ACAD

SEC source: 0001209191-22-013277 · doc4.xml · nonDerivative · entry 1

KIM AUSTIN D. · CIK 0001746240 · EVP & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,413

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-22-013281 · doc4.xml · derivative · entry 3

Schneyer Mark C. · CIK 0001899977 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,059

Underlying: Common Stock · 1,352 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: The restricted stock units vest in four equal annual installments beginning February 23 2022.

F3 · derivative.expiration_date: The restricted stock units vest in four equal annual installments beginning February 23 2022.

SEC source: 0001209191-22-013281 · doc4.xml · nonDerivative · entry 2

Schneyer Mark C. · CIK 0001899977 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,102

F1 · kind: The sales reported in this Form 4 were made to cover the tax obligation that occurred upon the vesting of restricted stock units.

SEC source: 0001209191-22-013281 · doc4.xml · nonDerivative · entry 1

Schneyer Mark C. · CIK 0001899977 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,655

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-22-013273 · doc4.xml · derivative · entry 3

DAVIS STEPHEN · CIK 0001131146 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,837

Underlying: Common Stock · 10,945 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: The restricted stock units vest in four equal annual installments beginning February 23 2022.

F3 · derivative.expiration_date: The restricted stock units vest in four equal annual installments beginning February 23 2022.

SEC source: 0001209191-22-013273 · doc4.xml · nonDerivative · entry 2

DAVIS STEPHEN · CIK 0001131146 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 65,733

F1 · kind: The sales reported in this Form 4 were made to cover the tax obligation that occurred upon the vesting of restricted stock units.

SEC source: 0001209191-22-013273 · doc4.xml · nonDerivative · entry 1

DAVIS STEPHEN · CIK 0001131146 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 69,661

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-22-002751 · doc4.xml · derivative · entry 3

Teehan Brendan · CIK 0001891900 · EVP, COO, Head of Commercial

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,573

Underlying: Common Stock · 1,286 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F4 · derivative.exercise_date: The restricted stock units vest in four equal annual installments beginning January 6, 2021.

F4 · derivative.expiration_date: The restricted stock units vest in four equal annual installments beginning January 6, 2021.

SEC source: 0001209191-22-002751 · doc4.xml · nonDerivative · entry 2

Teehan Brendan · CIK 0001891900 · EVP, COO, Head of Commercial

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,788

F3 · kind: The sales reported in this Form 4 were made to cover the tax obligation that occurred upon the vesting of restricted stock units.

SEC source: 0001209191-22-002751 · doc4.xml · nonDerivative · entry 1

Teehan Brendan · CIK 0001891900 · EVP, COO, Head of Commercial

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,326

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F2 · balance_after: Includes 233 shares of the Issuer's common stock acquired by the reporting person on November 15, 2021 pursuant to an employee stock purchase program.

SEC source: 0001209191-22-002750 · doc4.xml · derivative · entry 3

KIM AUSTIN D. · CIK 0001746240 · EVP & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,267

Underlying: Common Stock · 1,633 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F4 · derivative.exercise_date: The restricted stock units vest in four equal annual installments beginning January 6, 2021.

F4 · derivative.expiration_date: The restricted stock units vest in four equal annual installments beginning January 6, 2021.

SEC source: 0001209191-22-002750 · doc4.xml · nonDerivative · entry 2

KIM AUSTIN D. · CIK 0001746240 · EVP & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,200

F3 · kind: The sales reported in this Form 4 were made to cover the tax obligation that occurred upon the vesting of restricted stock units.

SEC source: 0001209191-22-002750 · doc4.xml · nonDerivative · entry 1

KIM AUSTIN D. · CIK 0001746240 · EVP & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,774

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F2 · balance_after: Includes 365 shares of the Issuer's common stock acquired by the reporting person on May 15, 2021 and 405 shares acquired by the reporting person on November 15, 2021, pursuant to an employee stock purchase program.

SEC source: 0001209191-22-002749 · doc4.xml · derivative · entry 3

Stankovic Srdjan R. · CIK 0001432545 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,889

Underlying: Common Stock · 5,444 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: The restricted stock units vest in four equal annual installments beginning January 6, 2021.

F3 · derivative.expiration_date: The restricted stock units vest in four equal annual installments beginning January 6, 2021.

SEC source: 0001209191-22-002749 · doc4.xml · nonDerivative · entry 2

Stankovic Srdjan R. · CIK 0001432545 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,019

F2 · kind: The sales reported in this Form 4 were made to cover the tax obligation that occurred upon the vesting of restricted stock units.

SEC source: 0001209191-22-002749 · doc4.xml · nonDerivative · entry 1

Stankovic Srdjan R. · CIK 0001432545 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,956

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001209191-22-002748 · doc4.xml · derivative · entry 3

DAVIS STEPHEN · CIK 0001131146 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,056

Underlying: Common Stock · 9,527 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F4 · derivative.exercise_date: The restricted stock units vest in four equal annual installments beginning January 6, 2021.

F4 · derivative.expiration_date: The restricted stock units vest in four equal annual installments beginning January 6, 2021.

SEC source: 0001209191-22-002748 · doc4.xml · nonDerivative · entry 2

DAVIS STEPHEN · CIK 0001131146 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 58,716

F3 · kind: The sales reported in this Form 4 were made to cover the tax obligation that occurred upon the vesting of restricted stock units.

SEC source: 0001209191-22-002748 · doc4.xml · nonDerivative · entry 1

DAVIS STEPHEN · CIK 0001131146 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 62,434

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F2 · balance_after: Includes 1 share of the Issuer's common stock acquired by the reporting person on November 15, 2021 pursuant to an employee stock purchase program.

SEC source: 0001209191-23-002895 · doc4.xml · derivative · entry 3

Teehan Brendan · CIK 0001891900 · EVP, COO, Head of Commercial

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,573

Underlying: Common Stock · 1,286 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Acadia common stock.

F5 · derivative.exercise_date: This restricted stock units is being re-reported solely to correct vesting terms on the Form 4 filed on January 10, 2022, which erroneously indicated that the restricted stock units vest in four equal annual installments beginning January 6, 2021. The correct vesting is one-third of the shares subject to the restricted stock units vest on each of January 6, 2022, January 6, 2023 and January 6, 2024. Except as noted in this footnote, all other information as disclosed in the Reporting Person's original Form 4 was accurately reported.

F5 · derivative.expiration_date: This restricted stock units is being re-reported solely to correct vesting terms on the Form 4 filed on January 10, 2022, which erroneously indicated that the restricted stock units vest in four equal annual installments beginning January 6, 2021. The correct vesting is one-third of the shares subject to the restricted stock units vest on each of January 6, 2022, January 6, 2023 and January 6, 2024. Except as noted in this footnote, all other information as disclosed in the Reporting Person's original Form 4 was accurately reported.

SEC source: 0001209191-21-066570 · doc4.xml · nonDerivative · entry 2

Stankovic Srdjan R. · CIK 0001432545 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,512

F2 · kind: The sales reported in this Form 4 were made to cover the tax obligation that occurred upon the vesting of restricted stock units.

SEC source: 0001209191-21-066570 · doc4.xml · derivative · entry 3

Stankovic Srdjan R. · CIK 0001432545 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,250

Underlying: Common Stock · 6,250 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: The restricted stock units vest in four equal annual installments beginning 11/19/2019.

F3 · derivative.expiration_date: The restricted stock units vest in four equal annual installments beginning 11/19/2019.

SEC source: 0001209191-21-066570 · doc4.xml · nonDerivative · entry 1

Stankovic Srdjan R. · CIK 0001432545 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 44,315

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001209191-21-065928 · doc4.xml · derivative · entry 2

Kihara James · CIK 0001816160 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,860

Underlying: Common Stock · 15,860 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of ACADIA common stock.

F3 · derivative.exercise_date: The restricted stock units vest as follows: 37.5% of the shares vest 18 months from the grant date; 12.5% of the shares vest on the second anniversary of the grant date; and 25% of the shares vest on each of the third and fourth anniversaries of the grant date. In addition, these restricted stock units may vest earlier upon the Issuer's common stock achieving a specified price per share over a specified trading period.

F3 · derivative.expiration_date: The restricted stock units vest as follows: 37.5% of the shares vest 18 months from the grant date; 12.5% of the shares vest on the second anniversary of the grant date; and 25% of the shares vest on each of the third and fourth anniversaries of the grant date. In addition, these restricted stock units may vest earlier upon the Issuer's common stock achieving a specified price per share over a specified trading period.

SEC source: 0001209191-21-065928 · doc4.xml · derivative · entry 1

Kihara James · CIK 0001816160 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,860

Underlying: Common Stock · 15,860 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of ACADIA common stock.

F2 · derivative.exercise_date: The restricted stock units vest as follows: 37.5% of the shares vest 18 months from the grant date; 12.5% of the shares vest on the second anniversary of the grant date; and 25% of the shares vest on each of the third and fourth anniversaries of the grant date.

F2 · derivative.expiration_date: The restricted stock units vest as follows: 37.5% of the shares vest 18 months from the grant date; 12.5% of the shares vest on the second anniversary of the grant date; and 25% of the shares vest on each of the third and fourth anniversaries of the grant date.

SEC source: 0001209191-21-065926 · doc4.xml · derivative · entry 2

Teehan Brendan · CIK 0001891900 · EVP, COO, Head of Commercial

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,651

Underlying: Common Stock · 39,651 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of ACADIA common stock.

F3 · derivative.exercise_date: The restricted stock units vest as follows: 37.5% of the shares vest 18 months from the grant date; 12.5% of the shares vest on the second anniversary of the grant date; and 25% of the shares vest on each of the third and fourth anniversaries of the grant date. In addition, these restricted stock units may vest earlier upon the Issuer's common stock achieving a specified price per share over a specified trading period.

F3 · derivative.expiration_date: The restricted stock units vest as follows: 37.5% of the shares vest 18 months from the grant date; 12.5% of the shares vest on the second anniversary of the grant date; and 25% of the shares vest on each of the third and fourth anniversaries of the grant date. In addition, these restricted stock units may vest earlier upon the Issuer's common stock achieving a specified price per share over a specified trading period.

SEC source: 0001209191-21-065926 · doc4.xml · derivative · entry 1

Teehan Brendan · CIK 0001891900 · EVP, COO, Head of Commercial

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,651

Underlying: Common Stock · 39,651 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of ACADIA common stock.

F2 · derivative.exercise_date: The restricted stock units vest as follows: 37.5% of the shares vest 18 months from the grant date; 12.5% of the shares vest on the second anniversary of the grant date; and 25% of the shares vest on each of the third and fourth anniversaries of the grant date.

F2 · derivative.expiration_date: The restricted stock units vest as follows: 37.5% of the shares vest 18 months from the grant date; 12.5% of the shares vest on the second anniversary of the grant date; and 25% of the shares vest on each of the third and fourth anniversaries of the grant date.

SEC source: 0001209191-21-060957 · doc4.xml · nonDerivative · entry 2

DAVIS STEPHEN · CIK 0001131146 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,906

F3 · kind: The sales reported in this Form 4 were made to cover the tax obligation that occurred upon the vesting of restricted stock units.

SEC source: 0001209191-21-060958 · doc4.xml · nonDerivative · entry 2

Stankovic Srdjan R. · CIK 0001432545 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,065

F2 · kind: The sales reported in this Form 4 were made to cover the tax obligation that occurred upon the vesting of restricted stock units.

SEC source: 0001209191-21-060957 · doc4.xml · derivative · entry 3

DAVIS STEPHEN · CIK 0001131146 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,938

Underlying: Common Stock · 5,938 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F4 · derivative.exercise_date: The restricted stock units vest in four equal annual installments beginning 10/15/19.

F4 · derivative.expiration_date: The restricted stock units vest in four equal annual installments beginning 10/15/19.

SEC source: 0001209191-21-060957 · doc4.xml · nonDerivative · entry 1

DAVIS STEPHEN · CIK 0001131146 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 55,869

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F2 · balance_after: Includes 619 shares of the Issuer's common stock acquired by the reporting person on May 14, 2021 pursuant to an employee stock purchase program.

SEC source: 0001209191-21-060958 · doc4.xml · derivative · entry 3

Stankovic Srdjan R. · CIK 0001432545 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,969

Underlying: Common Stock · 2,969 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: The restricted stock units vest in four equal annual installments beginning 10/15/19.

F3 · derivative.expiration_date: The restricted stock units vest in four equal annual installments beginning 10/15/19.

SEC source: 0001209191-21-060958 · doc4.xml · nonDerivative · entry 1

Stankovic Srdjan R. · CIK 0001432545 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,403

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001209191-21-058556 · doc4.xml · derivative · entry 2

GAROFALO ELIZABETH A. · CIK 0001826361 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,919

Underlying: Common Stock · 1,918 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of ACADIA common stock.

F2 · derivative.exercise_date: The restricted stock units shall vest in two equal annual installments commencing September 29, 2021.

F2 · derivative.expiration_date: The restricted stock units shall vest in two equal annual installments commencing September 29, 2021.

SEC source: 0001209191-21-058556 · doc4.xml · nonDerivative · entry 1

GAROFALO ELIZABETH A. · CIK 0001826361 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,918

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of ACADIA common stock.

SEC source: 0001638599-21-000591 · doc4_7284.xml · derivative · entry 5

BAKER BROS. ADVISORS LP · CIK 0001263508 · Director · 10% owner

667, L.P. · CIK 0001551139 · Director · 10% owner

Baker Bros. Advisors (GP) LLC · CIK 0001580575 · Director · 10% owner

Baker Brothers Life Sciences LP · CIK 0001363364 · Director · 10% owner

BAKER FELIX · CIK 0001087940 · Director · 10% owner

BAKER JULIAN · CIK 0001087939 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 23,274

Underlying: Common Stock · 23,274 shares

Expires 2031-06-21

F10 · derivative.exercise_date: 11,637 Stock Options exercisable solely into Common Stock were granted under the Incentive Plan to each of Julian C. Baker and Dr. Biggar in their capacity as directors of the Issuer. The Stock Options with a strike price of $24.88 vest in 4 equal quarterly installments beginning on June 22, 2021 and expire on June 21, 2031, with the final installment vesting upon the earlier of one year following the date of grant or the date of the next annual meeting of the Issuer.

F4 · ownership.nature: Julian C. Baker and Dr. Biggar serve on the board of directors of the Issuer (the "Board") as representatives of Baker Brothers Life Sciences, L.P. ("Life Sciences") and 667, L.P. ("667", and together with Life Sciences, the "Funds"). Pursuant to the policies of the Adviser, Julian C. Baker and Dr. Biggar do not have any right to any of the Issuer's securities issued as part of their service on the Board and the Funds are entitled to receive all of the pecuniary interest in the securities issued. The Funds each own an indirect proportionate pecuniary interest in the RSUs and non-qualified options to purchase Common Stock ("Stock Options").

F5 · ownership.nature: Solely as a result of Felix J. Baker's and Julian C. Baker's ownership interest in (i) the general partners of the Funds and (ii) the Funds, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in the RSUs, Stock Options, Common Stock received upon vesting of RSUs and Common Stock received upon exercise of Stock Options (i.e. no direct pecuniary interest).

F8 · ownership.nature: The Adviser serves as the investment adviser to the Funds. In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held by the Funds. The Adviser GP is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are managing members of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held by the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held by the Funds. The Adviser has voting and dispositive power over the Stock Options, RSUs and any Common Stock received as a result of the exercise of Stock Options or vesting of RSUs.

F9 · ownership.nature: Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose.

F10 · ownership.nature: 11,637 Stock Options exercisable solely into Common Stock were granted under the Incentive Plan to each of Julian C. Baker and Dr. Biggar in their capacity as directors of the Issuer. The Stock Options with a strike price of $24.88 vest in 4 equal quarterly installments beginning on June 22, 2021 and expire on June 21, 2031, with the final installment vesting upon the earlier of one year following the date of grant or the date of the next annual meeting of the Issuer.

SEC source: 0001638599-21-000591 · doc4_7284.xml · nonDerivative · entry 4

BAKER BROS. ADVISORS LP · CIK 0001263508 · Director · 10% owner

667, L.P. · CIK 0001551139 · Director · 10% owner

Baker Bros. Advisors (GP) LLC · CIK 0001580575 · Director · 10% owner

Baker Brothers Life Sciences LP · CIK 0001363364 · Director · 10% owner

BAKER FELIX · CIK 0001087940 · Director · 10% owner

BAKER JULIAN · CIK 0001087939 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 38,452,877

F3 · ownership.nature: Restricted Stock Units (each an "RSU") payable solely in Common Stock granted to each of Julian C. Baker, a managing member of Baker Bros. Advisors (GP) LLC (the "Adviser GP") and Dr. Stephen R. Biggar, a full-time employee of Baker Bros. Advisors LP (the "Adviser") on June 22, 2021, pursuant to the Issuer's 2010 Equity Incentive Plan ("Incentive Plan"). The RSUs fully vest on the earlier of June 22, 2022 or the date of the next annual meeting of the Issuer.

F4 · ownership.nature: Julian C. Baker and Dr. Biggar serve on the board of directors of the Issuer (the "Board") as representatives of Baker Brothers Life Sciences, L.P. ("Life Sciences") and 667, L.P. ("667", and together with Life Sciences, the "Funds"). Pursuant to the policies of the Adviser, Julian C. Baker and Dr. Biggar do not have any right to any of the Issuer's securities issued as part of their service on the Board and the Funds are entitled to receive all of the pecuniary interest in the securities issued. The Funds each own an indirect proportionate pecuniary interest in the RSUs and non-qualified options to purchase Common Stock ("Stock Options").

F5 · ownership.nature: Solely as a result of Felix J. Baker's and Julian C. Baker's ownership interest in (i) the general partners of the Funds and (ii) the Funds, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in the RSUs, Stock Options, Common Stock received upon vesting of RSUs and Common Stock received upon exercise of Stock Options (i.e. no direct pecuniary interest).

F7 · ownership.nature: After giving effect to the transaction reported herein and as a result of their ownership interest in (i) Baker Brothers Life Sciences Capital, L.P. and (ii) Life Sciences, Julian C. Baker and Felix J. Baker each may be deemed to have an indirect pecuniary interest in Common Stock of the Issuer reported in column 5 of Table I directly held by Life Sciences, a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital, L.P., a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital (GP), LLC, due to their interest in Life Sciences and Baker Brothers Life Sciences Capital, L.P.'s right to receive an allocation of a portion of the profits from Life Sciences.

F8 · ownership.nature: The Adviser serves as the investment adviser to the Funds. In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held by the Funds. The Adviser GP is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are managing members of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held by the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held by the Funds. The Adviser has voting and dispositive power over the Stock Options, RSUs and any Common Stock received as a result of the exercise of Stock Options or vesting of RSUs.

F9 · ownership.nature: Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose.

F11 · ownership.nature: The disclosure of the grant of RSUs reported on this form is the sum of two grants totaling 12,782 shares. The 12,782 shares are reported for each of the Funds as each has an indirect pecuniary interest.

F12 · ownership.nature: Includes beneficial ownership of 6,118 previously issued RSUs payable solely in Common Stock issued to Julian C. Baker and Dr. Biggar in their capacity as directors of the Issuer pursuant to the Incentive Plan of which the Funds may be deemed to own a portion.

SEC source: 0001638599-21-000591 · doc4_7284.xml · nonDerivative · entry 3

BAKER BROS. ADVISORS LP · CIK 0001263508 · Director · 10% owner

667, L.P. · CIK 0001551139 · Director · 10% owner

Baker Bros. Advisors (GP) LLC · CIK 0001580575 · Director · 10% owner

Baker Brothers Life Sciences LP · CIK 0001363364 · Director · 10% owner

BAKER FELIX · CIK 0001087940 · Director · 10% owner

BAKER JULIAN · CIK 0001087939 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,489,509

F3 · ownership.nature: Restricted Stock Units (each an "RSU") payable solely in Common Stock granted to each of Julian C. Baker, a managing member of Baker Bros. Advisors (GP) LLC (the "Adviser GP") and Dr. Stephen R. Biggar, a full-time employee of Baker Bros. Advisors LP (the "Adviser") on June 22, 2021, pursuant to the Issuer's 2010 Equity Incentive Plan ("Incentive Plan"). The RSUs fully vest on the earlier of June 22, 2022 or the date of the next annual meeting of the Issuer.

F4 · ownership.nature: Julian C. Baker and Dr. Biggar serve on the board of directors of the Issuer (the "Board") as representatives of Baker Brothers Life Sciences, L.P. ("Life Sciences") and 667, L.P. ("667", and together with Life Sciences, the "Funds"). Pursuant to the policies of the Adviser, Julian C. Baker and Dr. Biggar do not have any right to any of the Issuer's securities issued as part of their service on the Board and the Funds are entitled to receive all of the pecuniary interest in the securities issued. The Funds each own an indirect proportionate pecuniary interest in the RSUs and non-qualified options to purchase Common Stock ("Stock Options").

F5 · ownership.nature: Solely as a result of Felix J. Baker's and Julian C. Baker's ownership interest in (i) the general partners of the Funds and (ii) the Funds, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in the RSUs, Stock Options, Common Stock received upon vesting of RSUs and Common Stock received upon exercise of Stock Options (i.e. no direct pecuniary interest).

F6 · ownership.nature: After giving effect to the transaction reported herein and as a result of their ownership interest in (i) Baker Biotech Capital, L.P. and (ii) 667, Julian C. Baker and Felix J. Baker each may be deemed to have an indirect pecuniary interest in Common Stock reported in column 5 of Table I directly held by 667, a limited partnership of which the sole general partner is Baker Biotech Capital, L.P., a limited partnership of which the sole general partner is Baker Biotech Capital (GP), LLC, due to their interest in 667 and Baker Biotech Capital, L.P.'s right to receive an allocation of a portion of the profits from 667.

F8 · ownership.nature: The Adviser serves as the investment adviser to the Funds. In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held by the Funds. The Adviser GP is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are managing members of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held by the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held by the Funds. The Adviser has voting and dispositive power over the Stock Options, RSUs and any Common Stock received as a result of the exercise of Stock Options or vesting of RSUs.

F9 · ownership.nature: Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose.

F11 · ownership.nature: The disclosure of the grant of RSUs reported on this form is the sum of two grants totaling 12,782 shares. The 12,782 shares are reported for each of the Funds as each has an indirect pecuniary interest.

F12 · ownership.nature: Includes beneficial ownership of 6,118 previously issued RSUs payable solely in Common Stock issued to Julian C. Baker and Dr. Biggar in their capacity as directors of the Issuer pursuant to the Incentive Plan of which the Funds may be deemed to own a portion.

SEC source: 0001209191-21-043043 · doc4.xml · derivative · entry 2

SOLAND DANIEL B · CIK 0001318485 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,391

Underlying: Common Stock · 6,391 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of ACADIA common stock.

F3 · derivative.exercise_date: The restricted stock units shall vest in full upon the earlier of one year following the date of grant or the next annual meeting date.

F3 · derivative.expiration_date: The restricted stock units shall vest in full upon the earlier of one year following the date of grant or the next annual meeting date.

SEC source: 0001209191-21-043043 · doc4.xml · derivative · entry 1

SOLAND DANIEL B · CIK 0001318485 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,637

Underlying: Common Stock · 11,637 shares

Expires 2031-06-21

F1 · derivative.exercise_date: The shares subject to the option shall vest quarterly over one year following the date of grant, with the final tranche vesting upon the earlier of one year following the date of grant or the next annual meeting date.

SEC source: 0001209191-21-043041 · doc4.xml · derivative · entry 2

HARRIGAN EDMUND · CIK 0001177917 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,391

Underlying: Common Stock · 6,391 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of ACADIA common stock.

F3 · derivative.exercise_date: The restricted stock units shall vest in full upon the earlier of one year following the date of grant or the next annual meeting date.

F3 · derivative.expiration_date: The restricted stock units shall vest in full upon the earlier of one year following the date of grant or the next annual meeting date.

SEC source: 0001209191-21-043041 · doc4.xml · derivative · entry 1

HARRIGAN EDMUND · CIK 0001177917 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,637

Underlying: Common Stock · 11,637 shares

Expires 2031-06-21

F1 · derivative.exercise_date: The shares subject to the option shall vest quarterly over one year following the date of grant, with the final tranche vesting upon the earlier of one year following the date of grant or the next annual meeting date.

SEC source: 0001209191-21-043039 · doc4.xml · derivative · entry 2

GAROFALO ELIZABETH A. · CIK 0001826361 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,391

Underlying: Common Stock · 6,391 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of ACADIA common stock.

F3 · derivative.exercise_date: The restricted stock units shall vest in full upon the earlier of one year following the date of grant or the next annual meeting date.

F3 · derivative.expiration_date: The restricted stock units shall vest in full upon the earlier of one year following the date of grant or the next annual meeting date.

SEC source: 0001209191-21-043039 · doc4.xml · derivative · entry 1

GAROFALO ELIZABETH A. · CIK 0001826361 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,637

Underlying: Common Stock · 11,637 shares

Expires 2031-06-21

F1 · derivative.exercise_date: The shares subject to the option shall vest quarterly over one year following the date of grant, with the final tranche vesting upon the earlier of one year following the date of grant or the next annual meeting date.

SEC source: 0001209191-21-043037 · doc4.xml · derivative · entry 2

Daly James M · CIK 0001560782 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,391

Underlying: Common Stock · 6,391 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of ACADIA common stock.

F3 · derivative.exercise_date: The restricted stock units shall vest in full upon the earlier of one year following the date of grant or the next annual meeting date.

F3 · derivative.expiration_date: The restricted stock units shall vest in full upon the earlier of one year following the date of grant or the next annual meeting date.

SEC source: 0001209191-21-043037 · doc4.xml · derivative · entry 1

Daly James M · CIK 0001560782 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,637

Underlying: Common Stock · 11,637 shares

Expires 2031-06-21

F1 · derivative.exercise_date: The shares subject to the option shall vest quarterly over one year following the date of grant, with the final tranche vesting upon the earlier of one year following the date of grant or the next annual meeting date.

SEC source: 0001209191-21-043035 · doc4.xml · derivative · entry 2

Brege Laura · CIK 0001365619 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,391

Underlying: Common Stock · 6,391 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of ACADIA common stock.

F3 · derivative.exercise_date: The restricted stock units shall vest in full upon the earlier of one year following the date of grant or the next annual meeting date.

F3 · derivative.expiration_date: The restricted stock units shall vest in full upon the earlier of one year following the date of grant or the next annual meeting date.

SEC source: 0001209191-21-043035 · doc4.xml · derivative · entry 1

Brege Laura · CIK 0001365619 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,637

Underlying: Common Stock · 11,637 shares

Expires 2031-06-21

F1 · derivative.exercise_date: The shares subject to the option shall vest quarterly over one year following the date of grant, with the final tranche vesting upon the earlier of one year following the date of grant or the next annual meeting date.

SEC source: 0001209191-23-034699 · doc4.xml · derivative · entry 4

SOLAND DANIEL B · CIK 0001318485 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,059 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Acadia common stock.

F2 · derivative.exercise_date: The restricted stock units shall vest in full upon the earlier of one year following the date of grant or the next annual meeting date.

F2 · derivative.expiration_date: The restricted stock units shall vest in full upon the earlier of one year following the date of grant or the next annual meeting date.

SEC source: 0001209191-23-034699 · doc4.xml · nonDerivative · entry 1

SOLAND DANIEL B · CIK 0001318485 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,059

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of Acadia common stock.