is a managing member of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM Funds. The reporting person disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM Funds, except to the extent of his pecuniary interest therein.

F3 · ownership.nature: Shares are held directly by 5AM Co-Investors IV, L.P

SEC source: 0001209191-20-037715 · doc4.xml · nonDerivative · entry 1

ROCKLAGE SCOTT M · CIK 0001219014 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · see footnotes

Disclosed balance after: 1,823,192

F1 · ownership.direct: Shares are held directly by 5AM Ventures IV, L.P.

F2 · ownership.direct: The reporting person is a managing member of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM Funds. The reporting person disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM Funds, except to the extent of his pecuniary interest therein.

F1 · ownership.nature: Shares are held directly by 5AM Ventures IV, L.P.

F2 · ownership.nature: The reporting person is a managing member of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM Funds. The reporting person disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM Funds, except to the extent of his pecuniary interest therein.

SEC source: 0001209191-20-036845 · doc4.xml · nonDerivative · entry 2

5AM Ventures IV, L.P. · CIK 0001589315 · 10% owner

5AM Co-Investors IV, L.P. · CIK 0001593361 · 10% owner

5AM Partners IV, LLC · CIK 0001589314 · 10% owner

DIEKMAN JOHN D · CIK 0001240357 · 10% owner

Schwab Andrew J. · CIK 0001598549 · 10% owner

5AM Opportunities I, L.P. · CIK 0001753000 · 10% owner

5AM Opportunities I (GP), LLC · CIK 0001790778 · 10% owner

PARMAR KUSH · CIK 0001664281 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 80,772

F2 · ownership.direct: 5AM Partners IV, LLC is the sole general partner of each of 5AM Ventures IV, L.P. and 5AM Co-Investors IV, L.P. (collectively, the "5AM IV Funds"). Dr. John D. Diekman, Andrew J. Schwab and Dr. Scott M. Rocklage are managing members of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM IV Funds. Each of 5AM Partners IV, LLC, Dr. Diekman, Mr. Schwab and Dr. Rocklage disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM IV Funds, except to the extent of its or his pecuniary interest therein.

F3 · ownership.direct: Shares are held directly by 5AM Co-Investors IV, L.P.

F2 · ownership.nature: 5AM Partners IV, LLC is the sole general partner of each of 5AM Ventures IV, L.P. and 5AM Co-Investors IV, L.P. (collectively, the "5AM IV Funds"). Dr. John D. Diekman, Andrew J. Schwab and Dr. Scott M. Rocklage are managing members of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM IV Funds. Each of 5AM Partners IV, LLC, Dr. Diekman, Mr. Schwab and Dr. Rocklage disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM IV Funds, except to the extent of its or his pecuniary interest therein.

F3 · ownership.nature: Shares are held directly by 5AM Co-Investors IV, L.P.

SEC source: 0001209191-20-036845 · doc4.xml · nonDerivative · entry 1

5AM Ventures IV, L.P. · CIK 0001589315 · 10% owner

5AM Co-Investors IV, L.P. · CIK 0001593361 · 10% owner

5AM Partners IV, LLC · CIK 0001589314 · 10% owner

DIEKMAN JOHN D · CIK 0001240357 · 10% owner

Schwab Andrew J. · CIK 0001598549 · 10% owner

5AM Opportunities I, L.P. · CIK 0001753000 · 10% owner

5AM Opportunities I (GP), LLC · CIK 0001790778 · 10% owner

PARMAR KUSH · CIK 0001664281 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 1,938,549

F1 · ownership.direct: Shares are held directly by 5AM Ventures IV, L.P.

F2 · ownership.direct: 5AM Partners IV, LLC is the sole general partner of each of 5AM Ventures IV, L.P. and 5AM Co-Investors IV, L.P. (collectively, the "5AM IV Funds"). Dr. John D. Diekman, Andrew J. Schwab and Dr. Scott M. Rocklage are managing members of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM IV Funds. Each of 5AM Partners IV, LLC, Dr. Diekman, Mr. Schwab and Dr. Rocklage disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM IV Funds, except to the extent of its or his pecuniary interest therein.

F1 · ownership.nature: Shares are held directly by 5AM Ventures IV, L.P.

F2 · ownership.nature: 5AM Partners IV, LLC is the sole general partner of each of 5AM Ventures IV, L.P. and 5AM Co-Investors IV, L.P. (collectively, the "5AM IV Funds"). Dr. John D. Diekman, Andrew J. Schwab and Dr. Scott M. Rocklage are managing members of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM IV Funds. Each of 5AM Partners IV, LLC, Dr. Diekman, Mr. Schwab and Dr. Rocklage disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM IV Funds, except to the extent of its or his pecuniary interest therein.

SEC source: 0001209191-20-036847 · doc4.xml · nonDerivative · entry 2

ROCKLAGE SCOTT M · CIK 0001219014 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · see footnotes

Disclosed balance after: 80,772

F2 · ownership.direct: The reporting person is a managing member of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM Funds. The reporting person disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM Funds, except to the extent of his pecuniary interest therein.

F3 · ownership.direct: Shares are held directly by 5AM Co-Investors IV, L.P

F2 · ownership.nature: The reporting person is a managing member of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM Funds. The reporting person disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM Funds, except to the extent of his pecuniary interest therein.

F3 · ownership.nature: Shares are held directly by 5AM Co-Investors IV, L.P

SEC source: 0001209191-20-036847 · doc4.xml · nonDerivative · entry 1

ROCKLAGE SCOTT M · CIK 0001219014 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · see footnotes

Disclosed balance after: 1,938,549

F1 · ownership.direct: Shares are held directly by 5AM Ventures IV, L.P.

F2 · ownership.direct: The reporting person is a managing member of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM Funds. The reporting person disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM Funds, except to the extent of his pecuniary interest therein.

F1 · ownership.nature: Shares are held directly by 5AM Ventures IV, L.P.

F2 · ownership.nature: The reporting person is a managing member of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM Funds. The reporting person disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM Funds, except to the extent of his pecuniary interest therein.

SEC source: 0001209191-20-031545 · doc4.xml · nonDerivative · entry 2

5AM Ventures IV, L.P. · CIK 0001589315 · 10% owner

5AM Co-Investors IV, L.P. · CIK 0001593361 · 10% owner

5AM Partners IV, LLC · CIK 0001589314 · 10% owner

DIEKMAN JOHN D · CIK 0001240357 · 10% owner

Schwab Andrew J. · CIK 0001598549 · 10% owner

5AM Opportunities I, L.P. · CIK 0001753000 · 10% owner

5AM Opportunities I (GP), LLC · CIK 0001790778 · 10% owner

PARMAR KUSH · CIK 0001664281 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 90,572

F2 · ownership.direct: 5AM Partners IV, LLC is the sole general partner of each of 5AM Ventures IV, L.P. and 5AM Co-Investors IV, L.P. (collectively, the "5AM IV Funds"). Dr. John D. Diekman, Andrew J. Schwab and Dr. Scott M. Rocklage are managing members of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM IV Funds. Each of 5AM Partners IV, LLC, Dr. Diekman, Mr. Schwab and Dr. Rocklage disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM IV Funds, except to the extent of its or his pecuniary interest therein.

F3 · ownership.direct: Shares are held directly by 5AM Co-Investors IV, L.P.

F2 · ownership.nature: 5AM Partners IV, LLC is the sole general partner of each of 5AM Ventures IV, L.P. and 5AM Co-Investors IV, L.P. (collectively, the "5AM IV Funds"). Dr. John D. Diekman, Andrew J. Schwab and Dr. Scott M. Rocklage are managing members of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM IV Funds. Each of 5AM Partners IV, LLC, Dr. Diekman, Mr. Schwab and Dr. Rocklage disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM IV Funds, except to the extent of its or his pecuniary interest therein.

F3 · ownership.nature: Shares are held directly by 5AM Co-Investors IV, L.P.

SEC source: 0001209191-20-031545 · doc4.xml · nonDerivative · entry 1

5AM Ventures IV, L.P. · CIK 0001589315 · 10% owner

5AM Co-Investors IV, L.P. · CIK 0001593361 · 10% owner

5AM Partners IV, LLC · CIK 0001589314 · 10% owner

DIEKMAN JOHN D · CIK 0001240357 · 10% owner

Schwab Andrew J. · CIK 0001598549 · 10% owner

5AM Opportunities I, L.P. · CIK 0001753000 · 10% owner

5AM Opportunities I (GP), LLC · CIK 0001790778 · 10% owner

PARMAR KUSH · CIK 0001664281 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 2,173,748

F1 · ownership.direct: Shares are held directly by 5AM Ventures IV, L.P.

F2 · ownership.direct: 5AM Partners IV, LLC is the sole general partner of each of 5AM Ventures IV, L.P. and 5AM Co-Investors IV, L.P. (collectively, the "5AM IV Funds"). Dr. John D. Diekman, Andrew J. Schwab and Dr. Scott M. Rocklage are managing members of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM IV Funds. Each of 5AM Partners IV, LLC, Dr. Diekman, Mr. Schwab and Dr. Rocklage disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM IV Funds, except to the extent of its or his pecuniary interest therein.

F1 · ownership.nature: Shares are held directly by 5AM Ventures IV, L.P.

F2 · ownership.nature: 5AM Partners IV, LLC is the sole general partner of each of 5AM Ventures IV, L.P. and 5AM Co-Investors IV, L.P. (collectively, the "5AM IV Funds"). Dr. John D. Diekman, Andrew J. Schwab and Dr. Scott M. Rocklage are managing members of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM IV Funds. Each of 5AM Partners IV, LLC, Dr. Diekman, Mr. Schwab and Dr. Rocklage disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM IV Funds, except to the extent of its or his pecuniary interest therein.

SEC source: 0001209191-20-031546 · doc4.xml · nonDerivative · entry 2

ROCKLAGE SCOTT M · CIK 0001219014 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · see footnotes

Disclosed balance after: 90,572

F2 · ownership.direct: The reporting person is a managing member of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM Funds. The reporting person disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM Funds, except to the extent of his pecuniary interest therein.

F3 · ownership.direct: Shares are held directly by 5AM Co-Investors IV, L.P

F2 · ownership.nature: The reporting person is a managing member of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM Funds. The reporting person disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM Funds, except to the extent of his pecuniary interest therein.

F3 · ownership.nature: Shares are held directly by 5AM Co-Investors IV, L.P

SEC source: 0001209191-20-031546 · doc4.xml · nonDerivative · entry 1

ROCKLAGE SCOTT M · CIK 0001219014 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · see footnotes

Disclosed balance after: 2,173,748

F1 · ownership.direct: Shares are held directly by 5AM Ventures IV, L.P.

F2 · ownership.direct: The reporting person is a managing member of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM Funds. The reporting person disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM Funds, except to the extent of his pecuniary interest therein.

F1 · ownership.nature: Shares are held directly by 5AM Ventures IV, L.P.

F2 · ownership.nature: The reporting person is a managing member of 5AM Partners IV, LLC and may be deemed to have shared voting and investment power over the shares beneficially owned by the 5AM Funds. The reporting person disclaims beneficial ownership of the shares of Common Stock and Preferred Stock held directly by the 5AM Funds, except to the extent of his pecuniary interest therein.

SEC source: 0001104659-20-064447 · a4.xml · nonDerivative · entry 5

Versant Vantage I, L.P. · CIK 0001765253 · 10% owner

Versant Vantage I GP, L.P. · CIK 0001777651 · 10% owner

Versant Vantage I GP-GP, LLC · CIK 0001777653 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 0

F8 · kind: Represents a pro-rata in-kind distribution of Common Stock of the Issuer by Vantage GP-GP without consideration to its members.

F7 · ownership.nature: The shares are held by Vantage GP-GP.

SEC source: 0001104659-20-064447 · a4.xml · nonDerivative · entry 4

Versant Vantage I, L.P. · CIK 0001765253 · 10% owner

Versant Vantage I GP, L.P. · CIK 0001777651 · 10% owner

Versant Vantage I GP-GP, LLC · CIK 0001777653 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 1,734

F6 · kind: Represents a change in the form of ownership of Vantage GP-GP by virtue of the receipt of shares in the pro-rata in-kind distribution of Common Stock of the Issuer for no consideration by Vantage GP.

F7 · ownership.nature: The shares are held by Vantage GP-GP.

SEC source: 0001104659-20-064447 · a4.xml · nonDerivative · entry 3

Versant Vantage I, L.P. · CIK 0001765253 · 10% owner

Versant Vantage I GP, L.P. · CIK 0001777651 · 10% owner

Versant Vantage I GP-GP, LLC · CIK 0001777653 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 0

F5 · kind: Represents a pro-rata in-kind distribution of Common Stock of the Issuer by Vantage GP without consideration to its partners.

F4 · ownership.nature: The shares are held by Vantage GP.

SEC source: 0001104659-20-064447 · a4.xml · nonDerivative · entry 2

Versant Vantage I, L.P. · CIK 0001765253 · 10% owner

Versant Vantage I GP, L.P. · CIK 0001777651 · 10% owner

Versant Vantage I GP-GP, LLC · CIK 0001777653 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 1,750

F3 · kind: Represents a change in the form of ownership of Vantage GP by virtue of the receipt of shares in the pro-rata in-kind distribution of Common Stock of the Issuer for no consideration by Vantage.

F4 · ownership.nature: The shares are held by Vantage GP.

SEC source: 0001104659-20-064447 · a4.xml · nonDerivative · entry 1

Versant Vantage I, L.P. · CIK 0001765253 · 10% owner

Versant Vantage I GP, L.P. · CIK 0001777651 · 10% owner

Versant Vantage I GP-GP, LLC · CIK 0001777653 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 216,669

F1 · kind: Represents a pro-rata in-kind distribution of Common Stock of the Issuer by Versant Vantage I, L.P. ("Vantage") without consideration to its partners.

F2 · ownership.direct: These Shares are directly held by Vantage. Versant Vantage I GP-GP, LLC ("Vantage GP-GP") is the general partner of Versant Vantage I GP, L.P. ("Vantage GP"), which is the general partner of Vantage. Each of Vantage GP-GP and Vantage GP may be deemed to indirectly beneficially own the shares beneficially owned by Vantage, but each disclaims such beneficial ownership except to the extent of its pecuniary interest therein.