ALT

SEC source: 0001104659-25-008772 · tm255357-3_4seq1.xml · nonDerivative · entry 6

Harris Matthew Scott · CIK 0001787762 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 84,564

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · price: Vesting transaction: Shares surrendered to the Issuer solely to cover taxes associated with vesting of RSUs.

SEC source: 0001104659-25-008773 · tm255357-4_4seq1.xml · derivative · entry 10

Garg Vipin K · CIK 0001515813 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,950

Underlying: Common Stock, par value $0.0001 · 18,950 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

F7 · derivative.exercise_date: The RSUs vest in substantially equal annual installments over the 4 years following February 2, 2022, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

F7 · derivative.expiration_date: The RSUs vest in substantially equal annual installments over the 4 years following February 2, 2022, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

SEC source: 0001104659-25-008773 · tm255357-4_4seq1.xml · nonDerivative · entry 7

Garg Vipin K · CIK 0001515813 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 355,082

F1 · kind: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

SEC source: 0001104659-25-008773 · tm255357-4_4seq1.xml · nonDerivative · entry 6

Garg Vipin K · CIK 0001515813 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 363,364

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · price: Vesting transaction: Shares surrendered to the Issuer solely to cover taxes associated with vesting of RSUs.

SEC source: 0001104659-25-008770 · tm255357-1_4seq1.xml · derivative · entry 10

Roberts M Scot · CIK 0001705905 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,775

Underlying: Common Stock, par value $0.0001 · 7,775 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

F7 · derivative.exercise_date: The RSUs vest in substantially equal annual installments over the 4 years following February 2, 2022, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date

F7 · derivative.expiration_date: The RSUs vest in substantially equal annual installments over the 4 years following February 2, 2022, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date

SEC source: 0001104659-25-008770 · tm255357-1_4seq1.xml · nonDerivative · entry 7

Roberts M Scot · CIK 0001705905 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 73,220

F1 · kind: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

SEC source: 0001104659-25-008770 · tm255357-1_4seq1.xml · nonDerivative · entry 6

Roberts M Scot · CIK 0001705905 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 75,536

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · price: Vesting transaction: Shares surrendered to the Issuer solely to cover taxes associated with vesting of RSUs.

SEC source: 0001104659-25-008772 · tm255357-3_4seq1.xml · derivative · entry 9

Harris Matthew Scott · CIK 0001787762 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock, par value $0.0001 · 6,166 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

F6 · derivative.exercise_date: The RSUs vest in substantially equal annual installments over the 4 years following February 1, 2021, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

F6 · derivative.expiration_date: The RSUs vest in substantially equal annual installments over the 4 years following February 1, 2021, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

SEC source: 0001104659-25-008772 · tm255357-3_4seq1.xml · nonDerivative · entry 5

Harris Matthew Scott · CIK 0001787762 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 76,789

F1 · kind: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

SEC source: 0001104659-25-008772 · tm255357-3_4seq1.xml · nonDerivative · entry 4

Harris Matthew Scott · CIK 0001787762 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 78,898

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · price: Vesting transaction: Shares surrendered to the Issuer solely to cover taxes associated with vesting of RSUs.

SEC source: 0001104659-25-008773 · tm255357-4_4seq1.xml · derivative · entry 9

Garg Vipin K · CIK 0001515813 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock, par value $0.0001 · 16,545 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

F6 · derivative.exercise_date: The RSUs vest in substantially equal annual installments over the 4 years following February 1, 2021, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

F6 · derivative.expiration_date: The RSUs vest in substantially equal annual installments over the 4 years following February 1, 2021, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

SEC source: 0001104659-25-008773 · tm255357-4_4seq1.xml · nonDerivative · entry 5

Garg Vipin K · CIK 0001515813 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 344,414

F1 · kind: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

SEC source: 0001104659-25-008773 · tm255357-4_4seq1.xml · nonDerivative · entry 4

Garg Vipin K · CIK 0001515813 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 351,645

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · price: Vesting transaction: Shares surrendered to the Issuer solely to cover taxes associated with vesting of RSUs.

SEC source: 0001104659-25-008770 · tm255357-1_4seq1.xml · derivative · entry 9

Roberts M Scot · CIK 0001705905 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock, par value $0.0001 · 6,166 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

F6 · derivative.exercise_date: The RSUs vest in substantially equal annual installments over the 4 years following February 1, 2021, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

F6 · derivative.expiration_date: The RSUs vest in substantially equal annual installments over the 4 years following February 1, 2021, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

SEC source: 0001104659-25-008770 · tm255357-1_4seq1.xml · nonDerivative · entry 5

Roberts M Scot · CIK 0001705905 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,761

F1 · kind: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

SEC source: 0001104659-25-008770 · tm255357-1_4seq1.xml · nonDerivative · entry 4

Roberts M Scot · CIK 0001705905 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 69,562

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · price: Vesting transaction: Shares surrendered to the Issuer solely to cover taxes associated with vesting of RSUs.

SEC source: 0001104659-25-008772 · tm255357-3_4seq1.xml · nonDerivative · entry 3

Harris Matthew Scott · CIK 0001787762 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 72,732

F3 · kind: These shares were purchased due to participation by the reporting individual in the Issuer's 2019 Employee Stock Purchase Plan ("ESPP"). It pertains to the ESPP purchase period from August 1, 2024 through January 31, 2025.

F4 · price: In accordance with the ESPP, these shares were purchased based on 85% of the closing price of the Issuer's common stock on August 1, 2024.

SEC source: 0001104659-25-008773 · tm255357-4_4seq1.xml · nonDerivative · entry 3

Garg Vipin K · CIK 0001515813 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 335,100

F3 · kind: These shares were purchased due to participation by the reporting individual in the Issuer's 2019 Employee Stock Purchase Plan ("ESPP"). It pertains to the ESPP purchase period from August 1, 2024 through January 31, 2025.

F4 · price: In accordance with the ESPP, these shares were purchased based on 85% of the closing price of the Issuer's common stock on August 1, 2024.

SEC source: 0001104659-25-008771 · tm255357-2_4seq1.xml · nonDerivative · entry 1

Jordt Raymond M · CIK 0001960780 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,902

F1 · kind: These shares were purchased due to participation by the reporting individual in the Issuer's 2019 Employee Stock Purchase Plan ("ESPP"). It pertains to the ESPP purchase period from August 1, 2024 through January 31, 2025.

F2 · price: In accordance with the ESPP, these shares were purchased based on 85% of the closing price of the issuer's common stock on August 1, 2024.

SEC source: 0001104659-25-008770 · tm255357-1_4seq1.xml · nonDerivative · entry 3

Roberts M Scot · CIK 0001705905 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 63,396

F3 · kind: These shares were purchased due to participation by the reporting individual in the Issuer's 2019 Employee Stock Purchase Plan ("ESPP"). It pertains to the ESPP purchase period from August 1, 2024 through January 31, 2025.

F4 · price: In accordance with the ESPP, these shares were purchased based on 85% of the closing price of the Issuer's common stock on August 1, 2024.

SEC source: 0001104659-25-008772 · tm255357-3_4seq1.xml · derivative · entry 8

Harris Matthew Scott · CIK 0001787762 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,550

Underlying: Common Stock, par value $0.0001 · 9,275 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

F5 · derivative.exercise_date: The RSUs vest in substantially equal annual installments over the 4 years following January 30, 2023, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

F5 · derivative.expiration_date: The RSUs vest in substantially equal annual installments over the 4 years following January 30, 2023, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

SEC source: 0001104659-25-008772 · tm255357-3_4seq1.xml · nonDerivative · entry 2

Harris Matthew Scott · CIK 0001787762 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 70,827

F1 · kind: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

SEC source: 0001104659-25-008772 · tm255357-3_4seq1.xml · nonDerivative · entry 1

Harris Matthew Scott · CIK 0001787762 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 74,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · price: Vesting transaction: Shares surrendered to the Issuer solely to cover taxes associated with vesting of RSUs.

SEC source: 0001104659-25-008773 · tm255357-4_4seq1.xml · derivative · entry 8

Garg Vipin K · CIK 0001515813 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,550

Underlying: Common Stock, par value $0.0001 · 26,775 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

F5 · derivative.exercise_date: The RSUs vest in substantially equal annual installments over the 4 years following January 30, 2023, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

F5 · derivative.expiration_date: The RSUs vest in substantially equal annual installments over the 4 years following January 30, 2023, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

SEC source: 0001104659-25-008773 · tm255357-4_4seq1.xml · nonDerivative · entry 2

Garg Vipin K · CIK 0001515813 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 330,995

F1 · kind: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

SEC source: 0001104659-25-008773 · tm255357-4_4seq1.xml · nonDerivative · entry 1

Garg Vipin K · CIK 0001515813 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 342,696

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · price: Vesting transaction: Shares surrendered to the Issuer solely to cover taxes associated with vesting of RSUs.

SEC source: 0001104659-25-008770 · tm255357-1_4seq1.xml · derivative · entry 8

Roberts M Scot · CIK 0001705905 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,550

Underlying: Common Stock, par value $0.0001 · 9,275 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

F5 · derivative.exercise_date: The RSUs vest in substantially equal annual installments over the 4 years following January 30, 2023, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date

F5 · derivative.expiration_date: The RSUs vest in substantially equal annual installments over the 4 years following January 30, 2023, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date

SEC source: 0001104659-25-008770 · tm255357-1_4seq1.xml · nonDerivative · entry 2

Roberts M Scot · CIK 0001705905 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 60,212

F1 · kind: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

SEC source: 0001104659-25-008770 · tm255357-1_4seq1.xml · nonDerivative · entry 1

Roberts M Scot · CIK 0001705905 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 62,921

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · price: Vesting transaction: Shares surrendered to the Issuer solely to cover taxes associated with vesting of RSUs.

SEC source: 0001104659-25-006845 · tm254755-4_4seq1.xml · derivative · entry 6

Roberts M Scot · CIK 0001705905 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 63,400

Underlying: Common Stock, par value $0.0001 · 63,400 shares

Expires not disclosed

F1 · derivative.exercise_price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

F5 · derivative.exercise_date: The RSUs vest in substantially equal annual installments over the 4 years following January 27, 2025, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

F5 · derivative.expiration_date: The RSUs vest in substantially equal annual installments over the 4 years following January 27, 2025, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

SEC source: 0001104659-25-006845 · tm254755-4_4seq1.xml · derivative · entry 5

Roberts M Scot · CIK 0001705905 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 183,600

Underlying: Common Stock, par value $0.0001 · 183,600 shares

Expires 2035-01-27

F4 · derivative.exercise_date: Twenty-five percent of the shares underlying the option become vested and released on January 27, 2026 and the remaining 75% of the shares underlying the option become vested and released in substantially equal monthly installments over the 36 months following January 27, 2026, subject to the reporting person's continued service through the applicable vesting date.

SEC source: 0001104659-25-006843 · tm254755-3_4seq1.xml · derivative · entry 5

Jordt Raymond M · CIK 0001960780 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 63,400

Underlying: Common Stock, par value $0.0001 · 63,400 shares

Expires not disclosed

F1 · derivative.exercise_price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

F5 · derivative.exercise_date: The RSUs vest in substantially equal annual installments over the 4 years following January 27, 2025, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

F5 · derivative.expiration_date: The RSUs vest in substantially equal annual installments over the 4 years following January 27, 2025, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

SEC source: 0001104659-25-006843 · tm254755-3_4seq1.xml · derivative · entry 4

Jordt Raymond M · CIK 0001960780 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 183,600

Underlying: Common Stock, par value $0.0001 · 183,600 shares

Expires 2035-01-27

F4 · derivative.exercise_date: Twenty-five percent of the shares underlying the option become vested and released on January 27, 2026 and the remaining 75% of the shares underlying the option become vested and released in substantially equal monthly installments over the 36 months following January 27, 2026, subject to the reporting person's continued service through the applicable vesting date.

SEC source: 0001104659-25-006841 · tm254755-2_4seq1.xml · derivative · entry 5

Harris Matthew Scott · CIK 0001787762 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 63,400

Underlying: Common Stock, par value $0.0001 · 63,400 shares

Expires not disclosed

F1 · derivative.exercise_price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

F5 · derivative.exercise_date: The RSUs vest in substantially equal annual installments over the 4 years following January 27, 2025, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

F5 · derivative.expiration_date: The RSUs vest in substantially equal annual installments over the 4 years following January 27, 2025, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

SEC source: 0001104659-25-006841 · tm254755-2_4seq1.xml · derivative · entry 4

Harris Matthew Scott · CIK 0001787762 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 183,600

Underlying: Common Stock, par value $0.0001 · 183,600 shares

Expires 2035-01-27

F4 · derivative.exercise_date: Twenty-five percent of the shares underlying the option become vested and released on January 27, 2026 and the remaining 75% of the shares underlying the option become vested and released in substantially equal monthly installments over the 36 months following January 27, 2026, subject to the reporting person's continued service through the applicable vesting date.

SEC source: 0001104659-25-006837 · tm254755-1_4seq1.xml · derivative · entry 5

Garg Vipin K · CIK 0001515813 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 164,800

Underlying: Common Stock, par value $0.0001 · 164,800 shares

Expires not disclosed

F1 · derivative.exercise_price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

F5 · derivative.exercise_date: The RSUs vest in substantially equal annual installments over the 4 years following January 27, 2025, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

F5 · derivative.expiration_date: The RSUs vest in substantially equal annual installments over the 4 years following January 27, 2025, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

SEC source: 0001104659-25-006837 · tm254755-1_4seq1.xml · derivative · entry 4

Garg Vipin K · CIK 0001515813 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 477,500

Underlying: Common Stock, par value $0.0001 · 477,500 shares

Expires 2035-01-27

F4 · derivative.exercise_date: Twenty-five percent of the shares underlying the option become vested and released on January 27, 2026 and the remaining 75% of the shares underlying the option become vested and released in substantially equal monthly installments over the 36 months following January 27, 2026, subject to the reporting person's continued service through the applicable vesting date.

SEC source: 0001104659-25-006845 · tm254755-4_4seq1.xml · derivative · entry 4

Roberts M Scot · CIK 0001705905 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,800

Underlying: Common Stock, par value $0.0001 · 14,600 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

F3 · derivative.exercise_date: The RSUs vest in substantially equal annual installments over the 4 years following January 25, 2024, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

F3 · derivative.expiration_date: The RSUs vest in substantially equal annual installments over the 4 years following January 25, 2024, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

SEC source: 0001104659-25-006845 · tm254755-4_4seq1.xml · nonDerivative · entry 2

Roberts M Scot · CIK 0001705905 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,646

F2 · kind: Vesting transaction: Shares surrendered to the Issuer solely to cover taxes associated with vesting of RSUs.

SEC source: 0001104659-25-006845 · tm254755-4_4seq1.xml · nonDerivative · entry 1

Roberts M Scot · CIK 0001705905 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 57,910

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

SEC source: 0001104659-25-006843 · tm254755-3_4seq1.xml · derivative · entry 3

Jordt Raymond M · CIK 0001960780 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,800

Underlying: Common Stock, par value $0.0001 · 14,600 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

F3 · derivative.exercise_date: The RSUs vest in substantially equal annual installments over the 4 years following January 25, 2024, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

F3 · derivative.expiration_date: The RSUs vest in substantially equal annual installments over the 4 years following January 25, 2024, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

SEC source: 0001104659-25-006843 · tm254755-3_4seq1.xml · nonDerivative · entry 2

Jordt Raymond M · CIK 0001960780 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,288

F2 · kind: Vesting transaction: Shares surrendered to the Issuer solely to cover taxes associated with vesting of RSUs.

SEC source: 0001104659-25-006843 · tm254755-3_4seq1.xml · nonDerivative · entry 1

Jordt Raymond M · CIK 0001960780 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,150

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

SEC source: 0001104659-25-006841 · tm254755-2_4seq1.xml · derivative · entry 3

Harris Matthew Scott · CIK 0001787762 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,800

Underlying: Common Stock, par value $0.0001 · 14,600 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

F3 · derivative.exercise_date: The RSUs vest in substantially equal annual installments over the 4 years following January 25, 2024, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

F3 · derivative.expiration_date: The RSUs vest in substantially equal annual installments over the 4 years following January 25, 2024, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

SEC source: 0001104659-25-006841 · tm254755-2_4seq1.xml · nonDerivative · entry 2

Harris Matthew Scott · CIK 0001787762 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 64,725

F2 · kind: Vesting transaction: Shares surrendered to the Issuer solely to cover taxes associated with vesting of RSUs.

SEC source: 0001104659-25-006841 · tm254755-2_4seq1.xml · nonDerivative · entry 1

Harris Matthew Scott · CIK 0001787762 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 69,719

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

SEC source: 0001104659-25-006837 · tm254755-1_4seq1.xml · derivative · entry 3

Garg Vipin K · CIK 0001515813 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 126,150

Underlying: Common Stock, par value $0.0001 · 42,050 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

F3 · derivative.exercise_date: The RSUs vest in substantially equal annual installments over the 4 years following January 25, 2024, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

F3 · derivative.expiration_date: The RSUs vest in substantially equal annual installments over the 4 years following January 25, 2024, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

SEC source: 0001104659-25-006837 · tm254755-1_4seq1.xml · nonDerivative · entry 2

Garg Vipin K · CIK 0001515813 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 315,921

F2 · kind: Vesting transaction: Shares surrendered to the Issuer solely to cover taxes associated with vesting of RSUs.

SEC source: 0001104659-25-006837 · tm254755-1_4seq1.xml · nonDerivative · entry 1

Garg Vipin K · CIK 0001515813 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 334,078

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

SEC source: 0001104659-25-000836 · tm251877-1_4seq1.xml · derivative · entry 3

Jordt Raymond M · CIK 0001960780 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,750

Underlying: Common Stock, par value $0.0001 · 9,375 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of Common Stock, par value $0.0001, when vested.

F3 · derivative.exercise_date: The RSUs become vested and released over four (4) years with 25% of the shares vesting on January 1, 2024, with the remainder vesting in equal annual installments for the following three (3) years, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.

F3 · derivative.expiration_date: The RSUs become vested and released over four (4) years with 25% of the shares vesting on January 1, 2024, with the remainder vesting in equal annual installments for the following three (3) years, subject to the reporting person's continued service through the applicable vesting date, and have no expiration date.