ACRS

SEC source: 0001209191-16-156178 · doc4.xml · nonDerivative · entry 1

Powala Christopher · CIK 0001654301 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 132,059

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001209191-16-156177 · doc4.xml · derivative · entry 3

Ruffo Frank · CIK 0001654450 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,750

Underlying: Common Stock · 1,250 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F3 · derivative.exercise_date: On December 18, 2015, the reporting person was granted 5,000 restricted stock units, vesting in four equal annual installments beginning on December 18, 2016, subject to the reporting person's continuous service with the issuer as of the applicable vesting date.

F3 · derivative.expiration_date: On December 18, 2015, the reporting person was granted 5,000 restricted stock units, vesting in four equal annual installments beginning on December 18, 2016, subject to the reporting person's continuous service with the issuer as of the applicable vesting date.

SEC source: 0001209191-16-156177 · doc4.xml · nonDerivative · entry 2

Ruffo Frank · CIK 0001654450 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 143,572

F2 · kind: The transaction reported represents the withholding of shares by the issuer to satisfy the reporting person's tax withholding obligations in connection with the vesting and settlement of the restricted stock units being reported in this Form 4.

SEC source: 0001209191-16-156177 · doc4.xml · nonDerivative · entry 1

Ruffo Frank · CIK 0001654450 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 143,952

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001209191-16-156175 · doc4.xml · derivative · entry 3

Walker Neal · CIK 0001604457 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,775

Underlying: Common Stock · 2,925 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F3 · derivative.exercise_date: On December 18, 2015, the reporting person was granted 11,700 restricted stock units, vesting in four equal annual installments beginning on December 18, 2016, subject to the reporting person's continuous service with the issuer as of the applicable vesting date.

F3 · derivative.expiration_date: On December 18, 2015, the reporting person was granted 11,700 restricted stock units, vesting in four equal annual installments beginning on December 18, 2016, subject to the reporting person's continuous service with the issuer as of the applicable vesting date.

SEC source: 0001209191-16-156175 · doc4.xml · nonDerivative · entry 2

Walker Neal · CIK 0001604457 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 874,019

F2 · kind: The transaction reported represents the withholding of shares by the issuer to satisfy the reporting person's tax withholding obligations in connection with the vesting and settlement of the restricted stock units being reported in this Form 4.

SEC source: 0001209191-16-156175 · doc4.xml · nonDerivative · entry 1

Walker Neal · CIK 0001604457 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 874,908

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001209191-16-155971 · doc4.xml · derivative · entry 2

Shanler Stuart · CIK 0001654332 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,400

Underlying: Common Stock · 10,400 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F3 · derivative.exercise_date: Subject to the reporting person's continuous service with the issuer as of the applicable vesting date, 50% of the shares underlying these restricted stock units will vest in four equal annual installments beginning on December 15, 2017 and the other 50% of the shares underlying these restricted stock units will vest upon the achievement of a specified commercial milestone.

F3 · derivative.expiration_date: Subject to the reporting person's continuous service with the issuer as of the applicable vesting date, 50% of the shares underlying these restricted stock units will vest in four equal annual installments beginning on December 15, 2017 and the other 50% of the shares underlying these restricted stock units will vest upon the achievement of a specified commercial milestone.

SEC source: 0001209191-16-155971 · doc4.xml · derivative · entry 1

Shanler Stuart · CIK 0001654332 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 62,400

Underlying: Common Stock · 62,400 shares

Expires 2026-12-14

F1 · derivative.exercise_date: The option will vest over a period of four years, with 25% of the shares underlying the option vesting on the first, second, third and fourth anniversaries of the date of grant.

SEC source: 0001209191-16-155969 · doc4.xml · derivative · entry 2

Powala Christopher · CIK 0001654301 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,400

Underlying: Common Stock · 10,400 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F3 · derivative.exercise_date: Subject to the reporting person's continuous service with the issuer as of the applicable vesting date, 50% of the shares underlying these restricted stock units will vest in four equal annual installments beginning on December 15, 2017 and the other 50% of the shares underlying these restricted stock units will vest upon the achievement of a specified commercial milestone.

F3 · derivative.expiration_date: Subject to the reporting person's continuous service with the issuer as of the applicable vesting date, 50% of the shares underlying these restricted stock units will vest in four equal annual installments beginning on December 15, 2017 and the other 50% of the shares underlying these restricted stock units will vest upon the achievement of a specified commercial milestone.

SEC source: 0001209191-16-155969 · doc4.xml · derivative · entry 1

Powala Christopher · CIK 0001654301 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 62,400

Underlying: Common Stock · 62,400 shares

Expires 2026-12-14

F1 · derivative.exercise_date: The option will vest over a period of four years, with 25% of the shares underlying the option vesting on the first, second, third and fourth anniversaries of the date of grant.

SEC source: 0001209191-16-155965 · doc4.xml · derivative · entry 2

Ali-Jackson Kamil · CIK 0001654337 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,866

Underlying: Common Stock · 13,866 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F3 · derivative.exercise_date: Subject to the reporting person's continuous service with the issuer as of the applicable vesting date, 50% of the shares underlying these restricted stock units will vest in four equal annual installments beginning on December 15, 2017 and the other 50% of the shares underlying these restricted stock units will vest upon the achievement of a specified commercial milestone.

F3 · derivative.expiration_date: Subject to the reporting person's continuous service with the issuer as of the applicable vesting date, 50% of the shares underlying these restricted stock units will vest in four equal annual installments beginning on December 15, 2017 and the other 50% of the shares underlying these restricted stock units will vest upon the achievement of a specified commercial milestone.

SEC source: 0001209191-16-155965 · doc4.xml · derivative · entry 1

Ali-Jackson Kamil · CIK 0001654337 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 83,200

Underlying: Common Stock · 83,200 shares

Expires 2026-12-14

F1 · derivative.exercise_date: The option will vest over a period of four years, with 25% of the shares underlying the option vesting on the first, second, third and fourth anniversaries of the date of grant.

SEC source: 0001209191-16-155968 · doc4.xml · derivative · entry 2

Ruffo Frank · CIK 0001654450 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,400

Underlying: Common Stock · 10,400 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F3 · derivative.exercise_date: Subject to the reporting person's continuous service with the issuer as of the applicable vesting date, 50% of the shares underlying these restricted stock units will vest in four equal annual installments beginning on December 15, 2017 and the other 50% of the shares underlying these restricted stock units will vest upon the achievement of a specified commercial milestone.

F3 · derivative.expiration_date: Subject to the reporting person's continuous service with the issuer as of the applicable vesting date, 50% of the shares underlying these restricted stock units will vest in four equal annual installments beginning on December 15, 2017 and the other 50% of the shares underlying these restricted stock units will vest upon the achievement of a specified commercial milestone.

SEC source: 0001209191-16-155968 · doc4.xml · derivative · entry 1

Ruffo Frank · CIK 0001654450 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 62,400

Underlying: Common Stock · 62,400 shares

Expires 2026-12-14

F1 · derivative.exercise_date: The option will vest over a period of four years, with 25% of the shares underlying the option vesting on the first, second, third and fourth anniversaries of the date of grant.

SEC source: 0001209191-16-155966 · doc4.xml · derivative · entry 2

Walker Neal · CIK 0001604457 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,266

Underlying: Common Stock · 24,266 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F3 · derivative.exercise_date: Subject to the reporting person's continuous service with the issuer as of the applicable vesting date, 50% of the shares underlying these restricted stock units will vest in four equal annual installments beginning on December 15, 2017 and the other 50% of the shares underlying these restricted stock units will vest upon the achievement of a specified commercial milestone.

F3 · derivative.expiration_date: Subject to the reporting person's continuous service with the issuer as of the applicable vesting date, 50% of the shares underlying these restricted stock units will vest in four equal annual installments beginning on December 15, 2017 and the other 50% of the shares underlying these restricted stock units will vest upon the achievement of a specified commercial milestone.

SEC source: 0001209191-16-155966 · doc4.xml · derivative · entry 1

Walker Neal · CIK 0001604457 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 145,600

Underlying: Common Stock · 145,600 shares

Expires 2026-12-14

F1 · derivative.exercise_date: The option will vest over a period of four years, with 25% of the shares underlying the option vesting on the first, second, third and fourth anniversaries of the date of grant.

SEC source: 0001615774-16-008485 · s104763_form4.xml · nonDerivative · entry 4

VIVO VENTURES VII, LLC · CIK 0001565020 · 10% owner

Vivo Ventures Fund VII, L.P. · CIK 0001509160 · 10% owner

Vivo Ventures VII Affiliates Fund, L.P. · CIK 0001538309 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Vivo Ventures VII Affiliates Fund, L.P.

Disclosed balance after: 70,037

SEC source: 0001615774-16-008485 · s104763_form4.xml · nonDerivative · entry 3

VIVO VENTURES VII, LLC · CIK 0001565020 · 10% owner

Vivo Ventures Fund VII, L.P. · CIK 0001509160 · 10% owner

Vivo Ventures VII Affiliates Fund, L.P. · CIK 0001538309 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Vivo Ventures Fund VII, L.P.

Disclosed balance after: 3,213,532

SEC source: 0001615774-16-008485 · s104763_form4.xml · nonDerivative · entry 2

VIVO VENTURES VII, LLC · CIK 0001565020 · 10% owner

Vivo Ventures Fund VII, L.P. · CIK 0001509160 · 10% owner

Vivo Ventures VII Affiliates Fund, L.P. · CIK 0001538309 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Vivo Ventures VII Affiliates Fund, L.P.

Disclosed balance after: 79,635

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $22.50 to $24.90, inclusive. The reporting person undertakes to provide to Aclaris Therapeutics, Inc., any security holder of Aclaris Therapeutics, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (1) to this Form 4.

F3 · ownership.nature: VV LLC is the general partner of Vivo Ventures VII Affiliates Fund, L.P. ("VVAF"), the record holder of the securities, and disclaims beneficial ownership over such securities except to the extent of its pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purposes. In addition, each of Albert Cha, a director of the issuer, Frank Kung and Edgar Engleman is a managing member of VV LLC and may be deemed to share voting and dispositive power over the securities held by VVAF. Each of such individuals disclaims beneficial ownership over such securities except to the extent of his pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purposes.

SEC source: 0001615774-16-008485 · s104763_form4.xml · nonDerivative · entry 1

VIVO VENTURES VII, LLC · CIK 0001565020 · 10% owner

Vivo Ventures Fund VII, L.P. · CIK 0001509160 · 10% owner

Vivo Ventures VII Affiliates Fund, L.P. · CIK 0001538309 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Vivo Ventures Fund VII, L.P.

Disclosed balance after: 3,653,934

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $22.50 to $24.90, inclusive. The reporting person undertakes to provide to Aclaris Therapeutics, Inc., any security holder of Aclaris Therapeutics, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (1) to this Form 4.

F2 · ownership.nature: Vivo Ventures VII, LLC ("VV LLC") is the general partner of Vivo Ventures Fund VII, L.P. ("VVF"), the record holder of the securities, and disclaims beneficial ownership over such securities except to the extent of its pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purposes. In addition, each of Albert Cha, a director of the issuer, Frank Kung and Edgar Engleman is a managing member of VV LLC and may be deemed to share voting and dispositive power over the securities held by VVF. Each of such individuals disclaims beneficial ownership over such securities except to the extent of his pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purposes.

SEC source: 0000315066-16-006303 · primary_doc.xml · nonDerivative · entry 2

FMR LLC · CIK 0000315066 · 10% owner · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 2,571,354

F1 · ownership.nature: By F-Prime Capital Partners Healthcare Fund III LP (456,514 shares of Common Stock), F-Prime Capital Partners Healthcare Advisors Fund III LP (8,765 shares of Common Stock), Impresa Fund III Limited Partnership (2,103,015 shares of Common Stock) and F-Prime Inc (3,060 shares of Common Stock). The general partner of F-Prime Capital Partners Healthcare Fund III LP is F-Prime Capital Partners Healthcare Advisors Fund III LP (FPCPHA). FPCPHA and Impresa Fund III Limited Partnership are each solely managed by Impresa Management LLC, their general partner and investment manager. Impresa Management LLC is owned, directly or indirectly, by various shareholders and employees of FMR LLC, including certain members of the Johnson family. F-Prime Inc. is a wholly-owned subsidiary of FMR LLC.

SEC source: 0000315066-16-006303 · primary_doc.xml · nonDerivative · entry 1

FMR LLC · CIK 0000315066 · 10% owner · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 2,571,454

F2 · price: The price reported for this transaction is the weighted average price of multiple trades at prices ranging from $21.86 to $22.19. FMR LLC hereby undertakes to provide upon request by the Commission staff, the issuer, or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F1 · ownership.nature: By F-Prime Capital Partners Healthcare Fund III LP (456,514 shares of Common Stock), F-Prime Capital Partners Healthcare Advisors Fund III LP (8,765 shares of Common Stock), Impresa Fund III Limited Partnership (2,103,015 shares of Common Stock) and F-Prime Inc (3,060 shares of Common Stock). The general partner of F-Prime Capital Partners Healthcare Fund III LP is F-Prime Capital Partners Healthcare Advisors Fund III LP (FPCPHA). FPCPHA and Impresa Fund III Limited Partnership are each solely managed by Impresa Management LLC, their general partner and investment manager. Impresa Management LLC is owned, directly or indirectly, by various shareholders and employees of FMR LLC, including certain members of the Johnson family. F-Prime Inc. is a wholly-owned subsidiary of FMR LLC.

SEC source: 0001209191-16-147288 · doc4.xml · derivative · entry 3

Ali-Jackson Kamil · CIK 0001654337 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,522

Underlying: Common Stock · 3,912 shares

Expires 2024-12-07

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: 25% of the shares underlying this option, representing a right to purchase a total of 10,434 shares, vested on December 8, 2015 and the remaining shares vest in 36 equal monthly installments thereafter, subject to the reporting person's continued service with the issuer as of the applicable vesting date.

SEC source: 0001209191-16-147288 · doc4.xml · nonDerivative · entry 2

Ali-Jackson Kamil · CIK 0001654337 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,957

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 14, 2016.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $21.36 to $22.20, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-16-147288 · doc4.xml · nonDerivative · entry 1

Ali-Jackson Kamil · CIK 0001654337 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 79,869

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000315066-16-006302 · primary_doc.xml · nonDerivative · entry 1

FMR LLC · CIK 0000315066 · 10% owner · See Remark 1

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote 1

Disclosed balance after: 2,575,104

F1 · ownership.nature: F-Prime Capital Partners Healthcare Fund III LP (FPCPH) made a pro-rata distribution to its partners, without payment of consideration, of 114,128 shares of Aclaris Therapeutics Inc. previously reported by FMR LLC. FPCPH distributed 17,079 shares to Impresa Fund III Limited Partnership (IFLP), 87,851 shares to F-Prime Capital Partners Healthcare Advisors Fund III LP (FPCPHA) and 9,198 shares to a recipient whose shares are not subject to reporting by the undersigned (an Other Recipient). FPCPHA made a pro-rata distribution to its partners, without payment of consideration, of 8,542 shares to F-Prime Inc., a wholly-owned subsidiary of FMR LLC, and 70,544 shares to Other Recipients. Finally, F-Prime Inc. made a distribution, without payment of consideration, of 4,481 shares to Other Recipients. As a result, FPCPH beneficially owns 456,514 shares, FPCPHA beneficially owns 8,765 shares, IFLP beneficially owns 2,103,015 shares and F-Prime Inc. beneficially owns 6,810 shares.

SEC source: 0001209191-16-143056 · doc4.xml · nonDerivative · entry 2

Ali-Jackson Kamil · CIK 0001654337 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,957

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 14, 2016.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $24.31 to $24.84, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-16-143056 · doc4.xml · nonDerivative · entry 1

Ali-Jackson Kamil · CIK 0001654337 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 77,798

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-16-143056 · doc4.xml · derivative · entry 3

Ali-Jackson Kamil · CIK 0001654337 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,176

Underlying: Common Stock · 1,841 shares

Expires 2024-08-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: 25% of the shares underlying this option, representing a right to purchase a total of 4,017 shares, vested on August 13, 2015 and the remaining shares vest in 36 equal monthly installments thereafter, subject to the reporting person's continued service with the issuer as of the applicable vesting date.

SEC source: 0001144204-16-124443 · v449058_4.xml · nonDerivative · entry 5

RA CAPITAL MANAGEMENT, LLC · CIK 0001346824 · 10% owner

Kolchinsky Peter · CIK 0001384859 · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 2,102,169

F2 · balance_after: The reported securities are owned by RA Capital Healthcare Fund, L.P. (the "Fund") and an account owned by Blackwell Partners, LLC - Series A (the "Blackwell Account"). Following the reported transactions, the Fund held 1,770,522 shares and the Blackwell Account held 331,647 shares. The Adviser is the general partner of the Fund and the investment adviser of the Blackwell Account. Mr. Kolchinsky is the sole manager of the Adviser. In their respective capacities, each of Mr. Kolchinsky and the Adviser may be deemed to beneficially own the reported securities for purposes of Section 13(d) of the Exchange Act.

F1 · ownership.nature: RA Capital Management, LLC (the "Adviser") and Peter Kolchinsky disclaim beneficial ownership of the reported securities for purposes of Rule 16a-1(a)(1) under the Securities Exchange Act of 1934 (the "Exchange Act") in reliance on Rule 16a-1(a)(1)(v) and (vii), respectively, and, therefore, disclaim any obligation to report ownership of or transactions in the reported securities under Section 16a of the Exchange Act. The filing of this Form 4 shall not be construed as an admission that either the Adviser or Mr. Kolchinsky is or was, for purposes of Section 16 of the Exchange Act, the beneficial owner of any of the securities reported herein.

SEC source: 0001144204-16-124443 · v449058_4.xml · nonDerivative · entry 4

RA CAPITAL MANAGEMENT, LLC · CIK 0001346824 · 10% owner

Kolchinsky Peter · CIK 0001384859 · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 2,125,769

F1 · ownership.nature: RA Capital Management, LLC (the "Adviser") and Peter Kolchinsky disclaim beneficial ownership of the reported securities for purposes of Rule 16a-1(a)(1) under the Securities Exchange Act of 1934 (the "Exchange Act") in reliance on Rule 16a-1(a)(1)(v) and (vii), respectively, and, therefore, disclaim any obligation to report ownership of or transactions in the reported securities under Section 16a of the Exchange Act. The filing of this Form 4 shall not be construed as an admission that either the Adviser or Mr. Kolchinsky is or was, for purposes of Section 16 of the Exchange Act, the beneficial owner of any of the securities reported herein.

SEC source: 0001209191-16-142070 · doc4.xml · nonDerivative · entry 2

Ali-Jackson Kamil · CIK 0001654337 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,957

F2 · kind: Pro rata distribution from NST, LLC, of which the reporting person is a non-managing member, in accordance with NST, LLC's Limited Liability Company Operating Agreement.

SEC source: 0001209191-16-142070 · doc4.xml · nonDerivative · entry 1

Ali-Jackson Kamil · CIK 0001654337 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 71,167

F1 · kind: Liquidating distribution from NeXeption, LLC, of which the reporting person is a non-managing member, in accordance with NeXeption, LLC's Limited Liability Company Operating Agreement.

SEC source: 0001209191-16-142071 · doc4.xml · nonDerivative · entry 5

Tullman Stephen A. · CIK 0001654343 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 121,789

F3 · kind: Pro rata distribution by NST, LLC, of which the reporting person is a member, in accordance with NST, LLC's Limited Liability Company Operating Agreement. NST, LLC received 144,153 shares of the issuer's common stock as a liquidating distribution from NeXeption, LLC described in footnotes (1) and (2) above and immediately distributed 50,002 of the shares on a pro rata basis to its members.

SEC source: 0001209191-16-142071 · doc4.xml · nonDerivative · entry 4

Tullman Stephen A. · CIK 0001654343 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By NST, LLC

Disclosed balance after: 94,151

F3 · kind: Pro rata distribution by NST, LLC, of which the reporting person is a member, in accordance with NST, LLC's Limited Liability Company Operating Agreement. NST, LLC received 144,153 shares of the issuer's common stock as a liquidating distribution from NeXeption, LLC described in footnotes (1) and (2) above and immediately distributed 50,002 of the shares on a pro rata basis to its members.

F2 · ownership.nature: These shares are held by NST, LLC of which the reporting person is a member and the sole Manager. The reporting person has sole voting and dispositive power over the shares held by NST, LLC. The reporting person disclaims beneficial ownership over the shares held by NST, LLC except to the extent of his pecuniary interest therein.

SEC source: 0001209191-16-142071 · doc4.xml · nonDerivative · entry 3

Tullman Stephen A. · CIK 0001654343 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By NST, LLC

Disclosed balance after: 144,153

F1 · kind: Liquidating distribution by NeXeption, LLC, of which the reporting person is a member, in accordance with NeXeption, LLC's Limited Liability Company Operating Agreement. The reporting person was also the sole Manager of NeXeption, LLC prior to its liquidation. In prior reports, the reporting person reported beneficial ownership of 521,739 shares of the issuer's common stock held by NeXeption, LLC. The reporting person disclaims beneficial ownership of the shares held by NeXeption, LLC except to the extent of his pecuniary interest therein.

F2 · ownership.nature: These shares are held by NST, LLC of which the reporting person is a member and the sole Manager. The reporting person has sole voting and dispositive power over the shares held by NST, LLC. The reporting person disclaims beneficial ownership over the shares held by NST, LLC except to the extent of his pecuniary interest therein.

SEC source: 0001209191-16-142071 · doc4.xml · nonDerivative · entry 2

Tullman Stephen A. · CIK 0001654343 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 116,999

F1 · kind: Liquidating distribution by NeXeption, LLC, of which the reporting person is a member, in accordance with NeXeption, LLC's Limited Liability Company Operating Agreement. The reporting person was also the sole Manager of NeXeption, LLC prior to its liquidation. In prior reports, the reporting person reported beneficial ownership of 521,739 shares of the issuer's common stock held by NeXeption, LLC. The reporting person disclaims beneficial ownership of the shares held by NeXeption, LLC except to the extent of his pecuniary interest therein.

SEC source: 0001209191-16-142071 · doc4.xml · nonDerivative · entry 1

Tullman Stephen A. · CIK 0001654343 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By NeXeption, LLC

Disclosed balance after: 0

F1 · kind: Liquidating distribution by NeXeption, LLC, of which the reporting person is a member, in accordance with NeXeption, LLC's Limited Liability Company Operating Agreement. The reporting person was also the sole Manager of NeXeption, LLC prior to its liquidation. In prior reports, the reporting person reported beneficial ownership of 521,739 shares of the issuer's common stock held by NeXeption, LLC. The reporting person disclaims beneficial ownership of the shares held by NeXeption, LLC except to the extent of his pecuniary interest therein.

F1 · ownership.nature: Liquidating distribution by NeXeption, LLC, of which the reporting person is a member, in accordance with NeXeption, LLC's Limited Liability Company Operating Agreement. The reporting person was also the sole Manager of NeXeption, LLC prior to its liquidation. In prior reports, the reporting person reported beneficial ownership of 521,739 shares of the issuer's common stock held by NeXeption, LLC. The reporting person disclaims beneficial ownership of the shares held by NeXeption, LLC except to the extent of his pecuniary interest therein.

SEC source: 0001144204-16-124443 · v449058_4.xml · nonDerivative · entry 3

RA CAPITAL MANAGEMENT, LLC · CIK 0001346824 · 10% owner

Kolchinsky Peter · CIK 0001384859 · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 2,275,769

F1 · ownership.nature: RA Capital Management, LLC (the "Adviser") and Peter Kolchinsky disclaim beneficial ownership of the reported securities for purposes of Rule 16a-1(a)(1) under the Securities Exchange Act of 1934 (the "Exchange Act") in reliance on Rule 16a-1(a)(1)(v) and (vii), respectively, and, therefore, disclaim any obligation to report ownership of or transactions in the reported securities under Section 16a of the Exchange Act. The filing of this Form 4 shall not be construed as an admission that either the Adviser or Mr. Kolchinsky is or was, for purposes of Section 16 of the Exchange Act, the beneficial owner of any of the securities reported herein.

SEC source: 0001144204-16-124443 · v449058_4.xml · nonDerivative · entry 2

RA CAPITAL MANAGEMENT, LLC · CIK 0001346824 · 10% owner

Kolchinsky Peter · CIK 0001384859 · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 2,334,719

F1 · ownership.nature: RA Capital Management, LLC (the "Adviser") and Peter Kolchinsky disclaim beneficial ownership of the reported securities for purposes of Rule 16a-1(a)(1) under the Securities Exchange Act of 1934 (the "Exchange Act") in reliance on Rule 16a-1(a)(1)(v) and (vii), respectively, and, therefore, disclaim any obligation to report ownership of or transactions in the reported securities under Section 16a of the Exchange Act. The filing of this Form 4 shall not be construed as an admission that either the Adviser or Mr. Kolchinsky is or was, for purposes of Section 16 of the Exchange Act, the beneficial owner of any of the securities reported herein.

SEC source: 0001144204-16-124443 · v449058_4.xml · nonDerivative · entry 1

RA CAPITAL MANAGEMENT, LLC · CIK 0001346824 · 10% owner

Kolchinsky Peter · CIK 0001384859 · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 2,607,719

F1 · ownership.nature: RA Capital Management, LLC (the "Adviser") and Peter Kolchinsky disclaim beneficial ownership of the reported securities for purposes of Rule 16a-1(a)(1) under the Securities Exchange Act of 1934 (the "Exchange Act") in reliance on Rule 16a-1(a)(1)(v) and (vii), respectively, and, therefore, disclaim any obligation to report ownership of or transactions in the reported securities under Section 16a of the Exchange Act. The filing of this Form 4 shall not be construed as an admission that either the Adviser or Mr. Kolchinsky is or was, for purposes of Section 16 of the Exchange Act, the beneficial owner of any of the securities reported herein.

SEC source: 0001209191-16-142068 · doc4.xml · nonDerivative · entry 2

Walker Neal · CIK 0001604457 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 871,983

F2 · kind: Pro rata distribution from NST, LLC, of which the reporting person is a non-managing member, in accordance with NST, LLC's Limited Liability Company Operating Agreement.

SEC source: 0001209191-16-142068 · doc4.xml · nonDerivative · entry 1

Walker Neal · CIK 0001604457 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 867,193

F1 · kind: Liquidating distribution from NeXeption, LLC, of which the reporting person is a non-managing member, in accordance with NeXeption, LLC's Limited Liability Company Operating Agreement.

SEC source: 0001209191-16-142069 · doc4.xml · nonDerivative · entry 1

Ruffo Frank · CIK 0001654450 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 142,702

F1 · kind: Pro rata distribution from NST, LLC, of which the reporting person is a non-managing member, in accordance with NST, LLC's Limited Liability Company Operating Agreement.