ANAB

SEC source: 0001209191-23-002878 · doc4.xml · derivative · entry 2

FENTON DENNIS M · CIK 0001184627 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,900

Underlying: Common Stock · 3,900 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock award ("RSU") represents a contingent right to receive 1 share of the Issuer's Common Stock upon settlement for no consideration.

F3 · derivative.exercise_date: The RSUs vests as to 100% of the total RSUs on the date of the Issuer's 2024 annual meeting of shareholders, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

F3 · derivative.expiration_date: The RSUs vests as to 100% of the total RSUs on the date of the Issuer's 2024 annual meeting of shareholders, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-23-002878 · doc4.xml · derivative · entry 1

FENTON DENNIS M · CIK 0001184627 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,600

Underlying: Common Stock · 10,600 shares

Expires 2033-01-05

F1 · derivative.exercise_date: The stock option vests as to 1/12 of the total shares monthly commencing on February 6, 2023 until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-23-002884 · doc4.xml · derivative · entry 2

RENTON HOLLINGS · CIK 0001187333 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,900

Underlying: Common Stock · 3,900 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock award ("RSU") represents a contingent right to receive 1 share of the Issuer's Common Stock upon settlement for no consideration.

F3 · derivative.exercise_date: The RSUs vests as to 100% of the total RSUs on the date of the Issuer's 2024 annual meeting of shareholders, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

F3 · derivative.expiration_date: The RSUs vests as to 100% of the total RSUs on the date of the Issuer's 2024 annual meeting of shareholders, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-23-002884 · doc4.xml · derivative · entry 1

RENTON HOLLINGS · CIK 0001187333 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,600

Underlying: Common Stock · 10,600 shares

Expires 2033-01-05

F1 · derivative.exercise_date: The stock option vests as to 1/12 of the total shares monthly commencing on February 6, 2023 until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-23-002883 · doc4.xml · derivative · entry 2

MULROY DENNIS · CIK 0001276840 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,980

Underlying: Common Stock · 20,980 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock award ("RSU") represents a contingent right to receive 1 share of the Issuer's Common Stock upon settlement for no consideration.

F3 · derivative.exercise_date: The RSUs vests as to 25% of the total RSUs annually commencing on January 6, 2024 until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

F3 · derivative.expiration_date: The RSUs vests as to 25% of the total RSUs annually commencing on January 6, 2024 until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-23-002883 · doc4.xml · derivative · entry 1

MULROY DENNIS · CIK 0001276840 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 57,260

Underlying: Common Stock · 57,260 shares

Expires 2033-01-05

F1 · derivative.exercise_date: The stock option vests as to 25% of the total shares on January 6, 2024, and thereafter vests as to 1/48 of the total shares monthly until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-23-002882 · doc4.xml · derivative · entry 2

Marquet Magda · CIK 0001631486 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,900

Underlying: Common Stock · 3,900 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock award ("RSU") represents a contingent right to receive 1 share of the Issuer's Common Stock upon settlement for no consideration.

F3 · derivative.exercise_date: The RSUs vests as to 100% of the total RSUs on the date of the Issuer's 2024 annual meeting of shareholders, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

F3 · derivative.expiration_date: The RSUs vests as to 100% of the total RSUs on the date of the Issuer's 2024 annual meeting of shareholders, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-23-002882 · doc4.xml · derivative · entry 1

Marquet Magda · CIK 0001631486 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,600

Underlying: Common Stock · 10,600 shares

Expires 2033-01-05

F1 · derivative.exercise_date: The stock option vests as to 1/12 of the total shares monthly commencing on February 6, 2023 until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-23-002887 · doc4.xml · derivative · entry 2

Topper James N · CIK 0001341382 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,900

Underlying: Common Stock · 3,900 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock award ("RSU") represents a contingent right to receive 1 share of the Issuer's Common Stock upon settlement for no consideration.

F3 · derivative.exercise_date: The RSUs vests as to 100% of the total RSUs on the date of the Issuer's 2024 annual meeting of shareholders, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

F3 · derivative.expiration_date: The RSUs vests as to 100% of the total RSUs on the date of the Issuer's 2024 annual meeting of shareholders, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-23-002887 · doc4.xml · derivative · entry 1

Topper James N · CIK 0001341382 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,600

Underlying: Common Stock · 10,600 shares

Expires 2033-01-05

F1 · derivative.exercise_date: The stock option vests as to 1/12 of the total shares monthly commencing on February 6, 2023 until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-23-002879 · doc4.xml · derivative · entry 2

Hamill Laura · CIK 0001751804 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,900

Underlying: Common Stock · 3,900 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock award ("RSU") represents a contingent right to receive 1 share of the Issuer's Common Stock upon settlement for no consideration.

F3 · derivative.exercise_date: The RSUs vests as to 100% of the total RSUs on the date of the Issuer's 2024 annual meeting of shareholders, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

F3 · derivative.expiration_date: The RSUs vests as to 100% of the total RSUs on the date of the Issuer's 2024 annual meeting of shareholders, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-23-002879 · doc4.xml · derivative · entry 1

Hamill Laura · CIK 0001751804 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,600

Underlying: Common Stock · 10,600 shares

Expires 2033-01-05

F1 · derivative.exercise_date: The stock option vests as to 1/12 of the total shares monthly commencing on February 6, 2023 until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-22-050354 · doc4.xml · derivative · entry 1

Lizzul Paul F. · CIK 0001711462 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,000

Underlying: Common Stock · 12,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Represents a one-time retention grant of restricted stock units ("RSUs"). Each RSU represents a contingent right to receive 1 share of the Issuer's Common Stock upon settlement for no consideration.

F2 · derivative.exercise_date: 50% of the total RSUs vest on September 14, 2023 and September 14, 2024, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

F2 · derivative.expiration_date: 50% of the total RSUs vest on September 14, 2023 and September 14, 2024, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

F3 · balance_after: In addition to the remaining options to purchase 12,000 shares of common stock as set forth in Table II above, the Reporting Person also holds (i) additional options to purchase up to an aggregate of 215,000 shares of common stock, which options vest according to their terms, and (ii) 1,751 shares of common stock held directly.

SEC source: 0001209191-22-050351 · doc4.xml · derivative · entry 1

LOUMEAU ERIC J · CIK 0001239648 · COO, General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,000

Underlying: Common Stock · 12,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Represents a one-time retention grant of restricted stock units ("RSUs"). Each RSU represents a contingent right to receive 1 share of the Issuer's Common Stock upon settlement for no consideration.

F2 · derivative.exercise_date: 50% of the total RSUs vest on September 14, 2023 and September 14, 2024, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

F2 · derivative.expiration_date: 50% of the total RSUs vest on September 14, 2023 and September 14, 2024, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

F3 · balance_after: In addition to the remaining options to purchase 12,000 shares of common stock as set forth in Table II above, the Reporting Person also holds an additional options to purchase up to an aggregate of 308,000 shares of common stock, which options vest according to their terms.

SEC source: 0001209191-22-050350 · doc4.xml · derivative · entry 1

MULROY DENNIS · CIK 0001276840 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,000

Underlying: Common Stock · 12,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Represents a one-time retention grant of restricted stock units ("RSUs"). Each RSU represents a contingent right to receive 1 share of the Issuer's Common Stock upon settlement for no consideration.

F2 · derivative.exercise_date: 50% of the total RSUs vest on September 14, 2023 and September 14, 2024, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

F2 · derivative.expiration_date: 50% of the total RSUs vest on September 14, 2023 and September 14, 2024, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

F3 · balance_after: In addition to the remaining options to purchase 12,000 shares of common stock as set forth in Table II above, the Reporting Person also holds (i) additional options to purchase up to an aggregate of 215,600 shares of common stock, which options vest according to their terms, and (ii) 964 shares of common stock held directly.

SEC source: 0001209191-22-045061 · doc4.xml · nonDerivative · entry 1

LOUMEAU ERIC J · CIK 0001239648 · COO, General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · shares: The shares sold represent 523 shares purchased pursuant to the Company's ESPP at 85% of the lesser of the closing price of the Issuer's Common Stock on November 15, 2021.

SEC source: 0001209191-22-039534 · doc4.xml · derivative · entry 1

MULROY DENNIS · CIK 0001276840 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2031-02-09

F1 · derivative.exercise_date: On February 10, 2021, the reporting person was granted a performance-based option to purchase 10,000 shares of the Issuer's common stock, subject to the achievement of certain corporate performance criteria and the reporting person's continued service to the Issuer upon achievement thereof. The performance criteria were achieved on the date in Column 3, resulting in the vesting of the entire award.

F2 · balance_after: In addition to the remaining options to purchase 10,000 shares of common stock as set forth in Table II above, the Reporting Person also holds (i) additional options to purchase up to an aggregate of 205,600 shares of common stock, which options vest according to their terms, and (ii) 964 shares of common stock held directly.

SEC source: 0001209191-22-039531 · doc4.xml · derivative · entry 1

Lizzul Paul F. · CIK 0001711462 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2031-02-09

F1 · derivative.exercise_date: On February 10, 2021, the reporting person was granted a performance-based option to purchase 10,000 shares of the Issuer's common stock, subject to the achievement of certain corporate performance criteria and the reporting person's continued service to the Issuer upon achievement thereof. The performance criteria were achieved on the date in Column 3, resulting in the vesting of the entire award.

F2 · balance_after: In addition to the remaining options to purchase 10,000 shares of common stock as set forth in Table II above, the Reporting Person also holds (i) additional options to purchase up to an aggregate of 205,000 shares of common stock, which options vest according to their terms, and (ii) 1,751 shares of common stock held directly.

SEC source: 0001209191-22-039532 · doc4.xml · derivative · entry 1

LOUMEAU ERIC J · CIK 0001239648 · COO, General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2031-02-09

F1 · derivative.exercise_date: On February 10, 2021, the reporting person was granted a performance-based option to purchase 10,000 shares of the Issuer's common stock, subject to the achievement of certain corporate performance criteria and the reporting person's continued service to the Issuer upon achievement thereof. The performance criteria were achieved on the date in Column 3, resulting in the vesting of the entire award.

F2 · balance_after: In addition to the remaining options to purchase 10,000 shares of common stock as set forth in Table II above, the Reporting Person also holds (i) additional options to purchase up to an aggregate of 298,000 shares of common stock, which options vest according to their terms, and (ii) 523 shares of common stock held directly.

SEC source: 0001209191-22-036020 · doc4.xml · derivative · entry 3

LOUMEAU ERIC J · CIK 0001239648 · COO, General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 83,000

Underlying: Common Stock · 2,500 shares

Expires 2029-12-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock option vested and is exercisable as to 25% of the shares subject to the option on December 6, 2020, and thereafter vests as to 1/48th of the shares in equal monthly installments, until such time as the option is 100% vested, subject to the continuing employment of the Reporting Person on each vesting date.

F3 · balance_after: In addition to the remaining options to purchase 83,000 shares of common stock as set forth in Table II, the Reporting Person also holds additional options to purchase up to an aggregate of 215,000 shares of common stock, which options vest according to their terms.

SEC source: 0001209191-22-036020 · doc4.xml · nonDerivative · entry 2

LOUMEAU ERIC J · CIK 0001239648 · COO, General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 523

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the reporting person.

SEC source: 0001209191-22-036020 · doc4.xml · nonDerivative · entry 1

LOUMEAU ERIC J · CIK 0001239648 · COO, General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,023

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-22-031028 · doc4.xml · nonDerivative · entry 1

LOUMEAU ERIC J · CIK 0001239648 · COO, General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 523

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · shares: The shares sold represent 1,146 shares purchased pursuant to the Company's ESPP at 85% of the lesser of the closing price of the Issuer's Common Stock on May 13, 2022 and November 16, 2022.

SEC source: 0001567619-22-009732 · doc1.xml · nonDerivative · entry 2

EcoR1 Capital, LLC · CIK 0001587114 · 10% owner

NODELMAN OLEG · CIK 0001454385 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note

Disclosed balance after: 7,521,024

F1 · kind: EcoR1 Capital Fund, L.P. ("Capital Fund") and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund") are private investment funds managed by EcoR1 Capital, LLC ("EcoR1") on a parri passu basis. These securities were transferred from Capital Fund to Qualified Fund as part of a periodic rebalancing of the portfolios of the funds.

F2 · ownership.nature: The filing persons (the "Filers") are EcoR1, Oleg Nodelman and Qualified Fund. EcoR1 is the investment adviser and general partner of private funds, including Qualified Fund and Capital Fund (collectively, the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1 and a director of the Issuer. EcoR1 is filing this Form 4 for itself and Qualified Fund. The Filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to beneficially own the securities indirectly as the investment adviser to the Funds, and Mr. Nodelman may be deemed to beneficially own them indirectly as the control person of EcoR1. The Filers disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein.

SEC source: 0001567619-22-009732 · doc1.xml · nonDerivative · entry 1

EcoR1 Capital, LLC · CIK 0001587114 · 10% owner

NODELMAN OLEG · CIK 0001454385 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Notes

Disclosed balance after: 7,521,024

F1 · kind: EcoR1 Capital Fund, L.P. ("Capital Fund") and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund") are private investment funds managed by EcoR1 Capital, LLC ("EcoR1") on a parri passu basis. These securities were transferred from Capital Fund to Qualified Fund as part of a periodic rebalancing of the portfolios of the funds.

F2 · ownership.nature: The filing persons (the "Filers") are EcoR1, Oleg Nodelman and Qualified Fund. EcoR1 is the investment adviser and general partner of private funds, including Qualified Fund and Capital Fund (collectively, the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1 and a director of the Issuer. EcoR1 is filing this Form 4 for itself and Qualified Fund. The Filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to beneficially own the securities indirectly as the investment adviser to the Funds, and Mr. Nodelman may be deemed to beneficially own them indirectly as the control person of EcoR1. The Filers disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein.

F3 · ownership.nature: After this transaction, Qualified Fund held 7,042,903 shares of the Issuer's Common Stock.

SEC source: 0001209191-22-020792 · doc4.xml · nonDerivative · entry 1

Faga Daniel · CIK 0001673528 · Director · Interim CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 887,043

F1 · balance_after: Certain of the restricted stock units are subject to forfeiture to the Issuer if underlying vesting conditions are not met.

SEC source: 0001209191-22-009315 · doc4.xml · derivative · entry 1

Ware J. Anthony · CIK 0001715429 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,200

Underlying: Common Stock · 9,200 shares

Expires 2032-02-09

F1 · derivative.exercise_date: The stock option vests as of 1/12 of the total shares monthly beginning on March 10, 2022 until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-22-009364 · doc4.xml · derivative · entry 1

Lizzul Paul F. · CIK 0001711462 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 70,000

Underlying: Common Stock · 70,000 shares

Expires 2032-02-09

F1 · derivative.exercise_date: The stock option vests and becomes exercisable as to 25% of the shares subject to the option on February 10, 2023, and thereafter vests as to 1/48th of the shares in equal monthly installments, until such time as the option is 100% vested, subject to the continuing employment of the Reporting Person on each vesting date.

F2 · balance_after: In addition to the remaining options to purchase 70,000 shares of common stock as set forth in Table II above, the Reporting Person also holds (i) additional options to purchase up to an aggregate of 135,000 shares of common stock, which options vest according to their terms, and (ii) 964 shares of common stock held directly.

SEC source: 0001209191-22-009320 · doc4.xml · derivative · entry 1

Faga Daniel · CIK 0001673528 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,200

Underlying: Common Stock · 9,200 shares

Expires 2032-02-09

F1 · derivative.exercise_date: The stock option vests as of 1/12 of the total shares monthly beginning on March 10, 2022 until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-22-009347 · doc4.xml · derivative · entry 1

Schmid John P. · CIK 0001478916 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,200

Underlying: Common Stock · 9,200 shares

Expires 2032-02-09

F1 · derivative.exercise_date: The stock option vests as of 1/12 of the total shares monthly beginning on March 10, 2022 until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-22-009335 · doc4.xml · derivative · entry 1

LOUMEAU ERIC J · CIK 0001239648 · COO, General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 70,000

Underlying: Common Stock · 70,000 shares

Expires 2032-02-09

F1 · derivative.exercise_date: The stock option vests and becomes exercisable as to 25% of the shares subject to the option on February 10, 2023, and thereafter vests as to 1/48th of the shares in equal monthly installments, until such time as the option is 100% vested, subject to the continuing employment of the Reporting Person on each vesting date.

F2 · balance_after: In addition to the remaining options to purchase 70,000 shares of common stock as set forth in Table II above, the Reporting Person also holds (i) additional options to purchase up to an aggregate of 230,500 shares of common stock, which options vest according to their terms, and (ii) 523 shares of common stock held directly.

SEC source: 0001209191-22-009339 · doc4.xml · derivative · entry 1

RENTON HOLLINGS · CIK 0001187333 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,200

Underlying: Common Stock · 9,200 shares

Expires 2032-02-09

F1 · derivative.exercise_date: The stock option vests as of 1/12 of the total shares monthly beginning on March 10, 2022 until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-22-009323 · doc4.xml · derivative · entry 1

FENTON DENNIS M · CIK 0001184627 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,200

Underlying: Common Stock · 9,200 shares

Expires 2032-02-09

F1 · derivative.exercise_date: The stock option vests as of 1/12 of the total shares monthly beginning on March 10, 2022 until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-22-009329 · doc4.xml · derivative · entry 1

MULROY DENNIS · CIK 0001276840 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 70,000

Underlying: Common Stock · 70,000 shares

Expires 2032-02-09

F1 · derivative.exercise_date: The stock option vests and becomes exercisable as to 25% of the shares subject to the option on February 10, 2023, and thereafter vests as to 1/48th of the shares in equal monthly installments, until such time as the option is 100% vested, subject to the continuing employment of the Reporting Person on each vesting date.

F2 · balance_after: In addition to the remaining options to purchase 70,000 shares of common stock as set forth in Table II above, the Reporting Person also holds (i) additional options to purchase up to an aggregate of 135,600 shares of common stock, which options vest according to their terms, and (ii) 964 shares of common stock held directly.

SEC source: 0001209191-22-009352 · doc4.xml · derivative · entry 1

Topper James N · CIK 0001341382 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,200

Underlying: Common Stock · 9,200 shares

Expires 2032-02-09

F1 · derivative.exercise_date: The stock option vests as of 1/12 of the total shares monthly beginning on March 10, 2022 until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-22-009341 · doc4.xml · derivative · entry 1

Suria Hamza · CIK 0001654495 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 200,000

Underlying: Common Stock · 200,000 shares

Expires 2032-02-09

F1 · derivative.exercise_date: The stock option vests and becomes exercisable as to 25% of the shares subject to the option on February 10, 2023, and thereafter vests as to 1/48th of the shares in equal monthly installments, until such time as the option is 100% vested, subject to the continuing employment of the Reporting Person on each vesting date.

F2 · balance_after: In addition to the remaining options to purchase 200,000 shares of common stock as set forth in Table II above, the Reporting Person also holds (i) additional options to purchase up to an aggregate of 1,118,893 shares of common stock, which options vest according to their terms, and (ii) 68,600 shares of common stock held directly.

SEC source: 0001209191-22-009355 · doc4.xml · derivative · entry 1

Hamill Laura · CIK 0001751804 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,200

Underlying: Common Stock · 9,200 shares

Expires 2032-02-09

F1 · derivative.exercise_date: The stock option vests as of 1/12 of the total shares monthly beginning on March 10, 2022 until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-22-009361 · doc4.xml · derivative · entry 1

Marquet Magda · CIK 0001631486 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,200

Underlying: Common Stock · 9,200 shares

Expires 2032-02-09

F1 · derivative.exercise_date: The stock option vests as of 1/12 of the total shares monthly beginning on March 10, 2022 until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-21-070986 · doc4.xml · derivative · entry 5

Suria Hamza · CIK 0001654495 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 36,645 shares

Expires 2022-01-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The stock option grant was issued on February 1, 2012, is fully vested and exercisable until its expiration date of January 31, 2022.

F6 · balance_after: In addition to the remaining options to purchase 0 shares of common stock as set forth in Table II above, the Reporting Person also holds (i) additional options to purchase up to an aggregate of 1,118,893 shares of common stock, which options vest according to their terms, and (ii) 68,600 shares of common stock held directly.

SEC source: 0001209191-21-070986 · doc4.xml · nonDerivative · entry 4

Suria Hamza · CIK 0001654495 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 68,600

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the reporting person.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $36.26 to $36.52, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth herein.

SEC source: 0001209191-21-070986 · doc4.xml · nonDerivative · entry 3

Suria Hamza · CIK 0001654495 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 74,122

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the reporting person.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $35.26 to $36.25, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth herein.

SEC source: 0001209191-21-070986 · doc4.xml · nonDerivative · entry 2

Suria Hamza · CIK 0001654495 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 93,330

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the reporting person.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $34.25 to $35.23, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth herein.

SEC source: 0001209191-21-070986 · doc4.xml · nonDerivative · entry 1

Suria Hamza · CIK 0001654495 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 105,245

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-21-067159 · doc4.xml · derivative · entry 2

Faga Daniel · CIK 0001673528 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,321

Underlying: Common Stock · 2,321 shares

Expires 2031-11-25

F2 · derivative.exercise_date: The option shall vest and become exercisable in full on February 10, 2022, subject to the reporting person's continuous status as a director through February 10, 2022.

SEC source: 0001209191-21-067159 · doc4.xml · derivative · entry 1

Faga Daniel · CIK 0001673528 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock · 11,000 shares

Expires 2031-11-25

F1 · derivative.exercise_date: 1/36th of the total shares subject to the option shall vest on December 26, 2021 and 1/36th of the total shares subject to the option shall vest on each monthly anniversary thereafter, subject to the reporting person's continuous status as a director through each such date.

SEC source: 0001209191-21-065178 · doc4.xml · nonDerivative · entry 1

Lizzul Paul F. · CIK 0001711462 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 964

F1 · shares: Represents shares of Common Stock acquired pursuant to the Issuer's Employee Stock Purchase Plan ("ESPP"), for the purchase period through November 15, 2021. In accordance with the ESPP, these shares were purchased at 85% of the lesser of the closing price of the Issuer's Common Stock on May 17, 2021 and November 15, 2021.

SEC source: 0001209191-21-065168 · doc4.xml · nonDerivative · entry 1

LOUMEAU ERIC J · CIK 0001239648 · COO, General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 523

F1 · shares: Represents shares of Common Stock acquired pursuant to the Issuer's Employee Stock Purchase Plan ("ESPP"), for the purchase period through November 15, 2021. In accordance with the ESPP, these shares were purchased at 85% of the lesser of the closing price of the Issuer's Common Stock on May 17, 2021 and November 15, 2021.

F2 · balance_after: In addition to the reporting person's common stock directly held as set forth in Table I above, the Reporting Person also holds (i) additional options to purchase up to an aggregate of 230,500 shares of common stock, which options vest according to their terms.

SEC source: 0001209191-21-065166 · doc4.xml · nonDerivative · entry 1

MULROY DENNIS · CIK 0001276840 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 964

F1 · shares: Represents shares of Common Stock acquired pursuant to the Issuer's Employee Stock Purchase Plan ("ESPP"), for the purchase period through November 15, 2021. In accordance with the ESPP, these shares were purchased at 85% of the lesser of the closing price of the Issuer's Common Stock on May 17, 2021 and November 15, 2021.

SEC source: 0001209191-21-065173 · doc4.xml · nonDerivative · entry 1

Suria Hamza · CIK 0001654495 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 68,600

F1 · shares: Represents shares of Common Stock acquired pursuant to the Issuer's Employee Stock Purchase Plan ("ESPP"), for the purchase period through November 15, 2021. In accordance with the ESPP, these shares were purchased at 85% of the lesser of the closing price of the Issuer's Common Stock on May 17, 2021 and November 15, 2021.

F2 · balance_after: In addition to the reporting person's common stock directly held as set forth in Table I above, the Reporting Person also holds (i) additional options to purchase up to an aggregate of 1,155,538 shares of common stock, which options vest according to their terms.

SEC source: 0001209191-21-063263 · doc4.xml · derivative · entry 6

Suria Hamza · CIK 0001654495 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 14,302 shares

Expires 2021-12-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock option grant was issued on December 9, 2011, is fully vested and exercisable until its expiration date of December 8, 2021.

F3 · balance_after: In addition to the remaining options to purchase 0 shares of common stock as set forth in Table II above, the Reporting Person also holds (i) additional options to purchase up to an aggregate of 1,155,538 shares of common stock, which options vest according to their terms, and (ii) 67,636 shares of common stock held directly.