ABOS

SEC source: 0001628280-26-043987 · wk-form4_1781730613.xml · derivative · entry 7

Porter Derrell · CIK 0001706400 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 13,040 shares

Expires 2035-06-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The shares subject to the option vested in full on the date of the 2026 annual stockholder meeting.

SEC source: 0001628280-26-043987 · wk-form4_1781730613.xml · nonDerivative · entry 5

Porter Derrell · CIK 0001706400 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,500

SEC source: 0001628280-26-043987 · wk-form4_1781730613.xml · nonDerivative · entry 4

Porter Derrell · CIK 0001706400 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,540

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-26-043987 · wk-form4_1781730613.xml · nonDerivative · entry 3

Porter Derrell · CIK 0001706400 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,500

F1 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $2.305 to $2.345. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001628280-26-043987 · wk-form4_1781730613.xml · derivative · entry 6

Porter Derrell · CIK 0001706400 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,040

Underlying: Common Stock · 6,460 shares

Expires 2035-06-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The shares subject to the option vested in full on the date of the 2026 annual stockholder meeting.

SEC source: 0001628280-26-043987 · wk-form4_1781730613.xml · nonDerivative · entry 2

Porter Derrell · CIK 0001706400 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,300

SEC source: 0001628280-26-043987 · wk-form4_1781730613.xml · nonDerivative · entry 1

Porter Derrell · CIK 0001706400 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 54,760

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-26-042280 · wk-form4_1781124671.xml · nonDerivative · entry 1

Fountain Nathan B · CIK 0001869596 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,150

F1 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $2.2300 to $2.2311. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001628280-26-041281 · wk-form4_1780691540.xml · derivative · entry 2

Fountain Nathan B · CIK 0001869596 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,250

Underlying: Common Stock · 53,250 shares

Expires 2036-06-03

F2 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of the first anniversary of the date of grant or the 2027 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0001628280-26-041281 · wk-form4_1780691540.xml · nonDerivative · entry 1

Fountain Nathan B · CIK 0001869596 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 54,550

F1 · shares: Represents a restricted stock unit ("RSU") award. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs will vest in full on the earlier of the first anniversary of the date of grant or the 2027 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0001628280-26-041263 · wk-form4_1780691244.xml · derivative · entry 2

Stoppel Laura · CIK 0001865119 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,250

Underlying: Common Stock · 53,250 shares

Expires 2036-06-03

F3 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of the first anniversary of the date of grant or the 2027 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date.

F2 · ownership.direct: Under the Reporting Person's arrangement with RA Capital Management, L.P. (the "Adviser"), the Reporting Person holds the option and RSUs for the benefit of the RA Capital Healthcare Fund, L.P. (the "Fund"), RA Capital Nexus Fund II, L.P. (the "Nexus Fund II") and a separately managed account (the "Account"). The Reporting Person is obligated to turn over to the Adviser any net cash or stock received upon exercise of the option or settlement of the RSUs, as applicable, which will offset advisory fees owed by the Fund, the Nexus Fund II and the Account to the Adviser. The Reporting Person therefore disclaims beneficial ownership of the option and RSUs and underlying common stock.

SEC source: 0001628280-26-041263 · wk-form4_1780691244.xml · nonDerivative · entry 1

Stoppel Laura · CIK 0001865119 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,300

F1 · shares: Represents a restricted stock unit ("RSU") award. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs will vest in full on the earlier of the first anniversary of the date of grant or the 2027 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date.

F2 · ownership.direct: Under the Reporting Person's arrangement with RA Capital Management, L.P. (the "Adviser"), the Reporting Person holds the option and RSUs for the benefit of the RA Capital Healthcare Fund, L.P. (the "Fund"), RA Capital Nexus Fund II, L.P. (the "Nexus Fund II") and a separately managed account (the "Account"). The Reporting Person is obligated to turn over to the Adviser any net cash or stock received upon exercise of the option or settlement of the RSUs, as applicable, which will offset advisory fees owed by the Fund, the Nexus Fund II and the Account to the Adviser. The Reporting Person therefore disclaims beneficial ownership of the option and RSUs and underlying common stock.

SEC source: 0001628280-26-041272 · wk-form4_1780691403.xml · derivative · entry 2

Porter Derrell · CIK 0001706400 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,250

Underlying: Common Stock · 53,250 shares

Expires 2036-06-03

F2 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of the first anniversary of the date of grant or the 2027 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0001628280-26-041272 · wk-form4_1780691403.xml · nonDerivative · entry 1

Porter Derrell · CIK 0001706400 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,300

F1 · shares: Represents a restricted stock unit ("RSU") award. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs will vest in full on the earlier of the first anniversary of the date of grant or the 2027 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0001231919-26-000604 · form4-06052026_090630.xml · derivative · entry 5

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner

RA Capital Nexus Fund II, L.P. · CIK 0001825376 · Director

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Shah Rajeev M. · CIK 0001619841 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 53,250

Underlying: Common Stock · 53,250 shares

Expires 2036-06-03

F7 · derivative.exercise_date: Represents the award of an option to Dr. Stoppel. The shares subject to the option will vest in full on the earlier of the first anniversary of the date of grant or the 2027 annual stockholder meeting, subject to Dr. Stoppel's continuous service through such vesting date.

F2 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund"), RA Capital Nexus Fund II, L.P. (the "Nexus Fund II") and a separately managed account (the "Account"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. Each of the Adviser, the Adviser GP, the Fund, the Nexus Fund II, Dr. Kolchinsky, and Mr. Shah disclaims beneficial ownership of any of the reported securities, except to the extent of its or his respective pecuniary interest therein.

F3 · ownership.nature: Under Dr. Stoppel's arrangement with the Adviser, Dr. Stoppel holds the RSUs and the option for the benefit of the Fund, the Nexus Fund II and the Account. Dr. Stoppel is obligated to turn over to the Adviser any net cash or stock received upon exercise of the option or settlement of the RSUs, as applicable, which will offset advisory fees owed by the Fund, the Nexus Fund II and the Account to the Adviser. The Reporting Persons therefore disclaim beneficial ownership of the RSUs, the option and the underlying common stock.

SEC source: 0001231919-26-000604 · form4-06052026_090630.xml · nonDerivative · entry 1

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner

RA Capital Nexus Fund II, L.P. · CIK 0001825376 · Director

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Shah Rajeev M. · CIK 0001619841 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 48,300

F1 · shares: Represents a restricted stock unit ("RSU") award to Laura Stoppel. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs will vest in full on the earlier of the first anniversary of the date of grant or the 2027 annual stockholder meeting, subject to Dr. Stoppel's continuous service through such vesting date.

F2 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund"), RA Capital Nexus Fund II, L.P. (the "Nexus Fund II") and a separately managed account (the "Account"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. Each of the Adviser, the Adviser GP, the Fund, the Nexus Fund II, Dr. Kolchinsky, and Mr. Shah disclaims beneficial ownership of any of the reported securities, except to the extent of its or his respective pecuniary interest therein.

F3 · ownership.nature: Under Dr. Stoppel's arrangement with the Adviser, Dr. Stoppel holds the RSUs and the option for the benefit of the Fund, the Nexus Fund II and the Account. Dr. Stoppel is obligated to turn over to the Adviser any net cash or stock received upon exercise of the option or settlement of the RSUs, as applicable, which will offset advisory fees owed by the Fund, the Nexus Fund II and the Account to the Adviser. The Reporting Persons therefore disclaim beneficial ownership of the RSUs, the option and the underlying common stock.

SEC source: 0001628280-26-041276 · wk-form4_1780691492.xml · derivative · entry 2

Drapkin Kimberlee C · CIK 0001340881 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,250

Underlying: Common Stock · 53,250 shares

Expires 2036-06-03

F2 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of the first anniversary of the date of grant or the 2027 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0001628280-26-041276 · wk-form4_1780691492.xml · nonDerivative · entry 1

Drapkin Kimberlee C · CIK 0001340881 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,300

F1 · shares: Represents a restricted stock unit ("RSU") award. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs will vest in full on the earlier of the first anniversary of the date of grant or the 2027 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0001628280-26-041273 · wk-form4_1780691449.xml · derivative · entry 2

Stalfort John A III · CIK 0001709418 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,250

Underlying: Common Stock · 53,250 shares

Expires 2036-06-03

F2 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of the first anniversary of the date of grant or the 2027 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0001628280-26-041273 · wk-form4_1780691449.xml · nonDerivative · entry 1

Stalfort John A III · CIK 0001709418 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 220,624

F1 · shares: Represents a restricted stock unit ("RSU") award. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs will vest in full on the earlier of the first anniversary of the date of grant or the 2027 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0001628280-26-041270 · wk-form4_1780691363.xml · derivative · entry 2

Ives Jeffrey L. · CIK 0001614096 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,250

Underlying: Common Stock · 53,250 shares

Expires 2036-06-03

F2 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of the first anniversary of the date of grant or the 2027 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0001628280-26-041270 · wk-form4_1780691363.xml · nonDerivative · entry 1

Ives Jeffrey L. · CIK 0001614096 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,300

F1 · shares: Represents a restricted stock unit ("RSU") award. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs will vest in full on the earlier of the first anniversary of the date of grant or the 2027 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0001628280-26-041268 · wk-form4_1780691316.xml · derivative · entry 2

Golumbeski George · CIK 0001586660 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,250

Underlying: Common Stock · 53,250 shares

Expires 2036-06-03

F2 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of the first anniversary of the date of grant or the 2027 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0001628280-26-041268 · wk-form4_1780691316.xml · nonDerivative · entry 1

Golumbeski George · CIK 0001586660 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,500

F1 · shares: Represents a restricted stock unit ("RSU") award. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs will vest in full on the earlier of the first anniversary of the date of grant or the 2027 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0001231919-26-000262 · form4-03182026_040301.xml · nonDerivative · entry 1

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner

RA Capital Nexus Fund II, L.P. · CIK 0001825376 · Director

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Shah Rajeev M. · CIK 0001619841 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 19,103,785

F1 · ownership.nature: Held directly by RA Capital Healthcare Fund, L.P. (the "Fund").

F2 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for the Fund, RA Capital Nexus Fund II, L.P. (the "Nexus Fund II") and a separately managed account (the "Account"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. Each of the Adviser, the Adviser GP, the Fund, the Nexus Fund II, Dr. Kolchinsky, and Mr. Shah disclaims beneficial ownership of any of the reported securities, except to the extent of its or his respective pecuniary interest therein.

SEC source: 0001628280-26-016645 · wk-form4_1773193523.xml · derivative · entry 3

Meisner Derek M · CIK 0001752461 · Chief Legal Officer & Corp Sec

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 71,048

Underlying: Common Stock · 2,090 shares

Expires 2035-01-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The shares subject to the option will vest in 48 equal monthly installments such that the option is fully vested on the fourth anniversary of the date of grant, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001628280-26-016645 · wk-form4_1773193523.xml · nonDerivative · entry 2

Meisner Derek M · CIK 0001752461 · Chief Legal Officer & Corp Sec

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 173,999

F1 · kind: The reported sales occurred automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 29, 2025.

SEC source: 0001628280-26-016645 · wk-form4_1773193523.xml · nonDerivative · entry 1

Meisner Derek M · CIK 0001752461 · Chief Legal Officer & Corp Sec

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 176,089

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-26-014365 · wk-form4_1772592146.xml · derivative · entry 3

Meisner Derek M · CIK 0001752461 · Chief Legal Officer & Corp Sec

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 73,138

Underlying: Common Stock · 9,406 shares

Expires 2035-01-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The shares subject to the employee stock option vest in 48 equal monthly installments starting on the date the option was granted, such that the option will be fully vested on the fourth anniversary of the date of grant, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001628280-26-014365 · wk-form4_1772592146.xml · nonDerivative · entry 2

Meisner Derek M · CIK 0001752461 · Chief Legal Officer & Corp Sec

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 173,999

F1 · kind: The reported sales occurred automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 29, 2025.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $3.0000 to $3.0300. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001628280-26-014365 · wk-form4_1772592146.xml · nonDerivative · entry 1

Meisner Derek M · CIK 0001752461 · Chief Legal Officer & Corp Sec

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 183,405

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-26-003948 · wk-form4_1769647801.xml · derivative · entry 6

Meisner Derek M · CIK 0001752461 · Chief Legal Officer & Corp Sec

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 82,544

Underlying: Common Stock · 2,671 shares

Expires 2035-01-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The shares subject to the employee stock option vest in 48 equal monthly installments starting on the date the option was granted, such that the option will be fully vested on the fourth anniversary of the date of grant, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001628280-26-003948 · wk-form4_1769647801.xml · nonDerivative · entry 4

Meisner Derek M · CIK 0001752461 · Chief Legal Officer & Corp Sec

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 173,999

F1 · kind: The reported sales occurred automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 29, 2025.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $3.0000 to $3.0100. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001628280-26-003948 · wk-form4_1769647801.xml · nonDerivative · entry 3

Meisner Derek M · CIK 0001752461 · Chief Legal Officer & Corp Sec

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 176,670

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-26-003948 · wk-form4_1769647801.xml · derivative · entry 5

Meisner Derek M · CIK 0001752461 · Chief Legal Officer & Corp Sec

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 85,215

Underlying: Common Stock · 15,085 shares

Expires 2035-01-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The shares subject to the employee stock option vest in 48 equal monthly installments starting on the date the option was granted, such that the option will be fully vested on the fourth anniversary of the date of grant, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001628280-26-003948 · wk-form4_1769647801.xml · nonDerivative · entry 2

Meisner Derek M · CIK 0001752461 · Chief Legal Officer & Corp Sec

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 173,999

F1 · kind: The reported sales occurred automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 29, 2025.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $3.0000 to $3.0100. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001628280-26-003948 · wk-form4_1769647801.xml · nonDerivative · entry 1

Meisner Derek M · CIK 0001752461 · Chief Legal Officer & Corp Sec

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 189,084

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-26-003349 · wk-form4_1769209972.xml · nonDerivative · entry 3

Meisner Derek M · CIK 0001752461 · Chief Legal Officer & Corp Sec

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 173,999

F3 · shares: Represents the number of shares sold by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 29, 2025.

F4 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $1.8800 to $1.9400. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001628280-26-003348 · wk-form4_1769209918.xml · nonDerivative · entry 2

Siemers Eric · CIK 0001866239 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 255,371

F1 · shares: Represents the number of shares sold by the Reporting Person through an automatic "sell to cover" transaction to satisfy tax withholding obligations in connection with the vesting of restricted stock units pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 3, 2024.

SEC source: 0001628280-26-003346 · wk-form4_1769209845.xml · nonDerivative · entry 2

OConnell Daniel Joseph · CIK 0001865136 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 881,275

F1 · shares: Represents the number of shares sold by the Reporting Person through an automatic "sell to cover" transaction to satisfy tax withholding obligations in connection with the vesting of restricted stock units pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 24, 2024.

F3 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $1.8700 to $1.9000. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001628280-26-003349 · wk-form4_1769209972.xml · nonDerivative · entry 2

Meisner Derek M · CIK 0001752461 · Chief Legal Officer & Corp Sec

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 179,632

F1 · shares: Represents the number of shares sold by the Reporting Person through an automatic "sell to cover" transaction to satisfy tax withholding obligations in connection with the vesting of restricted stock units pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 15, 2024.

SEC source: 0001628280-26-003347 · wk-form4_1769209883.xml · nonDerivative · entry 2

Zuga Matt · CIK 0001790214 · CFO & Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 304,924

F1 · shares: Represents the number of shares sold by the Reporting Person through an automatic "sell to cover" transaction to satisfy tax withholding obligations in connection with the vesting of restricted stock units pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 30, 2024.

SEC source: 0001628280-26-003344 · wk-form4_1769209803.xml · nonDerivative · entry 2

Barton Russell · CIK 0001867418 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 205,092

F1 · shares: Represents the number of shares sold by the Reporting Person through an automatic "sell to cover" transaction to satisfy tax withholding obligations in connection with the vesting of restricted stock units pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 30, 2024.

SEC source: 0001628280-26-003348 · wk-form4_1769209918.xml · nonDerivative · entry 1

Siemers Eric · CIK 0001866239 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 256,266

F1 · shares: Represents the number of shares sold by the Reporting Person through an automatic "sell to cover" transaction to satisfy tax withholding obligations in connection with the vesting of restricted stock units pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 3, 2024.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $1.7600 to $1.8700. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001628280-26-003346 · wk-form4_1769209845.xml · nonDerivative · entry 1

OConnell Daniel Joseph · CIK 0001865136 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 883,964

F1 · shares: Represents the number of shares sold by the Reporting Person through an automatic "sell to cover" transaction to satisfy tax withholding obligations in connection with the vesting of restricted stock units pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 24, 2024.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $1.7600 to $1.8800. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001628280-26-003349 · wk-form4_1769209972.xml · nonDerivative · entry 1

Meisner Derek M · CIK 0001752461 · Chief Legal Officer & Corp Sec

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 180,686

F1 · shares: Represents the number of shares sold by the Reporting Person through an automatic "sell to cover" transaction to satisfy tax withholding obligations in connection with the vesting of restricted stock units pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 15, 2024.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $1.7600 to $1.8700. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001628280-26-003347 · wk-form4_1769209883.xml · nonDerivative · entry 1

Zuga Matt · CIK 0001790214 · CFO & Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 306,611

F1 · shares: Represents the number of shares sold by the Reporting Person through an automatic "sell to cover" transaction to satisfy tax withholding obligations in connection with the vesting of restricted stock units pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 30, 2024.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $1.7650 to $1.8700. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001628280-26-003344 · wk-form4_1769209803.xml · nonDerivative · entry 1

Barton Russell · CIK 0001867418 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 205,554

F1 · shares: Represents the number of shares sold by the Reporting Person through an automatic "sell to cover" transaction to satisfy tax withholding obligations in connection with the vesting of restricted stock units pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 30, 2024.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $1.7600 to $1.8700. Upon request, the Reporting Person will provide to the staff of the Securities and Exchange Commission, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001628280-26-002962 · wk-form4_1769038356.xml · derivative · entry 2

OConnell Daniel Joseph · CIK 0001865136 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 450,000

Underlying: Common Stock · 450,000 shares

Expires 2036-01-20

F2 · derivative.exercise_date: The shares subject to the option will vest in 48 equal monthly installments such that the option is fully vested on the fourth anniversary of the date of grant, subject to the Reporting Person's continuous service through each such vesting date.

SEC source: 0001628280-26-002962 · wk-form4_1769038356.xml · nonDerivative · entry 1

OConnell Daniel Joseph · CIK 0001865136 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 893,310

F1 · shares: Represents a restricted stock unit ("RSU") award. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs will vest in three equal annual installments commencing one year after the grant date, subject to the Reporting Person's continuous service through each such vesting date.