ABOS

SEC source: 0001576885-25-000081 · wk-form4_1749156855.xml · derivative · entry 2

Drapkin Kimberlee C · CIK 0001340881 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,500

Underlying: Common Stock · 19,500 shares

Expires 2035-06-04

F2 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of the first anniversary of the date of grant or the 2026 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0001576885-25-000081 · wk-form4_1749156855.xml · nonDerivative · entry 1

Drapkin Kimberlee C · CIK 0001340881 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,800

F1 · shares: Represents a restricted stock unit ("RSU") award. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs will vest in full on the earlier of the first anniversary of the date of grant or the 2026 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0001576885-25-000082 · wk-form4_1749157011.xml · derivative · entry 2

Stalfort John A III · CIK 0001709418 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,500

Underlying: Common Stock · 19,500 shares

Expires 2035-06-04

F2 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of the first anniversary of the date of grant or the 2026 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0001576885-25-000082 · wk-form4_1749157011.xml · nonDerivative · entry 1

Stalfort John A III · CIK 0001709418 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 185,124

F1 · shares: Represents a restricted stock unit ("RSU") award. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs will vest in full on the earlier of the first anniversary of the date of grant or the 2026 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0001576885-25-000079 · wk-form4_1749156704.xml · derivative · entry 2

Ives Jeffrey L. · CIK 0001614096 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,500

Underlying: Common Stock · 19,500 shares

Expires 2035-06-04

F2 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of the first anniversary of the date of grant or the 2026 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0001576885-25-000079 · wk-form4_1749156704.xml · nonDerivative · entry 1

Ives Jeffrey L. · CIK 0001614096 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,800

F1 · shares: Represents a restricted stock unit ("RSU") award. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs will vest in full on the earlier of the first anniversary of the date of grant or the 2026 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0001576885-25-000037 · wk-form4_1737685161.xml · nonDerivative · entry 2

Zuga Matt · CIK 0001790214 · CFO & Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 231,744

F3 · shares: Represents the number of shares sold by the Reporting Person in connection with the vesting of RSUs pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 24, 2024.

F4 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $1.6705 to $1.7699. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001576885-25-000029 · wk-form4_1737670003.xml · nonDerivative · entry 1

Siemers Eric · CIK 0001866239 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 170,298

F1 · shares: Represents the number of shares sold by the Reporting Person through an automatic "sell to cover" transaction to satisfy tax withholding obligations in connection with the vesting of restricted stock units pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 3, 2024.

SEC source: 0001576885-25-000035 · wk-form4_1737670677.xml · nonDerivative · entry 1

OConnell Daniel Joseph · CIK 0001865136 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 667,488

F1 · shares: Represents the number of shares sold by the Reporting Person through an automatic "sell to cover" transaction to satisfy tax withholding obligations in connection with the vesting of restricted stock units pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 24, 2024.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $1.5700 to $1.6100. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001576885-25-000033 · wk-form4_1737670600.xml · nonDerivative · entry 1

Meisner Derek M · CIK 0001752461 · Chief Legal Officer & Corp Sec

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 161,127

F1 · shares: Represents the number of shares sold by the Reporting Person through an automatic "sell to cover" transaction to satisfy tax withholding obligations in connection with the vesting of restricted stock units pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 15, 2024.

SEC source: 0001576885-25-000031 · wk-form4_1737670478.xml · nonDerivative · entry 1

Barton Russell · CIK 0001867418 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 136,117

F1 · shares: Represents the number of shares sold by the Reporting Person through an automatic "sell to cover" transaction to satisfy tax withholding obligations in connection with the vesting of restricted stock units pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 31, 2024.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $1.6100 to $1.6150. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001576885-25-000037 · wk-form4_1737685161.xml · nonDerivative · entry 1

Zuga Matt · CIK 0001790214 · CFO & Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 260,646

F1 · shares: Represents the number of shares sold by the Reporting Person through an automatic "sell to cover" transaction to satisfy tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 30, 2024.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $1.5800 to $1.6100. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001576885-25-000021 · wk-form4_1736298537.xml · derivative · entry 3

OConnell Daniel Joseph · CIK 0001865136 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 338,000

Underlying: Common Stock · 338,000 shares

Expires 2035-01-07

F4 · derivative.exercise_date: The shares subject to the option will vest in 48 equal monthly installments such that the option is fully vested on the fourth anniversary of the date of grant, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001576885-25-000021 · wk-form4_1736298537.xml · nonDerivative · entry 2

OConnell Daniel Joseph · CIK 0001865136 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 680,107

F3 · shares: Represents an RSU award. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs will vest in three equal annual installments commencing one year after the grant date, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001576885-25-000019 · wk-form4_1736298170.xml · derivative · entry 2

Schacterle Amy · CIK 0002042021 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,200

Underlying: Common Stock · 13,200 shares

Expires 2035-01-06

F2 · derivative.exercise_date: The shares subject to the option will vest in 48 equal monthly installments such that the option is fully vested on the fourth anniversary of the date of grant, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001576885-25-000019 · wk-form4_1736298170.xml · nonDerivative · entry 1

Schacterle Amy · CIK 0002042021 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,800

F1 · shares: Represents a restricted stock unit ("RSU") award. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs will vest in three equal annual installments commencing one year after the grant date, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001576885-25-000017 · wk-form4_1736298041.xml · derivative · entry 2

Doherty James J. · CIK 0002009718 · President and CDO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 93,300

Underlying: Common Stock · 93,300 shares

Expires 2035-01-06

F2 · derivative.exercise_date: The shares subject to the option will vest in 48 equal monthly installments such that the option is fully vested on the fourth anniversary of the date of grant, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001576885-25-000017 · wk-form4_1736298041.xml · nonDerivative · entry 1

Doherty James J. · CIK 0002009718 · President and CDO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 62,600

F1 · shares: Represents a restricted stock unit ("RSU") award. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs will vest in three equal annual installments commencing one year after the grant date, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001576885-25-000009 · wk-form4_1736297327.xml · derivative · entry 3

Siemers Eric · CIK 0001866239 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 100,300

Underlying: Common Stock · 100,300 shares

Expires 2035-01-06

F4 · derivative.exercise_date: The shares subject to the option will vest in 48 equal monthly installments such that the option is fully vested on the fourth anniversary of the date of grant, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001576885-25-000009 · wk-form4_1736297327.xml · nonDerivative · entry 2

Siemers Eric · CIK 0001866239 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 173,517

F3 · shares: Represents an RSU award. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs will vest in three equal annual installments commencing one year after the grant date, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001576885-25-000015 · wk-form4_1736297850.xml · derivative · entry 3

Meisner Derek M · CIK 0001752461 · Chief Legal Officer & Corp Sec

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 100,300

Underlying: Common Stock · 100,300 shares

Expires 2035-01-06

F4 · derivative.exercise_date: The shares subject to the option will vest in 48 equal monthly installments such that the option is fully vested on the fourth anniversary of the date of grant, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001576885-25-000015 · wk-form4_1736297850.xml · nonDerivative · entry 2

Meisner Derek M · CIK 0001752461 · Chief Legal Officer & Corp Sec

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 164,545

F3 · shares: Represents an RSU award. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs will vest in three equal annual installments commencing one year after the grant date, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001576885-25-000013 · wk-form4_1736297739.xml · derivative · entry 3

Barton Russell · CIK 0001867418 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 74,700

Underlying: Common Stock · 74,700 shares

Expires 2035-01-06

F4 · derivative.exercise_date: The shares subject to the option will vest in 48 equal monthly installments such that the option is fully vested on the fourth anniversary of the date of grant, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001576885-25-000013 · wk-form4_1736297739.xml · nonDerivative · entry 2

Barton Russell · CIK 0001867418 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 139,031

F3 · shares: Represents an RSU award. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs will vest in three equal annual installments commencing one year after the grant date, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001576885-25-000011 · wk-form4_1736297601.xml · derivative · entry 3

Zuga Matt · CIK 0001790214 · CFO & Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 100,300

Underlying: Common Stock · 100,300 shares

Expires 2035-01-06

F4 · derivative.exercise_date: The shares subject to the option will vest in 48 equal monthly installments such that the option is fully vested on the fourth anniversary of the date of grant, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001576885-25-000011 · wk-form4_1736297601.xml · nonDerivative · entry 2

Zuga Matt · CIK 0001790214 · CFO & Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 265,010

F3 · shares: Represents an RSU award. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs will vest in three equal annual installments commencing one year after the grant date, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001576885-25-000009 · wk-form4_1736297327.xml · nonDerivative · entry 1

Siemers Eric · CIK 0001866239 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 106,717

F1 · shares: Represents the number of shares sold by the Reporting Person through an automatic "sell to cover" transaction to satisfy tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 3, 2024.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $1.7750 to $1.9100. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001576885-25-000021 · wk-form4_1736298537.xml · nonDerivative · entry 1

OConnell Daniel Joseph · CIK 0001865136 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 454,707

F1 · shares: Represents the number of shares sold by the Reporting Person through an automatic "sell to cover" transaction to satisfy tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 24, 2024.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $1.7772 to $1.9150. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001576885-25-000015 · wk-form4_1736297850.xml · nonDerivative · entry 1

Meisner Derek M · CIK 0001752461 · Chief Legal Officer & Corp Sec

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 97,745

F1 · shares: Represents the number of shares sold by the Reporting Person through an automatic "sell to cover" transaction to satisfy tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 15, 2024.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $1.7750 to $1.9300. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001576885-25-000013 · wk-form4_1736297739.xml · nonDerivative · entry 1

Barton Russell · CIK 0001867418 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 89,231

F1 · shares: Represents the number of shares sold by the Reporting Person through an automatic "sell to cover" transaction to satisfy tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 31, 2024.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $1.7700 to $1.9000. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001576885-25-000011 · wk-form4_1736297601.xml · nonDerivative · entry 1

Zuga Matt · CIK 0001790214 · CFO & Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 198,210

F1 · shares: Represents the number of shares sold by the Reporting Person through an automatic "sell to cover" transaction to satisfy tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 30, 2024.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $1.7700 to $1.9000. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000950170-24-122484 · ownership.xml · derivative · entry 1

Schacterle Amy · CIK 0002042021 · Chief Regulatory Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 340,000

Underlying: Common Stock · 340,000 shares

Expires 2034-11-05

F1 · derivative.exercise_date: Twenty-five percent (25%) of the shares subject to the option shall vest and become exercisable on November 5, 2025, and one thirty-sixth (1/36th) of the remaining shares subject to the option shall vest and become exercisable each month thereafter, subject to Reporting Person continuing to provide service through each such date.

SEC source: 0001576885-24-000077 · wk-form4_1718052104.xml · derivative · entry 1

Fountain Nathan B · CIK 0001869596 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2034-06-09

F1 · derivative.exercise_date: The shares subject to the option will vest on the earlier of June 10, 2025 or the 2025 annual stockholder meeting, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001576885-24-000084 · wk-form4_1718052712.xml · derivative · entry 1

Stoppel Laura · CIK 0001865119 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2034-06-09

F1 · derivative.exercise_date: The shares subject to the option will vest on the earlier of June 10, 2025 or the 2025 annual stockholder meeting, subject to the Reporting Person's continuous service through each such vesting date.

F2 · ownership.direct: Under the Reporting Person's arrangement with RA Capital Management, L.P. (the "Adviser"), the Reporting Person holds the option for the benefit of the R.A. Capital Healthcare Fund, L.P. (the "Fund"), R.A. Capital Nexus Fund II, L.P. (the "Nexus Fund II") and a separately managed account (the "Account"). The Reporting Person is obligated to turn over to the Adviser any net cash or stock received upon exercise of the option, which will offset advisory fees owed by the Fund, Nexus Fund II and the Account to the Adviser. The Reporting Person therefore disclaims beneficial ownership of the option and underlying common stock.

SEC source: 0001576885-24-000080 · wk-form4_1718052386.xml · derivative · entry 1

Porter Derrell · CIK 0001706400 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2034-06-09

F1 · derivative.exercise_date: The shares subject to the option will vest on the earlier of June 10, 2025 or the 2025 annual stockholder meeting, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001415889-24-016256 · form4-06102024_090635.xml · derivative · entry 1

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner

RA Capital Nexus Fund II, L.P. · CIK 0001825376 · Director · 10% owner

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Shah Rajeev M. · CIK 0001619841 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2034-06-09

F1 · derivative.exercise_date: The shares subject to the option will vest on the earlier of June 10, 2025 or the 2025 annual stockholder meeting, subject to Ms. Stoppel's continuous service through each such vesting date.

F2 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund"), RA Capital Nexus Fund II, L.P. (the "Nexus Fund II") and a separately managed account (the "Account"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, the Fund, the Nexus Fund II, Dr. Kolchinsky, and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein.

F3 · ownership.nature: Laura Stoppel is a Principal of the Adviser who serves on the Issuer's board of directors. Under Ms. Stoppel's arrangement with the Adviser, Ms. Stoppel holds the option for the benefit of the Fund and the Nexus Fund II. Ms. Stoppel is obligated to turn over to the Adviser any net cash or stock received upon exercise of the option, which will offset advisory fees owed by the Fund and the Nexus Fund II to the Adviser. The Reporting Persons therefore disclaim beneficial ownership of the option and underlying common stock.

SEC source: 0001576885-24-000075 · wk-form4_1718052003.xml · derivative · entry 1

Drapkin Kimberlee C · CIK 0001340881 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2034-06-09

F1 · derivative.exercise_date: The shares subject to the option will vest on the earlier of June 10, 2025 or the 2025 annual stockholder meeting, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001576885-24-000086 · wk-form4_1718052886.xml · derivative · entry 1

Ives Jeffrey L. · CIK 0001614096 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2034-06-09

F1 · derivative.exercise_date: The shares subject to the option will vest on the earlier of June 10, 2025 or the 2025 annual stockholder meeting, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001576885-24-000082 · wk-form4_1718052537.xml · derivative · entry 1

Stalfort John A III · CIK 0001709418 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2034-06-09

F1 · derivative.exercise_date: The shares subject to the option will vest on the earlier of June 10, 2025 or the 2025 annual stockholder meeting, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001576885-24-000036 · wk-form4_1706824917.xml · derivative · entry 1

Doherty James J. · CIK 0002009718 · President and CDO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 601,000

Underlying: Common Stock · 601,000 shares

Expires 2034-02-01

F1 · derivative.exercise_date: Twenty-five percent (25%) of the shares subject to the option shall vest and become exercisable on February 1, 2025, and one thirty-sixth (1/36th) of the remaining shares subject to the option shall vest and become exercisable each month thereafter, subject to Reporting Person continuing to provide service through each such date.

SEC source: 0001576885-24-000029 · wk-form4_1705709243.xml · nonDerivative · entry 1

OConnell Daniel Joseph · CIK 0001865136 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 502,485

F1 · shares: Represents the number of shares sold by the Reporting Person in connection with the vesting of restricted stock units ("RSUs") pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 9, 2023.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $3.3950 to $3.6500. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001576885-24-000027 · wk-form4_1705709183.xml · nonDerivative · entry 1

Meisner Derek M · CIK 0001752461 · Chief Legal Officer & Corp Sec

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 108,867

F1 · shares: Represents the number of shares sold by the Reporting Person in connection with the vesting of restricted stock units ("RSUs") pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 28, 2023.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $3.4000 to $3.6500. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001576885-24-000025 · wk-form4_1705709102.xml · nonDerivative · entry 1

Siemers Eric · CIK 0001866239 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 117,576

F1 · shares: Represents the number of shares sold by the Reporting Person through an automatic "sell to cover" transaction to satisfy tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 15, 2023.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $3.7103 and $3.7150. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001576885-24-000026 · wk-form4_1705709143.xml · nonDerivative · entry 1

Zuga Matt · CIK 0001790214 · CFO & Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 211,445

F1 · shares: Represents the number of shares sold by the Reporting Person through an automatic "sell to cover" transaction to satisfy tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 13, 2023.

SEC source: 0001576885-24-000024 · wk-form4_1705709048.xml · nonDerivative · entry 1

Barton Russell · CIK 0001867418 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 96,867

F1 · shares: Represents the number of shares sold by the Reporting Person through an automatic "sell to cover" transaction to satisfy tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 14, 2023.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $3.7250 to $3.7300. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001576885-24-000011 · wk-form4_1704403255.xml · derivative · entry 2

Siemers Eric · CIK 0001866239 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 141,000

Underlying: Common Stock · 141,000 shares

Expires 2034-01-01

F2 · derivative.exercise_date: The shares subject to the option will vest in 48 equal monthly installments such that the option is fully vested on the fourth anniversary of the date of grant, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001576885-24-000011 · wk-form4_1704403255.xml · nonDerivative · entry 1

Siemers Eric · CIK 0001866239 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 120,700

F1 · shares: Represents a restricted stock unit ("RSU") award. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs will vest in three equal annual installments commencing one year after the grant date, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001576885-24-000009 · wk-form4_1704403087.xml · derivative · entry 2

OConnell Daniel Joseph · CIK 0001865136 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 602,000

Underlying: Common Stock · 602,000 shares

Expires 2034-01-01

F2 · derivative.exercise_date: The shares subject to the option will vest in 48 equal monthly installments such that the option is fully vested on the fourth anniversary of the date of grant, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001576885-24-000009 · wk-form4_1704403087.xml · nonDerivative · entry 1

OConnell Daniel Joseph · CIK 0001865136 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 517,685

F1 · shares: Represents a restricted stock unit ("RSU") award. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs will vest in three equal annual installments commencing one year after the grant date, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001576885-24-000012 · wk-form4_1704403314.xml · derivative · entry 2

Meisner Derek M · CIK 0001752461 · Chief Legal Officer & Corp Sec

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 137,000

Underlying: Common Stock · 137,000 shares

Expires 2034-01-01

F2 · derivative.exercise_date: The shares subject to the option will vest in 48 equal monthly installments such that the option is fully vested on the fourth anniversary of the date of grant, subject to the Reporting Person's continuous service through each such vesting date.