ANAB

SEC source: 0001209191-20-059179 · doc4.xml · nonDerivative · entry 1

Topper James N · CIK 0001341382 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By: Frazier Healthcare V, L.P.

Disclosed balance after: 0

F1 · kind: Represents a pro rata distribution in-kind by Frazier Healthcare V, L.P. to its limited partners for no consideration.

F2 · ownership.nature: The reportable securities were held directly by Frazier Healthcare V, L.P. FHM V, L.P. is the general partner of Frazier Healthcare V, L.P. FHM V, L.L.C. is the general partner of FHM V, L.P. James Topper is one of five managing members of FHM V, L.L.C. Dr. Topper disclaims beneficial ownership of the securities held by Frazier Healthcare V, L.P., except to the extent of his pecuniary interest therein, if any.

SEC source: 0001209191-20-044259 · doc4.xml · derivative · entry 1

Lizzul Paul F. · CIK 0001711462 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 90,000

Underlying: Common Stock · 90,000 shares

Expires 2030-07-30

F1 · derivative.exercise_date: The stock option vests and becomes exercisable as to 25% of the shares subject to the option on July 31, 2021, and thereafter vests as to 1/48th of the shares in equal monthly installments, until such time as the option is 100% vested, subject to the continuing employment of the Reporting Person on each vesting date.

SEC source: 0001209191-20-042506 · doc4.xml · derivative · entry 1

LOUMEAU ERIC J · CIK 0001239648 · COO, General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2030-07-12

F1 · derivative.exercise_date: The stock option vests and becomes exercisable as to 25% of the shares subject to the option on July 15, 2021, and thereafter vests as to 1/48th of the shares in equal monthly installments, until such time as the option is 100% vested, subject to the continuing employment of the Reporting Person on each vesting date.

SEC source: 0001209191-20-042505 · doc4.xml · derivative · entry 1

MULROY DENNIS · CIK 0001276840 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 90,600

Underlying: Common Stock · 90,600 shares

Expires 2030-07-12

F1 · derivative.exercise_date: The stock option vests and becomes exercisable as to 25% of the shares subject to the option on July 15, 2021, and thereafter vests as to 1/48th of the shares in equal monthly installments, until such time as the option is 100% vested, subject to the continuing employment of the Reporting Person on each vesting date.

SEC source: 0001209191-20-017742 · doc4.xml · derivative · entry 2

Suria Hamza · CIK 0001654495 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,361

Underlying: Common Stock · 10,000 shares

Expires 2021-12-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The stock option is fully vested and immediately exercisable.

F2 · balance_after: In addition to the remaining options to purchase 40,361 shares of common stock as set forth in Table II above, the Reporting Person also holds (i) additional options to purchase up to an aggregate of 1,088,477 shares of common stock, which options vest according to their terms, and (ii) 47,636 shares of common stock held directly.

SEC source: 0001209191-20-017742 · doc4.xml · nonDerivative · entry 1

Suria Hamza · CIK 0001654495 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,636

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-20-009329 · doc4.xml · derivative · entry 1

Ware J. Anthony · CIK 0001715429 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock · 11,000 shares

Expires 2030-02-11

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on March 12, 2020, until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001209191-20-009325 · doc4.xml · derivative · entry 1

Schmid John P. · CIK 0001478916 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock · 11,000 shares

Expires 2030-02-11

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on March 12, 2020, until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001209191-20-009322 · doc4.xml · derivative · entry 1

RENTON HOLLINGS · CIK 0001187333 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock · 11,000 shares

Expires 2030-02-11

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on March 12, 2020, until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001209191-20-009309 · doc4.xml · derivative · entry 1

FENTON DENNIS M · CIK 0001184627 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock · 11,000 shares

Expires 2030-02-11

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on March 12, 2020, until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001209191-20-009327 · doc4.xml · derivative · entry 1

Topper James N · CIK 0001341382 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock · 11,000 shares

Expires 2030-02-11

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on March 12, 2020, until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001209191-20-009316 · doc4.xml · derivative · entry 1

Hamill Laura · CIK 0001751804 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock · 11,000 shares

Expires 2030-02-11

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on March 12, 2020, until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001209191-20-007246 · doc4.xml · derivative · entry 2

Suria Hamza · CIK 0001654495 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,361

Underlying: Common Stock · 10,000 shares

Expires 2021-12-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The stock option is fully vested and immediately exercisable.

F2 · balance_after: In addition to the remaining options to purchase 50,361 shares of common stock as set forth in Table II above, the Reporting Person also holds (i) additional options to purchase up to an aggregate of 1,088,477 shares of common stock, which options vest according to their terms, and (ii) 37,636 shares of common stock held directly.

SEC source: 0001209191-20-007246 · doc4.xml · nonDerivative · entry 1

Suria Hamza · CIK 0001654495 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,636

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-19-060981 · doc4.xml · derivative · entry 1

Suria Hamza · CIK 0001654495 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 280,000

Underlying: Common Stock · 280,000 shares

Expires 2029-12-12

F1 · derivative.exercise_date: The stock option vests and becomes exercisable as to 25% of the shares subject to the option on December 6, 2020, and thereafter vests as to 1/48th of the shares in equal monthly installments, until such time as the option is 100% vested, subject to the continuing employment of the Reporting Person on each vesting date.

SEC source: 0001209191-20-007251 · doc4.xml · nonDerivative · entry 1

Ware J. Anthony · CIK 0001715429 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,600

SEC source: 0001209191-19-059924 · doc4.xml · derivative · entry 1

LOUMEAU ERIC J · CIK 0001239648 · General Counsel & Interim CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 98,000

Underlying: Common Stock · 98,000 shares

Expires 2029-12-05

F1 · derivative.exercise_date: The stock option vests and becomes exercisable as to 25% of the shares subject to the option on December 6, 2020, and thereafter vests as to 1/48th of the shares in equal monthly installments, until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001209191-19-059923 · doc4.xml · derivative · entry 1

Londei Marco · CIK 0001654500 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 98,000

Underlying: Common Stock · 98,000 shares

Expires 2029-12-05

F1 · derivative.exercise_date: The stock option vests and becomes exercisable as to 25% of the shares subject to the option on December 6, 2020, and thereafter vests as to 1/48th of the shares in equal monthly installments, until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001209191-19-058549 · doc4.xml · derivative · entry 2

Londei Marco · CIK 0001654500 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,946

Underlying: Common Stock · 46,202 shares

Expires 2025-08-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The stock option is fully vested and immediately exercisable.

F2 · balance_after: In addition to the remaining options to purchase 4,946 shares of common stock as set forth in Table II, the Reporting Person also holds (i) additional options to purchase up to an aggregate of 173,000 shares of common stock, which options vest according to their terms, and (ii) 68,579 shares of common stock held directly.

SEC source: 0001209191-19-058549 · doc4.xml · nonDerivative · entry 1

Londei Marco · CIK 0001654500 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 68,579

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-19-057952 · doc4.xml · derivative · entry 2

Suria Hamza · CIK 0001654495 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 60,361

Underlying: Common Stock · 10,000 shares

Expires 2021-12-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The stock option is fully vested and immediately exercisable.

F2 · balance_after: In addition to the remaining options to purchase 60,361 shares of common stock as set forth in Table II above, the Reporting Person also holds (i) additional options to purchase up to an aggregate of 808,477 shares of common stock, which options vest according to their terms, and (ii) 27,636 shares of common stock held directly.

SEC source: 0001209191-19-057952 · doc4.xml · nonDerivative · entry 1

Suria Hamza · CIK 0001654495 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,636

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-19-050889 · doc4.xml · derivative · entry 2

Hamill Laura · CIK 0001751804 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,268

Underlying: Common Stock · 2,268 shares

Expires 2029-09-24

F2 · derivative.exercise_date: The option vests as follows: 1/4th of the total shares subject to the option shall vest on November 8, 2019 and 1/4th of the total shares subject to the option shall vest each month thereafter on each monthly anniversary of November 8, 2019, subject to the reporting person's continuous status as a director through each such date.

SEC source: 0001209191-19-050889 · doc4.xml · derivative · entry 1

Hamill Laura · CIK 0001751804 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,000

Underlying: Common Stock · 6,000 shares

Expires 2029-09-24

F1 · derivative.exercise_date: The option vests as follows: 1/36th of the total shares subject to the option shall vest on October 24, 2019 and 1/36th of the total shares subject to the option shall vest each month thereafter on each monthly anniversary of October 24, 2019, subject to the reporting person's continuous status as a director through each such date.

SEC source: 0001209191-19-046820 · doc4.xml · derivative · entry 1

LOUMEAU ERIC J · CIK 0001239648 · General Counsel & Interim CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,500

Underlying: Common Stock · 17,500 shares

Expires 2029-08-17

F1 · derivative.exercise_date: The option vests over a 4 year period: 25% vest and become exercisable on August 18, 2020, after which 1/48th of the total shares vest and become exercisable monthly thereafter, subject to reporting person's continuous service through each vesting date.

SEC source: 0001209191-19-036426 · doc4.xml · nonDerivative · entry 5

Suria Hamza · CIK 0001654495 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,636

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the reporting person.

F6 · balance_after: The Reporting Person also holds options to purchase up to an aggregate of 878,838 shares of common stock, which options vest according to their terms, in addition to the 17,636 shares of common stock held directly as set forth in Table I above.

SEC source: 0001209191-19-036426 · doc4.xml · nonDerivative · entry 4

Suria Hamza · CIK 0001654495 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,090

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the reporting person.

F5 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $75.24 to $76.13 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001209191-19-036426 · doc4.xml · nonDerivative · entry 3

Suria Hamza · CIK 0001654495 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,084

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the reporting person.

F4 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $74.20 to $75.12 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001209191-19-036426 · doc4.xml · nonDerivative · entry 2

Suria Hamza · CIK 0001654495 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,084

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the reporting person.

F3 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $73.20 to $74.15 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001209191-19-036426 · doc4.xml · nonDerivative · entry 1

Suria Hamza · CIK 0001654495 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,524

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the reporting person.

F2 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $72.16 to $73.15 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001209191-19-034870 · doc4.xml · derivative · entry 5

Londei Marco · CIK 0001654500 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 10,060 shares

Expires 2024-10-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The stock option vested and became exercisable as to 25% of the shares subject to the option on October 24, 2015, and thereafter vests as to 1/48th of the shares in equal monthly installments, until such time as the option is 100% vested, subject to the continuing employment of the Reporting Person on each vesting date.

F6 · balance_after: The Reporting Person also holds (i) additional options to purchase up to an aggregate of 224,148 shares of common stock, which options vest according to their terms, and (ii) 22,377 shares of common stock held directly.

SEC source: 0001209191-19-034870 · doc4.xml · nonDerivative · entry 4

Londei Marco · CIK 0001654500 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,377

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the reporting person.

F4 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $74.085 to $74.78 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001209191-19-034870 · doc4.xml · nonDerivative · entry 3

Londei Marco · CIK 0001654500 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,380

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the reporting person.

F3 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $73.04 to $73.98 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001209191-19-034870 · doc4.xml · nonDerivative · entry 2

Londei Marco · CIK 0001654500 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,428

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the reporting person.

F2 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $72.00 to $72.99 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001209191-19-034870 · doc4.xml · nonDerivative · entry 1

Londei Marco · CIK 0001654500 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,437

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-19-025283 · doc4.xml · derivative · entry 2

Suria Hamza · CIK 0001654495 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 70,361

Underlying: Common Stock · 10,000 shares

Expires 2021-12-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The stock option is fully vested and immediately exercisable.

F2 · balance_after: In addition to the remaining option to purchase 70,361 shares of common stock as set forth in Table II, the Reporting Person also holds (i) additional options to purchase up to an aggregate of 808,477 shares of common stock, which options vest according to their terms, and (ii) 40,064 shares of common stock held directly.

SEC source: 0001209191-19-025283 · doc4.xml · nonDerivative · entry 1

Suria Hamza · CIK 0001654495 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,064

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-19-009046 · doc4.xml · derivative · entry 1

Ware J. Anthony · CIK 0001715429 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,000

Underlying: Common Stock · 6,000 shares

Expires 2029-02-07

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on March 8, 2019, until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001209191-19-009034 · doc4.xml · derivative · entry 1

Piscitelli Dominic · CIK 0001695028 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,000

Underlying: Common Stock · 35,000 shares

Expires 2029-02-07

F1 · derivative.exercise_date: The stock option vests and becomes exercisable as to 25% of the shares subject to the option on February 8, 2020, and thereafter vests as to 1/48th of the shares in equal monthly installments, until such time as the option is 100% vested, subject to the continuing employment of the Reporting Person on each vesting date.

SEC source: 0001209191-19-009038 · doc4.xml · derivative · entry 1

Schmid John P. · CIK 0001478916 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,000

Underlying: Common Stock · 6,000 shares

Expires 2019-02-07

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on March 8, 2019, until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001209191-19-009028 · doc4.xml · derivative · entry 1

LOUMEAU ERIC J · CIK 0001239648 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,000

Underlying: Common Stock · 35,000 shares

Expires 2029-02-07

F1 · derivative.exercise_date: The stock option vests and becomes exercisable as to 25% of the shares subject to the option on February 8, 2020, and thereafter vests as to 1/48th of the shares in equal monthly installments, until such time as the option is 100% vested, subject to the continuing employment of the Reporting Person on each vesting date.

SEC source: 0001209191-19-009006 · doc4.xml · derivative · entry 1

FENTON DENNIS M · CIK 0001184627 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,000

Underlying: Common Stock · 6,000 shares

Expires 2029-02-07

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on March 8, 2019, until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001209191-19-009036 · doc4.xml · derivative · entry 1

RENTON HOLLINGS · CIK 0001187333 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,000

Underlying: Common Stock · 6,000 shares

Expires 2019-02-07

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on March 8, 2019, until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001209191-19-009044 · doc4.xml · derivative · entry 1

Topper James N · CIK 0001341382 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,000

Underlying: Common Stock · 6,000 shares

Expires 2029-02-07

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on March 8, 2019, until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001209191-19-009043 · doc4.xml · derivative · entry 1

Suria Hamza · CIK 0001654495 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,000

Underlying: Common Stock · 94,000 shares

Expires 2029-02-07

F1 · derivative.exercise_date: The stock option vests and becomes exercisable as to 25% of the shares subject to the option on February 8, 2020, and thereafter vests as to 1/48th of the shares in equal monthly installments, until such time as the option is 100% vested, subject to the continuing employment of the Reporting Person on each vesting date.

SEC source: 0001209191-19-009031 · doc4.xml · derivative · entry 1

Lydon Nicholas · CIK 0001639935 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,000

Underlying: Common Stock · 6,000 shares

Expires 2029-02-07

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on March 8, 2019, until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001209191-19-009024 · doc4.xml · derivative · entry 1

Londei Marco · CIK 0001654500 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,000

Underlying: Common Stock · 35,000 shares

Expires 2029-02-07

F1 · derivative.exercise_date: The stock option vests and becomes exercisable as to 25% of the shares subject to the option on February 8, 2020, and thereafter vests as to 1/48th of the shares in equal monthly installments, until such time as the option is 100% vested, subject to the continuing employment of the Reporting Person on each vesting date.

SEC source: 0001209191-19-003996 · doc4.xml · derivative · entry 5

Londei Marco · CIK 0001654500 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 51,148

Underlying: Common Stock · 19,075 shares

Expires 2025-08-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · kind: The transactions reported on this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the reporting person.

F5 · derivative.exercise_date: The stock option vested and became exercisable as to 25% of the shares subject to the option on August 13, 2016, and thereafter vests as to 1/48th of the shares in equal monthly installments, until such time as the option is 100% vested, subject to the continuing employment of the Reporting Person on each vesting date.

F6 · balance_after: In addition to the remaining options to purchase 51,148 shares of common stock as set forth in Table II above, the Reporting Person also holds (i) additional options to purchase up to an aggregate of 148,060 shares of common stock, which options vest according to their terms, and (ii) 22,377 shares of common stock held directly.

SEC source: 0001209191-19-003996 · doc4.xml · nonDerivative · entry 4

Londei Marco · CIK 0001654500 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,377

F2 · kind: The transactions reported on this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the reporting person.

F4 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $69.63 to $70.37 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001209191-19-003996 · doc4.xml · nonDerivative · entry 3

Londei Marco · CIK 0001654500 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,271

F2 · kind: The transactions reported on this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the reporting person.

F3 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $68.63 to $69.60 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.